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Items: 1 to 50 of 220

1.

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function.

Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R.

Diabetes. 2019 Sep;68(9):1806-1818. doi: 10.2337/db19-0349. Epub 2019 Jun 14.

PMID:
31201281
2.

Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis.

Wen HJ, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC.

Cell Mol Gastroenterol Hepatol. 2019;8(2):173-192. doi: 10.1016/j.jcmgh.2019.05.006. Epub 2019 May 21.

3.

Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences.

Stancill JS, Osipovich AB, Cartailler JP, Magnuson MA.

Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E196-E209. doi: 10.1152/ajpendo.00229.2018. Epub 2018 Dec 11.

PMID:
30532991
4.

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells.

Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL.

Nat Cell Biol. 2018 Nov;20(11):1267-1277. doi: 10.1038/s41556-018-0216-y. Epub 2018 Oct 22.

5.

ROCK-nmMyoII, Notch and Neurog3 gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche.

Bankaitis ED, Bechard ME, Gu G, Magnuson MA, Wright CVE.

Development. 2018 Sep 21;145(18). pii: dev162115. doi: 10.1242/dev.162115.

6.

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain.

Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima YI, Yanagisawa M, Funato H, Hoshino M.

Cell Rep. 2018 Jul 3;24(1):79-94. doi: 10.1016/j.celrep.2018.06.010.

7.

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles.

Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ Jr, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G.

Dev Cell. 2018 May 7;45(3):347-361.e5. doi: 10.1016/j.devcel.2018.03.013. Epub 2018 Apr 12.

8.

Cytosolic phosphoenolpyruvate carboxykinase as a cataplerotic pathway in the small intestine.

Potts A, Uchida A, Deja S, Berglund ED, Kucejova B, Duarte JA, Fu X, Browning JD, Magnuson MA, Burgess SC.

Am J Physiol Gastrointest Liver Physiol. 2018 Aug 1;315(2):G249-G258. doi: 10.1152/ajpgi.00039.2018. Epub 2018 Apr 6.

9.

Alpha to Beta Cell Reprogramming: Stepping toward a New Treatment for Diabetes.

Osipovich AB, Magnuson MA.

Cell Stem Cell. 2018 Jan 4;22(1):12-13. doi: 10.1016/j.stem.2017.12.012.

10.

FUCCI tracking shows cell-cycle-dependent Neurog3 variation in pancreatic progenitors.

Bechard ME, Bankaitis ED, Ustione A, Piston DW, Magnuson MA, Wright CVE.

Genesis. 2017 Sep;55(9). doi: 10.1002/dvg.23050.

11.

Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning.

Spaeth JM, Gupte M, Perelis M, Yang YP, Cyphert H, Guo S, Liu JH, Guo M, Bass J, Magnuson MA, Wright C, Stein R.

Diabetes. 2017 Nov;66(11):2830-2839. doi: 10.2337/db16-1516. Epub 2017 Jul 13.

12.

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes.

Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA.

Diabetes. 2017 Aug;66(8):2175-2187. doi: 10.2337/db16-1355. Epub 2017 May 26.

13.

Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.

Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E.

Cell Death Differ. 2017 Apr;24(4):731-746. doi: 10.1038/cdd.2017.8. Epub 2017 Feb 17.

14.

The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation.

Yang YP, Magnuson MA, Stein R, Wright CV.

Development. 2017 Jan 15;144(2):248-257. doi: 10.1242/dev.143123. Epub 2016 Dec 19.

15.

Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation.

Osipovich AB, Gangula R, Vianna PG, Magnuson MA.

Development. 2016 Dec 15;143(24):4595-4607. Epub 2016 Nov 18.

16.

Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming.

Clayton HW, Osipovich AB, Stancill JS, Schneider JD, Vianna PG, Shanks CM, Yuan W, Gu G, Manduchi E, Stoeckert CJ Jr, Magnuson MA.

Cell Rep. 2016 Nov 15;17(8):2028-2041. doi: 10.1016/j.celrep.2016.10.068.

17.

Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.

Hoang CQ, Hale MA, Azevedo-Pouly AC, Elsässer HP, Deering TG, Willet SG, Pan FC, Magnuson MA, Wright CV, Swift GH, MacDonald RJ.

Mol Cell Biol. 2016 Nov 28;36(24):3033-3047. Print 2016 Dec 15.

18.

Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells.

Bechard ME, Bankaitis ED, Hipkens SB, Ustione A, Piston DW, Yang YP, Magnuson MA, Wright CV.

Genes Dev. 2016 Aug 15;30(16):1852-65. doi: 10.1101/gad.284729.116. Epub 2016 Sep 1.

19.

BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction.

Sanders LN, Schoenhard JA, Saleh MA, Mukherjee A, Ryzhov S, McMaster WG Jr, Nolan K, Gumina RJ, Thompson TB, Magnuson MA, Harrison DG, Hatzopoulos AK.

Circ Res. 2016 Jul 22;119(3):434-49. doi: 10.1161/CIRCRESAHA.116.308700. Epub 2016 Jun 9.

20.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC.

J Clin Invest. 2016 Apr 1;126(4):1605. doi: 10.1172/JCI86695. Epub 2016 Apr 1. No abstract available.

21.

p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.

Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I.

Nat Med. 2016 Apr;22(4):412-20. doi: 10.1038/nm.4054. Epub 2016 Mar 7.

22.

p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network.

Marshall CB, Mays DJ, Beeler JS, Rosenbluth JM, Boyd KL, Santos Guasch GL, Shaver TM, Tang LJ, Liu Q, Shyr Y, Venters BJ, Magnuson MA, Pietenpol JA.

Cell Rep. 2016 Mar 15;14(10):2289-300. doi: 10.1016/j.celrep.2016.02.035. Epub 2016 Mar 3.

23.

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC.

J Clin Invest. 2015 Dec;125(12):4447-62. doi: 10.1172/JCI82204. Epub 2015 Nov 16. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1605. Livingston, Kenneth [corrected to Livingston, Kenneth A].

24.

Insm1 promotes neurogenic proliferation in delaminated otic progenitors.

Lorenzen SM, Duggan A, Osipovich AB, Magnuson MA, García-Añoveros J.

Mech Dev. 2015 Nov;138 Pt 3:233-45. doi: 10.1016/j.mod.2015.11.001. Epub 2015 Nov 3.

25.

A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells.

Shih HP, Seymour PA, Patel NA, Xie R, Wang A, Liu PP, Yeo GW, Magnuson MA, Sander M.

Cell Rep. 2015 Oct 13;13(2):326-36. doi: 10.1016/j.celrep.2015.08.082. Epub 2015 Oct 1.

26.

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion.

Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M.

Diabetes. 2015 Nov;64(11):3829-38. doi: 10.2337/db15-0465. Epub 2015 Aug 6.

27.

mTORC2 regulates cardiac response to stress by inhibiting MST1.

Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H, Sadoshima J.

Cell Rep. 2015 Apr 7;11(1):125-36. doi: 10.1016/j.celrep.2015.03.010. Epub 2015 Apr 2.

28.

Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.

Brouwers B, de Faudeur G, Osipovich AB, Goyvaerts L, Lemaire K, Boesmans L, Cauwelier EJ, Granvik M, Pruniau VP, Van Lommel L, Van Schoors J, Stancill JS, Smolders I, Goffin V, Binart N, in't Veld P, Declercq J, Magnuson MA, Creemers JW, Schuit F, Schraenen A.

Cell Metab. 2014 Dec 2;20(6):979-90. doi: 10.1016/j.cmet.2014.11.004.

29.

Dominant and context-specific control of endodermal organ allocation by Ptf1a.

Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV.

Development. 2014 Nov;141(22):4385-94. doi: 10.1242/dev.114165.

30.

Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3.

Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ Jr, Takada S, Magnuson MA.

Development. 2014 Aug;141(15):2939-49. doi: 10.1242/dev.104810.

31.

Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.

Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson MA, Wright CV, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M.

Nat Commun. 2014;5:3337. doi: 10.1038/ncomms4337.

32.

Cytokine-driven beta-cell production in vivo.

Worchel HN, Magnuson MA.

Nat Biotechnol. 2014 Jan;32(1):63-4. doi: 10.1038/nbt.2788. No abstract available.

PMID:
24406931
33.

Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in β cells.

Tornovsky-Babeay S, Dadon D, Ziv O, Tzipilevich E, Kadosh T, Schyr-Ben Haroush R, Hija A, Stolovich-Rain M, Furth-Lavi J, Granot Z, Porat S, Philipson LH, Herold KC, Bhatti TR, Stanley C, Ashcroft FM, In't Veld P, Saada A, Magnuson MA, Glaser B, Dor Y.

Cell Metab. 2014 Jan 7;19(1):109-21. doi: 10.1016/j.cmet.2013.11.007. Epub 2013 Dec 12.

34.

Nkx2.2:Cre knock-in mouse line: a novel tool for pancreas- and CNS-specific gene deletion.

Balderes DA, Magnuson MA, Sussel L.

Genesis. 2013 Dec;51(12):844-51. doi: 10.1002/dvg.22715. Epub 2013 Oct 1.

35.

Pancreas-specific Cre driver lines and considerations for their prudent use.

Magnuson MA, Osipovich AB.

Cell Metab. 2013 Jul 2;18(1):9-20. doi: 10.1016/j.cmet.2013.06.011. Review.

36.

The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation.

Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A.

EMBO J. 2013 May 15;32(10):1393-408. doi: 10.1038/emboj.2013.78. Epub 2013 Apr 12.

37.

Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.

Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M.

Stem Cell Res. 2013 Jul;11(1):503-15. doi: 10.1016/j.scr.2013.02.005. Epub 2013 Feb 18.

38.

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.

Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M.

PLoS Genet. 2013;9(1):e1003274. doi: 10.1371/journal.pgen.1003274. Epub 2013 Jan 31.

39.

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration.

Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV.

Development. 2013 Feb;140(4):751-64. doi: 10.1242/dev.090159. Epub 2013 Jan 16.

40.

Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population.

Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L.

PLoS One. 2012;7(12):e52026. doi: 10.1371/journal.pone.0052026. Epub 2012 Dec 12.

41.

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice.

Serup P, Gustavsen C, Klein T, Potter LA, Lin R, Mullapudi N, Wandzioch E, Hines A, Davis A, Bruun C, Engberg N, Petersen DR, Peterslund JM, Macdonald RJ, Grapin-Botton A, Magnuson MA, Zaret KS.

Dis Model Mech. 2012 Nov;5(6):956-66. doi: 10.1242/dmm.009696. Epub 2012 Aug 10.

42.

Dual lineage-specific expression of Sox17 during mouse embryogenesis.

Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ Jr, Grapin-Botton A, Magnuson MA.

Stem Cells. 2012 Oct;30(10):2297-308. doi: 10.1002/stem.1192.

43.

Research resource: dkCOIN, the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) consortium interconnectivity network: a pilot program to aggregate research resources generated by multiple research consortia.

McKenna NJ, Howard CL, Aufiero M, Easton-Marks J, Steffen DL, Becnel LB, Magnuson MA, McIndoe RA, Cartailler JP.

Mol Endocrinol. 2012 Oct;26(10):1675-81. Epub 2012 Jun 25.

44.

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells.

Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K.

J Biol Chem. 2012 Jun 29;287(27):23236-45. doi: 10.1074/jbc.M112.368779. Epub 2012 May 15.

45.

Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology.

Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L.

Genesis. 2012 Aug;50(8):612-24. doi: 10.1002/dvg.22037. Epub 2012 May 19.

46.

Mind bomb 1 is required for pancreatic β-cell formation.

Horn S, Kobberup S, Jørgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Rønne J, Jensen JN.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61. doi: 10.1073/pnas.1203605109. Epub 2012 Apr 23.

47.

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas.

Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC.

Dev Biol. 2012 Feb 1;362(1):57-64. doi: 10.1016/j.ydbio.2011.11.010. Epub 2011 Nov 29.

48.

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L.

Genes Dev. 2011 Nov 1;25(21):2291-305. doi: 10.1101/gad.173039.111.

49.

Engineering artificial signaling centers to polarize embryoid body differentiation.

Petersen DR, Gustavsen C, Lindskog SR, Magnuson MA, Zaret KS, Serup P.

Stem Cells Dev. 2012 Mar 1;21(4):647-53. doi: 10.1089/scd.2011.0344. Epub 2011 Sep 29.

50.

Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy.

Plank JL, Frist AY, LeGrone AW, Magnuson MA, Labosky PA.

Endocrinology. 2011 Dec;152(12):4589-600. doi: 10.1210/en.2010-1462. Epub 2011 Sep 27.

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