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Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection.

Ferguson SH, Foster DM, Sherry B, Magness ST, Nielsen DM, Gookin JL.

Cell Mol Gastroenterol Hepatol. 2019;8(1):1-20. doi: 10.1016/j.jcmgh.2019.02.007. Epub 2019 Mar 5.


Preservation of reserve intestinal epithelial stem cells following severe ischemic injury.

Gonzalez LM, Stewart AS, Freund J, Kucera CR, Dekaney CM, Magness ST, Blikslager AT.

Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G482-G494. doi: 10.1152/ajpgi.00262.2018. Epub 2019 Feb 4.


IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model.

Zwarycz B, Gracz AD, Rivera KR, Williamson IA, Samsa LA, Starmer J, Daniele MA, Salter-Cid L, Zhao Q, Magness ST.

Cell Mol Gastroenterol Hepatol. 2018 Jul 4;7(1):1-17. doi: 10.1016/j.jcmgh.2018.06.008. eCollection 2019.


A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies.

Gunasekara DB, Speer J, Wang Y, Nguyen DL, Reed MI, Smiddy NM, Parker JS, Fallon JK, Smith PC, Sims CE, Magness ST, Allbritton NL.

Anal Chem. 2018 Nov 20;90(22):13331-13340. doi: 10.1021/acs.analchem.8b02845. Epub 2018 Oct 30.


Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity.

Jin Y, Ibrahim D, Magness ST, Blikslager AT.

Am J Physiol Gastrointest Liver Physiol. 2018 Dec 1;315(6):G966-G979. doi: 10.1152/ajpgi.00087.2018. Epub 2018 Oct 4.


Quantitative Analysis of Intestinal Stem Cell Dynamics Using Microfabricated Cell Culture Arrays.

Samsa LA, Williamson IA, Magness ST.

Methods Mol Biol. 2018;1842:139-166. doi: 10.1007/978-1-4939-8697-2_10.


A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology.

Williamson IA, Arnold JW, Samsa LA, Gaynor L, DiSalvo M, Cocchiaro JL, Carroll I, Azcarate-Peril MA, Rawls JF, Allbritton NL, Magness ST.

Cell Mol Gastroenterol Hepatol. 2018 May 22;6(3):301-319. doi: 10.1016/j.jcmgh.2018.05.004. eCollection 2018.


Reserve Stem Cells in Intestinal Homeostasis and Injury.

Bankaitis ED, Ha A, Kuo CJ, Magness ST.

Gastroenterology. 2018 Nov;155(5):1348-1361. doi: 10.1053/j.gastro.2018.08.016. Epub 2018 Aug 15. Review.


Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems.

Rivera KR, Pozdin VA, Young AT, Erb PD, Wisniewski NA, Magness ST, Daniele M.

Biosens Bioelectron. 2019 Jan 1;123:131-140. doi: 10.1016/j.bios.2018.07.035. Epub 2018 Jul 21.


Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates.

Gracz AD, Samsa LA, Fordham MJ, Trotier DC, Zwarycz B, Lo YH, Bao K, Starmer J, Raab JR, Shroyer NF, Reinhardt RL, Magness ST.

Gastroenterology. 2018 Nov;155(5):1508-1523.e10. doi: 10.1053/j.gastro.2018.07.023. Epub 2018 Jul 25.


Organoid Cultures for Assessing Intestinal Epithelial Differentiation and Function in Response to Type-2 Inflammation.

Zwarycz B, Gracz AD, Magness ST.

Methods Mol Biol. 2018;1799:397-417. doi: 10.1007/978-1-4939-7896-0_29.


Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations.

Smith NR, Swain JR, Davies PS, Gallagher AC, Parappilly MS, Beach CZ, Streeter PR, Williamson IA, Magness ST, Wong MH.

Cell Mol Gastroenterol Hepatol. 2018 Mar 10;6(1):79-96. doi: 10.1016/j.jcmgh.2018.02.007. eCollection 2018.


Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer.

Wang Y, Kim R, Gunasekara DB, Reed MI, DiSalvo M, Nguyen DL, Bultman SJ, Sims CE, Magness ST, Allbritton NL.

Cell Mol Gastroenterol Hepatol. 2017 Nov 3;5(2):113-130. doi: 10.1016/j.jcmgh.2017.10.007. eCollection 2018.


Bioengineered Systems and Designer Matrices That Recapitulate the Intestinal Stem Cell Niche.

Wang Y, Kim R, Hinman SS, Zwarycz B, Magness ST, Allbritton NL.

Cell Mol Gastroenterol Hepatol. 2018 Jan 17;5(3):440-453.e1. doi: 10.1016/j.jcmgh.2018.01.008. eCollection 2018 Mar. Review.


Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine.

Strubberg AM, Liu J, Walker NM, Stefanski CD, MacLeod RJ, Magness ST, Clarke LL.

Cell Mol Gastroenterol Hepatol. 2017 Dec 7;5(3):253-271. doi: 10.1016/j.jcmgh.2017.11.013. eCollection 2018 Mar.


Development of Arrayed Colonic Organoids for Screening of Secretagogues Associated with Enterotoxins.

Gunasekara DB, DiSalvo M, Wang Y, Nguyen DL, Reed MI, Speer J, Sims CE, Magness ST, Allbritton NL.

Anal Chem. 2018 Feb 6;90(3):1941-1950. doi: 10.1021/acs.analchem.7b04032. Epub 2018 Jan 12.


Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells.

Wang Y, DiSalvo M, Gunasekara DB, Dutton J, Proctor A, Lebhar MS, Williamson IA, Speer J, Howard RL, Smiddy NM, Bultman SJ, Sims CE, Magness ST, Allbritton NL.

Cell Mol Gastroenterol Hepatol. 2017 Mar 6;4(1):165-182.e7. doi: 10.1016/j.jcmgh.2017.02.011. eCollection 2017 Jul.


Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells.

Bhatt AP, Gunasekara DB, Speer J, Reed MI, Peña AN, Midkiff BR, Magness ST, Bultman SJ, Allbritton NL, Redinbo MR.

ACS Infect Dis. 2018 Jan 12;4(1):46-52. doi: 10.1021/acsinfecdis.7b00139. Epub 2017 Nov 10.


In Vitro Generation of Mouse Colon Crypts.

Wang Y, Gunasekara DB, Attayek PJ, Reed MI, DiSalvo M, Nguyen DL, Dutton JS, Lebhar MS, Bultman SJ, Sims CE, Magness ST, Allbritton NL.

ACS Biomater Sci Eng. 2017 Oct 9;3(10):2502-2513. doi: 10.1021/acsbiomaterials.7b00368. Epub 2017 Aug 29.


A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium.

Wang Y, Gunasekara DB, Reed MI, DiSalvo M, Bultman SJ, Sims CE, Magness ST, Allbritton NL.

Biomaterials. 2017 Jun;128:44-55. doi: 10.1016/j.biomaterials.2017.03.005. Epub 2017 Mar 6.


Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.

Kechele DO, Blue RE, Zwarycz B, Espenschied ST, Mah AT, Siegel MB, Perou CM, Ding S, Magness ST, Lund PK, Caron KM.

J Clin Invest. 2017 Feb 1;127(2):593-607. doi: 10.1172/JCI87588. Epub 2017 Jan 17.


Impact of short-chain galactooligosaccharides on the gut microbiome of lactose-intolerant individuals.

Azcarate-Peril MA, Ritter AJ, Savaiano D, Monteagudo-Mera A, Anderson C, Magness ST, Klaenhammer TR.

Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E367-E375. doi: 10.1073/pnas.1606722113. Epub 2017 Jan 3.


Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior.

Mazzone CM, Pati D, Michaelides M, DiBerto J, Fox JH, Tipton G, Anderson C, Duffy K, McKlveen JM, Hardaway JA, Magness ST, Falls WA, Hammack SE, McElligott ZA, Hurd YL, Kash TL.

Mol Psychiatry. 2018 Jan;23(1):143-153. doi: 10.1038/mp.2016.218. Epub 2016 Dec 13.


In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment.

Attayek PJ, Ahmad AA, Wang Y, Williamson I, Sims CE, Magness ST, Allbritton NL.

PLoS One. 2016 Apr 21;11(4):e0153795. doi: 10.1371/journal.pone.0153795. eCollection 2016.


Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma.

Bagó JR, Alfonso-Pecchio A, Okolie O, Dumitru R, Rinkenbaugh A, Baldwin AS, Miller CR, Magness ST, Hingtgen SD.

Nat Commun. 2016 Feb 2;7:10593. doi: 10.1038/ncomms10593.


SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine.

Roche KC, Gracz AD, Liu XF, Newton V, Akiyama H, Magness ST.

Gastroenterology. 2015 Nov;149(6):1553-1563.e10. doi: 10.1053/j.gastro.2015.07.004. Epub 2015 Jul 11.


IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations.

Van Landeghem L, Santoro MA, Mah AT, Krebs AE, Dehmer JJ, McNaughton KK, Helmrath MA, Magness ST, Lund PK.

FASEB J. 2015 Jul;29(7):2828-42. doi: 10.1096/fj.14-264010. Epub 2015 Apr 2.


A high-throughput platform for stem cell niche co-cultures and downstream gene expression analysis.

Gracz AD, Williamson IA, Roche KC, Johnston MJ, Wang F, Wang Y, Attayek PJ, Balowski J, Liu XF, Laurenza RJ, Gaynor LT, Sims CE, Galanko JA, Li L, Allbritton NL, Magness ST.

Nat Cell Biol. 2015 Mar;17(3):340-9. doi: 10.1038/ncb3104. Epub 2015 Feb 9.


Defining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathways.

Gracz AD, Magness ST.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G260-73. doi: 10.1152/ajpgi.00066.2014. Epub 2014 Jun 12. Review.


Impact of diet-induced obesity on intestinal stem cells: hyperproliferation but impaired intrinsic function that requires insulin/IGF1.

Mah AT, Van Landeghem L, Gavin HE, Magness ST, Lund PK.

Endocrinology. 2014 Sep;155(9):3302-14. doi: 10.1210/en.2014-1112. Epub 2014 Jun 10.


Optimization of 3-D organotypic primary colonic cultures for organ-on-chip applications.

Ahmad AA, Wang Y, Gracz AD, Sims CE, Magness ST, Allbritton NL.

J Biol Eng. 2014 Apr 1;8:9. doi: 10.1186/1754-1611-8-9. eCollection 2014.


In vitro generation of colonic epithelium from primary cells guided by microstructures.

Wang Y, Ahmad AA, Sims CE, Magness ST, Allbritton NL.

Lab Chip. 2014 May 7;14(9):1622-31. doi: 10.1039/c3lc51353j. Epub 2014 Mar 20.


Capture and 3D culture of colonic crypts and colonoids in a microarray platform.

Wang Y, Ahmad AA, Shah PK, Sims CE, Magness ST, Allbritton NL.

Lab Chip. 2013 Dec 7;13(23):4625-34. doi: 10.1039/c3lc50813g.


A multicenter study to standardize reporting and analyses of fluorescence-activated cell-sorted murine intestinal epithelial cells.

Magness ST, Puthoff BJ, Crissey MA, Dunn J, Henning SJ, Houchen C, Kaddis JS, Kuo CJ, Li L, Lynch J, Martin MG, May R, Niland JC, Olack B, Qian D, Stelzner M, Swain JR, Wang F, Wang J, Wang X, Yan K, Yu J, Wong MH.

Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15;305(8):G542-51. doi: 10.1152/ajpgi.00481.2012. Epub 2013 Aug 8.


Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration.

Gonzalez LM, Williamson I, Piedrahita JA, Blikslager AT, Magness ST.

PLoS One. 2013 Jun 28;8(6):e66465. doi: 10.1371/journal.pone.0066465. Print 2013.


Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay.

Wang F, Scoville D, He XC, Mahe MM, Box A, Perry JM, Smith NR, Lei NY, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JC, Magness ST, Wong MH, Martin MG, Helmrath M, Li L.

Gastroenterology. 2013 Aug;145(2):383-95.e1-21. doi: 10.1053/j.gastro.2013.04.050. Epub 2013 May 2.


Brief report: CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cells.

Gracz AD, Fuller MK, Wang F, Li L, Stelzner M, Dunn JC, Martin MG, Magness ST.

Stem Cells. 2013 Sep;31(9):2024-30. doi: 10.1002/stem.1391.


Restriction of intestinal stem cell expansion and the regenerative response by YAP.

Barry ER, Morikawa T, Butler BL, Shrestha K, de la Rosa R, Yan KS, Fuchs CS, Magness ST, Smits R, Ogino S, Kuo CJ, Camargo FD.

Nature. 2013 Jan 3;493(7430):106-10. doi: 10.1038/nature11693. Epub 2012 Nov 25.


Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen α1(I)-promoter-GFP reporter mice.

Ding S, Walton KL, Blue RE, McNaughton K, Magness ST, Lund PK.

PLoS One. 2012;7(8):e42568. doi: 10.1371/journal.pone.0042568. Epub 2012 Aug 3. Erratum in: PLoS One. 2012;7(10). doi:10.1371/annotation/91f1d7f8-b09d-4067-943c-148e926b403b. Macnaughton, Kirk [corrected to McNaughton, Kirk K].


Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine.

Gracz AD, Puthoff BJ, Magness ST.

Methods Mol Biol. 2012;879:89-107. doi: 10.1007/978-1-61779-815-3_6.


A nomenclature for intestinal in vitro cultures.

Stelzner M, Helmrath M, Dunn JC, Henning SJ, Houchen CW, Kuo C, Lynch J, Li L, Magness ST, Martin MG, Wong MH, Yu J; NIH Intestinal Stem Cell Consortium.

Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1359-63. doi: 10.1152/ajpgi.00493.2011. Epub 2012 Mar 29. Review.


Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.

Van Landeghem L, Santoro MA, Krebs AE, Mah AT, Dehmer JJ, Gracz AD, Scull BP, McNaughton K, Magness ST, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1111-32. doi: 10.1152/ajpgi.00519.2011. Epub 2012 Feb 23.


Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.

VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud Å, Grosse AS, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ, Samuelson LC.

Development. 2012 Feb;139(3):488-97. doi: 10.1242/dev.070763. Epub 2011 Dec 21.


Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture.

Ramalingam S, Daughtridge GW, Johnston MJ, Gracz AD, Magness ST.

Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1;302(1):G10-20. doi: 10.1152/ajpgi.00277.2011. Epub 2011 Oct 13.


Sry-box (Sox) transcription factors in gastrointestinal physiology and disease.

Gracz AD, Magness ST.

Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G503-15. doi: 10.1152/ajpgi.00489.2010. Epub 2011 Feb 3. Review.


Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells.

von Furstenberg RJ, Gulati AS, Baxi A, Doherty JM, Stappenbeck TS, Gracz AD, Magness ST, Henning SJ.

Am J Physiol Gastrointest Liver Physiol. 2011 Mar;300(3):G409-17. doi: 10.1152/ajpgi.00453.2010. Epub 2010 Dec 23.


Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro.

Gracz AD, Ramalingam S, Magness ST.

Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G590-600. doi: 10.1152/ajpgi.00470.2009. Epub 2010 Feb 25.


Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium.

Formeister EJ, Sionas AL, Lorance DK, Barkley CL, Lee GH, Magness ST.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1108-18. doi: 10.1152/ajpgi.00004.2009. Epub 2009 Feb 19.


Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9.

Ramocki NM, Wilkins HR, Magness ST, Simmons JG, Scull BP, Lee GH, McNaughton KK, Lund PK.

Endocrinology. 2008 Jan;149(1):261-7. Epub 2007 Oct 4.


Gnotobiotic IL-10-/-;NF-kappa B(EGFP) mice reveal the critical role of TLR/NF-kappa B signaling in commensal bacteria-induced colitis.

Karrasch T, Kim JS, Muhlbauer M, Magness ST, Jobin C.

J Immunol. 2007 May 15;178(10):6522-32.

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