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Items: 23

1.

Correction to Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.

Menichincheri M, Ardini E, Magnaghi P, Avanzi N, Banfi P, Bossi R, Buffa L, Canevari G, Ceriani L, Colombo M, Corti L, Donati D, Fasolini M, Felder E, Fiorelli C, Fiorentini F, Galvani A, Isacchi A, Borgia AL, Marchionni C, Nesi M, Orrenius C, Panzeri A, Pesenti E, Rusconi L, Saccardo MB, Vanotti E, Perrone E, Orsini P.

J Med Chem. 2019 Sep 12;62(17):8364. doi: 10.1021/acs.jmedchem.9b01259. Epub 2019 Aug 19. No abstract available.

PMID:
31424209
2.

A fast and straightforward procedure for vault nanoparticle purification and the characterization of its endocytic uptake.

Galbiati E, Avvakumova S, La Rocca A, Pozzi M, Messali S, Magnaghi P, Colombo M, Prosperi D, Tortora P.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2254-2260. doi: 10.1016/j.bbagen.2018.07.018. Epub 2018 Jul 20.

PMID:
30036602
3.

Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury.

Magnaghi P, Salom B, Cozzi L, Amboldi N, Ballinari D, Tamborini E, Gasparri F, Montagnoli A, Raddrizzani L, Somaschini A, Bosotti R, Orrenius C, Bozzi F, Pilotti S, Galvani A, Sommer J, Stacchiotti S, Isacchi A.

Mol Cancer Ther. 2018 Mar;17(3):603-613. doi: 10.1158/1535-7163.MCT-17-0324. Epub 2017 Dec 13.

4.

Establishment and genomic characterization of the new chordoma cell line Chor-IN-1.

Bosotti R, Magnaghi P, Di Bella S, Cozzi L, Cusi C, Bozzi F, Beltrami N, Carapezza G, Ballinari D, Amboldi N, Lupi R, Somaschini A, Raddrizzani L, Salom B, Galvani A, Stacchiotti S, Tamborini E, Isacchi A.

Sci Rep. 2017 Aug 23;7(1):9226. doi: 10.1038/s41598-017-10044-3.

5.

Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor.

Menichincheri M, Ardini E, Magnaghi P, Avanzi N, Banfi P, Bossi R, Buffa L, Canevari G, Ceriani L, Colombo M, Corti L, Donati D, Fasolini M, Felder E, Fiorelli C, Fiorentini F, Galvani A, Isacchi A, Borgia AL, Marchionni C, Nesi M, Orrenius C, Panzeri A, Pesenti E, Rusconi L, Saccardo MB, Vanotti E, Perrone E, Orsini P.

J Med Chem. 2016 Apr 14;59(7):3392-408. doi: 10.1021/acs.jmedchem.6b00064. Epub 2016 Mar 30. Erratum in: J Med Chem. 2019 Sep 12;62(17):8364.

PMID:
27003761
6.

Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications.

Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, Ballinari D, Ciomei M, Texido G, Degrassi A, Avanzi N, Amboldi N, Saccardo MB, Casero D, Orsini P, Bandiera T, Mologni L, Anderson D, Wei G, Harris J, Vernier JM, Li G, Felder E, Donati D, Isacchi A, Pesenti E, Magnaghi P, Galvani A.

Mol Cancer Ther. 2016 Apr;15(4):628-39. doi: 10.1158/1535-7163.MCT-15-0758. Epub 2016 Mar 3.

7.

Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors.

Cervi G, Magnaghi P, Asa D, Avanzi N, Badari A, Borghi D, Caruso M, Cirla A, Cozzi L, Felder E, Galvani A, Gasparri F, Lomolino A, Magnuson S, Malgesini B, Motto I, Pasi M, Rizzi S, Salom B, Sorrentino G, Troiani S, Valsasina B, O'Brien T, Isacchi A, Donati D, D'Alessio R.

J Med Chem. 2014 Dec 26;57(24):10443-54. doi: 10.1021/jm501313x. Epub 2014 Dec 12.

PMID:
25474526
8.

The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition.

Ardini E, Bosotti R, Borgia AL, De Ponti C, Somaschini A, Cammarota R, Amboldi N, Raddrizzani L, Milani A, Magnaghi P, Ballinari D, Casero D, Gasparri F, Banfi P, Avanzi N, Saccardo MB, Alzani R, Bandiera T, Felder E, Donati D, Pesenti E, Sartore-Bianchi A, Gambacorta M, Pierotti MA, Siena S, Veronese S, Galvani A, Isacchi A.

Mol Oncol. 2014 Dec;8(8):1495-507. doi: 10.1016/j.molonc.2014.06.001. Epub 2014 Jun 12.

9.

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

Magnaghi P, D'Alessio R, Valsasina B, Avanzi N, Rizzi S, Asa D, Gasparri F, Cozzi L, Cucchi U, Orrenius C, Polucci P, Ballinari D, Perrera C, Leone A, Cervi G, Casale E, Xiao Y, Wong C, Anderson DJ, Galvani A, Donati D, O'Brien T, Jackson PK, Isacchi A.

Nat Chem Biol. 2013 Sep;9(9):548-56. doi: 10.1038/nchembio.1313. Epub 2013 Jul 28.

PMID:
23892893
10.

Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.

Polucci P, Magnaghi P, Angiolini M, Asa D, Avanzi N, Badari A, Bertrand J, Casale E, Cauteruccio S, Cirla A, Cozzi L, Galvani A, Jackson PK, Liu Y, Magnuson S, Malgesini B, Nuvoloni S, Orrenius C, Sirtori FR, Riceputi L, Rizzi S, Trucchi B, O'Brien T, Isacchi A, Donati D, D'Alessio R.

J Med Chem. 2013 Jan 24;56(2):437-50. doi: 10.1021/jm3013213. Epub 2013 Jan 4.

PMID:
23245311
11.

Development of biochemical assays for the identification of eIF4E-specific inhibitors.

Visco C, Perrera C, Thieffine S, Sirtori FR, D'Alessio R, Magnaghi P.

J Biomol Screen. 2012 Jun;17(5):581-92. doi: 10.1177/1087057112438554. Epub 2012 Mar 5.

PMID:
22392810
12.

Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.

Ardini E, Magnaghi P, Orsini P, Galvani A, Menichincheri M.

Cancer Lett. 2010 Dec 28;299(2):81-94. doi: 10.1016/j.canlet.2010.09.001. Epub 2010 Oct 8. Review.

PMID:
20934803
13.

Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors.

Bossi RT, Saccardo MB, Ardini E, Menichincheri M, Rusconi L, Magnaghi P, Orsini P, Avanzi N, Borgia AL, Nesi M, Bandiera T, Fogliatto G, Bertrand JA.

Biochemistry. 2010 Aug 17;49(32):6813-25. doi: 10.1021/bi1005514.

PMID:
20695522
14.

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3.

Magnaghi P, Roberts C, Lorain S, Lipinski M, Scambler PJ.

Nat Genet. 1998 Sep;20(1):74-7.

PMID:
9731536
15.

Genomic structure and organization of kringles type 3 to 10 of the apolipoprotein(a) gene in 6q26-27.

Mihalich A, Magnaghi P, Sessa L, Trubia M, Acquati F, Taramelli R.

Gene. 1997 Sep 1;196(1-2):1-8.

PMID:
9322734
16.

Short direct repeats at the breakpoints of a novel large deletion in the CFTR gene suggest a likely slipped mispairing mechanism.

Magnani C, Cremonesi L, Giunta A, Magnaghi P, Taramelli R, Ferrari M.

Hum Genet. 1996 Jul;98(1):102-8.

PMID:
8682493
17.

Ten allelic apolipoprotein[a] 5' flanking fragments exhibit comparable promoter activities in HepG2 cells.

Bopp S, Köchl S, Acquati F, Magnaghi P, Pethö-Schramm A, Kraft HG, Utermann G, Müller HJ, Taramelli R.

J Lipid Res. 1995 Aug;36(8):1721-8.

18.

A TaqI polymorphism in a gene belonging to the human apoprotein(a)-plasminogen gene family on the telomeric region of chromosome 6 (6q26-27).

Magnaghi P, Ferrari M, Taramelli R.

Clin Genet. 1995 Jun;47(6):330. No abstract available.

PMID:
7554370
19.

A recombination event in the closely linked plasminogen and apolipoprotein(a) gene loci.

Magnaghi P, Agazzi A, Semino O, Ferrari M, Barbui T, D'Angelo A, Taramelli R.

Clin Genet. 1995 Jun;47(6):285-9.

PMID:
7554360
20.

Several liver specific DNAse hypersensitive sites are present in the intergenic region separating human plasminogen and apoprotein(A) genes.

Magnaghi P, Mihalich A, Taramelli R.

Biochem Biophys Res Commun. 1994 Nov 30;205(1):930-5.

PMID:
7999134
21.

Molecular characterisation of the human apo(a)-plasminogen gene family clustered on the telomeric region of chromosome 6 (6q26-27).

Magnaghi P, Citterio E, Malgaretti N, Acquati F, Ottolenghi S, Taramelli R.

Hum Mol Genet. 1994 Mar;3(3):437-42.

PMID:
8012354
22.

Characterization by yeast artificial chromosome cloning of the linked apolipoprotein(a) and plasminogen genes and identification of the apolipoprotein(a) 5' flanking region.

Malgaretti N, Acquati F, Magnaghi P, Bruno L, Pontoglio M, Rocchi M, Saccone S, Della Valle G, D'Urso M, LePaslier D, et al.

Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11584-8. Erratum in: Proc Natl Acad Sci U S A 1993 Feb 15;90(4):1634.

23.

Nucleotide sequence of the cDNA for lecithin-cholesterol acyl transferase (LCAT) from the rat.

Meroni G, Malgaretti N, Magnaghi P, Taramelli R.

Nucleic Acids Res. 1990 Sep 11;18(17):5308. No abstract available.

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