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Items: 33


Multi-Omic Biological Age Estimation and Its Correlation With Wellness and Disease Phenotypes: A Longitudinal Study of 3,558 Individuals.

Earls JC, Rappaport N, Heath L, Wilmanski T, Magis AT, Schork NJ, Omenn GS, Lovejoy J, Hood L, Price ND.

J Gerontol A Biol Sci Med Sci. 2019 Nov 13;74(Supplement_1):S52-S60. doi: 10.1093/gerona/glz220.


Mcl-1 interacts with Akt to promote lung cancer progression.

Chen G, Park D, Magis AT, Behera M, Ramalingam SS, Owonikoko TK, Sica GL, Ye K, Zhang C, Chen Z, Curran WJ, Deng X.

Cancer Res. 2019 Oct 29. pii: canres.0950.2019. doi: 10.1158/0008-5472.CAN-19-0950. [Epub ahead of print]


Blood metabolome predicts gut microbiome α-diversity in humans.

Wilmanski T, Rappaport N, Earls JC, Magis AT, Manor O, Lovejoy J, Omenn GS, Hood L, Gibbons SM, Price ND.

Nat Biotechnol. 2019 Oct;37(10):1217-1228. doi: 10.1038/s41587-019-0233-9. Epub 2019 Sep 2.


Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program.

Zubair N, Conomos MP, Hood L, Omenn GS, Price ND, Spring BJ, Magis AT, Lovejoy JC.

Sci Rep. 2019 May 2;9(1):6805. doi: 10.1038/s41598-019-43058-0.


Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy.

Xu K, Park D, Magis AT, Zhang J, Zhou W, Sica GL, Ramalingam SS, Curran WJ, Deng X.

Mol Cancer. 2019 Apr 10;18(1):85. doi: 10.1186/s12943-019-1012-4.


Reply to "Precision medicine in the clouds".

Magis AT, Earls JC, Glusman G, Omenn GS, Lovejoy JC, Price ND, Hood L.

Nat Biotechnol. 2018 Aug 6;36(8):680-682. doi: 10.1038/nbt.4211. No abstract available.


A Multi-omic Association Study of Trimethylamine N-Oxide.

Manor O, Zubair N, Conomos MP, Xu X, Rohwer JE, Krafft CE, Lovejoy JC, Magis AT.

Cell Rep. 2018 Jul 24;24(4):935-946. doi: 10.1016/j.celrep.2018.06.096.


Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy.

Chen G, Magis AT, Xu K, Park D, Yu DS, Owonikoko TK, Sica GL, Satola SW, Ramalingam SS, Curran WJ, Doetsch PW, Deng X.

J Clin Invest. 2018 Jan 2;128(1):500-516. doi: 10.1172/JCI92742. Epub 2017 Dec 11.


Habitual sleep duration and sleep duration variation are independently associated with body mass index.

Xu X, Conomos MP, Manor O, Rohwer JE, Magis AT, Lovejoy JC.

Int J Obes (Lond). 2018 Apr;42(4):794-800. doi: 10.1038/ijo.2017.223. Epub 2017 Sep 12.


A wellness study of 108 individuals using personal, dense, dynamic data clouds.

Price ND, Magis AT, Earls JC, Glusman G, Levy R, Lausted C, McDonald DT, Kusebauch U, Moss CL, Zhou Y, Qin S, Moritz RL, Brogaard K, Omenn GS, Lovejoy JC, Hood L.

Nat Biotechnol. 2017 Aug;35(8):747-756. doi: 10.1038/nbt.3870. Epub 2017 Jul 17.


Modulation of Bax and mTOR for Cancer Therapeutics.

Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus AI, Sun SY, Chen ZG, Sica GL, Ramalingam SS, Magis AT, Fu H, Khuri FR, Curran WJ, Owonikoko TK, Shin DM, Zhou J, Deng X.

Cancer Res. 2017 Jun 1;77(11):3001-3012. doi: 10.1158/0008-5472.CAN-16-2356. Epub 2017 Apr 5.


Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.

Buschard K, Bracey AW, McElroy DL, Magis AT, Osterbye T, Atkinson MA, Bailey KM, Posgai AL, Ostrov DA.

J Diabetes Res. 2016;2016:6179635. doi: 10.1155/2016/6179635. Epub 2016 Feb 14.


SNAPR: a bioinformatics pipeline for efficient and accurate RNA-seq alignment and analysis.

Magis AT, Funk CC, Price ND.

IEEE Life Sci Lett. 2015 Aug;1(2):22-25. doi: 10.1109/LLS.2015.2465870. Epub 2015 Aug 28.


Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy.

Han B, Park D, Li R, Xie M, Owonikoko TK, Zhang G, Sica GL, Ding C, Zhou J, Magis AT, Chen ZG, Shin DM, Ramalingam SS, Khuri FR, Curran WJ, Deng X.

Cancer Cell. 2015 Jun 8;27(6):852-63. doi: 10.1016/j.ccell.2015.04.010. Epub 2015 May 21.


Measuring the effect of inter-study variability on estimating prediction error.

Ma S, Sung J, Magis AT, Wang Y, Geman D, Price ND.

PLoS One. 2014 Oct 17;9(10):e110840. doi: 10.1371/journal.pone.0110840. eCollection 2014.


Small-molecule Bax agonists for cancer therapy.

Xin M, Li R, Xie M, Park D, Owonikoko TK, Sica GL, Corsino PE, Zhou J, Ding C, White MA, Magis AT, Ramalingam SS, Curran WJ, Khuri FR, Deng X.

Nat Commun. 2014 Sep 17;5:4935. doi: 10.1038/ncomms5935.


Design, synthesis, and biological evaluation of novel FAK scaffold inhibitors targeting the FAK-VEGFR3 protein-protein interaction.

Gogate PN, Ethirajan M, Kurenova EV, Magis AT, Pandey RK, Cance WG.

Eur J Med Chem. 2014 Jun 10;80:154-166. doi: 10.1016/j.ejmech.2014.04.041. Epub 2014 Apr 15.


Detection of 1α,25-dihydroxyvitamin D-regulated miRNAs in zebrafish by whole transcriptome sequencing.

Craig TA, Zhang Y, Magis AT, Funk CC, Price ND, Ekker SC, Kumar R.

Zebrafish. 2014 Jun;11(3):207-18. doi: 10.1089/zeb.2013.0899. Epub 2014 Mar 20.


Multi-study integration of brain cancer transcriptomes reveals organ-level molecular signatures.

Sung J, Kim PJ, Ma S, Funk CC, Magis AT, Wang Y, Hood L, Geman D, Price ND.

PLoS Comput Biol. 2013;9(7):e1003148. doi: 10.1371/journal.pcbi.1003148. Epub 2013 Jul 25.


Novel small-molecule inhibitors of Bcl-XL to treat lung cancer.

Park D, Magis AT, Li R, Owonikoko TK, Sica GL, Sun SY, Ramalingam SS, Khuri FR, Curran WJ, Deng X.

Cancer Res. 2013 Sep 1;73(17):5485-96. doi: 10.1158/0008-5472.CAN-12-2272. Epub 2013 Jul 3.


AUREA: an open-source software system for accurate and user-friendly identification of relative expression molecular signatures.

Earls JC, Eddy JA, Funk CC, Ko Y, Magis AT, Price ND.

BMC Bioinformatics. 2013 Mar 5;14:78. doi: 10.1186/1471-2105-14-78.


Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo.

Ucar DA, Magis AT, He DH, Lawrence NJ, Sebti SM, Kurenova E, Zajac-Kaye M, Zhang J, Hochwald SN.

Anticancer Agents Med Chem. 2013 May;13(4):595-602.


The top-scoring 'N' algorithm: a generalized relative expression classification method from small numbers of biomolecules.

Magis AT, Price ND.

BMC Bioinformatics. 2012 Sep 11;13:227. doi: 10.1186/1471-2105-13-227.


Research resource: whole transcriptome RNA sequencing detects multiple 1α,25-dihydroxyvitamin D(3)-sensitive metabolic pathways in developing zebrafish.

Craig TA, Zhang Y, McNulty MS, Middha S, Ketha H, Singh RJ, Magis AT, Funk C, Price ND, Ekker SC, Kumar R.

Mol Endocrinol. 2012 Sep;26(9):1630-42. doi: 10.1210/me.2012-1113. Epub 2012 Jun 25.


A shift in the salt bridge interaction of residues D620 and E621 mediates the constitutive activation of Jak2-H538Q/K539L.

Gnanasambandan K, Magis AT, Sayeski PP.

Mol Cell Biochem. 2012 Aug;367(1-2):125-40. doi: 10.1007/s11010-012-1326-7. Epub 2012 May 15.


A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth.

Majumder A, Magis AT, Park SO, Figueroa NC, Baskin R, Kirabo A, Allan RW, Zhao ZJ, Bisht KS, Keseru GM, Sayeski PP.

Exp Hematol. 2012 Jan;40(1):22-34. doi: 10.1016/j.exphem.2011.10.003. Epub 2011 Oct 20.


Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3.

Graham WV, Magis AT, Bailey KM, Turner JR, Ostrov DA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):221-3. doi: 10.1107/S1744309110050323. Epub 2011 Jan 22.


Graphics processing unit implementations of relative expression analysis algorithms enable dramatic computational speedup.

Magis AT, Earls JC, Ko YH, Eddy JA, Price ND.

Bioinformatics. 2011 Mar 15;27(6):872-3. doi: 10.1093/bioinformatics/btr033. Epub 2011 Jan 20.


Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening.

Ostrov DA, Magis AT, Wronski TJ, Chan EK, Toro EJ, Donatelli RE, Sajek K, Haroun IN, Nagib MI, Piedrahita A, Harris A, Holliday LS.

J Med Chem. 2009 Aug 27;52(16):5144-51. doi: 10.1021/jm900277z.


A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.

Cannon JP, Haire RN, Magis AT, Eason DD, Winfrey KN, Hernandez Prada JA, Bailey KM, Jakoncic J, Litman GW, Ostrov DA.

Immunity. 2008 Aug 15;29(2):228-37. doi: 10.1016/j.immuni.2008.05.018. Epub 2008 Jul 31.


Crystallization of the focal adhesion kinase targeting (FAT) domain in a primitive orthorhombic space group.

Magis AT, Bailey KM, Kurenova EV, Hernández Prada JA, Cance WG, Ostrov DA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):564-6. doi: 10.1107/S1744309108011421. Epub 2008 May 30.


Crystallization and X-ray diffraction analysis of a novel immune-type receptor from Ictalurus punctatus and phasing by selenium anomalous dispersion methods.

Ostrov DA, Hernández Prada JA, Haire RN, Cannon JP, Magis AT, Bailey K, Litman GW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1035-7. Epub 2007 Nov 21.

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