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Items: 1 to 50 of 117

1.

Orf virus (ORFV) infection in a three-dimensional human skin model: Characteristic cellular alterations and interference with keratinocyte differentiation.

Muhsen M, Protschka M, Schneider LE, Müller U, Köhler G, Magin TM, Büttner M, Alber G, Siegemund S.

PLoS One. 2019 Jan 30;14(1):e0210504. doi: 10.1371/journal.pone.0210504. eCollection 2019.

2.

Orf virus infection of human keratinocytes and dermal fibroblasts: Limited virus detection and interference with intercellular adhesion molecule-1 up-regulation.

Schneider LE, Protschka M, Müller U, Muhsen M, Magin TM, Anderegg U, Saalbach A, Büttner M, Alber G, Siegemund S.

Exp Dermatol. 2019 Feb;28(2):142-151. doi: 10.1111/exd.13861.

PMID:
30554456
3.

High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype.

Golob-Schwarzl N, Bettermann K, Mehta AK, Kessler SM, Unterluggauer J, Krassnig S, Kojima K, Chen X, Hoshida Y, Bardeesy NM, Müller H, Svendova V, Schimek MG, Diwoky C, Lipfert A, Mahajan V, Stumptner C, Thüringer A, Fröhlich LF, Stojakovic T, Nilsson KPR, Kolbe T, Rülicke T, Magin TM, Strnad P, Kiemer AK, Moriggl R, Haybaeck J.

Transl Oncol. 2019 Feb;12(2):256-268. doi: 10.1016/j.tranon.2018.10.010. Epub 2018 Nov 12.

4.

Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly.

Weingarten G, Ben Yaakov A, Dror E, Russ J, Magin TM, Kahn CR, Wertheimer E.

FASEB J. 2019 Feb;33(2):2241-2251. doi: 10.1096/fj.201800847R. Epub 2018 Oct 17.

PMID:
30332298
5.

Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus.

Vielmuth F, Walter E, Fuchs M, Radeva MY, Buechau F, Magin TM, Spindler V, Waschke J.

Front Immunol. 2018 Mar 19;9:528. doi: 10.3389/fimmu.2018.00528. eCollection 2018.

6.

KLHL16 Degrades Epidermal Keratins.

Büchau F, Munz C, Has C, Lehmann R, Magin TM.

J Invest Dermatol. 2018 Aug;138(8):1871-1873. doi: 10.1016/j.jid.2018.02.017. Epub 2018 Feb 23. No abstract available.

PMID:
29481904
7.

Mitogen-activated protein kinase pathway inhibitors rescue lethal phenotypes in a BRAF gain-of-function Drosophila melanogaster model.

Volkhardt A, Bohnekamp J, Pfeifle I, Engel C, Magin TM, Kunz M.

Pigment Cell Melanoma Res. 2018 Jul;31(4):545-548. doi: 10.1111/pcmr.12683. Epub 2018 Jan 15. No abstract available.

PMID:
29288529
8.

Threonine 150 Phosphorylation of Keratin 5 Is Linked to Epidermolysis Bullosa Simplex and Regulates Filament Assembly and Cell Viability.

Sawant M, Schwarz N, Windoffer R, Magin TM, Krieger J, Mücke N, Obara B, Jankowski V, Jankowski J, Wally V, Lettner T, Leube RE.

J Invest Dermatol. 2018 Mar;138(3):627-636. doi: 10.1016/j.jid.2017.10.011. Epub 2017 Dec 6.

9.

Keratins Regulate the Adhesive Properties of Desmosomal Cadherins through Signaling.

Vielmuth F, Wanuske MT, Radeva MY, Hiermaier M, Kugelmann D, Walter E, Buechau F, Magin TM, Waschke J, Spindler V.

J Invest Dermatol. 2018 Jan;138(1):121-131. doi: 10.1016/j.jid.2017.08.033. Epub 2017 Sep 9.

10.

Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway.

Fischer M, Uxa S, Stanko C, Magin TM, Engeland K.

Sci Rep. 2017 Jun 1;7(1):2603. doi: 10.1038/s41598-017-02831-9.

11.

Lessons from Animal Models of Cytoplasmic Intermediate Filament Proteins.

Bouameur JE, Magin TM.

Subcell Biochem. 2017;82:171-230. doi: 10.1007/978-3-319-49674-0_7. Review.

PMID:
28101863
12.

Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics.

Hatzfeld M, Keil R, Magin TM.

Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6). pii: a029157. doi: 10.1101/cshperspect.a029157. Review.

PMID:
28096266
13.

Keratin-dependent thymic stromal lymphopoietin expression suggests a link between skin blistering and atopic disease.

Kumar V, Behr M, Kiritsi D, Scheffschick A, Grahnert A, Homberg M, Schwieger-Briel A, Jakob T, Bruckner-Tuderman L, Magin TM.

J Allergy Clin Immunol. 2016 Nov;138(5):1461-1464.e6. doi: 10.1016/j.jaci.2016.04.046. Epub 2016 Jun 15. No abstract available.

PMID:
27527262
14.

Cross talk between the cytoplasm and nucleus during development and disease.

Wallrath LL, Bohnekamp J, Magin TM.

Curr Opin Genet Dev. 2016 Apr;37:129-136. doi: 10.1016/j.gde.2016.03.007. Epub 2016 Apr 23. Review.

PMID:
27110666
15.

Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo.

Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M.

J Invest Dermatol. 2016 Jul;136(7):1471-1478. doi: 10.1016/j.jid.2016.03.021. Epub 2016 Mar 28.

16.

Correction: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM.

J Cell Biol. 2016 Mar 28;212(7):877. doi: 10.1083/jcb.20140414703042016c. Epub 2016 Mar 21. No abstract available.

17.

Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades.

Hering L, Bouameur JE, Reichelt J, Magin TM, Mayer G.

Elife. 2016 Feb 3;5:e11117. doi: 10.7554/eLife.11117.

18.

Using Drosophila for Studies of Intermediate Filaments.

Bohnekamp J, Cryderman DE, Thiemann DA, Magin TM, Wallrath LL.

Methods Enzymol. 2016;568:707-26. doi: 10.1016/bs.mie.2015.08.028. Epub 2015 Oct 24.

PMID:
26795490
19.

Keratin Isotypes Control Desmosome Stability and Dynamics through PKCα.

Loschke F, Homberg M, Magin TM.

J Invest Dermatol. 2016 Jan;136(1):202-13. doi: 10.1038/JID.2015.403.

20.

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM.

J Cell Biol. 2015 Dec 7;211(5):1057-75. doi: 10.1083/jcb.201404147. Erratum in: J Cell Biol. 2016 Mar 28;212(7):877.

21.

Keratin Isotypes Control Desmosome Stability and Dynamics through PKCα.

Loschke F, Homberg M, Magin TM.

J Invest Dermatol. 2015 Oct 12. doi: 10.1038/jid.2015.403. [Epub ahead of print]

PMID:
26458010
22.

Small molecule targeting of a myosin partner restores an intact keratin cytoskeleton despite presence of a dominant keratin mutation.

Bohnekamp J, Magin TM.

Hepatology. 2015 Dec;62(6):1667-9. doi: 10.1002/hep.28126. Epub 2015 Sep 30. No abstract available.

PMID:
26387879
23.

Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function.

Kant S, Holthöfer B, Magin TM, Krusche CA, Leube RE.

Circ Cardiovasc Genet. 2015 Aug;8(4):553-63. doi: 10.1161/CIRCGENETICS.114.000974. Epub 2015 Jun 17.

PMID:
26085008
24.

Distinct Impact of Two Keratin Mutations Causing Epidermolysis Bullosa Simplex on Keratinocyte Adhesion and Stiffness.

Homberg M, Ramms L, Schwarz N, Dreissen G, Leube RE, Merkel R, Hoffmann B, Magin TM.

J Invest Dermatol. 2015 Oct;135(10):2437-2445. doi: 10.1038/jid.2015.184. Epub 2015 May 11. Erratum in: J Invest Dermatol. 2016 Jun;136(6):1306.

25.

A Drosophila Model of Epidermolysis Bullosa Simplex.

Bohnekamp J, Cryderman DE, Paululat A, Baccam GC, Wallrath LL, Magin TM.

J Invest Dermatol. 2015 Aug;135(8):2031-2039. doi: 10.1038/jid.2015.129. Epub 2015 Apr 1.

26.

Dissection of keratin network formation, turnover and reorganization in living murine embryos.

Schwarz N, Windoffer R, Magin TM, Leube RE.

Sci Rep. 2015 Mar 11;5:9007. doi: 10.1038/srep09007.

27.

Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover.

Seltmann K, Cheng F, Wiche G, Eriksson JE, Magin TM.

J Invest Dermatol. 2015 Jun;135(6):1609-1620. doi: 10.1038/jid.2015.46. Epub 2015 Feb 10.

28.

Regulation of keratin network organization.

Loschke F, Seltmann K, Bouameur JE, Magin TM.

Curr Opin Cell Biol. 2015 Feb;32:56-64. doi: 10.1016/j.ceb.2014.12.006. Epub 2015 Jan 13. Review.

PMID:
25594948
29.

Beyond expectations: novel insights into epidermal keratin function and regulation.

Homberg M, Magin TM.

Int Rev Cell Mol Biol. 2014;311:265-306. doi: 10.1016/B978-0-12-800179-0.00007-6. Review.

PMID:
24952920
30.

HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis.

Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D, Adams IR, Magin TM, Fleischmann BK, Höhfeld J.

Mol Biol Cell. 2014 Aug 1;25(15):2260-71. doi: 10.1091/mbc.E14-02-0742. Epub 2014 Jun 4.

31.

Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis.

Schönherr M, Bhattacharya A, Kottek T, Szymczak S, Köberle M, Wickenhauser C, Siebolts U, Saalbach A, Koczan D, Magin TM, Simon JC, Kunz M.

Pigment Cell Melanoma Res. 2014 May;27(3):418-30. doi: 10.1111/pcmr.12216. Epub 2014 Jan 31.

PMID:
24406113
32.

Keratins significantly contribute to cell stiffness and impact invasive behavior.

Seltmann K, Fritsch AW, Käs JA, Magin TM.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18507-12. doi: 10.1073/pnas.1310493110. Epub 2013 Oct 28.

33.

Keratins as the main component for the mechanical integrity of keratinocytes.

Ramms L, Fabris G, Windoffer R, Schwarz N, Springer R, Zhou C, Lazar J, Stiefel S, Hersch N, Schnakenberg U, Magin TM, Leube RE, Merkel R, Hoffmann B.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18513-8. doi: 10.1073/pnas.1313491110. Epub 2013 Oct 28.

34.

Skin fragility and impaired desmosomal adhesion in mice lacking all keratins.

Bär J, Kumar V, Roth W, Schwarz N, Richter M, Leube RE, Magin TM.

J Invest Dermatol. 2014 Apr;134(4):1012-1022. doi: 10.1038/jid.2013.416. Epub 2013 Oct 11.

35.

Keratins control intercellular adhesion involving PKC-α-mediated desmoplakin phosphorylation.

Kröger C, Loschke F, Schwarz N, Windoffer R, Leube RE, Magin TM.

J Cell Biol. 2013 May 27;201(5):681-92. doi: 10.1083/jcb.201208162. Epub 2013 May 20.

36.

Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model.

König K, Meder L, Kröger C, Diehl L, Florin A, Rommerscheidt-Fuss U, Kahl P, Wardelmann E, Magin TM, Buettner R, Heukamp LC.

PLoS One. 2013;8(3):e57996. doi: 10.1371/journal.pone.0057996. Epub 2013 Mar 11.

37.

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.

Roth W, Kumar V, Beer HD, Richter M, Wohlenberg C, Reuter U, Thiering S, Staratschek-Jox A, Hofmann A, Kreusch F, Schultze JL, Vogl T, Roth J, Reichelt J, Hausser I, Magin TM.

J Cell Sci. 2012 Nov 15;125(Pt 22):5269-79. doi: 10.1242/jcs.116574. Epub 2012 Nov 6.

38.

Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch.

Duan Y, Sun Y, Zhang F, Zhang WK, Wang D, Wang Y, Cao X, Hu W, Xie C, Cuppoletti J, Magin TM, Wang H, Wu Z, Li N, Huang P.

J Biol Chem. 2012 Nov 23;287(48):40547-59. doi: 10.1074/jbc.M112.403584. Epub 2012 Oct 8.

39.

Genes encoding cytoplasmic intermediate filament proteins of vertebrates revisited: identification of a cytoplasmic intermediate filament protein in the sea anemone Nematostella.

Zimek A, Thiering S, Weber K, Magin TM.

Eur J Cell Biol. 2012 Oct;91(10):809-17. doi: 10.1016/j.ejcb.2012.08.003. Epub 2012 Sep 1.

PMID:
22944282
40.

Keratins mediate localization of hemidesmosomes and repress cell motility.

Seltmann K, Roth W, Kröger C, Loschke F, Lederer M, Hüttelmaier S, Magin TM.

J Invest Dermatol. 2013 Jan;133(1):181-90. doi: 10.1038/jid.2012.256. Epub 2012 Aug 16.

41.

Involvement of the ubiquitin-proteasome system in the stabilization of cell-cell contacts in human keratinocytes.

Löffek S, Bruckner-Tuderman L, Magin TM.

Exp Dermatol. 2012 Oct;21(10):791-3. doi: 10.1111/j.1600-0625.2012.01564.x. Epub 2012 Aug 7.

PMID:
22882483
42.

Verrucous carcinoma in epidermolysis bullosa simplex is possibly associated with a novel mutation in the keratin 5 gene.

Schumann H, Roth W, Has C, Volz A, Erfurt-Berge C, Magin TM, Bruckner-Tuderman L.

Br J Dermatol. 2012 Oct;167(4):929-36. doi: 10.1111/j.1365-2133.2012.11075.x. Epub 2012 Sep 7.

PMID:
22639907
43.

Targeting the palm: a leap forward toward treatment of keratin disorders.

Roth W, Hatzfeld M, Magin TM.

J Invest Dermatol. 2012 Jun;132(6):1541-2. doi: 10.1038/jid.2012.99.

44.

Keratin function and regulation in tissue homeostasis and pathogenesis.

Roth W, Hatzfeld M, Friedrich M, Thiering S, Magin TM.

Biomol Concepts. 2012 Apr;3(2):161-73. doi: 10.1515/bmc.2011.060.

PMID:
25436530
45.

Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.

Haybaeck J, Stumptner C, Thueringer A, Kolbe T, Magin TM, Hesse M, Fickert P, Tsybrovskyy O, Müller H, Trauner M, Zatloukal K, Denk H.

Lab Invest. 2012 Jun;92(6):857-67. doi: 10.1038/labinvest.2012.49. Epub 2012 Mar 26.

46.

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia.

Windoffer R, Beil M, Magin TM, Leube RE.

J Cell Biol. 2011 Sep 5;194(5):669-78. doi: 10.1083/jcb.201008095. Review.

47.

Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues.

Kröger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM.

Am J Pathol. 2011 Apr;178(4):1578-90. doi: 10.1016/j.ajpath.2010.12.055.

48.

The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation.

Löffek S, Wöll S, Höhfeld J, Leube RE, Has C, Bruckner-Tuderman L, Magin TM.

Hum Mutat. 2010 Apr;31(4):466-76. doi: 10.1002/humu.21222.

PMID:
20151404
49.

Keratins regulate yolk sac hematopoiesis and vasculogenesis through reduced BMP-4 signaling.

Vijayaraj P, Kroeger C, Reuter U, Hartmann D, Magin TM.

Eur J Cell Biol. 2010 Apr;89(4):299-306. doi: 10.1016/j.ejcb.2009.10.016. Epub 2010 Jan 25.

PMID:
20097443
50.

Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor.

Vijayaraj P, Kröger C, Reuter U, Windoffer R, Leube RE, Magin TM.

J Cell Biol. 2009 Oct 19;187(2):175-84. doi: 10.1083/jcb.200906094.

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