Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 52

1.

Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis.

Cheng D, Talib J, Stanley CP, Rashid I, Michaëlsson E, Lindstedt EL, Croft KD, Kettle AJ, Maghzal GJ, Stocker R.

Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1448-1457. doi: 10.1161/ATVBAHA.119.312725. Epub 2019 May 2.

PMID:
31043077
2.

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation.

Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y, Chadha P, Suarna C, Prysyazhna O, Scotcher J, Dunn LL, Prado FM, Nguyen N, Odiba JO, Baell JB, Stasch JP, Yamamoto Y, Di Mascio P, Eaton P, Payne RJ, Stocker R.

Nature. 2019 Feb;566(7745):548-552. doi: 10.1038/s41586-019-0947-3. Epub 2019 Feb 13.

PMID:
30760924
3.

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J.

Cell Metab. 2019 Feb 5;29(2):399-416.e10. doi: 10.1016/j.cmet.2018.10.014. Epub 2018 Nov 15.

PMID:
30449682
4.

Myeloperoxidase is a potential molecular imaging and therapeutic target for the identification and stabilization of high-risk atherosclerotic plaque.

Rashid I, Maghzal GJ, Chen YC, Cheng D, Talib J, Newington D, Ren M, Vajandar SK, Searle A, Maluenda A, Lindstedt EL, Jabbour A, Kettle AJ, Bongers A, Power C, Michaëlsson E, Peter K, Stocker R.

Eur Heart J. 2018 Sep 14;39(35):3301-3310. doi: 10.1093/eurheartj/ehy419.

PMID:
30219874
5.

Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.

Zardoya-Laguardia P, Blaschitz A, Hirschmugl B, Lang I, Herzog SA, Nikitina L, Gauster M, Häusler M, Cervar-Zivkovic M, Karpf E, Maghzal GJ, Stanley CP, Stocker R, Wadsack C, Frank S, Sedlmayr P.

Sci Rep. 2018 Apr 3;8(1):5488. doi: 10.1038/s41598-018-23896-0.

6.

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.

Fazakerley DJ, Minard AY, Krycer JR, Thomas KC, Stöckli J, Harney DJ, Burchfield JG, Maghzal GJ, Caldwell ST, Hartley RC, Stocker R, Murphy MP, James DE.

J Biol Chem. 2018 May 11;293(19):7315-7328. doi: 10.1074/jbc.RA117.001254. Epub 2018 Mar 29.

7.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

Fazakerley DJ, Chaudhuri R, Yang P, Maghzal GJ, Thomas KC, Krycer JR, Humphrey SJ, Parker BL, Fisher-Wellman KH, Meoli CC, Hoffman NJ, Diskin C, Burchfield JG, Cowley MJ, Kaplan W, Modrusan Z, Kolumam G, Yang JY, Chen DL, Samocha-Bonet D, Greenfield JR, Hoehn KL, Stocker R, James DE.

Elife. 2018 Feb 6;7. pii: e32111. doi: 10.7554/eLife.32111.

8.

Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress.

Chen W, Maghzal GJ, Ayer A, Suarna C, Dunn LL, Stocker R.

Free Radic Biol Med. 2018 Feb 1;115:156-165. doi: 10.1016/j.freeradbiomed.2017.11.020. Epub 2017 Dec 1.

PMID:
29195835
9.

NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

Shi H, Enriquez A, Rapadas M, Martin EMMA, Wang R, Moreau J, Lim CK, Szot JO, Ip E, Hughes JN, Sugimoto K, Humphreys DT, McInerney-Leo AM, Leo PJ, Maghzal GJ, Halliday J, Smith J, Colley A, Mark PR, Collins F, Sillence DO, Winlaw DS, Ho JWK, Guillemin GJ, Brown MA, Kikuchi K, Thomas PQ, Stocker R, Giannoulatou E, Chapman G, Duncan EL, Sparrow DB, Dunwoodie SL.

N Engl J Med. 2017 Aug 10;377(6):544-552. doi: 10.1056/NEJMoa1616361.

10.

Characterization of plasma labile heme in hemolytic conditions.

Gouveia Z, Carlos AR, Yuan X, Aires-da-Silva F, Stocker R, Maghzal GJ, Leal SS, Gomes CM, Todorovic S, Iranzo O, Ramos S, Santos AC, Hamza I, Gonçalves J, Soares MP.

FEBS J. 2017 Oct;284(19):3278-3301. doi: 10.1111/febs.14192. Epub 2017 Sep 11.

11.

Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques.

Htun NM, Chen YC, Lim B, Schiller T, Maghzal GJ, Huang AL, Elgass KD, Rivera J, Schneider HG, Wood BR, Stocker R, Peter K.

Nat Commun. 2017 Jul 13;8(1):75. doi: 10.1038/s41467-017-00138-x.

12.

Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.

Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK.

Differentiation. 2017 Mar - Apr;94:8-20. doi: 10.1016/j.diff.2016.11.004. Epub 2016 Dec 5.

PMID:
27930960
13.

The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture.

Teng N, Maghzal GJ, Talib J, Rashid I, Lau AK, Stocker R.

Redox Rep. 2017 Mar;22(2):51-73. doi: 10.1080/13510002.2016.1256119. Epub 2016 Nov 25. Review.

PMID:
27884085
14.

Behavioral and cognitive data in mice with different tryptophan-metabolizing enzymes knocked out.

Too LK, Li KM, Suarna C, Maghzal GJ, Stocker R, McGregor IS, Hunt NH.

Data Brief. 2016 Sep 6;9:275-87. doi: 10.1016/j.dib.2016.08.071. eCollection 2016 Dec.

15.

Correction: AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation.

Cullen JK, Abdul Murad N, Yeo A, McKenzie M, Ward M, Chong KL, Schieber NL, Parton RG, Lim YC, Wolvetang E, Maghzal GJ, Stocker R, Lavin MF.

PLoS One. 2016 Jul 21;11(7):e0160162. doi: 10.1371/journal.pone.0160162. eCollection 2016.

16.

Absence of systemic oxidative stress and increased CSF prostaglandin F2α in progressive MS.

Lam MA, Maghzal GJ, Khademi M, Piehl F, Ratzer R, Romme Christensen J, Sellebjerg FT, Olsson T, Stocker R.

Neurol Neuroimmunol Neuroinflamm. 2016 Jun 30;3(4):e256. doi: 10.1212/NXI.0000000000000256. eCollection 2016 Aug.

17.

Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.

Too LK, Li KM, Suarna C, Maghzal GJ, Stocker R, McGregor IS, Hunt NH.

Behav Brain Res. 2016 Oct 1;312:102-17. doi: 10.1016/j.bbr.2016.06.018. Epub 2016 Jun 15.

PMID:
27316339
18.

Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.

Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland DW, Aguzzi A, Stocker R, Krause KH, Jaquet V.

Free Radic Biol Med. 2016 Aug;97:95-108. doi: 10.1016/j.freeradbiomed.2016.05.016. Epub 2016 May 19.

19.

Detailed protocol to assess in vivo and ex vivo myeloperoxidase activity in mouse models of vascular inflammation and disease using hydroethidine.

Talib J, Maghzal GJ, Cheng D, Stocker R.

Free Radic Biol Med. 2016 Aug;97:124-135. doi: 10.1016/j.freeradbiomed.2016.05.004. Epub 2016 May 13.

PMID:
27184954
20.

AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation.

Cullen JK, Abdul Murad N, Yeo A, McKenzie M, Ward M, Chong KL, Schieber NL, Parton RG, Lim YC, Wolvetang E, Maghzal GJ, Stocker R, Lavin MF.

PLoS One. 2016 Feb 11;11(2):e0148213. doi: 10.1371/journal.pone.0148213. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0160162.

21.

Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications.

Casas AI, Dao VT, Daiber A, Maghzal GJ, Di Lisa F, Kaludercic N, Leach S, Cuadrado A, Jaquet V, Seredenina T, Krause KH, López MG, Stocker R, Ghezzi P, Schmidt HH.

Antioxid Redox Signal. 2015 Nov 10;23(14):1171-85. doi: 10.1089/ars.2015.6433. Review.

22.

Pharmacology and Clinical Drug Candidates in Redox Medicine.

Dao VT, Casas AI, Maghzal GJ, Seredenina T, Kaludercic N, Robledinos-Anton N, Di Lisa F, Stocker R, Ghezzi P, Jaquet V, Cuadrado A, Schmidt HH.

Antioxid Redox Signal. 2015 Nov 10;23(14):1113-29. doi: 10.1089/ars.2015.6430. Epub 2015 Nov 6. Review.

23.

Heme oxygenase-1 deficiency alters erythroblastic island formation, steady-state erythropoiesis and red blood cell lifespan in mice.

Fraser ST, Midwinter RG, Coupland LA, Kong S, Berger BS, Yeo JH, Andrade OC, Cromer D, Suarna C, Lam M, Maghzal GJ, Chong BH, Parish CR, Stocker R.

Haematologica. 2015 May;100(5):601-10. doi: 10.3324/haematol.2014.116368. Epub 2015 Feb 14.

24.

Tryptophan catabolism is unaffected in chronic granulomatous disease.

Maghzal GJ, Winter S, Wurzer B, Chong BH, Holmdahl R, Stocker R.

Nature. 2014 Oct 23;514(7523):E16-7. doi: 10.1038/nature13844. No abstract available.

PMID:
25341792
25.

Reactive species and oxidative stress in optic nerve vulnerable to secondary degeneration.

O'Hare Doig RL, Bartlett CA, Maghzal GJ, Lam M, Archer M, Stocker R, Fitzgerald M.

Exp Neurol. 2014 Nov;261:136-46. doi: 10.1016/j.expneurol.2014.06.007. Epub 2014 Jun 12.

PMID:
24931225
27.

Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium.

Maghzal GJ, Cergol KM, Shengule SR, Suarna C, Newington D, Kettle AJ, Payne RJ, Stocker R.

J Biol Chem. 2014 Feb 28;289(9):5580-95. doi: 10.1074/jbc.M113.539486. Epub 2014 Jan 16.

28.

Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1.

Shen Y, Ward NC, Hodgson JM, Puddey IB, Wang Y, Zhang D, Maghzal GJ, Stocker R, Croft KD.

Free Radic Biol Med. 2013 Dec;65:908-915. doi: 10.1016/j.freeradbiomed.2013.08.185. Epub 2013 Sep 7.

PMID:
24017971
29.

Detection of reactive oxygen species derived from the family of NOX NADPH oxidases.

Maghzal GJ, Krause KH, Stocker R, Jaquet V.

Free Radic Biol Med. 2012 Nov 15;53(10):1903-18. doi: 10.1016/j.freeradbiomed.2012.09.002. Epub 2012 Sep 13. Review.

PMID:
22982596
30.

DNAzyme targeting c-jun suppresses skin cancer growth.

Cai H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, Davenport MP, Maghzal GJ, Stocker R, Parish CR, Chong BH, Lieschke GJ, Wong TW, Chesterman CN, Francis DJ, Moloney FJ, Barnetson RS, Halliday GM, Khachigian LM.

Sci Transl Med. 2012 Jun 20;4(139):139ra82. doi: 10.1126/scitranslmed.3003960.

31.

Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells.

Li C, Lönn ME, Xu X, Maghzal GJ, Frazer DM, Thomas SR, Halliwell B, Richardson DR, Anderson GJ, Stocker R.

Free Radic Biol Med. 2012 Jul 15;53(2):366-74. doi: 10.1016/j.freeradbiomed.2012.03.007. Epub 2012 Apr 18.

PMID:
22579918
32.

Succinobucol induces apoptosis in vascular smooth muscle cells.

Midwinter RG, Maghzal GJ, Dennis JM, Wu BJ, Cai H, Kapralov AA, Belikova NA, Tyurina YY, Dong LF, Khachigian L, Neuzil J, Kagan VE, Stocker R.

Free Radic Biol Med. 2012 Mar 1;52(5):871-9. doi: 10.1016/j.freeradbiomed.2011.11.029. Epub 2011 Dec 21.

PMID:
22203369
33.

Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis.

Changsirivathanathamrong D, Wang Y, Rajbhandari D, Maghzal GJ, Mak WM, Woolfe C, Duflou J, Gebski V, dos Remedios CG, Celermajer DS, Stocker R.

Crit Care Med. 2011 Dec;39(12):2678-83. doi: 10.1097/CCM.0b013e31822827f2.

PMID:
21765346
34.

Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice.

Jackman KA, Brait VH, Wang Y, Maghzal GJ, Ball HJ, McKenzie G, De Silva TM, Stocker R, Sobey CG.

Naunyn Schmiedebergs Arch Pharmacol. 2011 May;383(5):471-81. doi: 10.1007/s00210-011-0611-4. Epub 2011 Feb 27.

PMID:
21359968
35.

Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2.

Austin CJ, Mailu BM, Maghzal GJ, Sanchez-Perez A, Rahlfs S, Zocher K, Yuasa HJ, Arthur JW, Becker K, Stocker R, Hunt NH, Ball HJ.

Amino Acids. 2010 Jul;39(2):565-78. doi: 10.1007/s00726-010-0475-9. Epub 2010 Feb 7.

PMID:
20140689
36.

Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione.

Ximenes VF, Maghzal GJ, Turner R, Kato Y, Winterbourn CC, Kettle AJ.

Biochem J. 2009 Dec 14;425(1):285-93. doi: 10.1042/BJ20090776.

PMID:
19828014
37.

Insulin resistance is a cellular antioxidant defense mechanism.

Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. doi: 10.1073/pnas.0902380106. Epub 2009 Sep 30.

38.

Oxidation of methionine to dehydromethionine by reactive halogen species generated by neutrophils.

Peskin AV, Turner R, Maghzal GJ, Winterbourn CC, Kettle AJ.

Biochemistry. 2009 Oct 27;48(42):10175-82. doi: 10.1021/bi901266w.

PMID:
19775156
39.

Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase.

Maghzal GJ, Leck MC, Collinson E, Li C, Stocker R.

J Biol Chem. 2009 Oct 23;284(43):29251-9. doi: 10.1074/jbc.M109.037119. Epub 2009 Aug 18.

40.

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials.

Yuasa HJ, Ball HJ, Ho YF, Austin CJ, Whittington CM, Belov K, Maghzal GJ, Jermiin LS, Hunt NH.

Comp Biochem Physiol B Biochem Mol Biol. 2009 Jun;153(2):137-144. Epub 2009 Feb 7.

PMID:
19416693
41.

Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases IDOs from monotremes and marsupials.

Yuasa HJ, Ball HJ, Ho YF, Austin CJ, Whittington CM, Belov K, Maghzal GJ, Jermiin LS, Hunt NH.

Comp Biochem Physiol B Biochem Mol Biol. 2009 Jun;153(2):137-44.

PMID:
19402226
42.

A phosphatidylcholine-BODIPY 581/591 conjugate allows mapping of oxidative stress in P. falciparum-infected erythrocytes.

Fu Y, Klonis N, Suarna C, Maghzal GJ, Stocker R, Tilley L.

Cytometry A. 2009 May;75(5):390-404. doi: 10.1002/cyto.a.20704.

43.

Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells.

Maghzal GJ, Thomas SR, Hunt NH, Stocker R.

J Biol Chem. 2008 May 2;283(18):12014-25. doi: 10.1074/jbc.M710266200. Epub 2008 Feb 25.

44.

The lipocalin alpha1-microglobulin has radical scavenging activity.

Akerström B, Maghzal GJ, Winterbourn CC, Kettle AJ.

J Biol Chem. 2007 Oct 26;282(43):31493-503. Epub 2007 Aug 31.

45.

Improved analysis of hydroethidine and 2-hydroxyethidium by HPLC and electrochemical detection.

Maghzal GJ, Stocker R.

Free Radic Biol Med. 2007 Oct 1;43(7):1095-6. Epub 2007 Jul 10. No abstract available.

PMID:
17761305
46.

The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents.

Peskin AV, Low FM, Paton LN, Maghzal GJ, Hampton MB, Winterbourn CC.

J Biol Chem. 2007 Apr 20;282(16):11885-92. Epub 2007 Feb 27.

47.

Fibrinogen Saint-Germain II: hypofibrinogenemia due to heterozygous gamma N345S mutation.

de Raucourt E, de Mazancourt P, Maghzal GJ, Brennan SO, Mosesson MW.

Thromb Haemost. 2005 Nov;94(5):965-8.

PMID:
16363237
48.

Superoxide-dependent oxidation of melatonin by myeloperoxidase.

Ximenes VF, Silva SO, Rodrigues MR, Catalani LH, Maghzal GJ, Kettle AJ, Campa A.

J Biol Chem. 2005 Nov 18;280(46):38160-9. Epub 2005 Sep 7.

49.

The sialic acid content of fibrinogen decreases during pregnancy and increases in response to fibrate therapy.

Maghzal GJ, Brennan SO, George PM.

Thromb Res. 2005;115(4):293-9. No abstract available.

PMID:
15668189
50.

The molecular mechanisms of congenital hypofibrinogenaemia.

Maghzal GJ, Brennan SO, Homer VM, George PM.

Cell Mol Life Sci. 2004 Jun;61(12):1427-38. Review.

PMID:
15197468

Supplemental Content

Loading ...
Support Center