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Items: 1 to 50 of 89

1.

Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis.

Kizilyer A, Singh MV, Singh VB, Suwunnakorn S, Palis J, Maggirwar SB.

Sci Rep. 2019 Feb 26;9(1):2781. doi: 10.1038/s41598-019-39385-x.

2.

Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.

Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates KJ, Hurley C, Fujiwara K, Maggirwar SB, Schifitto G, Abe JI.

Circulation. 2019 Feb 26;139(9):1199-1216. doi: 10.1161/CIRCULATIONAHA.118.036232.

PMID:
30586719
3.

HIV-1 infection renders brain vascular pericytes susceptible to the extracellular glutamate.

Piekna-Przybylska D, Nagumotu K, Reid DM, Maggirwar SB.

J Neurovirol. 2019 Feb;25(1):114-126. doi: 10.1007/s13365-018-0693-6. Epub 2018 Nov 6.

4.

CD4+ memory T cells infected with latent HIV-1 are susceptible to drugs targeting telomeres.

Piekna-Przybylska D, Maggirwar SB.

Cell Cycle. 2018;17(17):2187-2203. doi: 10.1080/15384101.2018.1520568. Epub 2018 Sep 20.

5.

Toll-Like Receptor Signaling Contributes to Proinflammatory Mediator Production in Localized Provoked Vulvodynia.

Falsetta ML, Foster DC, Woeller CF, Pollock SJ, Bonham AD, Piekna-Przybylska D, Maggirwar SB, Haidaris CG, Phipps RP.

J Low Genit Tract Dis. 2018 Jan;22(1):52-57. doi: 10.1097/LGT.0000000000000364.

6.

Sonic Hedgehog mimetic prevents leukocyte infiltration into the CNS during acute HIV infection.

Singh VB, Singh MV, Piekna-Przybylska D, Gorantla S, Poluektova LY, Maggirwar SB.

Sci Rep. 2017 Aug 29;7(1):9578. doi: 10.1038/s41598-017-10241-0.

7.

Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection.

Connor R, Jones LD, Qiu X, Thakar J, Maggirwar SB.

J Leukoc Biol. 2017 Oct;102(4):953-964. doi: 10.1189/jlb.6HI0217-043R. Epub 2017 Jun 29.

8.

Deficiency in DNA damage response, a new characteristic of cells infected with latent HIV-1.

Piekna-Przybylska D, Sharma G, Maggirwar SB, Bambara RA.

Cell Cycle. 2017 May 19;16(10):968-978. doi: 10.1080/15384101.2017.1312225. Epub 2017 Apr 7.

9.

Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer?

Singh MV, Weber EA, Singh VB, Stirpe NE, Maggirwar SB.

J Neurovirol. 2017 Jun;23(3):347-357. doi: 10.1007/s13365-017-0513-4. Epub 2017 Jan 23. Review.

10.

Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users.

Piepenbrink MS, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, Kiebala M, Khan AA, Thakar J, Maggirwar SB, Morse D, Rosenberg AF, Haughey NJ, Valenti W, Keefer MC, Kobie JJ.

PLoS One. 2016 Jul 5;11(7):e0158641. doi: 10.1371/journal.pone.0158641. eCollection 2016.

11.

Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis.

Jackson JW, Singh MV, Singh VB, Jones LD, Davidson GA, Ture S, Morrell CN, Schifitto G, Maggirwar SB.

PLoS One. 2016 Jun 6;11(6):e0157115. doi: 10.1371/journal.pone.0157115. eCollection 2016.

12.

Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice.

Singh VB, Singh MV, Gorantla S, Poluektova LY, Maggirwar SB.

Sci Rep. 2016 May 31;6:26876. doi: 10.1038/srep26876.

13.

Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction.

Jones LD, Jackson JW, Maggirwar SB.

PLoS One. 2016 Mar 17;11(3):e0151702. doi: 10.1371/journal.pone.0151702. eCollection 2016.

14.

Frog Virus 3 dissemination in the brain of tadpoles, but not in adult Xenopus, involves blood brain barrier dysfunction.

De Jesús Andino F, Jones L, Maggirwar SB, Robert J.

Sci Rep. 2016 Mar 2;6:22508. doi: 10.1038/srep22508.

15.

Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse.

Kiebala M, Singh MV, Piepenbrink MS, Qiu X, Kobie JJ, Maggirwar SB.

PLoS One. 2015 Jun 15;10(6):e0130061. doi: 10.1371/journal.pone.0130061. eCollection 2015.

16.

Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles.

Lannan KL, Sahler J, Kim N, Spinelli SL, Maggirwar SB, Garraud O, Cognasse F, Blumberg N, Phipps RP.

Front Immunol. 2015 Feb 13;6:48. doi: 10.3389/fimmu.2015.00048. eCollection 2015. Review.

17.

Investigating the role of ankyrin-rich membrane spanning protein in human immunodeficiency virus type-1 Tat-induced microglia activation.

Singh VB, Wooten AK, Jackson JW, Maggirwar SB, Kiebala M.

J Neurovirol. 2015 Apr;21(2):186-98. doi: 10.1007/s13365-015-0318-2. Epub 2015 Jan 31.

18.

Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: a novel synergistic therapeutic approach.

Kiebala M, Skalska J, Casulo C, Brookes PS, Peterson DR, Hilchey SP, Dai Y, Grant S, Maggirwar SB, Bernstein SH.

Exp Hematol. 2015 Feb;43(2):89-99. doi: 10.1016/j.exphem.2014.10.004. Epub 2014 Oct 22.

19.

Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation.

Singh MV, Davidson DC, Jackson JW, Singh VB, Silva J, Ramirez SH, Maggirwar SB.

J Immunol. 2014 May 15;192(10):4674-84. doi: 10.4049/jimmunol.1302318. Epub 2014 Apr 11.

20.

Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation?

Davidson DC, Jackson JW, Maggirwar SB.

J Neuroinflammation. 2013 Dec 1;10:144. doi: 10.1186/1742-2094-10-144. Review.

21.

Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.

Ma Q, Gelbard HA, Maggirwar SB, Dewhurst S, Gendelman HE, Peterson DR, DiFrancesco R, Hochreiter JS, Morse GD, Schifitto G.

J Neurovirol. 2013 Jun;19(3):254-60. doi: 10.1007/s13365-013-0172-z. Epub 2013 Jun 5.

22.

Attenuation of inflammatory mediator production by the NF-κB member RelB is mediated by microRNA-146a in lung fibroblasts.

McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP.

Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L774-81. doi: 10.1152/ajplung.00352.2012. Epub 2013 Apr 5.

23.

Valproic acid inhibits the release of soluble CD40L induced by non-nucleoside reverse transcriptase inhibitors in human immunodeficiency virus infected individuals.

Davidson DC, Schifitto G, Maggirwar SB.

PLoS One. 2013;8(3):e59950. doi: 10.1371/journal.pone.0059950. Epub 2013 Mar 28.

24.

Excess soluble CD40L contributes to blood brain barrier permeability in vivo: implications for HIV-associated neurocognitive disorders.

Davidson DC, Hirschman MP, Sun A, Singh MV, Kasischke K, Maggirwar SB.

PLoS One. 2012;7(12):e51793. doi: 10.1371/journal.pone.0051793. Epub 2012 Dec 12.

25.

Detection of circulating platelet-monocyte complexes in persons infected with human immunodeficiency virus type-1.

Singh MV, Davidson DC, Kiebala M, Maggirwar SB.

J Virol Methods. 2012 May;181(2):170-6. doi: 10.1016/j.jviromet.2012.02.005. Epub 2012 Feb 23.

26.

Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation.

Xu X, Steere RR, Fedorchuk CA, Pang J, Lee JY, Lim JH, Xu H, Pan ZK, Maggirwar SB, Li JD.

PLoS One. 2011;6(11):e28216. doi: 10.1371/journal.pone.0028216. Epub 2011 Nov 23.

27.

Recently recognized platelet agonists.

Morrell CN, Maggirwar SB.

Curr Opin Hematol. 2011 Sep;18(5):309-14. doi: 10.1097/MOH.0b013e3283497dfb. Review.

PMID:
21730836
28.

Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS.

Cao S, Wu C, Yang Y, Sniderhan LF, Maggirwar SB, Dewhurst S, Lu Y.

J Neuroinflammation. 2011 May 14;8:48. doi: 10.1186/1742-2094-8-48.

29.
30.

PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.

Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ.

PLoS One. 2011 Jan 6;6(1):e15909. doi: 10.1371/journal.pone.0015909.

31.

Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.

Davidson DC, Hirschman MP, Spinelli SL, Morrell CN, Schifitto G, Phipps RP, Maggirwar SB.

J Immunol. 2011 Jan 1;186(1):584-91. doi: 10.4049/jimmunol.1001911. Epub 2010 Nov 29.

32.

Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.

Polesskaya O, Cunningham LL, Francis SP, Luebke AE, Zhu X, Collins D, Vasilyeva ON, Sahler J, Desmet EA, Gelbard HA, Maggirwar SB, Walton JP, Frisina RD Jr, Dewhurst S.

Hear Res. 2010 Dec 1;270(1-2):21-7. doi: 10.1016/j.heares.2010.10.008. Epub 2010 Oct 27.

33.

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

Perry SW, Barbieri J, Tong N, Polesskaya O, Pudasaini S, Stout A, Lu R, Kiebala M, Maggirwar SB, Gelbard HA.

J Neurosci. 2010 Oct 20;30(42):14153-64. doi: 10.1523/JNEUROSCI.1042-10.2010.

34.

Nuclear emancipation: a platelet tour de force.

Spinelli SL, Maggirwar SB, Blumberg N, Phipps RP.

Sci Signal. 2010 Oct 19;3(144):pe37. doi: 10.1126/scisignal.3144pe37. Review.

PMID:
20959522
35.

Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase.

Gelbard HA, Dewhurst S, Maggirwar SB, Kiebala M, Polesskaya O, Gendelman HE.

Neurotherapeutics. 2010 Oct;7(4):392-8. doi: 10.1016/j.nurt.2010.08.001. Review.

36.

Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production.

Kiebala M, Polesskaya O, Yao Z, Perry SW, Maggirwar SB.

PLoS One. 2010 Jul 29;5(7):e11875. doi: 10.1371/journal.pone.0011875.

37.

Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: implications for HIV-1 encephalitis.

Ramirez SH, Fan S, Dykstra H, Reichenbach N, Del Valle L, Potula R, Phipps RP, Maggirwar SB, Persidsky Y.

J Neurosci. 2010 Jul 14;30(28):9454-64. doi: 10.1523/JNEUROSCI.5796-09.2010.

38.

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.

Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB.

Virology. 2010 May 10;400(2):224-32. doi: 10.1016/j.virol.2010.02.001. Epub 2010 Feb 25.

39.

Platelets and megakaryocytes contain functional nuclear factor-kappaB.

Spinelli SL, Casey AE, Pollock SJ, Gertz JM, McMillan DH, Narasipura SD, Mody NA, King MR, Maggirwar SB, Francis CW, Taubman MB, Blumberg N, Phipps RP.

Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):591-8. doi: 10.1161/ATVBAHA.109.197343. Epub 2009 Dec 30.

40.

Neuroprotective activities of CEP-1347 in models of neuroAIDS.

Eggert D, Dash PK, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA, Gendelman HE.

J Immunol. 2010 Jan 15;184(2):746-56. doi: 10.4049/jimmunol.0902962. Epub 2009 Dec 4.

41.

Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.

Skalska J, Brookes PS, Nadtochiy SM, Hilchey SP, Jordan CT, Guzman ML, Maggirwar SB, Briehl MM, Bernstein SH.

PLoS One. 2009 Dec 2;4(12):e8115. doi: 10.1371/journal.pone.0008115.

42.

Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma.

Sniderhan LF, Garcia-Bates TM, Burgart M, Bernstein SH, Phipps RP, Maggirwar SB.

Exp Hematol. 2009 Nov;37(11):1295-309. doi: 10.1016/j.exphem.2009.08.005. Epub 2009 Aug 28.

43.

Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.

Schifitto G, Zhong J, Gill D, Peterson DR, Gaugh MD, Zhu T, Tivarus M, Cruttenden K, Maggirwar SB, Gendelman HE, Dewhurst S, Gelbard HA.

J Neurovirol. 2009 Apr;15(2):176-86. doi: 10.1080/13550280902758973.

44.

Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survival.

Garcia-Bates TM, Peslak SA, Baglole CJ, Maggirwar SB, Bernstein SH, Phipps RP.

Cancer Immunol Immunother. 2009 Jul;58(7):1071-83. doi: 10.1007/s00262-008-0625-z. Epub 2008 Nov 19.

45.

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

Norman JP, Perry SW, Reynolds HM, Kiebala M, De Mesy Bentley KL, Trejo M, Volsky DJ, Maggirwar SB, Dewhurst S, Masliah E, Gelbard HA.

PLoS One. 2008;3(11):e3731. doi: 10.1371/journal.pone.0003731. Epub 2008 Nov 14.

46.

The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.

Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ.

J Biol Chem. 2008 Oct 24;283(43):28944-57. doi: 10.1074/jbc.M800685200. Epub 2008 Aug 12.

47.

Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signaling.

Sniderhan LF, Stout A, Lu Y, Chao MV, Maggirwar SB.

Mol Cell Neurosci. 2008 Jul;38(3):404-16. doi: 10.1016/j.mcn.2008.04.001. Epub 2008 Apr 16.

48.

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.

Chugh P, Bradel-Tretheway B, Monteiro-Filho CM, Planelles V, Maggirwar SB, Dewhurst S, Kim B.

Retrovirology. 2008 Jan 31;5:11. doi: 10.1186/1742-4690-5-11.

49.

Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.

Dewhurst S, Maggirwar SB, Schifitto G, Gendelman HE, Gelbard HA.

J Neuroimmune Pharmacol. 2007 Mar;2(1):93-6. Epub 2006 Dec 16. Review.

PMID:
18040831
50.

Activation of the adenosine A1 receptor inhibits HIV-1 tat-induced apoptosis by reducing nuclear factor-kappaB activation and inducible nitric-oxide synthase.

Pingle SC, Jajoo S, Mukherjea D, Sniderhan LF, Jhaveri KA, Marcuzzi A, Rybak LP, Maggirwar SB, Ramkumar V.

Mol Pharmacol. 2007 Oct;72(4):856-67. Epub 2007 Jul 3.

PMID:
17609415

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