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The Peptide ERα17p Is a GPER Inverse Agonist that Exerts Antiproliferative Effects in Breast Cancer Cells.

Lappano R, Mallet C, Rizzuti B, Grande F, Galli GR, Byrne C, Broutin I, Boudieu L, Eschalier A, Jacquot Y, Maggiolini M.

Cells. 2019 Jun 14;8(6). pii: E590. doi: 10.3390/cells8060590.


Differential MicroRNA Landscape Triggered by Estrogens in Cancer Associated Fibroblasts (CAFs) of Primary and Metastatic Breast Tumors.

Vivacqua A, Muoio MG, Miglietta AM, Maggiolini M.

Cancers (Basel). 2019 Mar 23;11(3). pii: E412. doi: 10.3390/cancers11030412.


GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression.

Santolla MF, Vivacqua A, Lappano R, Rigiracciolo DC, Cirillo F, Galli GR, Talia M, Brunetti G, Miglietta AM, Belfiore A, Maggiolini M.

Cells. 2019 Mar 7;8(3). pii: E223. doi: 10.3390/cells8030223.


A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK.

Feng X, Arang N, Rigiracciolo DC, Lee JS, Yeerna H, Wang Z, Lubrano S, Kishore A, Pachter JA, König GM, Maggiolini M, Kostenis E, Schlaepfer DD, Tamayo P, Chen Q, Ruppin E, Gutkind JS.

Cancer Cell. 2019 Mar 18;35(3):457-472.e5. doi: 10.1016/j.ccell.2019.01.009. Epub 2019 Feb 14.


Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells.

Rigiracciolo DC, Santolla MF, Lappano R, Vivacqua A, Cirillo F, Galli GR, Talia M, Muglia L, Pellegrino M, Nohata N, Di Martino MT, Maggiolini M.

J Exp Clin Cancer Res. 2019 Feb 6;38(1):58. doi: 10.1186/s13046-019-1056-8.


GPCR Modulation in Breast Cancer.

Lappano R, Jacquot Y, Maggiolini M.

Int J Mol Sci. 2018 Dec 2;19(12). pii: E3840. doi: 10.3390/ijms19123840. Review.


miR-338-3p Is Regulated by Estrogens through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts (CAFs).

Vivacqua A, Sebastiani A, Miglietta AM, Rigiracciolo DC, Cirillo F, Galli GR, Talia M, Santolla MF, Lappano R, Giordano F, Panno ML, Maggiolini M.

Cells. 2018 Nov 9;7(11). pii: E203. doi: 10.3390/cells7110203.


Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT.

De Francesco EM, Maggiolini M, Musti AM.

Int J Mol Sci. 2018 Jul 10;19(7). pii: E2011. doi: 10.3390/ijms19072011. Review.


Functional characterization of the partially purified Sac1p independent adenine nucleotide transport system (ANTS) from yeast endoplasmic reticulum.

Li Y, Cappello AR, Muto L, Martello E, Madeo M, Curcio R, Lunetti P, Raho S, Zaffino F, Frattaruolo L, Lappano R, Malivindi R, Maggiolini M, Aiello D, Piazzolla C, Capobianco L, Fiermonte G, Dolce V.

J Biochem. 2018 Oct 1;164(4):313-322. doi: 10.1093/jb/mvy054.


Notch1 Mediates Preconditioning Protection Induced by GPER in Normotensive and Hypertensive Female Rat Hearts.

Rocca C, Femminò S, Aquila G, Granieri MC, De Francesco EM, Pasqua T, Rigiracciolo DC, Fortini F, Cerra MC, Maggiolini M, Pagliaro P, Rizzo P, Angelone T, Penna C.

Front Physiol. 2018 May 15;9:521. doi: 10.3389/fphys.2018.00521. eCollection 2018.


The Physiopathological Role of the Exchangers Belonging to the SLC37 Family.

Cappello AR, Curcio R, Lappano R, Maggiolini M, Dolce V.

Front Chem. 2018 Apr 17;6:122. doi: 10.3389/fchem.2018.00122. eCollection 2018. Review.


miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling.

Santolla MF, Lappano R, Cirillo F, Rigiracciolo DC, Sebastiani A, Abonante S, Tassone P, Tagliaferri P, Di Martino MT, Maggiolini M, Vivacqua A.

J Exp Clin Cancer Res. 2018 May 2;37(1):94. doi: 10.1186/s13046-018-0767-6.


GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer.

Cirillo F, Pellegrino M, Malivindi R, Rago V, Avino S, Muto L, Dolce V, Vivacqua A, Rigiracciolo DC, De Marco P, Sebastiani A, Abonante S, Nakajima M, Lappano R, Maggiolini M.

Oncotarget. 2017 Nov 20;8(63):106608-106624. doi: 10.18632/oncotarget.22541. eCollection 2017 Dec 5.


G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts.

De Francesco EM, Sotgia F, Clarke RB, Lisanti MP, Maggiolini M.

Int J Mol Sci. 2017 Dec 14;18(12). pii: E2713. doi: 10.3390/ijms18122713. Review.


GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment.

De Francesco EM, Sims AH, Maggiolini M, Sotgia F, Lisanti MP, Clarke RB.

Breast Cancer Res. 2017 Dec 6;19(1):129. doi: 10.1186/s13058-017-0923-5.


Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs).

De Francesco EM, Bonuccelli G, Maggiolini M, Sotgia F, Lisanti MP.

Oncotarget. 2017 Jun 9;8(40):67269-67286. doi: 10.18632/oncotarget.18428. eCollection 2017 Sep 15.


The lauric acid-activated signaling prompts apoptosis in cancer cells.

Lappano R, Sebastiani A, Cirillo F, Rigiracciolo DC, Galli GR, Curcio R, Malaguarnera R, Belfiore A, Cappello AR, Maggiolini M.

Cell Death Discov. 2017 Sep 18;3:17063. doi: 10.1038/cddiscovery.2017.63. eCollection 2017.


Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy.

De Francesco EM, Maggiolini M, Tanowitz HB, Sotgia F, Lisanti MP.

Oncotarget. 2017 Jun 12;8(34):56126-56142. doi: 10.18632/oncotarget.18445. eCollection 2017 Aug 22.


Recent Advances on the Role of microRNAs in both Insulin Resistance and Cancer.

Vivacqua A, De Marco P, Belfiore A, Maggiolini M.

Curr Pharm Des. 2017;23(25):3658-3666. doi: 10.2174/1381612823666170622105123. Review.


Pharmacotherapeutic Targeting of G Protein-Coupled Receptors in Oncology: Examples of Approved Therapies and Emerging Concepts.

Lappano R, Maggiolini M.

Drugs. 2017 Jun;77(9):951-965. doi: 10.1007/s40265-017-0738-9. Review.


Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives.

Barton M, Filardo EJ, Lolait SJ, Thomas P, Maggiolini M, Prossnitz ER.

J Steroid Biochem Mol Biol. 2018 Feb;176:4-15. doi: 10.1016/j.jsbmb.2017.03.021. Epub 2017 Mar 25. Review.


GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs).

Lappano R, Maggiolini M.

J Steroid Biochem Mol Biol. 2018 Feb;176:49-56. doi: 10.1016/j.jsbmb.2017.02.019. Epub 2017 Feb 27. Review.


Composition, Antifungal and Antiproliferative Activities of the Hydrodistilled Oils from Leaves and Flower Heads of Pterocephalus nestorianus Nábělek.

Abdullah FO, Hussain FHS, Mannucci B, Lappano R, Tosi S, Maggiolini M, Vidari G.

Chem Biodivers. 2017 Jul;14(7). doi: 10.1002/cbdv.201700009. Epub 2017 May 27.


Recent advances on the stimulatory effects of metals in breast cancer.

Lappano R, Malaguarnera R, Belfiore A, Maggiolini M.

Mol Cell Endocrinol. 2017 Dec 5;457:49-56. doi: 10.1016/j.mce.2016.10.017. Epub 2016 Oct 17. Review.


Recent views of heavy metals as possible risk factors and potential preventive and therapeutic agents in prostate cancer.

Vella V, Malaguarnera R, Lappano R, Maggiolini M, Belfiore A.

Mol Cell Endocrinol. 2017 Dec 5;457:57-72. doi: 10.1016/j.mce.2016.10.020. Epub 2016 Oct 20. Review.


Protective Role of GPER Agonist G-1 on Cardiotoxicity Induced by Doxorubicin.

De Francesco EM, Rocca C, Scavello F, Amelio D, Pasqua T, Rigiracciolo DC, Scarpelli A, Avino S, Cirillo F, Amodio N, Cerra MC, Maggiolini M, Angelone T.

J Cell Physiol. 2017 Jul;232(7):1640-1649. doi: 10.1002/jcp.25585. Epub 2017 Feb 16.


Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells.

Avino S, De Marco P, Cirillo F, Santolla MF, De Francesco EM, Perri MG, Rigiracciolo D, Dolce V, Belfiore A, Maggiolini M, Lappano R, Vivacqua A.

Oncotarget. 2016 Aug 16;7(33):52710-52728. doi: 10.18632/oncotarget.10348.


GPER, IGF-IR, and EGFR transduction signaling are involved in stimulatory effects of zinc in breast cancer cells and cancer-associated fibroblasts.

Pisano A, Santolla MF, De Francesco EM, De Marco P, Rigiracciolo DC, Perri MG, Vivacqua A, Abonante S, Cappello AR, Dolce V, Belfiore A, Maggiolini M, Lappano R.

Mol Carcinog. 2017 Feb;56(2):580-593. doi: 10.1002/mc.22518. Epub 2016 Jul 4.


Estrogen Receptors and Chronic Venous Disease.

Serra R, Gallelli L, Perri P, De Francesco EM, Rigiracciolo DC, Mastroroberto P, Maggiolini M, de Franciscis S.

Eur J Vasc Endovasc Surg. 2016 Jul;52(1):114-8. doi: 10.1016/j.ejvs.2016.04.020. Epub 2016 May 21.


GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response.

De Marco P, Lappano R, De Francesco EM, Cirillo F, Pupo M, Avino S, Vivacqua A, Abonante S, Picard D, Maggiolini M.

Sci Rep. 2016 Apr 13;6:24354. doi: 10.1038/srep24354.


Recent Advances on the Role of G Protein-Coupled Receptors in Hypoxia-Mediated Signaling.

Lappano R, Rigiracciolo D, De Marco P, Avino S, Cappello AR, Rosano C, Maggiolini M, De Francesco EM.

AAPS J. 2016 Mar;18(2):305-10. doi: 10.1208/s12248-016-9881-6. Epub 2016 Feb 10. Review.


IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway.

Matà R, Palladino C, Nicolosi ML, Lo Presti AR, Malaguarnera R, Ragusa M, Sciortino D, Morrione A, Maggiolini M, Vella V, Belfiore A.

Oncotarget. 2016 Feb 16;7(7):7683-700. doi: 10.18632/oncotarget.6524.


GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells.

Rigiracciolo DC, Scarpelli A, Lappano R, Pisano A, Santolla MF, Avino S, De Marco P, Bussolati B, Maggiolini M, De Francesco EM.

Oncotarget. 2016 Jan 5;7(1):94-111. doi: 10.18632/oncotarget.6475.


The G protein estrogen receptor (GPER) is regulated by endothelin-1 mediated signaling in cancer cells.

Bartella V, De Francesco EM, Perri MG, Curcio R, Dolce V, Maggiolini M, Vivacqua A.

Cell Signal. 2016 Feb;28(2):61-71. doi: 10.1016/j.cellsig.2015.11.010. Epub 2015 Nov 19.


GPER Mediates Non-Genomic Effects of Estrogen.

Pupo M, Maggiolini M, Musti AM.

Methods Mol Biol. 2016;1366:471-488. doi: 10.1007/978-1-4939-3127-9_37.


Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands.

Rosano C, Ponassi M, Santolla MF, Pisano A, Felli L, Vivacqua A, Maggiolini M, Lappano R.

AAPS J. 2016 Jan;18(1):41-6. doi: 10.1208/s12248-015-9844-3. Epub 2015 Nov 16. Review.


Pregnancy Augments G Protein Estrogen Receptor (GPER) Induced Vasodilation in Rat Uterine Arteries via the Nitric Oxide - cGMP Signaling Pathway.

Tropea T, De Francesco EM, Rigiracciolo D, Maggiolini M, Wareing M, Osol G, Mandalà M.

PLoS One. 2015 Nov 4;10(11):e0141997. doi: 10.1371/journal.pone.0141997. eCollection 2015.


Copper activates HIF-1α/GPER/VEGF signalling in cancer cells.

Rigiracciolo DC, Scarpelli A, Lappano R, Pisano A, Santolla MF, De Marco P, Cirillo F, Cappello AR, Dolce V, Belfiore A, Maggiolini M, De Francesco EM.

Oncotarget. 2015 Oct 27;6(33):34158-77. doi: 10.18632/oncotarget.5779.


A Bodipy as a luminescent probe for detection of the G protein estrogen receptor (GPER).

Papalia T, Lappano R, Barattucci A, Pisano A, Bruno G, Santolla MF, Campagna S, De Marco P, Puntoriero F, De Francesco EM, Rosano C, Maggiolini M, Bonaccorsi P.

Org Biomol Chem. 2015 Nov 14;13(42):10437-41. doi: 10.1039/c5ob01827g. Epub 2015 Sep 24.


SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer.

Santolla MF, Avino S, Pellegrino M, De Francesco EM, De Marco P, Lappano R, Vivacqua A, Cirillo F, Rigiracciolo DC, Scarpelli A, Abonante S, Maggiolini M.

Cell Death Dis. 2015 Jul 30;6:e1834. doi: 10.1038/cddis.2015.201.


A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models.

Lappano R, Rosano C, Pisano A, Santolla MF, De Francesco EM, De Marco P, Dolce V, Ponassi M, Felli L, Cafeo G, Kohnke FH, Abonante S, Maggiolini M.

Dis Model Mech. 2015 Oct 1;8(10):1237-46. doi: 10.1242/dmm.021071. Epub 2015 Jul 16.


Estrogenic gper signaling regulates mir144 expression in cancer cells and cancer-associated fibroblasts (cafs).

Vivacqua A, De Marco P, Santolla MF, Cirillo F, Pellegrino M, Panno ML, Abonante S, Maggiolini M.

Oncotarget. 2015 Jun 30;6(18):16573-87.


Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts.

Maggiolini M, Santolla MF, Avino S, Aiello F, Rosano C, Garofalo A, Grande F.

Future Med Chem. 2015;7(4):437-48. doi: 10.4155/fmc.15.3.


Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells.

De Marco P, Cirillo F, Vivacqua A, Malaguarnera R, Belfiore A, Maggiolini M.

Front Endocrinol (Lausanne). 2015 Mar 6;6:30. doi: 10.3389/fendo.2015.00030. eCollection 2015. Review.


(6-bromo-1,4-dimethyl-9H-carbazol-3-yl-methylene)-hydrazine (carbhydraz) acts as a GPER agonist in breast cancer cells.

Sinicropi MS, Lappano R, Caruso A, Santolla MF, Pisano A, Rosano C, Capasso A, Panno A, Lancelot JC, Rault S, Saturnino C, Maggiolini M.

Curr Top Med Chem. 2015;15(11):1035-42.


Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts.

Albanito L, Lappano R, Madeo A, Chimento A, Prossnitz ER, Cappello AR, Dolce V, Abonante S, Pezzi V, Maggiolini M.

Environ Health Perspect. 2015 May;123(5):493-9. doi: 10.1289/ehp.1408586. Epub 2015 Jan 16.


Different 6-Aryl-Fulvenes Exert Anti-proliferative effects on Cancer Cells.

Sirignano E, Pisano A, Caruso A, Saturnino C, Sinicropi MS, Lappano R, Botta A, Iacopetta D, Maggiolini M, Longo P.

Anticancer Agents Med Chem. 2015;15(4):468-74.


GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts.

De Marco P, Romeo E, Vivacqua A, Malaguarnera R, Abonante S, Romeo F, Pezzi V, Belfiore A, Maggiolini M.

Endocr Relat Cancer. 2014 Oct;21(5):739-53. doi: 10.1530/ERC-14-0245. Epub 2014 Jul 10.


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