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Hypersensitivity reactions to biologics used in rheumatology.

Matucci A, Nencini F, Maggi E, Vultaggio A.

Expert Rev Clin Immunol. 2019 Oct 30:1-9. doi: 10.1080/1744666X.2020.1684264. [Epub ahead of print]


The intestinal expansion of TCRγδ+ and disappearance of IL4+ T cells suggest their involvement in the evolution from potential to overt celiac disease.

Vitale S, Santarlasci V, Camarca A, Picascia S, Pasquale AD, Maglio M, Maggi E, Cosmi L, Annunziato F, Troncone R, Auricchio R, Gianfrani C.

Eur J Immunol. 2019 Sep 25. doi: 10.1002/eji.201948098. [Epub ahead of print]


Insertional oncogenesis by HPV70 revealed by multiple genomic analyses in a clinically HPV-negative cervical cancer.

Van Arsdale A, Patterson NE, Maggi EC, Agoni L, Van Doorslaer K, Harmon B, Nevadunsky N, Kuo DYS, Einstein MH, Lenz J, Montagna C.

Genes Chromosomes Cancer. 2019 Aug 13. doi: 10.1002/gcc.22799. [Epub ahead of print]


A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses.

Andriani GA, Maggi E, Piqué D, Zimmerman SE, Lee M, Quispe-Tintaya W, Maslov A, Campisi J, Vijg J, Mar JC, Montagna C.

Sci Rep. 2019 Jul 19;9(1):10508. doi: 10.1038/s41598-019-46606-w.


Blueberry-Based Meals for Obese Patients with Metabolic Syndrome: A Multidisciplinary Metabolomic Pilot Study.

Sobolev AP, Ciampa A, Ingallina C, Mannina L, Capitani D, Ernesti I, Maggi E, Businaro R, Del Ben M, Engel P, Giusti AM, Donini LM, Pinto A.

Metabolites. 2019 Jul 10;9(7). pii: E138. doi: 10.3390/metabo9070138.


Aneuvis: web-based exploration of numerical chromosomal variation in single cells.

Piqué DG, Andriani GA, Maggi E, Zimmerman SE, Greally JM, Montagna C, Mar JC.

BMC Bioinformatics. 2019 Jun 17;20(1):336. doi: 10.1186/s12859-019-2842-1.


Medroxyprogesterone Acetate Decreases Th1, Th17, and Increases Th22 Responses via AHR Signaling Which Could Affect Susceptibility to Infections and Inflammatory Disease.

Piccinni MP, Lombardelli L, Logiodice F, Kullolli O, Maggi E, Barkley MS.

Front Immunol. 2019 Apr 3;10:642. doi: 10.3389/fimmu.2019.00642. eCollection 2019.


Rapid clinical improvement of atopic dermatitis in an Omalizumab treated patient.

Bormioli S, Matucci A, Dies L, Nencini F, Grosso F, Maggi E, Vultaggio A.

Clin Mol Allergy. 2019 Mar 12;17:5. doi: 10.1186/s12948-019-0109-z. eCollection 2019.


T Cell Response to Infliximab in Exposed Patients: A Longitudinal Analysis.

Pratesi S, Nencini F, Grosso F, Dies L, Bormioli S, Cammelli D, Maggi E, Matucci A, Vultaggio A; ABIRISK Consortium.

Front Immunol. 2019 Jan 11;9:3113. doi: 10.3389/fimmu.2018.03113. eCollection 2018.


Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy.

Logiodice F, Lombardelli L, Kullolli O, Haller H, Maggi E, Rukavina D, Piccinni MP.

Int J Mol Sci. 2019 Jan 19;20(2). pii: E428. doi: 10.3390/ijms20020428.


The percentage of patients achieving complete remission of urticaria increases with repeated courses of treatment.

Matucci A, Nencini F, Rossi O, Pratesi S, Parronchi P, Maggi E, Vultaggio A.

J Allergy Clin Immunol Pract. 2019 Jan;7(1):339-340. doi: 10.1016/j.jaip.2018.06.011. Epub 2018 Jul 2. No abstract available.


Decreased circulating lymphatic endothelial progenitor cells in digital ulcer-complicated systemic sclerosis.

Manetti M, Pratesi S, Romano E, Rosa I, Bruni C, Bellando-Randone S, Guiducci S, Maggi E, Ibba-Manneschi L, Matucci-Cerinic M.

Ann Rheum Dis. 2019 Apr;78(4):575-577. doi: 10.1136/annrheumdis-2018-214240. Epub 2018 Oct 12. No abstract available.


Omalizumab dampens type 2 inflammation in a group of long-term treated asthma patients and detaches IgE from FcεRI.

Maggi L, Rossettini B, Montaini G, Matucci A, Vultaggio A, Mazzoni A, Palterer B, Parronchi P, Maggi E, Liotta F, Annunziato F, Cosmi L.

Eur J Immunol. 2018 Dec;48(12):2005-2014. doi: 10.1002/eji.201847668. Epub 2018 Oct 9.


Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes β-cell proliferation.

Yuan Z, Gardiner JC, Maggi EC, Adem A, Zhang G, Lee S, Romanienko P, Du YN, Libutti SK.

Cancer Gene Ther. 2019 Mar;26(3-4):94-102. doi: 10.1038/s41417-018-0046-x. Epub 2018 Sep 7.


Hybrid datasets: integrating observations with experiments in the era of macroecology and big data.

Benedetti-Cecchi L, Bulleri F, Dal Bello M, Maggi E, Ravaglioli C, Rindi L.

Ecology. 2018 Dec;99(12):2654-2666. doi: 10.1002/ecy.2504. Epub 2018 Oct 18.


Eomes controls the development of Th17-derived (non-classic) Th1 cells during chronic inflammation.

Mazzoni A, Maggi L, Siracusa F, Ramazzotti M, Rossi MC, Santarlasci V, Montaini G, Capone M, Rossettini B, De Palma R, Kruglov A, Chang HD, Cimaz R, Maggi E, Romagnani S, Liotta F, Cosmi L, Annunziato F.

Eur J Immunol. 2019 Jan;49(1):79-95. doi: 10.1002/eji.201847677. Epub 2018 Nov 22.


Ecological feedback mechanisms and variable disturbance regimes: the uncertain future of Mediterranean macroalgal forests.

Maggi E, Puccinelli E, Benedetti-Cecchi L.

Mar Environ Res. 2018 Sep;140:342-357. doi: 10.1016/j.marenvres.2018.07.002. Epub 2018 Jul 9.


[Immunological mechanisms of allergic diseases].

Maggi E.

G Ital Med Lav Ergon. 2017 Nov;39(3):168-171. Italian.


Efficacy and Safety of Mepolizumab (Anti-Interleukin-5) Treatment in Gleich's Syndrome.

Matucci A, Liotta F, Vivarelli E, Dies L, Annunziato F, Piccinni MP, Nencini F, Pratesi S, Maggi E, Vultaggio A.

Front Immunol. 2018 May 29;9:1198. doi: 10.3389/fimmu.2018.01198. eCollection 2018.


Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?

Matucci A, Vultaggio A, Maggi E, Kasujee I.

Respir Res. 2018 Jun 8;19(1):113. doi: 10.1186/s12931-018-0813-0. Review.


Persistent unilateral ulcer of the ear as the first manifestation of relapsing polychondritis.

Tognetti L, Rubegni P, Vitiello G, Bormioli S, Carraro A, Cinotti E, Fimiani M, Maggi E.

Clin Exp Dermatol. 2018 Oct;43(7):823-824. doi: 10.1111/ced.13615. Epub 2018 May 16. No abstract available.


IgG4 anti-infliximab in treated patients: Clinical impact and temporal evolution.

Vultaggio A, Nencini F, Carraresi A, Pratesi S, Movérare R, Eriksson C, Venemalm L, Maggi E, Matucci A.

Allergy. 2018 Nov;73(11):2172-2181. doi: 10.1111/all.13471. Epub 2018 Oct 2.


Anti-Oxidant and Anti-Inflammatory Activity of Ketogenic Diet: New Perspectives for Neuroprotection in Alzheimer's Disease.

Pinto A, Bonucci A, Maggi E, Corsi M, Businaro R.

Antioxidants (Basel). 2018 Apr 28;7(5). pii: E63. doi: 10.3390/antiox7050063. Review.


The Kinetics of Antidrug Antibodies, Drug Levels, and Clinical Outcomes in Infliximab-Exposed Patients with Immune-Mediated Disorders.

Nencini F, Vultaggio A, Pratesi S, Cammelli D, Milla M, Fiori G, Bagnoli S, Prignano F, Romagnani S, Maggi E, Matucci A.

J Allergy Clin Immunol Pract. 2018 Nov - Dec;6(6):2065-2072.e2. doi: 10.1016/j.jaip.2018.04.007. Epub 2018 Apr 13.


Therapeutic Efficacy of Autologous Non-Mobilized Enriched Circulating Endothelial Progenitors in Patients With Critical Limb Ischemia - The SCELTA Trial.

Liotta F, Annunziato F, Castellani S, Boddi M, Alterini B, Castellini G, Mazzanti B, Cosmi L, Acquafresca M, Bartalesi F, Dilaghi B, Dorigo W, Graziani G, Bartolozzi B, Bellandi G, Carli G, Bartoloni A, Fargion A, Fassio F, Fontanari P, Landini G, Lucente EAM, Michelagnoli S, Orsi Battaglini C, Panigada G, Pigozzi C, Querci V, Santarlasci V, Parronchi P, Troisi N, Baggiore C, Romagnani P, Mannucci E, Saccardi R, Pratesi C, Gensini G, Romagnani S, Maggi E.

Circ J. 2018 May 25;82(6):1688-1698. doi: 10.1253/circj.CJ-17-0720. Epub 2018 Mar 23.


Development of a Method to Implement Whole-Genome Bisulfite Sequencing of cfDNA from Cancer Patients and a Mouse Tumor Model.

Maggi EC, Gravina S, Cheng H, Piperdi B, Yuan Z, Dong X, Libutti SK, Vijg J, Montagna C.

Front Genet. 2018 Jan 23;9:6. doi: 10.3389/fgene.2018.00006. eCollection 2018.


Tocilizumab in Giant Cell Arteritis: A Real-Life Retrospective Study.

Vitiello G, Orsi Battaglini C, Carli G, Radice A, Matucci A, Vultaggio A, Olianti C, Parronchi P, Maggi E, Cammelli D.

Angiology. 2018 Oct;69(9):763-769. doi: 10.1177/0003319717753223. Epub 2018 Jan 17.


Bioerosive and bioprotective role of barnacles on rocky shores.

Pappalardo M, Maggi E, Geppini C, Pannacciulli F.

Sci Total Environ. 2018 Apr 1;619-620:83-92. doi: 10.1016/j.scitotenv.2017.10.281. Epub 2017 Nov 13.


Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis.

Manetti M, Pratesi S, Romano E, Bellando-Randone S, Rosa I, Guiducci S, Fioretto BS, Ibba-Manneschi L, Maggi E, Matucci-Cerinic M.

PLoS One. 2017 Aug 10;12(8):e0183102. doi: 10.1371/journal.pone.0183102. eCollection 2017.


IL-10-Producing Infliximab-Specific T Cells Regulate the Antidrug T Cell Response in Exposed Patients.

Vultaggio A, Nencini F, Pratesi S, Cammelli D, Totaro M, Romagnani S, Maggi E, Matucci A; ABIRISK Consortium.

J Immunol. 2017 Aug 15;199(4):1283-1289. doi: 10.4049/jimmunol.1700008. Epub 2017 Jul 17.


Musculin inhibits human T-helper 17 cell response to interleukin 2 by controlling STAT5B activity.

Santarlasci V, Mazzoni A, Capone M, Rossi MC, Maggi L, Montaini G, Rossettini B, Cimaz R, Ramazzotti M, Barra G, De Palma R, Maggi E, Liotta F, Cosmi L, Romagnani S, Annunziato F.

Eur J Immunol. 2017 Sep;47(9):1427-1442. doi: 10.1002/eji.201746996. Epub 2017 Jul 6.


Cutaneous leucocytoclastic vasculitis with anti-EJ autoantibodies: mere coincidence or a manifestation of antisynthetase syndrome?

Palterer B, Grandi V, Antiga E, Maio V, Maggi E, Liotta F.

Clin Exp Dermatol. 2017 Apr;42(3):345-347. doi: 10.1111/ced.13063. Epub 2017 Feb 27. No abstract available.


Carry over effects of nutrient addition on the recovery of an invasive seaweed from the winter die-back.

Uyà M, Maggi E, Mori G, Nuccio C, Gribben PE, Bulleri F.

Mar Environ Res. 2017 May;126:37-44. doi: 10.1016/j.marenvres.2017.02.006. Epub 2017 Feb 20.


Preclinical evaluation of radiation and systemic, RGD-targeted, adeno-associated virus phage-TNF gene therapy in a mouse model of spontaneously metastatic melanoma.

Quinn TJ, Healy N, Sara A, Maggi E, Claros CS, Kabarriti R, Scandiuzzi L, Liu L, Gorecka J, Adem A, Basu I, Yuan Z, Guha C.

Cancer Gene Ther. 2017 Jan;24(1):13-19. doi: 10.1038/cgt.2016.70. Epub 2016 Dec 9.


Influence of anti-TNF immunogenicity on safety in rheumatic disease: a narrative review.

Matucci A, Cammelli D, Cantini F, Goletti D, Marino V, Milano GM, Scarpa R, Tocci G, Maggi E, Vultaggio A.

Expert Opin Drug Saf. 2016 Dec;15(sup1):3-10. Review.


Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients.

Capone M, Maggi L, Santarlasci V, Rossi MC, Mazzoni A, Montaini G, Cimaz R, Ramazzotti M, Piccinni MP, Barra G, De Palma R, Liotta F, Maggi E, Romagnani S, Annunziato F, Cosmi L.

Clin Mol Allergy. 2016 Nov 8;14:16. eCollection 2016.


Immunosuppressive Activity of Abatacept on Circulating T Helper Lymphocytes from Juvenile Idiopathic Arthritis Patients.

Maggi L, Cimaz R, Capone M, Santarlasci V, Rossi MC, Mazzoni A, Montaini G, Pagnini I, Giani T, Simonini G, Scaletti C, Liotta F, Maggi E, Annunziato F, Cosmi L.

Int Arch Allergy Immunol. 2016;171(1):45-53. Epub 2016 Nov 8.


Climate-related environmental stress in intertidal grazers: scaling-up biochemical responses to assemblage-level processes.

Maggi E, Cappiello M, Del Corso A, Lenzarini F, Peroni E, Benedetti-Cecchi L.

PeerJ. 2016 Oct 20;4:e2533. eCollection 2016.


An overview on safety of monoclonal antibodies.

Matucci A, Nencini F, Pratesi S, Maggi E, Vultaggio A.

Curr Opin Allergy Clin Immunol. 2016 Dec;16(6):576-581. Review.


Circulating T cells to infliximab are detectable mainly in treated patients developing anti-drug antibodies and hypersensitivity reactions.

Vultaggio A, Petroni G, Pratesi S, Nencini F, Cammelli D, Milla M, Prignano F, Annese V, Romagnani S, Maggi E, Matucci A; ABIRISK Consortium.

Clin Exp Immunol. 2016 Dec;186(3):364-372. doi: 10.1111/cei.12858. Epub 2016 Oct 26.


How the immune system responds to therapeutic biological agents.

Vultaggio A, Petroni G, Pratesi S, Nencini F, Cammelli D, Ferraro A, Maggi E, Matucci A.

J Int Med Res. 2016 Sep;44(1 suppl):38-42.


Technological advances in precision medicine and drug development.

Maggi E, Patterson NE, Montagna C.

Expert Rev Precis Med Drug Dev. 2016;1(3):331-343. Epub 2016 May 5.


Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects.

Loupe JM, Miller PJ, Bonner BP, Maggi EC, Vijayaraghavan J, Zabaleta J, Taylor CM, Tsien F, Crabtree JS, Hollenbach AD.

Oncotarget. 2016 Sep 27;7(39):62814-62835. doi: 10.18632/oncotarget.11716.


Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production.

Maggi L, Montaini G, Mazzoni A, Rossettini B, Capone M, Rossi MC, Santarlasci V, Liotta F, Rossi O, Gallo O, De Palma R, Maggi E, Cosmi L, Romagnani S, Annunziato F.

J Allergy Clin Immunol. 2017 Mar;139(3):964-976.e4. doi: 10.1016/j.jaci.2016.06.032. Epub 2016 Jul 27.


Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.

Maggi EC, Trillo-Tinoco J, Struckhoff AP, Vijayaraghavan J, Del Valle L, Crabtree JS.

Oncogenesis. 2016 Aug 22;5(8):e257. doi: 10.1038/oncsis.2016.58.


Dermatophagoides pteronyssinus group 2 allergen bound to 8-OH modified adenine reduces the Th2-mediated airway inflammation without inducing a Th17 response and autoimmunity.

Pratesi S, Nencini F, Filì L, Occhiato EG, Romagnani S, Parronchi P, Maggi E, Vultaggio A.

Mol Immunol. 2016 Sep;77:60-70. doi: 10.1016/j.molimm.2016.07.011. Epub 2016 Jul 29.


Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion.

Loupe JM, Miller PJ, Bonner BP, Maggi EC, Vijayaraghavan J, Crabtree JS, Taylor CM, Zabaleta J, Hollenbach AD.

Oncogenesis. 2016 Jul 25;5(7):e246. doi: 10.1038/oncsis.2016.53.


The safety of monoclonal antibodies in asthma.

Passalacqua G, Matucci A, Vultaggio A, Bagnasco D, Mincarini M, Maggi E, Canonica GW.

Expert Opin Drug Saf. 2016 Aug;15(8):1087-95. doi: 10.1080/14740338.2016.1186641. Review.


Th1-Induced CD106 Expression Mediates Leukocytes Adhesion on Synovial Fibroblasts from Juvenile Idiopathic Arthritis Patients.

Maggi L, Margheri F, Luciani C, Capone M, Rossi MC, Chillà A, Santarlasci V, Mazzoni A, Cimaz R, Liotta F, Maggi E, Cosmi L, Del Rosso M, Annunziato F.

PLoS One. 2016 Apr 28;11(4):e0154422. doi: 10.1371/journal.pone.0154422. eCollection 2016.


Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis.

Yuan Z, Sánchez Claros C, Suzuki M, Maggi EC, Kaner JD, Kinstlinger N, Gorecka J, Quinn TJ, Geha R, Corn A, Pastoriza J, Jing Q, Adem A, Wu H, Alemu G, Du YC, Zheng D, Greally JM, Libutti SK.

Oncotarget. 2016 Mar 15;7(11):12633-50. doi: 10.18632/oncotarget.7279.

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