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Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes.

Lanyon-Hogg T, Ritzefeld M, Sefer L, Bickel JK, Rudolf AF, Panyain N, Bineva-Todd G, Ocasio CA, O'Reilly N, Siebold C, Magee AI, Tate EW.

Chem Sci. 2019 Jul 1;10(39):8995-9000. doi: 10.1039/c9sc01785b. eCollection 2019 Oct 21.


Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation.

Lanyon-Hogg T, Patel NV, Ritzefeld M, Boxall KJ, Burke R, Blagg J, Magee AI, Tate EW.

SLAS Discov. 2017 Apr;22(4):418-424. doi: 10.1177/2472555216689529. Epub 2017 Jan 31.


Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW.

ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. Epub 2016 Oct 25.


Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Data Brief. 2016 Feb 10;7:257-81. doi: 10.1016/j.dib.2016.02.012. eCollection 2016 Jun.


Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Anal Biochem. 2015 Dec 1;490:66-72. doi: 10.1016/j.ab.2015.08.025. Epub 2015 Sep 1.


Sonic hedgehog multimerization: a self-organizing event driven by post-translational modifications?

Koleva MV, Rothery S, Spitaler M, Neil MA, Magee AI.

Mol Membr Biol. 2015;32(3):65-74. doi: 10.3109/09687688.2015.1066895. Epub 2015 Aug 27.


Myristoylation profiling in human cells and zebrafish.

Broncel M, Serwa RA, Ciepla P, Krause E, Dallman MJ, Magee AI, Tate EW.

Data Brief. 2015 Jul 2;4:379-83. doi: 10.1016/j.dib.2015.06.010. eCollection 2015 Sep.


Cholesterylation: a tail of hedgehog.

Ciepla P, Magee AI, Tate EW.

Biochem Soc Trans. 2015 Apr;43(2):262-7. doi: 10.1042/BST20150032. Review.


Membrane bound O-acyltransferases and their inhibitors.

Masumoto N, Lanyon-Hogg T, Rodgers UR, Konitsiotis AD, Magee AI, Tate EW.

Biochem Soc Trans. 2015 Apr;43(2):246-52. doi: 10.1042/BST20150018. Review.


Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

Broncel M, Serwa RA, Ciepla P, Krause E, Dallman MJ, Magee AI, Tate EW.

Angew Chem Int Ed Engl. 2015 May 11;54(20):5948-51. doi: 10.1002/anie.201500342. Epub 2015 Mar 25.


Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines.

Lanyon-Hogg T, Ritzefeld M, Masumoto N, Magee AI, Rzepa HS, Tate EW.

J Org Chem. 2015 May 1;80(9):4370-7. doi: 10.1021/acs.joc.5b00205. Epub 2015 Apr 9.


New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish.

Ciepla P, Konitsiotis AD, Serwa RA, Masumoto N, Leong WP, Dallman MJ, Magee AI, Tate EW.

Chem Sci. 2014 May 1;5(11):4249-4259. Epub 2014 Aug 15.


Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein.

Konitsiotis AD, Jovanović B, Ciepla P, Spitaler M, Lanyon-Hogg T, Tate EW, Magee AI.

J Biol Chem. 2015 Feb 6;290(6):3293-307. doi: 10.1074/jbc.M114.614578. Epub 2014 Dec 12.


Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

Konitsiotis AD, Chang SC, Jovanović B, Ciepla P, Masumoto N, Palmer CP, Tate EW, Couchman JR, Magee AI.

PLoS One. 2014 Mar 7;9(3):e89899. doi: 10.1371/journal.pone.0089899. eCollection 2014.


Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.

McDonald G, Deepak S, Miguel L, Hall CJ, Isenberg DA, Magee AI, Butters T, Jury EC.

J Clin Invest. 2014 Feb;124(2):712-24. doi: 10.1172/JCI69571. Epub 2014 Jan 27.


Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions.

Chang SC, Mulloy B, Magee AI, Couchman JR.

J Biol Chem. 2011 Dec 30;286(52):44391-402. doi: 10.1074/jbc.M111.285361. Epub 2011 Nov 2.


DHHC2 is a protein S-acyltransferase for Lck.

Zeidman R, Buckland G, Cebecauer M, Eissmann P, Davis DM, Magee AI.

Mol Membr Biol. 2011 Oct-Nov;28(7-8):473-86. doi: 10.3109/09687688.2011.630682.


Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.

Plaza-Menacho I, Morandi A, Mologni L, Boender P, Gambacorti-Passerini C, Magee AI, Hofstra RM, Knowles P, McDonald NQ, Isacke CM.

J Biol Chem. 2011 May 13;286(19):17292-302. doi: 10.1074/jbc.M110.168500. Epub 2011 Mar 22.


Primary human CD4+ T cells have diverse levels of membrane lipid order that correlate with their function.

Miguel L, Owen DM, Lim C, Liebig C, Evans J, Magee AI, Jury EC.

J Immunol. 2011 Mar 15;186(6):3505-16. doi: 10.4049/jimmunol.1002980. Epub 2011 Feb 9.


Bioorthogonal chemical tagging of protein cholesterylation in living cells.

Heal WP, Jovanovic B, Bessin S, Wright MH, Magee AI, Tate EW.

Chem Commun (Camb). 2011 Apr 14;47(14):4081-3. doi: 10.1039/c0cc04710d. Epub 2011 Jan 11.


Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas.

Salmond RJ, Filby A, Pirinen N, Magee AI, Zamoyska R.

Blood. 2011 Jan 6;117(1):108-17. doi: 10.1182/blood-2010-03-277160. Epub 2010 Sep 28.


Dynamic organization of lymphocyte plasma membrane: lessons from advanced imaging methods.

Owen DM, Gaus K, Magee AI, Cebecauer M.

Immunology. 2010 Sep;131(1):1-8. doi: 10.1111/j.1365-2567.2010.03319.x. Epub 2010 Jul 15. Review.


High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells.

Owen DM, Oddos S, Kumar S, Davis DM, Neil MA, French PM, Dustin ML, Magee AI, Cebecauer M.

Mol Membr Biol. 2010 Aug;27(4-6):178-89. doi: 10.3109/09687688.2010.495353.


Signalling complexes and clusters: functional advantages and methodological hurdles.

Cebecauer M, Spitaler M, Sergé A, Magee AI.

J Cell Sci. 2010 Feb 1;123(Pt 3):309-20. doi: 10.1242/jcs.061739. Review.


Lipid order and molecular assemblies in the plasma membrane of eukaryotic cells.

Cebecauer M, Owen DM, Markiewicz A, Magee AI.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1056-60. doi: 10.1042/BST0371056.


Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice.

Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJ, Tinker A, Mohun TJ.

J Mol Cell Cardiol. 2009 Jul;47(1):133-41. doi: 10.1016/j.yjmcc.2009.04.007. Epub 2009 Apr 17.


A compact, multidimensional spectrofluorometer exploiting supercontinuum generation.

Manning HB, Kennedy GT, Owen DM, Grant DM, Magee AI, Neil MA, Itoh Y, Dunsby C, French PM.

J Biophotonics. 2008 Dec;1(6):494-505. doi: 10.1002/jbio.200810051.


Analysis of protein acylation.

Zeidman R, Jackson CS, Magee AI.

Curr Protoc Protein Sci. 2009 Feb;Chapter 14:Unit 14.2. doi: 10.1002/0471140864.ps1402s55.


Acyltransferases for secreted signalling proteins (Review).

Chang SC, Magee AI.

Mol Membr Biol. 2009 Jan;26(1):104-13. doi: 10.1080/09687680802706432. Epub 2009 Jan 30. Review.


Foreword: Protein acylation and microdomains in membrane function.

Magee AI.

Mol Membr Biol. 2009 Jan;26(1):3-4. doi: 10.1080/09687680802708917. Epub 2009 Jan 16. No abstract available.


Protein acyl thioesterases (Review).

Zeidman R, Jackson CS, Magee AI.

Mol Membr Biol. 2009 Jan;26(1):32-41. doi: 10.1080/09687680802629329. Epub 2008 Dec 29. Review.


The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid : cholesterol acyltransferase activity.

Lossi NS, Rolhion N, Magee AI, Boyle C, Holden DW.

Microbiology. 2008 Sep;154(Pt 9):2680-8. doi: 10.1099/mic.0.2008/019075-0.


CD1a and MHC class I follow a similar endocytic recycling pathway.

Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB.

Traffic. 2008 Sep;9(9):1446-57. doi: 10.1111/j.1600-0854.2008.00781.x. Epub 2008 Jun 28.


Analysis of protein prenylation and carboxyl-methylation.

Magee AI.

Curr Protoc Protein Sci. 2001 May;Chapter 14:Unit14.3. doi: 10.1002/0471140864.ps1403s05.


Analysis of protein acylation.

Jackson CS, Magee AI.

Curr Protoc Protein Sci. 2001 May;Chapter 14:Unit14.2. doi: 10.1002/0471140864.ps1402s05.


Metabolic labeling of prenyl and carboxyl-methyl groups.

Magee AI.

Curr Protoc Cell Biol. 2001 May;Chapter 7:Unit 7.5. doi: 10.1002/0471143030.cb0705s05.


Metabolic labeling with fatty acids.

Jackson CS, Magee AI.

Curr Protoc Cell Biol. 2001 May;Chapter 7:Unit 7.4. doi: 10.1002/0471143030.cb0704s05.


High speed optically sectioned fluorescence lifetime imaging permits study of live cell signaling events.

Grant DM, McGinty J, McGhee EJ, Bunney TD, Owen DM, Talbot CB, Zhang W, Kumar S, Munro I, Lanigan PM, Kennedy GT, Dunsby C, Magee AI, Courtney P, Katan M, Neil MA, French PM.

Opt Express. 2007 Nov 26;15(24):15656-73.


Optical techniques for imaging membrane lipid microdomains in living cells.

Owen DM, Neil MA, French PM, Magee AI.

Semin Cell Dev Biol. 2007 Oct;18(5):591-8. Epub 2007 Jul 25. Review.


Sorafenib functions to potently suppress RET tyrosine kinase activity by direct enzymatic inhibition and promoting RET lysosomal degradation independent of proteasomal targeting.

Plaza-Menacho I, Mologni L, Sala E, Gambacorti-Passerini C, Magee AI, Links TP, Hofstra RM, Barford D, Isacke CM.

J Biol Chem. 2007 Oct 5;282(40):29230-40. Epub 2007 Jul 30.


Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.

Plaza-Menacho I, van der Sluis T, Hollema H, Gimm O, Buys CH, Magee AI, Isacke CM, Hofstra RM, Eggen BJ.

J Biol Chem. 2007 Mar 2;282(9):6415-24. Epub 2007 Jan 5.


Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation.

Leung KF, Baron R, Ali BR, Magee AI, Seabra MC.

J Biol Chem. 2007 Jan 12;282(2):1487-97. Epub 2006 Nov 18.


Single-molecule diffusion reveals similar mobility for the Lck, H-ras, and K-ras membrane anchors.

Lommerse PH, Vastenhoud K, Pirinen NJ, Magee AI, Spaink HP, Schmidt T.

Biophys J. 2006 Aug 1;91(3):1090-7.


Fluorescence lifetime imaging provides enhanced contrast when imaging the phase-sensitive dye di-4-ANEPPDHQ in model membranes and live cells.

Owen DM, Lanigan PM, Dunsby C, Munro I, Grant D, Neil MA, French PM, Magee AI.

Biophys J. 2006 Jun 1;90(11):L80-2. Epub 2006 Apr 14.


Cold-induced coalescence of T-cell plasma membrane microdomains activates signalling pathways.

Magee AI, Adler J, Parmryd I.

J Cell Sci. 2005 Jul 15;118(Pt 14):3141-51.


A Salmonella typhimurium effector protein SifA is modified by host cell prenylation and S-acylation machinery.

Reinicke AT, Hutchinson JL, Magee AI, Mastroeni P, Trowsdale J, Kelly AP.

J Biol Chem. 2005 Apr 15;280(15):14620-7. Epub 2005 Feb 14.


Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse.

Taner SB, Onfelt B, Pirinen NJ, McCann FE, Magee AI, Davis DM.

Traffic. 2004 Sep;5(9):651-61. Review.


Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.

Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM.

J Exp Med. 2004 Apr 5;199(7):1005-10. Epub 2004 Mar 29.


Are prenyl groups on proteins sticky fingers or greasy handles?

Magee AI, Seabra MC.

Biochem J. 2003 Dec 1;376(Pt 2):e3-4.

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