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Items: 50

1.

DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products.

Merwin NJ, Mousa WK, Dejong CA, Skinnider MA, Cannon MJ, Li H, Dial K, Gunabalasingam M, Johnston C, Magarvey NA.

Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):371-380. doi: 10.1073/pnas.1901493116. Epub 2019 Dec 23.

PMID:
31871149
2.

Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis.

Skinnider MA, Johnston CW, Merwin NJ, Dejong CA, Magarvey NA.

BMC Genomics. 2018 Jan 15;19(1):45. doi: 10.1186/s12864-018-4435-1.

3.

Comparative analysis of chemical similarity methods for modular natural products with a hypothetical structure enumeration algorithm.

Skinnider MA, Dejong CA, Franczak BC, McNicholas PD, Magarvey NA.

J Cheminform. 2017 Aug 16;9(1):46. doi: 10.1186/s13321-017-0234-y.

4.

Antibiotics and specialized metabolites from the human microbiota.

Mousa WK, Athar B, Merwin NJ, Magarvey NA.

Nat Prod Rep. 2017 Nov 15;34(11):1302-1331. doi: 10.1039/c7np00021a. Review.

PMID:
29018846
5.

Statistical reanalysis of natural products reveals increasing chemical diversity.

Skinnider MA, Magarvey NA.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6271-E6272. doi: 10.1073/pnas.1708560114. Epub 2017 Jul 14. No abstract available.

6.

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes.

Skinnider MA, Merwin NJ, Johnston CW, Magarvey NA.

Nucleic Acids Res. 2017 Jul 3;45(W1):W49-W54. doi: 10.1093/nar/gkx320.

7.

Pseudomonas aeruginosa-Derived Rhamnolipids and Other Detergents Modulate Colony Morphotype and Motility in the Burkholderia cepacia Complex.

Bernier SP, Hum C, Li X, O'Toole GA, Magarvey NA, Surette MG.

J Bacteriol. 2017 Jun 13;199(13). pii: e00171-17. doi: 10.1128/JB.00171-17. Print 2017 Jul 1.

8.

Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining.

Skinnider MA, Johnston CW, Edgar RE, Dejong CA, Merwin NJ, Rees PN, Magarvey NA.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6343-E6351. Epub 2016 Oct 3.

9.

Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching.

Dejong CA, Chen GM, Li H, Johnston CW, Edwards MR, Rees PN, Skinnider MA, Webster AL, Magarvey NA.

Nat Chem Biol. 2016 Dec;12(12):1007-1014. doi: 10.1038/nchembio.2188. Epub 2016 Oct 3.

PMID:
27694801
10.

Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity.

Caminero A, Galipeau HJ, McCarville JL, Johnston CW, Bernier SP, Russell AK, Jury J, Herran AR, Casqueiro J, Tye-Din JA, Surette MG, Magarvey NA, Schuppan D, Verdu EF.

Gastroenterology. 2016 Oct;151(4):670-83. doi: 10.1053/j.gastro.2016.06.041. Epub 2016 Jun 30.

PMID:
27373514
11.

Cyanide Toxicity to Burkholderia cenocepacia Is Modulated by Polymicrobial Communities and Environmental Factors.

Bernier SP, Workentine ML, Li X, Magarvey NA, O'Toole GA, Surette MG.

Front Microbiol. 2016 May 18;7:725. doi: 10.3389/fmicb.2016.00725. eCollection 2016.

12.

Draft Genome Sequence of Streptomyces canus ATCC 12647, a Producer of Telomycin.

Liu DY, Li Y, Magarvey NA.

Genome Announc. 2016 Mar 24;4(2). pii: e00173-16. doi: 10.1128/genomeA.00173-16.

13.

Draft Genome Sequence of Streptomyces silvensis ATCC 53525, a Producer of Novel Hormone Antagonists.

Johnston CW, Li Y, Magarvey NA.

Genome Announc. 2016 Feb 18;4(1). pii: e00001-16. doi: 10.1128/genomeA.00001-16.

14.

Informatic analysis reveals Legionella as a source of novel natural products.

Johnston CW, Plumb J, Li X, Grinstein S, Magarvey NA.

Synth Syst Biotechnol. 2016 Feb 5;1(2):130-136. doi: 10.1016/j.synbio.2015.12.001. eCollection 2016 Jun.

15.

Assembly and clustering of natural antibiotics guides target identification.

Johnston CW, Skinnider MA, Dejong CA, Rees PN, Chen GM, Walker CG, French S, Brown ED, Bérdy J, Liu DY, Magarvey NA.

Nat Chem Biol. 2016 Apr;12(4):233-9. doi: 10.1038/nchembio.2018. Epub 2016 Feb 1.

PMID:
26829473
16.

Molecular mechanisms of membrane targeting antibiotics.

Epand RM, Walker C, Epand RF, Magarvey NA.

Biochim Biophys Acta. 2016 May;1858(5):980-7. doi: 10.1016/j.bbamem.2015.10.018. Epub 2015 Oct 26. Review.

17.

Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM).

Skinnider MA, Dejong CA, Rees PN, Johnston CW, Li H, Webster AL, Wyatt MA, Magarvey NA.

Nucleic Acids Res. 2015 Nov 16;43(20):9645-62. doi: 10.1093/nar/gkv1012. Epub 2015 Oct 5.

18.

An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products.

Johnston CW, Skinnider MA, Wyatt MA, Li X, Ranieri MR, Yang L, Zechel DL, Ma B, Magarvey NA.

Nat Commun. 2015 Sep 28;6:8421. doi: 10.1038/ncomms9421.

19.

Exploration of Nonribosomal Peptide Families with an Automated Informatic Search Algorithm.

Yang L, Ibrahim A, Johnston CW, Skinnider MA, Ma B, Magarvey NA.

Chem Biol. 2015 Sep 17;22(9):1259-69. doi: 10.1016/j.chembiol.2015.08.008. Epub 2015 Sep 10.

20.

Informatic search strategies to discover analogues and variants of natural product archetypes.

Johnston CW, Connaty AD, Skinnider MA, Li Y, Grunwald A, Wyatt MA, Kerr RG, Magarvey NA.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):293-8. doi: 10.1007/s10295-015-1675-9. Epub 2015 Sep 8.

PMID:
26350080
21.

Characterization of cereulide synthetase, a toxin-producing macromolecular machine.

Alonzo DA, Magarvey NA, Schmeing TM.

PLoS One. 2015 Jun 4;10(6):e0128569. doi: 10.1371/journal.pone.0128569. eCollection 2015.

22.

Natural products: untwisting the antibiotic'ome.

Johnston CW, Magarvey NA.

Nat Chem Biol. 2015 Mar;11(3):177-8. doi: 10.1038/nchembio.1757. No abstract available.

PMID:
25689333
23.

Automated identification of depsipeptide natural products by an informatic search algorithm.

Skinnider MA, Johnston CW, Zvanych R, Magarvey NA.

Chembiochem. 2015 Jan 19;16(2):223-7. doi: 10.1002/cbic.201402434. Epub 2014 Dec 8.

PMID:
25487354
24.

Systems biosynthesis of secondary metabolic pathways within the oral human microbiome member Streptococcus mutans.

Zvanych R, Lukenda N, Li X, Kim JJ, Tharmarajah S, Magarvey NA.

Mol Biosyst. 2015 Jan;11(1):97-104. doi: 10.1039/c4mb00406j. Epub 2014 Sep 11.

PMID:
25209237
25.

Small molecule immunomodulins from cultures of the human microbiome member Lactobacillus plantarum.

Zvanych R, Lukenda N, Kim JJ, Li X, Petrof EO, Khan WI, Magarvey NA.

J Antibiot (Tokyo). 2014 Jan;67(1):85-8. doi: 10.1038/ja.2013.126. Epub 2013 Nov 27.

PMID:
24281660
26.

Chemical and biosynthetic evolution of the antimycin-type depsipeptides.

Vanner SA, Li X, Zvanych R, Torchia J, Sang J, Andrews DW, Magarvey NA.

Mol Biosyst. 2013 Nov;9(11):2712-9. doi: 10.1039/c3mb70219g.

PMID:
23989727
27.

Chemical variation from the neoantimycin depsipeptide assembly line.

Li X, Zvanych R, Vanner SA, Wang W, Magarvey NA.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5123-7. doi: 10.1016/j.bmcl.2013.07.031. Epub 2013 Jul 24.

PMID:
23932359
28.

A tribute to Leo C Vining.

Magarvey NA, Demain AL.

J Antibiot (Tokyo). 2013 Jul;66(7):359-60. doi: 10.1038/ja.2013.47. No abstract available.

PMID:
23892548
29.

Optimizing dimodular nonribosomal peptide synthetases and natural dipeptides in an Escherichia coli heterologous host.

Wyatt MA, Magarvey NA.

Biochem Cell Biol. 2013 Aug;91(4):203-8. doi: 10.1139/bcb-2012-0097. Epub 2013 Jan 2.

PMID:
23859013
30.

Bioinformatic evaluation of the secondary metabolism of antistaphylococcal environmental bacterial isolates.

Wyatt MA, Lee J, Ahilan Y, Magarvey NA.

Can J Microbiol. 2013 Jul;59(7):465-71. doi: 10.1139/cjm-2013-0016. Epub 2013 May 10.

PMID:
23826955
31.

Biosynthesis of ebelactone A: isotopic tracer, advanced precursor and genetic studies reveal a thioesterase-independent cyclization to give a polyketide β-lactone.

Wyatt MA, Ahilan Y, Argyropoulos P, Boddy CN, Magarvey NA, Harrison PH.

J Antibiot (Tokyo). 2013 Jul;66(7):421-30. doi: 10.1038/ja.2013.48. Epub 2013 Jun 26.

PMID:
23801186
32.

Macplocimine A, a new 18-membered macrolide isolated from the filamentous sulfur bacteria Thioploca sp.

Li X, Vanner S, Wang W, Li Y, Gallardo VA, Magarvey NA.

J Antibiot (Tokyo). 2013 Jul;66(7):443-6. doi: 10.1038/ja.2013.52. Epub 2013 Jun 19.

PMID:
23778115
33.

Structures and biosynthesis of 12-membered macrocyclic depsipeptides from Streptomyces sp. ML55.

Li X, Zvanych R, Torchia J, Magarvey NA.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4150-3. doi: 10.1016/j.bmcl.2013.05.042. Epub 2013 May 23.

PMID:
23756369
34.

Nonribosomal assembly of natural lipocyclocarbamate lipoprotein-associated phospholipase inhibitors.

Johnston CW, Zvanych R, Khyzha N, Magarvey NA.

Chembiochem. 2013 Mar 4;14(4):431-5. doi: 10.1002/cbic.201200598. Epub 2013 Feb 10.

PMID:
23401283
35.

Gold biomineralization by a metallophore from a gold-associated microbe.

Johnston CW, Wyatt MA, Li X, Ibrahim A, Shuster J, Southam G, Magarvey NA.

Nat Chem Biol. 2013 Apr;9(4):241-3. doi: 10.1038/nchembio.1179. Epub 2013 Feb 3.

PMID:
23377039
36.

Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery.

Ibrahim A, Yang L, Johnston C, Liu X, Ma B, Magarvey NA.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19196-201. doi: 10.1073/pnas.1206376109. Epub 2012 Nov 6.

37.

Heterologous expression and structural characterisation of a pyrazinone natural product assembly line.

Wyatt MA, Mok MC, Junop M, Magarvey NA.

Chembiochem. 2012 Nov 5;13(16):2408-15. doi: 10.1002/cbic.201200340. Epub 2012 Oct 15.

PMID:
23070851
38.

Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci.

Li J, Wang W, Xu SX, Magarvey NA, McCormick JK.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3360-5. doi: 10.1073/pnas.1017431108. Epub 2011 Jan 31.

39.

Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence.

Wyatt MA, Wang W, Roux CM, Beasley FC, Heinrichs DE, Dunman PM, Magarvey NA.

Science. 2010 Jul 16;329(5989):294-6. doi: 10.1126/science.1188888. Epub 2010 Jun 3. Erratum in: Science. 2011 Sep 9;333(6048):1381.

40.

A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth.

Calderone CT, Bumpus SB, Kelleher NL, Walsh CT, Magarvey NA.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12809-14. doi: 10.1073/pnas.0806305105. Epub 2008 Aug 22.

41.

Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis.

Bumpus SB, Magarvey NA, Kelleher NL, Walsh CT, Calderone CT.

J Am Chem Soc. 2008 Sep 3;130(35):11614-6. doi: 10.1021/ja8040042. Epub 2008 Aug 12.

42.

Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.

Magarvey NA, Fortin PD, Thomas PM, Kelleher NL, Walsh CT.

ACS Chem Biol. 2008 Sep 19;3(9):542-54. doi: 10.1021/cb800085g. Epub 2008 Jul 25.

43.

A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines.

Fortin PD, Walsh CT, Magarvey NA.

Nature. 2007 Aug 16;448(7155):824-7. Epub 2007 Jul 25.

PMID:
17653193
44.

Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts.

Magarvey NA, Beck ZQ, Golakoti T, Ding Y, Huber U, Hemscheidt TK, Abelson D, Moore RE, Sherman DH.

ACS Chem Biol. 2006 Dec 15;1(12):766-79.

PMID:
17240975
45.
46.

Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.

Magarvey NA, Haltli B, He M, Greenstein M, Hucul JA.

Antimicrob Agents Chemother. 2006 Jun;50(6):2167-77.

47.

Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins.

Haltli B, Tan Y, Magarvey NA, Wagenaar M, Yin X, Greenstein M, Hucul JA, Zabriskie TM.

Chem Biol. 2005 Nov;12(11):1163-8.

48.

Chemoenzymatic synthesis of cryptophycin/arenastatin natural products.

Beck ZQ, Aldrich CC, Magarvey NA, Georg GI, Sherman DH.

Biochemistry. 2005 Oct 18;44(41):13457-66.

PMID:
16216069
49.

Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites.

Magarvey NA, Keller JM, Bernan V, Dworkin M, Sherman DH.

Appl Environ Microbiol. 2004 Dec;70(12):7520-9.

50.

Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery.

Salomon CE, Magarvey NA, Sherman DH.

Nat Prod Rep. 2004 Feb;21(1):105-21. Epub 2003 Dec 15. Review.

PMID:
15039838

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