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Items: 1 to 50 of 123

1.

4-O-methylascochlorin stabilizes hypoxia-inducible factor-1 in a manner different from hydroxylase inhibition by iron chelating or substrate competition.

Magae J, Furukawa C, Kuwahara S, Jeong YJ, Nakajima H, Chang YC.

Biosci Biotechnol Biochem. 2019 Aug 8:1-5. doi: 10.1080/09168451.2019.1651626. [Epub ahead of print]

PMID:
31392931
2.

Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages.

Park J, Kim HD, Lee SH, Kwak CH, Chang YC, Lee YC, Chung TW, Magae J, Kim CH.

J Ethnopharmacol. 2019 Jul 15;239:111898. doi: 10.1016/j.jep.2019.111898. Epub 2019 Apr 24.

PMID:
31028855
3.

4-O-Carboxymethylascochlorin Inhibits Expression Levels of on Inflammation-Related Cytokines and Matrix Metalloproteinase-9 Through NF-κB/MAPK/TLR4 Signaling Pathway in LPS-Activated RAW264.7 Cells.

Park J, Ha SH, Abekura F, Lim H, Magae J, Ha KT, Chung TW, Chang YC, Lee YC, Chung E, Ku J, Kim CH.

Front Pharmacol. 2019 Mar 27;10:304. doi: 10.3389/fphar.2019.00304. eCollection 2019.

4.

[Vinorelbine, a Microtubule Toxin, Induces Apoptosis and Polyploidy in MX-1, a Human Triple-Negative Breast Cancer Cell Line].

Nakajima H, Furukawa C, Magae J.

Gan To Kagaku Ryoho. 2019 Mar;46(3):447-451. Japanese.

PMID:
30914582
5.

4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate.

Kondo T, Takeda K, Muko R, Ito A, Chang YC, Magae J, Kataoka T.

J Antibiot (Tokyo). 2019 May;72(5):271-281. doi: 10.1038/s41429-019-0157-0. Epub 2019 Feb 22.

PMID:
30796332
6.

Upregulation of AMPK by 4-O-methylascochlorin promotes autophagy via the HIF-1α expression.

Seok JY, Jeong YJ, Hwang SK, Kim CH, Magae J, Chang YC.

J Cell Mol Med. 2018 Dec;22(12):6345-6356. doi: 10.1111/jcmm.13933. Epub 2018 Oct 19.

7.

Suppression of c-Myc enhances p21WAF1/CIP1 -mediated G1 cell cycle arrest through the modulation of ERK phosphorylation by ascochlorin.

Jeong YJ, Hoe HS, Cho HJ, Park KK, Kim DD, Kim CH, Magae J, Kang DW, Lee SR, Chang YC.

J Cell Biochem. 2018 Feb;119(2):2036-2047. doi: 10.1002/jcb.26366. Epub 2017 Oct 4.

PMID:
28833404
8.

Delayed Growth Suppression and Radioresistance Induced by Long-Term Continuous Gamma Irradiation.

Nakajima H, Furukawa C, Chang YC, Ogata H, Magae J.

Radiat Res. 2017 Aug;188(2):181-190. doi: 10.1667/RR14666.1. Epub 2017 Jun 9.

PMID:
28598290
9.

Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy.

Min-Wen JC, Yan-Jiang BC, Mishra S, Dai X, Magae J, Shyh-Chang N, Kumar AP, Sethi G.

Adv Protein Chem Struct Biol. 2017;108:199-225. doi: 10.1016/bs.apcsb.2017.01.001. Epub 2017 Feb 15. Review.

PMID:
28427561
10.

Ascofuranone inhibits lipopolysaccharide-induced inflammatory response via NF-kappaB and AP-1, p-ERK, TNF-α, IL-6 and IL-1β in RAW 264.7 macrophages.

Park JY, Chung TW, Jeong YJ, Kwak CH, Ha SH, Kwon KM, Abekura F, Cho SH, Lee YC, Ha KT, Magae J, Chang YC, Kim CH.

PLoS One. 2017 Feb 16;12(2):e0171322. doi: 10.1371/journal.pone.0171322. eCollection 2017.

11.

Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma.

Dai X, Ahn KS, Wang LZ, Kim C, Deivasigamni A, Arfuso F, Um JY, Kumar AP, Chang YC, Kumar D, Kundu GC, Magae J, Goh BC, Hui KM, Sethi G.

Mol Cancer Ther. 2016 Dec;15(12):2966-2976. Epub 2016 Oct 7.

12.

Erratum to: Suppression of c-Myc induces apoptosis via an AMPK/mTOR-dependent pathway by 4-O-methyl-ascochlorin in leukemia cells.

Shin JM, Jeong YJ, Cho HJ, Magae J, Bae YS, Chang YC.

Apoptosis. 2016 May;21(5):669-70. doi: 10.1007/s10495-016-1239-0. No abstract available.

PMID:
27030036
13.

Suppression of c-Myc induces apoptosis via an AMPK/mTOR-dependent pathway by 4-O-methyl-ascochlorin in leukemia cells.

Shin JM, Jeong YJ, Cho HJ, Magae J, Bae YS, Chang YC.

Apoptosis. 2016 May;21(5):657-68. doi: 10.1007/s10495-016-1228-3. Erratum in: Apoptosis. 2016 May;21(5):669-70.

PMID:
26922069
14.

Anti-Inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-κB, ERK1/2, and p38 Signaling Pathway.

Lee SH, Kwak CH, Lee SK, Ha SH, Park J, Chung TW, Ha KT, Suh SJ, Chang YC, Chang HW, Lee YC, Kang BS, Magae J, Kim CH.

J Cell Biochem. 2016 Apr;117(4):978-87. doi: 10.1002/jcb.25383. Epub 2016 Feb 5.

PMID:
26399466
15.

4-O-methylascochlorin suppresses differentiation of 3T3-L1 preadipocytes by inhibiting PPARγ expression through regulation of AMPK/mTOR signaling pathways.

Kim M, Cho HJ, Jeong YJ, Chung IK, Magae J, Chang YC.

Arch Biochem Biophys. 2015 Oct 1;583:79-86. doi: 10.1016/j.abb.2015.07.007. Epub 2015 Aug 10.

PMID:
26271443
16.

Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3.

Dai X, Ahn KS, Kim C, Siveen KS, Ong TH, Shanmugam MK, Li F, Shi J, Kumar AP, Wang LZ, Goh BC, Magae J, Hui KM, Sethi G.

Mol Oncol. 2015 Apr;9(4):818-33. doi: 10.1016/j.molonc.2014.12.008. Epub 2015 Jan 5.

17.

Ascofuranone suppresses EGF-induced HIF-1α protein synthesis by inhibition of the Akt/mTOR/p70S6K pathway in MDA-MB-231 breast cancer cells.

Jeong YJ, Cho HJ, Magae J, Lee IK, Park KG, Chang YC.

Toxicol Appl Pharmacol. 2013 Dec 15;273(3):542-50. doi: 10.1016/j.taap.2013.09.027. Epub 2013 Oct 3.

PMID:
24096035
18.

Prolongation of life span in the accelerated aging klotho mouse model, by low-dose-rate continuous γ irradiation.

Nomura T, Sakai K, Ogata H, Magae J.

Radiat Res. 2013 Jun;179(6):717-24. doi: 10.1667/RR2977.1. Epub 2013 May 10.

PMID:
23662650
19.

Ionizing radiation leads to the replacement and de novo production of colonic Lgr5(+) stem cells.

Otsuka K, Hamada N, Magae J, Matsumoto H, Hoshi Y, Iwasaki T.

Radiat Res. 2013 Jun;179(6):637-46. doi: 10.1667/RR3253.1. Epub 2013 Apr 29.

PMID:
23627781
20.

Ascochlorin inhibits growth factor-induced HIF-1α activation and tumor-angiogenesis through the suppression of EGFR/ERK/p70S6K signaling pathway in human cervical carcinoma cells.

Jeong JH, Jeong YJ, Cho HJ, Shin JM, Kang JH, Park KK, Park YY, Chung IK, Chang HW, Magae J.

J Cell Biochem. 2012 Apr;113(4):1302-13. doi: 10.1002/jcb.24001.

PMID:
22109717
21.

Dose-rate effect on proliferation suppression in human cell lines continuously exposed to γ rays.

Magae J, Furukawa C, Ogata H.

Radiat Res. 2011 Oct;176(4):447-58. Epub 2011 Jul 8.

PMID:
21943187
22.

Cladribine enhances apoptotic cell death in lung carcinoma cells over-expressing DNase γ.

Hayakawa A, Suzuki H, Kamei Y, Tanuma S, Magae J.

Biol Pharm Bull. 2011;34(7):1001-4.

23.

Suppressive effects of continuous low-dose-rate γ irradiation on diabetic nephropathy in type II diabetes mellitus model mice.

Nomura T, Li XH, Ogata H, Sakai K, Kondo T, Takano Y, Magae J.

Radiat Res. 2011 Sep;176(3):356-65. Epub 2011 Jun 30.

PMID:
21718105
24.

4-O-methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1α via AMPK activation.

Jeong JH, Kang JH, Hwang SL, Cho HJ, Park KK, Park YY, Chung IK, Chang HW, Kim CH, Min KS, Kim HD, Magae J, Kang SS, Chang YC.

Biochem Biophys Res Commun. 2011 Mar 18;406(3):353-8. doi: 10.1016/j.bbrc.2011.02.043. Epub 2011 Feb 15.

PMID:
21329651
25.

p53-independent induction of G1 arrest and p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic, through downregulation of c-Myc.

Jeong JH, Kang SS, Park KK, Chang HW, Magae J, Chang YC.

Mol Cancer Ther. 2010 Jul;9(7):2102-13. doi: 10.1158/1535-7163.MCT-09-1159. Epub 2010 Jun 29.

26.

Enhancement of paclitaxel-induced apoptosis in HER2-overexpressing human breast cancer cells by a pertuzumab mimetic peptide, HRAP.

Nakajima H, Mizuta N, Sakaguchi K, Fujiwara I, Yoshimori A, Magae J, Tanuma S.

J Biosci Bioeng. 2010 Aug;110(2):250-3. doi: 10.1016/j.jbiosc.2010.02.007. Epub 2010 Mar 11.

PMID:
20547325
27.

Ascofuranone prevents ER stress-induced insulin resistance via activation of AMP-activated protein kinase in L6 myotube cells.

Hwang SL, Chang HW, Lee IK, Yang BK, Magae J, Chang YC.

Biochem Biophys Res Commun. 2010 Jun 11;396(4):967-72. doi: 10.1016/j.bbrc.2010.05.034. Epub 2010 May 9.

PMID:
20460103
28.

Clinical outcomes of video-assisted skin-sparing partial mastectomy for breast cancer and immediate reconstruction with latissimus dorsi muscle flap as breast-conserving therapy.

Nakajima H, Fujiwara I, Mizuta N, Sakaguchi K, Ohashi M, Nishiyama A, Umeda Y, Ichida M, Magae J.

World J Surg. 2010 Sep;34(9):2197-203. doi: 10.1007/s00268-010-0607-0.

PMID:
20458581
29.

Inhibition of septation in Bacillus subtilis by a peptide antibiotic, edeine B(1).

Shimotohno KW, Kawamura F, Natori Y, Nanamiya H, Magae J, Ogata H, Endo T, Suzuki T, Yamaki H.

Biol Pharm Bull. 2010;33(4):568-71.

30.

Relationship between peroxisome proliferator-activated receptor-gamma activation and the ameliorative effects of ascochlorin derivatives on type II diabetes.

Magae J, Tsuruga M, Maruyama A, Furukawa C, Kojima S, Shimizu H, Ando K.

J Antibiot (Tokyo). 2009 Jul;62(7):365-9. doi: 10.1038/ja.2009.43. Epub 2009 Jun 26.

PMID:
19557028
31.

Microarray analysis of differentially expressed genes in the kidneys and testes of mice after long-term irradiation with low-dose-rate gamma-rays.

Taki K, Wang B, Nakajima T, Wu J, Ono T, Uehara Y, Matsumoto T, Oghiso Y, Tanaka K, Ichinohe K, Nakamura S, Tanaka S, Magae J, Kakimoto A, Nenoi M.

J Radiat Res. 2009 May;50(3):241-52. Epub 2009 Apr 25.

32.

Video-assisted skin-sparing breast-conserving surgery for breast cancer and immediate reconstruction with autologous tissue: clinical outcomes.

Nakajima H, Fujiwara I, Mizuta N, Sakaguchi K, Hachimine Y, Magae J.

Ann Surg Oncol. 2009 Jul;16(7):1982-9. doi: 10.1245/s10434-009-0429-1. Epub 2009 Apr 24.

PMID:
19390899
33.

Suppression of PAI-1 expression through inhibition of the EGFR-mediated signaling cascade in rat kidney fibroblast by ascofuranone.

Cho HJ, Kang JH, Kim T, Park KK, Kim CH, Lee IS, Min KS, Magae J, Nakajima H, Bae YS, Chang YC.

J Cell Biochem. 2009 May 15;107(2):335-44. doi: 10.1002/jcb.22130.

PMID:
19306296
34.

Ascochlorin activates p53 in a manner distinct from DNA damaging agents.

Jeong JH, Nakajima H, Magae J, Furukawa C, Taki K, Otsuka K, Tomita M, Lee IS, Kim CH, Chang HW, Min KS, Park KK, Park KK, Chang YC.

Int J Cancer. 2009 Jun 15;124(12):2797-803. doi: 10.1002/ijc.24259.

35.

Reduction in mutation frequency by very low-dose gamma irradiation of Drosophila melanogaster germ cells.

Ogura K, Magae J, Kawakami Y, Koana T.

Radiat Res. 2009 Jan;171(1):1-8. doi: 10.1667/RR1288.1.

PMID:
19138046
36.

Prognosis of Japanese breast cancer based on hormone receptor and HER2 expression determined by immunohistochemical staining.

Nakajima H, Fujiwara I, Mizuta N, Sakaguchi K, Hachimine Y, Konishi E, Yanagisawa A, Magae J.

World J Surg. 2008 Nov;32(11):2477-82. doi: 10.1007/s00268-008-9712-8.

PMID:
18758851
37.

Blockade of the Fas/Fas ligand interaction suppresses hepatocyte apoptosis in ischemia-reperfusion rat liver.

Nakajima H, Mizuta N, Fujiwara I, Sakaguchi K, Ogata H, Magae J, Yagita H, Koji T.

Apoptosis. 2008 Aug;13(8):1013-21. doi: 10.1007/s10495-008-0234-5.

PMID:
18561025
38.

Fas ligand released by activated monocytes causes apoptosis of lung epithelial cells in human acute lung injury model in vitro.

Mizuta M, Nakajima H, Mizuta N, Kitamura Y, Nakajima Y, Hashimoto S, Matsuyama H, Shime N, Amaya F, Koh H, Ishizaka A, Magae J, Tanuma SI, Hashimoto S.

Biol Pharm Bull. 2008 Mar;31(3):386-90.

39.

Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis.

Hayakawa A, Kawamoto Y, Nakajima H, Sakai J, Takasawa R, Nakashima I, Magae J, Tanuma S.

Apoptosis. 2008 Apr;13(4):523-30. doi: 10.1007/s10495-008-0184-y.

PMID:
18297401
40.

Aberrant expression of Fra-1 in estrogen receptor-negative breast cancers and suppression of their propagation in vivo by ascochlorin, an antibiotic that inhibits cellular activator protein-1 activity.

Nakajima H, Mizuta N, Sakaguchi K, Fujiwara I, Mizuta M, Furukawa C, Chang YC, Magae J.

J Antibiot (Tokyo). 2007 Nov;60(11):682-9.

PMID:
18057697
41.

Mycophenolic acid as a latent agonist of PPARgamma.

Ubukata M, Takamori H, Ohashi M, Mitsuhashi S, Yamashita K, Asada T, Nakajima N, Matsuura N, Tsuruga M, Taki K, Magae J.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4767-70. Epub 2007 Jun 26.

PMID:
17618115
42.

Amelioration of type II diabetes in db/db mice by continuous low-dose-rate gamma irradiation.

Tsuruga M, Taki K, Ishii G, Sasaki Y, Furukawa C, Sugihara T, Nomura T, Ochiai A, Magae J.

Radiat Res. 2007 May;167(5):592-9.

PMID:
17474792
43.

[Apoptotic mechanisms induced in breast cancer cells by vinorelbine].

Nakajima H, Sakaguchi K, Mizuta N, Fujiwara I, Hayakawa A, Magae J.

Gan To Kagaku Ryoho. 2007 Apr;34(4):583-8. Japanese.

PMID:
17431345
44.

Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages.

Kang JH, Kim JK, Park WH, Park KK, Lee TS, Magae J, Nakajima H, Kim CH, Chang YC.

J Cell Biochem. 2007 Oct 1;102(2):506-14.

PMID:
17407144
45.

Immunosuppressive activity of 4-O-methylascochlorin.

Tsuruga M, Nakajima H, Magae J.

J Antibiot (Tokyo). 2007 Jan;60(1):20-6.

PMID:
17390585
46.

Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers.

Nakajima H, Sakaguchi K, Fujiwara I, Mizuta M, Tsuruga M, Magae J, Mizuta N.

Biochem Biophys Res Commun. 2007 Apr 27;356(1):260-5. Epub 2007 Mar 2.

PMID:
17350598
47.

Induction of mitochondria-dependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate.

Nakajima H, Magae J, Tsuruga M, Sakaguchi K, Fujiwara I, Mizuta M, Sawai K, Yamagishi H, Mizuta N.

Cancer Lett. 2007 Aug 8;253(1):89-96. Epub 2007 Feb 21.

PMID:
17316980
48.

Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms.

Cho HJ, Kang JH, Kwak JY, Lee TS, Lee IS, Park NG, Nakajima H, Magae J, Chang YC.

Carcinogenesis. 2007 May;28(5):1104-10. Epub 2006 Nov 17.

PMID:
17114644
49.

Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS.

Kang JH, Park KK, Lee IS, Magae J, Ando K, Kim CH, Chang YC.

J Proteome Res. 2006 Oct;5(10):2620-31.

PMID:
17022633
50.

The ascochlorin derivative, AS-6, inhibits TNF-alpha-induced adhesion molecule and chemokine expression in rat vascular smooth muscle cells.

Park KG, Lee KM, Chang YC, Magae J, Ando K, Kim KB, Kim YN, Kim HS, Park JY, Lee KU, Lee IK.

Life Sci. 2006 Dec 14;80(2):120-6. Epub 2006 Sep 1.

PMID:
16989870

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