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Items: 47

1.

Toward Single-Peak Dalbavancin Analogs through Biology and Chemistry.

Alt S, Bernasconi A, Sosio M, Brunati C, Donadio S, Maffioli SI.

ACS Chem Biol. 2019 Mar 15;14(3):356-360. doi: 10.1021/acschembio.9b00050. Epub 2019 Mar 7.

PMID:
30830742
2.

Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.

Monciardini P, Bernasconi A, Iorio M, Brunati C, Sosio M, Campochiaro L, Landini P, Maffioli SI, Donadio S.

J Nat Prod. 2019 Jan 25;82(1):35-44. doi: 10.1021/acs.jnatprod.8b00354. Epub 2019 Jan 7.

3.

Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase.

Maffioli SI, Sosio M, Ebright RH, Donadio S.

J Ind Microbiol Biotechnol. 2019 Mar;46(3-4):335-343. doi: 10.1007/s10295-018-2109-2. Epub 2018 Nov 21.

PMID:
30465105
4.

Iron chelation increases the tolerance of Escherichia coli to hyper-replication stress.

Charbon G, Klitgaard RN, Liboriussen CD, Thulstrup PW, Maffioli SI, Donadio S, Løbner-Olesen A.

Sci Rep. 2018 Jul 12;8(1):10550. doi: 10.1038/s41598-018-28841-9.

5.

Novel Polyethers from Screening Actinoallomurus spp.

Iorio M, Tocchetti A, Santos Cruz JC, Del Gatto G, Brunati C, Maffioli SI, Sosio M, Donadio S.

Antibiotics (Basel). 2018 Jun 14;7(2). pii: E47. doi: 10.3390/antibiotics7020047.

6.

Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights into the Formation of C-nucleoside Antibiotics.

Sosio M, Gaspari E, Iorio M, Pessina S, Medema MH, Bernasconi A, Simone M, Maffioli SI, Ebright RH, Donadio S.

Cell Chem Biol. 2018 May 17;25(5):540-549.e4. doi: 10.1016/j.chembiol.2018.02.008. Epub 2018 Mar 15.

PMID:
29551347
7.

Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells.

Brunati C, Thomsen TT, Gaspari E, Maffioli S, Sosio M, Jabes D, Løbner-Olesen A, Donadio S.

J Antimicrob Chemother. 2018 Feb 1;73(2):414-424. doi: 10.1093/jac/dkx395.

8.

Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

Maffioli SI, Zhang Y, Degen D, Carzaniga T, Del Gatto G, Serina S, Monciardini P, Mazzetti C, Guglierame P, Candiani G, Chiriac AI, Facchetti G, Kaltofen P, Sahl HG, Dehò G, Donadio S, Ebright RH.

Cell. 2017 Jun 15;169(7):1240-1248.e23. doi: 10.1016/j.cell.2017.05.042.

9.

Antibacterial Paramagnetic Quinones from Actinoallomurus.

Iorio M, Cruz J, Simone M, Bernasconi A, Brunati C, Sosio M, Donadio S, Maffioli SI.

J Nat Prod. 2017 Apr 28;80(4):819-827. doi: 10.1021/acs.jnatprod.6b00654. Epub 2017 Feb 20.

PMID:
28218529
10.

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.

Ortega MA, Cogan DP, Mukherjee S, Garg N, Li B, Thibodeaux GN, Maffioli SI, Donadio S, Sosio M, Escano J, Smith L, Nair SK, van der Donk WA.

ACS Chem Biol. 2017 Feb 17;12(2):548-557. doi: 10.1021/acschembio.6b01031. Epub 2017 Jan 13.

11.

Allocyclinones, hyperchlorinated angucyclinones from Actinoallomurus.

Cruz JC, Maffioli SI, Bernasconi A, Brunati C, Gaspari E, Sosio M, Wellington E, Donadio S.

J Antibiot (Tokyo). 2017 Jan;70(1):73-78. doi: 10.1038/ja.2016.62. Epub 2016 May 25.

PMID:
27220409
12.

Advancing cell wall inhibitors towards clinical applications.

Maffioli SI, Cruz JC, Monciardini P, Sosio M, Donadio S.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):177-84. doi: 10.1007/s10295-015-1703-9. Epub 2015 Oct 29. Review.

PMID:
26515981
13.

Brominated Variant of the Lantibiotic NAI-107 with Enhanced Antibacterial Potency.

Cruz JC, Iorio M, Monciardini P, Simone M, Brunati C, Gaspari E, Maffioli SI, Wellington E, Sosio M, Donadio S.

J Nat Prod. 2015 Nov 25;78(11):2642-7. doi: 10.1021/acs.jnatprod.5b00576. Epub 2015 Oct 29.

PMID:
26512731
14.

Erratum for Jabes et al., Pharmacological Properties of NAI-603, a Well-Tolerated Semisynthetic Derivative of Ramoplanin.

Jabes D, Brunati C, Candiani G, Riva S, Romanó G, Maffioli S, Rossi R, Simone M, Gaspari E, Donadio S.

Antimicrob Agents Chemother. 2015 Oct;59(10):6675. doi: 10.1128/AAC.01526-15. No abstract available.

15.

A Derivative of the Thiopeptide GE2270A Highly Selective against Propionibacterium acnes.

Fabbretti A, He CG, Gaspari E, Maffioli S, Brandi L, Spurio R, Sosio M, Jabes D, Donadio S.

Antimicrob Agents Chemother. 2015 Aug;59(8):4560-8. doi: 10.1128/AAC.05155-14. Epub 2015 May 18.

16.

Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727.

Lo Grasso L, Maffioli S, Sosio M, Bibb M, Puglia AM, Alduina R.

J Bacteriol. 2015 Aug 1;197(15):2536-44. doi: 10.1128/JB.00262-15. Epub 2015 May 18.

17.

Additional congeners of the macrolide neaumycin: structure revision and biological activity.

Simone M, Maffioli SI, Tocchetti A, Tretter S, Cattaneo M, Biunno I, Gaspari E, Donadio S.

J Antibiot (Tokyo). 2015 Jun;68(6):406-8. doi: 10.1038/ja.2014.168. Epub 2015 Jan 14. No abstract available.

PMID:
25586025
18.

Family of class I lantibiotics from actinomycetes and improvement of their antibacterial activities.

Maffioli SI, Monciardini P, Catacchio B, Mazzetti C, Münch D, Brunati C, Sahl HG, Donadio S.

ACS Chem Biol. 2015 Apr 17;10(4):1034-42. doi: 10.1021/cb500878h. Epub 2015 Jan 23.

PMID:
25574687
19.

GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.

Zhang Y, Degen D, Ho MX, Sineva E, Ebright KY, Ebright YW, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright RH.

Elife. 2014 Apr 22;3:e02450. doi: 10.7554/eLife.02450.

20.

Discovering new bioactive molecules from microbial sources.

Monciardini P, Iorio M, Maffioli S, Sosio M, Donadio S.

Microb Biotechnol. 2014 May;7(3):209-20. doi: 10.1111/1751-7915.12123. Epub 2014 Mar 24. Review.

21.

The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions.

Münch D, Müller A, Schneider T, Kohl B, Wenzel M, Bandow JE, Maffioli S, Sosio M, Donadio S, Wimmer R, Sahl HG.

J Biol Chem. 2014 Apr 25;289(17):12063-76. doi: 10.1074/jbc.M113.537449. Epub 2014 Mar 13.

22.

Characterization of the congeners in the lantibiotic NAI-107 complex.

Maffioli SI, Iorio M, Sosio M, Monciardini P, Gaspari E, Donadio S.

J Nat Prod. 2014 Jan 24;77(1):79-84. doi: 10.1021/np400702t. Epub 2014 Jan 14.

PMID:
24422756
23.

Pharmacological properties of NAI-603, a well-tolerated semisynthetic derivative of ramoplanin.

Jabes D, Brunati C, Candiani G, Riva S, Romanó G, Maffioli S, Rossi R, Simone M, Gaspari E, Donadio S.

Antimicrob Agents Chemother. 2014;58(4):1922-9. doi: 10.1128/AAC.01620-13. Epub 2014 Jan 13. Erratum in: Antimicrob Agents Chemother. 2015 Oct;59(10):6675.

24.

A glycosylated, labionin-containing lanthipeptide with marked antinociceptive activity.

Iorio M, Sasso O, Maffioli SI, Bertorelli R, Monciardini P, Sosio M, Bonezzi F, Summa M, Brunati C, Bordoni R, Corti G, Tarozzo G, Piomelli D, Reggiani A, Donadio S.

ACS Chem Biol. 2014 Feb 21;9(2):398-404. doi: 10.1021/cb400692w. Epub 2013 Nov 20.

25.

Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270.

Tocchetti A, Maffioli S, Iorio M, Alt S, Mazzei E, Brunati C, Sosio M, Donadio S.

Chem Biol. 2013 Aug 22;20(8):1067-77. doi: 10.1016/j.chembiol.2013.07.005. Epub 2013 Aug 8.

26.

Orthoformimycin, a selective inhibitor of bacterial translation elongation from Streptomyces containing an unusual orthoformate.

Maffioli SI, Fabbretti A, Brandi L, Savelsbergh A, Monciardini P, Abbondi M, Rossi R, Donadio S, Gualerzi CO.

ACS Chem Biol. 2013 Sep 20;8(9):1939-46. doi: 10.1021/cb4004095. Epub 2013 Aug 15.

PMID:
23895646
27.

Metformin impairs glucose consumption and survival in Calu-1 cells by direct inhibition of hexokinase-II.

Salani B, Marini C, Rio AD, Ravera S, Massollo M, Orengo AM, Amaro A, Passalacqua M, Maffioli S, Pfeffer U, Cordera R, Maggi D, Sambuceti G.

Sci Rep. 2013;3:2070. doi: 10.1038/srep02070.

28.

Caveolin-1 and polymerase I and transcript release factor: new players in insulin-like growth factor-I receptor signaling.

Hamoudane M, Maffioli S, Cordera R, Maggi D, Salani B.

J Endocrinol Invest. 2013 Mar;36(3):204-8. doi: 10.3275/8848. Epub 2013 Feb 12. Review.

PMID:
23404184
29.

Isolation and characterization of NAI-802, a new lantibiotic produced by two different Actinoplanes strains.

Simone M, Monciardini P, Gaspari E, Donadio S, Maffioli SI.

J Antibiot (Tokyo). 2013 Feb;66(2):73-8. doi: 10.1038/ja.2012.92. Epub 2012 Nov 21.

PMID:
23168402
30.

Chrolactomycins from the actinomycete actinospica.

Iorio M, Maffioli SI, Gaspari E, Rossi R, Mauri P, Sosio M, Donadio S.

J Nat Prod. 2012 Nov 26;75(11):1991-3. doi: 10.1021/np300470f. Epub 2012 Oct 22.

PMID:
23088751
31.

Structural and functional characterization of the bacterial translocation inhibitor GE82832.

Brandi L, Maffioli S, Donadio S, Quaglia F, Sette M, Milón P, Gualerzi CO, Fabbretti A.

FEBS Lett. 2012 Sep 21;586(19):3373-8. doi: 10.1016/j.febslet.2012.07.040. Epub 2012 Jul 24.

32.

Halogenated spirotetronates from Actinoallomurus.

Mazzetti C, Ornaghi M, Gaspari E, Parapini S, Maffioli S, Sosio M, Donadio S.

J Nat Prod. 2012 Jun 22;75(6):1044-50. doi: 10.1021/np300003n. Epub 2012 May 22.

PMID:
22616554
33.

Characterization of madurastatin C1, a novel siderophore from Actinomadura sp.

Mazzei E, Iorio M, Maffioli SI, Sosio M, Donadio S.

J Antibiot (Tokyo). 2012 May;65(5):267-9. doi: 10.1038/ja.2012.10. Epub 2012 Feb 29. No abstract available.

PMID:
22377537
34.

Solution structure by nuclear magnetic resonance of the two lantibiotics 97518 and NAI-107.

Vasile F, Potenza D, Marsiglia B, Maffioli S, Donadio S.

J Pept Sci. 2012 Feb;18(2):129-34. doi: 10.1002/psc.1425. Epub 2011 Nov 14.

PMID:
22083835
35.

Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells.

Salani B, Maffioli S, Hamoudane M, Parodi A, Ravera S, Passalacqua M, Alama A, Nhiri M, Cordera R, Maggi D.

FASEB J. 2012 Feb;26(2):788-98. doi: 10.1096/fj.11-192088. Epub 2011 Oct 28.

PMID:
22038047
36.

IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells.

Salani B, Passalacqua M, Maffioli S, Briatore L, Hamoudane M, Contini P, Cordera R, Maggi D.

PLoS One. 2010 Nov 30;5(11):e14157. doi: 10.1371/journal.pone.0014157.

37.

The genus Actinoallomurus and some of its metabolites.

Pozzi R, Simone M, Mazzetti C, Maffioli S, Monciardini P, Cavaletti L, Bamonte R, Sosio M, Donadio S.

J Antibiot (Tokyo). 2011 Jan;64(1):133-9. doi: 10.1038/ja.2010.149. Epub 2010 Dec 1.

PMID:
21119678
38.

Sources of novel antibiotics--aside the common roads.

Donadio S, Maffioli S, Monciardini P, Sosio M, Jabes D.

Appl Microbiol Biotechnol. 2010 Dec;88(6):1261-7. doi: 10.1007/s00253-010-2877-8. Epub 2010 Sep 24. Review.

PMID:
20865256
39.

Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.

Binz TM, Maffioli SI, Sosio M, Donadio S, Müller R.

J Biol Chem. 2010 Oct 22;285(43):32710-9. doi: 10.1074/jbc.M110.146803. Epub 2010 Aug 14.

40.

Antibiotic discovery in the twenty-first century: current trends and future perspectives.

Donadio S, Maffioli S, Monciardini P, Sosio M, Jabes D.

J Antibiot (Tokyo). 2010 Aug;63(8):423-30. doi: 10.1038/ja.2010.62. Epub 2010 Jun 16. Review.

PMID:
20551985
41.

Structure revision of the lantibiotic 97518.

Maffioli SI, Potenza D, Vasile F, De Matteo M, Sosio M, Marsiglia B, Rizzo V, Scolastico C, Donadio S.

J Nat Prod. 2009 Apr;72(4):605-7. doi: 10.1021/np800794y.

PMID:
19301921
43.

Synthesis and preliminary biological characterization of new semisynthetic derivatives of ramoplanin.

Ciabatti R, Maffioli SI, Panzone G, Canavesi A, Michelucci E, Tiseni PS, Marzorati E, Checchia A, Giannone M, Jabes D, Romano G, Brunati C, Candiani G, Castiglione F.

J Med Chem. 2007 Jun 28;50(13):3077-85. Epub 2007 Jun 2.

PMID:
17542573
44.

Mild and reversible dehydration of primary amides with PdCl2 in aqueous acetonitrile.

Maffioli SI, Marzorati E, Marazzi A.

Org Lett. 2005 Nov 10;7(23):5237-9.

PMID:
16268547
45.

Synthesis and antibacterial activity of alkyl derivatives of the glycopeptide antibiotic A40926 and their amides.

Maffioli SI, Ciabatti R, Romanò G, Marzorati E, Preobrazhenskaya M, Pavlov A.

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3801-5.

PMID:
15993054
46.

Antibiotics GE23077, novel inhibitors of bacterial RNA polymerase. Part 3: Chemical derivatization.

Mariani R, Granata G, Maffioli SI, Serina S, Brunati C, Sosio M, Marazzi A, Vannini A, Patel D, White R, Ciabatti R.

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3748-52.

PMID:
15990299
47.

Glycopeptide resistance determinants from the teicoplanin producer Actinoplanes teichomyceticus.

Serina S, Radice F, Maffioli S, Donadio S, Sosio M.

FEMS Microbiol Lett. 2004 Nov 1;240(1):69-74.

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