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The Ototoxic Potential of Cobalt From Metal-on-Metal Hip Implants: Objective Auditory and Vestibular Outcome.

Leyssens L, Vinck B, Van Der Straeten C, De Smet K, Dhooge I, Wuyts FL, Keppler H, Degeest S, Valette R, Lim R, Maes L.

Ear Hear. 2019 May 29. doi: 10.1097/AUD.0000000000000747. [Epub ahead of print]


Episodic Vestibular Symptoms in Children With a Congenital Cytomegalovirus Infection: A Case Series.

Dhondt C, Maes L, Oostra A, Dhooge I.

Otol Neurotol. 2019 Jul;40(6):e636-e642. doi: 10.1097/MAO.0000000000002244.


Pilot study on patients with Mal de Debarquement syndrome during pregnancy.

Mucci V, Canceri JM, Jacquemyn Y, Ombergen AV, Maes LK, Van de Heyning PH, Browne CJ.

Future Sci OA. 2019 Feb 21;5(4):FSO377. doi: 10.4155/fsoa-2018-0109. eCollection 2019 Apr.


Vestibular Function in Children with Neurodevelopmental Disorders: A Systematic Review.

Van Hecke R, Danneels M, Dhooge I, Van Waelvelde H, Wiersema JR, Deconinck FJA, Maes L.

J Autism Dev Disord. 2019 May 17. doi: 10.1007/s10803-019-04059-0. [Epub ahead of print]


Symptoms and signs in 22 patients with vestibular paroxysmia.

Ihtijarevic B, Van Ombergen A, Celis L, Maes LK, Wuyts FL, Van de Heyning PH, Van Rompaey V.

Clin Otolaryngol. 2019 Apr 30. doi: 10.1111/coa.13356. [Epub ahead of print] No abstract available.


Characterization of the role of N-glycosylation sites in the respiratory syncytial virus fusion protein in virus replication, syncytium formation and antigenicity.

Leemans A, Boeren M, Van der Gucht W, Martinet W, Caljon G, Maes L, Cos P, Delputte P.

Virus Res. 2019 Jun;266:58-68. doi: 10.1016/j.virusres.2019.04.006. Epub 2019 Apr 17.


Constrained mixture modeling affects material parameter identification from planar biaxial tests.

Maes L, Fehervary H, Vastmans J, Mousavi SJ, Avril S, Famaey N.

J Mech Behav Biomed Mater. 2019 Jul;95:124-135. doi: 10.1016/j.jmbbm.2019.03.029. Epub 2019 Apr 8.


Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents.

Courtens C, Risseeuw M, Caljon G, Maes L, Cos P, Martin A, Van Calenbergh S.

Bioorg Med Chem Lett. 2019 May 15;29(10):1232-1235. doi: 10.1016/j.bmcl.2019.03.009. Epub 2019 Mar 7.


Vestibular Infant Screening - Flanders: The implementation of a standard vestibular screening protocol for hearing-impaired children in Flanders.

Martens S, Dhooge I, Dhondt C, Leyssens L, Sucaet M, Vanaudenaerde S, Rombaut L, Maes L.

Int J Pediatr Otorhinolaryngol. 2019 May;120:196-201. doi: 10.1016/j.ijporl.2019.02.033. Epub 2019 Feb 25.


Optimization and Characterization of a Galleria mellonella Larval Infection Model for Virulence Studies and the Evaluation of Therapeutics Against Streptococcus pneumoniae.

Cools F, Torfs E, Aizawa J, Vanhoutte B, Maes L, Caljon G, Delputte P, Cappoen D, Cos P.

Front Microbiol. 2019 Feb 21;10:311. doi: 10.3389/fmicb.2019.00311. eCollection 2019.


In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

Kanyanga RC, Lumpu SN, Ehata MT, Maya BM, Munduku CK, Bool-Miting FM, Cos P, Maes L, Vlietinck AJ, Exarchou V, Tuenter E, Pieters L.

J Ethnopharmacol. 2019 Feb 11. pii: S0378-8741(18)34998-5. doi: 10.1016/j.jep.2019.02.019. [Epub ahead of print]


Amino acid based prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents.

Courtens C, Risseeuw M, Caljon G, Maes L, Martin A, Van Calenbergh S.

Bioorg Med Chem. 2019 Mar 1;27(5):729-747. doi: 10.1016/j.bmc.2019.01.016. Epub 2019 Jan 17.


Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity.

Hulpia F, Campagnaro GD, Scortichini M, Van Hecke K, Maes L, de Koning HP, Caljon G, Van Calenbergh S.

Eur J Med Chem. 2019 Feb 15;164:689-705. doi: 10.1016/j.ejmech.2018.12.050. Epub 2018 Dec 21.


Imidazole Derivatives as Promising Agents for the Treatment of Chagas Disease.

de Araújo JS, García-Rubia A, Sebastián-Pérez V, Kalejaiye TD, Bernardino da Silva P, Fonseca-Berzal CR, Maes L, De Koning HP, Soeiro MNC, Gil C.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02156-18. doi: 10.1128/AAC.02156-18. Print 2019 Apr.


Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.

Botros SS, William S, Sabra AA, El-Lakkany NM, Seif El-Din SH, García-Rubia A, Sebastián-Pérez V, Blaazer AR, de Heuvel E, Sijm M, Zheng Y, Salado IG, Munday JC, Maes L, de Esch IJP, Sterk GJ, Augustyns K, Leurs R, Gil C, De Koning HP.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:35-43. doi: 10.1016/j.ijpddr.2019.01.001. Epub 2019 Jan 14.


Synthesis and antimicrobial activities of N6-hydroxyagelasine analogs and revision of the structure of ageloximes.

Paulsen B, Fredriksen KA, Petersen D, Maes L, Matheeussen A, Naemi AO, Scheie AA, Simm R, Ma R, Wan B, Franzblau S, Gundersen LL.

Bioorg Med Chem. 2019 Feb 15;27(4):620-629. doi: 10.1016/j.bmc.2019.01.002. Epub 2019 Jan 4.


HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.

Zarev Y, Foubert K, Cos P, Maes L, Elgorashi E, Apers S, Ionkova I, Pieters L.

Nat Prod Res. 2019 Jan 3:1-4. doi: 10.1080/14786419.2018.1539976. [Epub ahead of print]


Immunosuppression of Syrian golden hamsters accelerates relapse but not the emergence of resistance in Leishmania infantum following recurrent miltefosine pressure.

Hendrickx S, Bulté D, Van den Kerkhof M, Cos P, Delputte P, Maes L, Caljon G.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:1-7. doi: 10.1016/j.ijpddr.2018.12.001. Epub 2018 Dec 11.


Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain.

Eberhardt E, Bulté D, Van Bockstal L, Van den Kerkhof M, Cos P, Delputte P, Hendrickx S, Maes L, Caljon G.

J Antimicrob Chemother. 2019 Feb 1;74(2):395-406. doi: 10.1093/jac/dky450.


Vestibular assessment in the pediatric population.

Dhondt C, Dhooge I, Maes L.

Laryngoscope. 2019 Feb;129(2):490-493. doi: 10.1002/lary.27255. Epub 2018 Nov 5. No abstract available.


Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.

Devisscher L, Van Coillie S, Hofmans S, Van Rompaey D, Goossens K, Meul E, Maes L, De Winter H, Van Der Veken P, Vandenabeele P, Berghe TV, Augustyns K.

J Med Chem. 2018 Nov 21;61(22):10126-10140. doi: 10.1021/acs.jmedchem.8b01299. Epub 2018 Nov 6.


Evaluation of a Brief Intervention for Promoting Mental Health among Employees in Social Enterprises: A Cluster Randomized Controlled Trial.

Deforche B, Mommen J, Hublet A, De Roover W, Huys N, Clays E, Maes L, De Bourdeaudhuij I, Van Cauwenberg J.

Int J Environ Res Public Health. 2018 Sep 25;15(10). pii: E2107. doi: 10.3390/ijerph15102107.


Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi.

Hulpia F, Van Hecke K, França da Silva C, da Gama Jaen Batista D, Maes L, Caljon G, de Nazaré C Soeiro M, Van Calenbergh S.

J Med Chem. 2018 Oct 25;61(20):9287-9300. doi: 10.1021/acs.jmedchem.8b00999. Epub 2018 Oct 3.


Streptococcus pneumoniae galU gene mutation has a direct effect on biofilm growth, adherence and phagocytosis in vitro and pathogenicity in vivo.

Cools F, Torfs E, Vanhoutte B, de Macedo MB, Bonofiglio L, Mollerach M, Maes L, Caljon G, Delputte P, Cappoen D, Cos P.

Pathog Dis. 2018 Oct 1;76(7). doi: 10.1093/femspd/fty069.


Impact of primary mouse macrophage cell types on Leishmania infection and in vitro drug susceptibility.

Van den Kerkhof M, Van Bockstal L, Gielis JF, Delputte P, Cos P, Maes L, Caljon G, Hendrickx S.

Parasitol Res. 2018 Nov;117(11):3601-3612. doi: 10.1007/s00436-018-6059-4. Epub 2018 Aug 23.


Removal of the N-Glycosylation Sequon at Position N116 Located in p27 of the Respiratory Syncytial Virus Fusion Protein Elicits Enhanced Antibody Responses after DNA Immunization.

Leemans A, Boeren M, Van der Gucht W, Pintelon I, Roose K, Schepens B, Saelens X, Bailey D, Martinet W, Caljon G, Maes L, Cos P, Delputte P.

Viruses. 2018 Aug 14;10(8). pii: E426. doi: 10.3390/v10080426.


Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy.

Sebastián-Pérez V, Hendrickx S, Munday JC, Kalejaiye T, Martínez A, Campillo NE, de Koning H, Caljon G, Maes L, Gil C.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00603-18. doi: 10.1128/AAC.00603-18. Print 2018 Oct.


The impact of the age of first blood meal and Zika virus infection on Aedes aegypti egg production and longevity.

Petersen MT, Silveira IDD, Tátila-Ferreira A, David MR, Chouin-Carneiro T, Van den Wouwer L, Maes L, Maciel-de-Freitas R.

PLoS One. 2018 Jul 26;13(7):e0200766. doi: 10.1371/journal.pone.0200766. eCollection 2018.


Discovery of benzimidazole-based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis.

De Luca L, Ferro S, Buemi MR, Monforte AM, Gitto R, Schirmeister T, Maes L, Rescifina A, Micale N.

Chem Biol Drug Des. 2018 Sep;92(3):1585-1596. doi: 10.1111/cbdd.13326. Epub 2018 May 31.


The test-retest reliability of questionnaires regarding attitudes and beliefs toward noise, hearing loss, and hearing protector devices in young adults.

Degeest S, Maes L, Leyssens L, Keppler H.

Noise Health. 2018 Mar-Apr;20(93):31-36. doi: 10.4103/nah.NAH_41_17.


Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.

Blaazer AR, Singh AK, de Heuvel E, Edink E, Orrling KM, Veerman JJN, van den Bergh T, Jansen C, Balasubramaniam E, Mooij WJ, Custers H, Sijm M, Tagoe DNA, Kalejaiye TD, Munday JC, Tenor H, Matheeussen A, Wijtmans M, Siderius M, de Graaf C, Maes L, de Koning HP, Bailey DS, Sterk GJ, de Esch IJP, Brown DG, Leurs R.

J Med Chem. 2018 May 10;61(9):3870-3888. doi: 10.1021/acs.jmedchem.7b01670. Epub 2018 May 1.


Feasibility and impact study of a reward-based mobile application to improve adolescents' snacking habits.

De Cock N, Van Lippevelde W, Vangeel J, Notebaert M, Beullens K, Eggermont S, Deforche B, Maes L, Goossens L, Verbeken S, Moens E, Vervoort L, Braet C, Huybregts L, Kolsteren P, Van Camp J, Lachat C.

Public Health Nutr. 2018 Aug;21(12):2329-2344. doi: 10.1017/S1368980018000678. Epub 2018 Apr 2.


Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives.

Salado IG, Baán A, Verdeyen T, Matheeussen A, Caljon G, Van der Veken P, Kiekens F, Maes L, Augustyns K.

Eur J Med Chem. 2018 May 10;151:18-26. doi: 10.1016/j.ejmech.2018.03.048. Epub 2018 Mar 23.


UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes.

Saad M, Bijttebier S, Matheeussen A, Verbueken E, Pype C, Casteleyn C, Van Ginneken C, Maes L, Cos P, Van Cruchten S.

Data Brief. 2017 Dec 6;16:644-648. doi: 10.1016/j.dib.2017.11.079. eCollection 2018 Feb.


Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.

Thompson AM, O'Connor PD, Marshall AJ, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Wan B, Franzblau SG, Ma Z, Cooper CB, Denny WA.

J Med Chem. 2018 Mar 22;61(6):2329-2352. doi: 10.1021/acs.jmedchem.7b01581. Epub 2018 Mar 6.


Problem drinking among Flemish students: beverage type, early drinking onset and negative personal & social consequences.

De Bruyn S, Wouters E, Ponnet K, Van Damme J, Maes L, Van Hal G; Task Force substance use in Flemish universities and colleges.

BMC Public Health. 2018 Feb 12;18(1):234. doi: 10.1186/s12889-018-5120-7.


In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series.

Van den Kerkhof M, Mabille D, Chatelain E, Mowbray CE, Braillard S, Hendrickx S, Maes L, Caljon G.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):81-86. doi: 10.1016/j.ijpddr.2018.01.006. Epub 2018 Jan 31.


Report of in vitro antileishmanial properties of Iberian macroalgae.

Bruno de Sousa C, Lago JHG, Macridachis J, Oliveira M, Brito L, Vizetto-Duarte C, Florindo C, Hendrickx S, Maes L, Morais T, Uemi M, Neto L, Dionísio L, Cortes S, Barreira L, Custódio L, Alberício F, Campino L, Varela J.

Nat Prod Res. 2019 Jun;33(12):1778-1782. doi: 10.1080/14786419.2018.1434637. Epub 2018 Feb 9.


Evaluation of a Pan-Leishmania Spliced-Leader RNA Detection Method in Human Blood and Experimentally Infected Syrian Golden Hamsters.

Eberhardt E, Van den Kerkhof M, Bulté D, Mabille D, Van Bockstal L, Monnerat S, Alves F, Mbui J, Delputte P, Cos P, Hendrickx S, Maes L, Caljon G.

J Mol Diagn. 2018 Mar;20(2):253-263. doi: 10.1016/j.jmoldx.2017.12.003. Epub 2018 Jan 31.


A school-based intervention improved dietary intake outcomes and reduced waist circumference in adolescents: a cluster randomized controlled trial.

Ochoa-Avilés A, Verstraeten R, Huybregts L, Andrade S, Van Camp J, Donoso S, Ramírez PL, Lachat C, Maes L, Kolsteren P.

Nutr J. 2017 Dec 11;16(1):79. doi: 10.1186/s12937-017-0299-5.


Novel triazine dimers with potent antitrypanosomal activity.

Venkatraj M, Salado IG, Heeres J, Joossens J, Lewi PJ, Caljon G, Maes L, Van der Veken P, Augustyns K.

Eur J Med Chem. 2018 Jan 1;143:306-319. doi: 10.1016/j.ejmech.2017.11.075. Epub 2017 Nov 27.


Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.

Thompson AM, Marshall AJ, Maes L, Yarlett N, Bacchi CJ, Gaukel E, Wring SA, Launay D, Braillard S, Chatelain E, Mowbray CE, Denny WA.

Bioorg Med Chem Lett. 2018 Jan 15;28(2):207-213. doi: 10.1016/j.bmcl.2017.10.067. Epub 2017 Oct 27.


Miltefosine-resistant Leishmania infantum strains with an impaired MT/ROS3 transporter complex retain amphotericin B susceptibility.

Mondelaers A, Hendrickx S, Van Bockstal L, Maes L, Caljon G.

J Antimicrob Chemother. 2018 Feb 1;73(2):392-394. doi: 10.1093/jac/dkx407.


Developing a systems-based framework of the factors influencing dietary and physical activity behaviours in ethnic minority populations living in Europe - a DEDIPAC study.

Holdsworth M, Nicolaou M, Langøien LJ, Osei-Kwasi HA, Chastin SFM, Stok FM, Capranica L, Lien N, Terragni L, Monsivais P, Mazzocchi M, Maes L, Roos G, Mejean C, Powell K, Stronks K.

Int J Behav Nutr Phys Act. 2017 Nov 7;14(1):154. doi: 10.1186/s12966-017-0608-6.


Biological and Phytochemical Investigations on Caesalpinia benthamiana, a Plant Traditionally Used as Antimalarial in Guinea.

Loua J, Traore MS, Camara A, Balde MA, Maes L, Pieters L, Balde AM.

Evid Based Complement Alternat Med. 2017;2017:9438607. doi: 10.1155/2017/9438607. Epub 2017 Sep 10.


Ensemble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE.

Scala A, Rescifina A, Micale N, Piperno A, Schirmeister T, Maes L, Grassi G.

Chem Biol Drug Des. 2018 Feb;91(2):597-604. doi: 10.1111/cbdd.13124. Epub 2017 Nov 10.


Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds.

Torfs E, Vajs J, de Macedo MB, Cools F, Vanhoutte B, Gorbanev Y, Bogaerts A, Verschaeve L, Caljon G, Maes L, Delputte P, Cos P, Košmrlj J, Cappoen D.

Chem Biol Drug Des. 2018 Feb;91(2):631-640. doi: 10.1111/cbdd.13087. Epub 2017 Sep 14.


Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection.

Van der Gucht W, Leemans A, De Schryver M, Heykers A, Caljon G, Maes L, Cos P, Delputte PL.

Virol J. 2017 Aug 17;14(1):157. doi: 10.1186/s12985-017-0824-3.


Who does not cut down? Comparing characteristics and drinking motives of drinkers and abstainers during the exam periods.

Van Damme J, Hublet A, De Clercq B, Kuntsche E, Maes L, Clays E.

J Am Coll Health. 2017 Nov-Dec;65(8):558-566. doi: 10.1080/07448481.2017.1356311. Epub 2017 Aug 4.


Ibudilast may improve attention during early abstinence from methamphetamine.

Birath JB, Briones M, Amaya S, Shoptaw S, Swanson AN, Tsuang J, Furst B, Heinzerling K, Obermeit L, Maes L, McKay C, Wright MJ.

Drug Alcohol Depend. 2017 Sep 1;178:386-390. doi: 10.1016/j.drugalcdep.2017.05.016. Epub 2017 Jun 23.


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