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Items: 45

1.

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression.

van der Linden AJ, Yelleswarapu M, Pieters PA, Swank Z, Huck WTS, Maerkl SJ, de Greef TFA.

J Vis Exp. 2019 Oct 6;(152). doi: 10.3791/59655.

PMID:
31633684
2.

Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals.

Wan X, Volpetti F, Petrova E, French C, Maerkl SJ, Wang B.

Nat Chem Biol. 2019 May;15(5):540-548. doi: 10.1038/s41589-019-0244-3. Epub 2019 Mar 25.

PMID:
30911179
3.

Cell-free gene-regulatory network engineering with synthetic transcription factors.

Swank Z, Laohakunakorn N, Maerkl SJ.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):5892-5901. doi: 10.1073/pnas.1816591116. Epub 2019 Mar 8.

4.

A Simple, Robust, and Low-Cost Method To Produce the PURE Cell-Free System.

Lavickova B, Maerkl SJ.

ACS Synth Biol. 2019 Feb 15;8(2):455-462. doi: 10.1021/acssynbio.8b00427. Epub 2019 Jan 25.

PMID:
30632751
5.

Microfluidic Transfection for High-Throughput Mammalian Protein Expression.

Woodruff K, Maerkl SJ.

Methods Mol Biol. 2018;1850:189-208. doi: 10.1007/978-1-4939-8730-6_13.

PMID:
30242688
6.

Microfluidic device for real-time formulation of reagents and their subsequent encapsulation into double emulsions.

Chang JC, Swank Z, Keiser O, Maerkl SJ, Amstad E.

Sci Rep. 2018 May 25;8(1):8143. doi: 10.1038/s41598-018-26542-x.

7.

Microfluidic Module for Real-Time Generation of Complex Multimolecule Temporal Concentration Profiles.

Woodruff K, Maerkl SJ.

Anal Chem. 2018 Jan 2;90(1):696-701. doi: 10.1021/acs.analchem.7b04099. Epub 2017 Dec 14.

PMID:
29183126
8.

A Microfluidic Biodisplay.

Volpetti F, Petrova E, Maerkl SJ.

ACS Synth Biol. 2017 Nov 17;6(11):1979-1987. doi: 10.1021/acssynbio.7b00088. Epub 2017 Aug 10.

PMID:
28771313
9.

Single Molecule Localization and Discrimination of DNA-Protein Complexes by Controlled Translocation Through Nanocapillaries.

Bulushev RD, Marion S, Petrova E, Davis SJ, Maerkl SJ, Radenovic A.

Nano Lett. 2016 Dec 14;16(12):7882-7890. Epub 2016 Nov 10.

PMID:
27960483
10.

GreA and GreB Enhance Expression of Escherichia coli RNA Polymerase Promoters in a Reconstituted Transcription-Translation System.

Maddalena LL, Niederholtmeyer H, Turtola M, Swank ZN, Belogurov GA, Maerkl SJ.

ACS Synth Biol. 2016 Sep 16;5(9):929-35. doi: 10.1021/acssynbio.6b00017. Epub 2016 May 19.

PMID:
27186988
11.

A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing.

Woodruff K, Maerkl SJ.

Sci Rep. 2016 Mar 31;6:23937. doi: 10.1038/srep23937.

12.

A Digital-Analog Microfluidic Platform for Patient-Centric Multiplexed Biomarker Diagnostics of Ultralow Volume Samples.

Piraino F, Volpetti F, Watson C, Maerkl SJ.

ACS Nano. 2016 Jan 26;10(1):1699-710. doi: 10.1021/acsnano.5b07939. Epub 2016 Jan 12.

PMID:
26741022
13.

Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering.

Blackburn MC, Petrova E, Correia BE, Maerkl SJ.

Nucleic Acids Res. 2016 Apr 20;44(7):e68. doi: 10.1093/nar/gkv1497. Epub 2015 Dec 23.

14.

Rapid cell-free forward engineering of novel genetic ring oscillators.

Niederholtmeyer H, Sun ZZ, Hori Y, Yeung E, Verpoorte A, Murray RM, Maerkl SJ.

Elife. 2015 Oct 5;4:e09771. doi: 10.7554/eLife.09771.

15.

Mechanically Induced Trapping of Molecular Interactions and Its Applications.

Garcia-Cordero JL, Maerkl SJ.

J Lab Autom. 2016 Jun;21(3):356-67. doi: 10.1177/2211068215578586. Epub 2015 Mar 24. Review.

PMID:
25805850
16.

A microfluidic platform for high-throughput multiplexed protein quantitation.

Volpetti F, Garcia-Cordero J, Maerkl SJ.

PLoS One. 2015 Feb 13;10(2):e0117744. doi: 10.1371/journal.pone.0117744. eCollection 2015.

17.

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription.

Knight B, Kubik S, Ghosh B, Bruzzone MJ, Geertz M, Martin V, Dénervaud N, Jacquet P, Ozkan B, Rougemont J, Maerkl SJ, Naef F, Shore D.

Genes Dev. 2014 Aug 1;28(15):1695-709. doi: 10.1101/gad.244434.114. Erratum in: Genes Dev. 2014 Oct 1;28(19):2188.

18.

LSPR chip for parallel, rapid, and sensitive detection of cancer markers in serum.

Aćimović SS, Ortega MA, Sanz V, Berthelot J, Garcia-Cordero JL, Renger J, Maerkl SJ, Kreuzer MP, Quidant R.

Nano Lett. 2014 May 14;14(5):2636-41. doi: 10.1021/nl500574n. Epub 2014 Apr 17.

PMID:
24730454
19.

Long-term single cell analysis of S. pombe on a microfluidic microchemostat array.

Nobs JB, Maerkl SJ.

PLoS One. 2014 Apr 7;9(4):e93466. doi: 10.1371/journal.pone.0093466. eCollection 2014.

20.

A 1024-sample serum analyzer chip for cancer diagnostics.

Garcia-Cordero JL, Maerkl SJ.

Lab Chip. 2014 Aug 7;14(15):2642-50. doi: 10.1039/c3lc51153g. Epub 2013 Dec 18.

PMID:
24345965
21.

Implementation of cell-free biological networks at steady state.

Niederholtmeyer H, Stepanova V, Maerkl SJ.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15985-90. doi: 10.1073/pnas.1311166110. Epub 2013 Sep 16.

22.

A chemostat array enables the spatio-temporal analysis of the yeast proteome.

Dénervaud N, Becker J, Delgado-Gonzalo R, Damay P, Rajkumar AS, Unser M, Shore D, Naef F, Maerkl SJ.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15842-7. doi: 10.1073/pnas.1308265110. Epub 2013 Sep 9.

23.

Mapping the fine structure of a eukaryotic promoter input-output function.

Rajkumar AS, Dénervaud N, Maerkl SJ.

Nat Genet. 2013 Oct;45(10):1207-15. doi: 10.1038/ng.2729. Epub 2013 Aug 18.

PMID:
23955598
24.

Rapid synthesis of defined eukaryotic promoter libraries.

Rajkumar AS, Maerkl SJ.

ACS Synth Biol. 2012 Oct 19;1(10):483-90. doi: 10.1021/sb300045j. Epub 2012 Jun 20.

PMID:
23656186
25.

Real-time mRNA measurement during an in vitro transcription and translation reaction using binary probes.

Niederholtmeyer H, Xu L, Maerkl SJ.

ACS Synth Biol. 2013 Aug 16;2(8):411-7. doi: 10.1021/sb300104f. Epub 2012 Dec 21.

PMID:
23654250
26.

Live mammalian cell arrays.

Woodruff K, Fidalgo LM, Gobaa S, Lutolf MP, Maerkl SJ.

Nat Methods. 2013 Jun;10(6):550-2. doi: 10.1038/nmeth.2473. Epub 2013 May 5.

PMID:
23644546
27.

A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening.

Garcia-Cordero JL, Nembrini C, Stano A, Hubbell JA, Maerkl SJ.

Integr Biol (Camb). 2013 Apr;5(4):650-8. doi: 10.1039/c3ib20263a. Epub 2013 Feb 26.

PMID:
23443913
28.

iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks.

Rockel S, Geertz M, Hens K, Deplancke B, Maerkl SJ.

Nucleic Acids Res. 2013 Feb 1;41(4):e52. doi: 10.1093/nar/gks1323. Epub 2012 Dec 20.

29.

Multiplexed surface micropatterning of proteins with a pressure-modulated microfluidic button-membrane.

Garcia-Cordero JL, Maerkl SJ.

Chem Commun (Camb). 2013 Feb 14;49(13):1264-6. doi: 10.1039/c2cc37740c. Epub 2012 Nov 26.

PMID:
23183795
30.

Massively parallel measurements of molecular interaction kinetics on a microfluidic platform.

Geertz M, Shore D, Maerkl SJ.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16540-5. doi: 10.1073/pnas.1206011109. Epub 2012 Sep 24.

31.

Topology and dynamics of the zebrafish segmentation clock core circuit.

Schröter C, Ares S, Morelli LG, Isakova A, Hens K, Soroldoni D, Gajewski M, Jülicher F, Maerkl SJ, Deplancke B, Oates AC.

PLoS Biol. 2012;10(7):e1001364. doi: 10.1371/journal.pbio.1001364. Epub 2012 Jul 24.

32.

Probing the informational and regulatory plasticity of a transcription factor DNA-binding domain.

Shultzaberger RK, Maerkl SJ, Kirsch JF, Eisen MB.

PLoS Genet. 2012;8(3):e1002614. doi: 10.1371/journal.pgen.1002614. Epub 2012 Mar 29.

33.

A high-throughput microfluidic method for generating and characterizing transcription factor mutant libraries.

Geertz M, Rockel S, Maerkl SJ.

Methods Mol Biol. 2012;813:107-23. doi: 10.1007/978-1-61779-412-4_6.

PMID:
22083738
34.

MITOMI: a microfluidic platform for in vitro characterization of transcription factor-DNA interaction.

Rockel S, Geertz M, Maerkl SJ.

Methods Mol Biol. 2012;786:97-114. doi: 10.1007/978-1-61779-292-2_6.

PMID:
21938622
35.

Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modules.

He BZ, Holloway AK, Maerkl SJ, Kreitman M.

PLoS Genet. 2011 Apr;7(4):e1002053. doi: 10.1371/journal.pgen.1002053. Epub 2011 Apr 28.

36.

A software-programmable microfluidic device for automated biology.

Fidalgo LM, Maerkl SJ.

Lab Chip. 2011 May 7;11(9):1612-9. doi: 10.1039/c0lc00537a. Epub 2011 Mar 17.

PMID:
21416077
37.

Experimental strategies for studying transcription factor-DNA binding specificities.

Geertz M, Maerkl SJ.

Brief Funct Genomics. 2010 Dec;9(5-6):362-73. doi: 10.1093/bfgp/elq023. Epub 2010 Sep 23. Review.

38.

Next generation microfluidic platforms for high-throughput protein biochemistry.

Maerkl SJ.

Curr Opin Biotechnol. 2011 Feb;22(1):59-65. doi: 10.1016/j.copbio.2010.08.010. Review.

PMID:
20832278
39.

Integration column: Microfluidic high-throughput screening.

Maerkl SJ.

Integr Biol (Camb). 2009 Jan;1(1):19-29. doi: 10.1039/b819762h. Epub 2008 Dec 9. Review.

PMID:
20023788
40.

Experimental determination of the evolvability of a transcription factor.

Maerkl SJ, Quake SR.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18650-5. doi: 10.1073/pnas.0907688106. Epub 2009 Oct 19.

41.

Integration of plasmonic trapping in a microfluidic environment.

Huang L, Maerkl SJ, Martin OJ.

Opt Express. 2009 Apr 13;17(8):6018-24.

PMID:
19365421
42.

An in vitro microfluidic approach to generating protein-interaction networks.

Gerber D, Maerkl SJ, Quake SR.

Nat Methods. 2009 Jan;6(1):71-4. doi: 10.1038/nmeth.1289. Epub 2008 Dec 21.

43.

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.

Einav S, Gerber D, Bryson PD, Sklan EH, Elazar M, Maerkl SJ, Glenn JS, Quake SR.

Nat Biotechnol. 2008 Sep;26(9):1019-27. doi: 10.1038/nbt.1490.

44.
45.

Microfluidic large-scale integration.

Thorsen T, Maerkl SJ, Quake SR.

Science. 2002 Oct 18;298(5593):580-4. Epub 2002 Sep 26.

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