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Items: 1 to 50 of 154

1.

First in human study with a prodrug of galantamine: Improved benefit-risk ratio?

Baakman AC, 't Hart E, Kay DG, Stevens J, Klaassen ES, Maelicke A, Groeneveld GJ.

Alzheimers Dement (N Y). 2016 Jan 20;2(1):13-22. doi: 10.1016/j.trci.2015.12.003. eCollection 2016 Jan.

2.

Nasal Application of the Galantamine Pro-drug Memogain Slows Down Plaque Deposition and Ameliorates Behavior in 5X Familial Alzheimer's Disease Mice.

Bhattacharya S, Maelicke A, Montag D.

J Alzheimers Dis. 2015;46(1):123-36. doi: 10.3233/JAD-142421.

PMID:
25720404
3.

Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer's disease.

Bhattacharya S, Haertel C, Maelicke A, Montag D.

PLoS One. 2014 Feb 21;9(2):e89454. doi: 10.1371/journal.pone.0089454. eCollection 2014.

4.

Localization by site-directed mutagenesis of a galantamine binding site on α7 nicotinic acetylcholine receptor extracellular domain.

Ludwig J, Höffle-Maas A, Samochocki M, Luttmann E, Albuquerque EX, Fels G, Maelicke A.

J Recept Signal Transduct Res. 2010 Dec;30(6):469-83. doi: 10.3109/10799893.2010.505239. Epub 2010 Nov 9.

PMID:
21062106
5.

Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors.

Takata K, Kitamura Y, Saeki M, Terada M, Kagitani S, Kitamura R, Fujikawa Y, Maelicke A, Tomimoto H, Taniguchi T, Shimohama S.

J Biol Chem. 2010 Dec 17;285(51):40180-91. doi: 10.1074/jbc.M110.142356. Epub 2010 Oct 14.

6.

Structural model for the binding sites of allosterically potentiating ligands on nicotinic acetylcholine receptors.

Luttmann E, Ludwig J, Höffle-Maas A, Samochocki M, Maelicke A, Fels G.

ChemMedChem. 2009 Nov;4(11):1874-82. doi: 10.1002/cmdc.200900320.

PMID:
19739198
7.

Memogain is a galantamine pro-drug having dramatically reduced adverse effects and enhanced efficacy.

Maelicke A, Hoeffle-Maas A, Ludwig J, Maus A, Samochocki M, Jordis U, Koepke AK.

J Mol Neurosci. 2010 Jan;40(1-2):135-7. doi: 10.1007/s12031-009-9269-5. Epub 2009 Aug 11.

PMID:
19669943
8.

Neuronal Ca2+ sensor VILIP-1 leads to the upregulation of functional alpha4beta2 nicotinic acetylcholine receptors in hippocampal neurons.

Zhao CJ, Noack C, Brackmann M, Gloveli T, Maelicke A, Heinemann U, Anand R, Braunewell KH.

Mol Cell Neurosci. 2009 Feb;40(2):280-92. doi: 10.1016/j.mcn.2008.11.001. Epub 2008 Nov 19.

9.

Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures.

Moser N, Mechawar N, Jones I, Gochberg-Sarver A, Orr-Urtreger A, Plomann M, Salas R, Molles B, Marubio L, Roth U, Maskos U, Winzer-Serhan U, Bourgeois JP, Le Sourd AM, De Biasi M, Schröder H, Lindstrom J, Maelicke A, Changeux JP, Wevers A.

J Neurochem. 2007 Jul;102(2):479-92. Epub 2007 Apr 10.

11.

Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity.

Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S.

Biochem Biophys Res Commun. 2004 Dec 17;325(3):976-82.

PMID:
15541385
12.

Memantine blocks alpha7* nicotinic acetylcholine receptors more potently than n-methyl-D-aspartate receptors in rat hippocampal neurons.

Aracava Y, Pereira EF, Maelicke A, Albuquerque EX.

J Pharmacol Exp Ther. 2005 Mar;312(3):1195-205. Epub 2004 Nov 2.

PMID:
15522999
13.

Neuronal networks in vitro: formation and organization on biofunctionalized surfaces.

Klein CL, Scholl M, Maelicke A.

J Mater Sci Mater Med. 1999 Dec;10(12):721-7.

PMID:
15347940
14.

The expression level of the orphan nuclear receptor GCNF (germ cell nuclear factor) is critical for neuronal differentiation.

Sattler U, Samochocki M, Maelicke A, Zechel C.

Mol Endocrinol. 2004 Nov;18(11):2714-26. Epub 2004 Aug 5.

PMID:
15297607
15.

Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation.

Almeida LE, Pereira EF, Camara AL, Maelicke A, Albuquerque EX.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1879-87.

PMID:
15050620
16.

Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors.

Nicke A, Samochocki M, Loughnan ML, Bansal PS, Maelicke A, Lewis RJ.

FEBS Lett. 2003 Nov 6;554(1-2):219-23. Erratum in: FEBS Lett. 2004 Jan 16;557(1-3):294.

17.

Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.

Samochocki M, Höffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C, Radina M, Zerlin M, Ullmer C, Pereira EF, Lübbert H, Albuquerque EX, Maelicke A.

J Pharmacol Exp Ther. 2003 Jun;305(3):1024-36. Epub 2003 Mar 20.

PMID:
12649296
18.

DEPD, a high resolution gene expression profiling technique capable of identifying new drug targets in the central nervous system.

Maelicke A, Lübbert H.

J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):283-95. Review.

PMID:
12503622
19.

Unconventional ligands and modulators of nicotinic receptors.

Pereira EF, Hilmas C, Santos MD, Alkondon M, Maelicke A, Albuquerque EX.

J Neurobiol. 2002 Dec;53(4):479-500. Review.

20.

[New theory! Galantamine and nicotinic-cholinergic transmission].

Maelicke A, Weichel C.

Pharm Unserer Zeit. 2002;31(4):390-3. Review. German. No abstract available.

PMID:
12162069
21.

The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system.

Santos MD, Alkondon M, Pereira EF, Aracava Y, Eisenberg HM, Maelicke A, Albuquerque EX.

Mol Pharmacol. 2002 May;61(5):1222-34.

PMID:
11961141
22.

Expression of the alpha4 isoform of the nicotinic acetylcholine receptor in the fetal human cerebral cortex.

Schröder H, Schütz U, Burghaus L, Lindstrom J, Kuryatov A, Monteggia L, deVos RA, van Noort G, Wevers A, Nowacki S, Happich E, Moser N, Arneric SP, Maelicke A.

Brain Res Dev Brain Res. 2001 Dec 14;132(1):33-45.

PMID:
11744105
23.

Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease.

Albuquerque EX, Santos MD, Alkondon M, Pereira EF, Maelicke A.

Alzheimer Dis Assoc Disord. 2001 Aug;15 Suppl 1:S19-25.

PMID:
11669505
24.
25.

The pharmacological rationale for treating vascular dementia with galantamine (Reminyl).

Maelicke A.

Int J Clin Pract Suppl. 2001 May;(120):24-8. Review.

PMID:
11406923
26.

Pharmacokinetic rationale for switching from donepezil to galantamine.

Maelicke A.

Clin Ther. 2001;23 Suppl A:A8-12.

PMID:
11396871
27.

Therapeutic continuity in Alzheimer's disease: switching patients to galantamine. Panel discussion: recommendations for prescribers.

Morris JC, Farlow MR, Ferris SH, Kurz AF, Maelicke A, Rasmusen L, Wilkinson D, Yan B.

Clin Ther. 2001;23 Suppl A:A31-9. No abstract available.

PMID:
11396870
28.

Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR.

Samochocki M, Zerlin M, Jostock R, Groot Kormelink PJ, Luyten WH, Albuquerque EX, Maelicke A.

Acta Neurol Scand Suppl. 2000;176:68-73.

PMID:
11261808
29.

Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer's disease.

Maelicke A, Samochocki M, Jostock R, Fehrenbacher A, Ludwig J, Albuquerque EX, Zerlin M.

Biol Psychiatry. 2001 Feb 1;49(3):279-88. Review.

PMID:
11230879
30.

Ordered networks of rat hippocampal neurons attached to silicon oxide surfaces.

Scholl M, Sprössler C, Denyer M, Krause M, Nakajima K, Maelicke A, Knoll W, Offenhäusser A.

J Neurosci Methods. 2000 Dec 15;104(1):65-75.

PMID:
11163412
31.

Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease.

Maelicke A.

Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:11-8. Review.

PMID:
10971047
32.

Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease.

Maelicke A, Schrattenholz A, Samochocki M, Radina M, Albuquerque EX.

Behav Brain Res. 2000 Aug;113(1-2):199-206. Review.

PMID:
10942046
33.

Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance.

Albuquerque EX, Pereira EF, Mike A, Eisenberg HM, Maelicke A, Alkondon M.

Behav Brain Res. 2000 Aug;113(1-2):131-41.

PMID:
10942040
34.

Production of ceramides causes apoptosis during early neural differentiation in vitro.

Herget T, Esdar C, Oehrlein SA, Heinrich M, Schütze S, Maelicke A, van Echten-Deckert G.

J Biol Chem. 2000 Sep 29;275(39):30344-54.

35.

Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease.

Maelicke A, Albuquerque EX.

Eur J Pharmacol. 2000 Mar 30;393(1-3):165-70.

PMID:
10771010
36.

alpha7 nicotinic acetylcholine receptors and modulation of gabaergic synaptic transmission in the hippocampus.

Alkondon M, Braga MF, Pereira EF, Maelicke A, Albuquerque EX.

Eur J Pharmacol. 2000 Mar 30;393(1-3):59-67.

PMID:
10770998
37.

Expression of functional alpha7 nicotinic acetylcholine receptor during mammalian muscle development and denervation.

Fischer U, Reinhardt S, Albuquerque EX, Maelicke A.

Eur J Neurosci. 1999 Aug;11(8):2856-64.

PMID:
10457182
38.

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein.

Wevers A, Monteggia L, Nowacki S, Bloch W, Schütz U, Lindstrom J, Pereira EF, Eisenberg H, Giacobini E, de Vos RA, Steur EN, Maelicke A, Albuquerque EX, Schröder H.

Eur J Neurosci. 1999 Jul;11(7):2551-65.

PMID:
10383644
39.

Analysis of NO synthase expression in neuronal, astroglial and fibroblast-like derivatives differentiating from PCC7-Mz1 embryonic carcinoma cells.

Gath I, Steppuhn A, Maelicke A, Reinhardt S, Förstermann U.

Eur J Cell Biol. 1999 Feb;78(2):134-42.

PMID:
10099936
40.

The protein kinase C (PKC) substrate GAP-43 is already expressed in neural precursor cells, colocalizes with PKCeta and binds calmodulin.

Esdar C, Oehrlein SA, Reinhardt S, Maelicke A, Herget T.

Eur J Neurosci. 1999 Feb;11(2):503-16.

PMID:
10051751
41.
42.

The murine nuclear orphan receptor GCNF is expressed in the XY body of primary spermatocytes.

Bauer UM, Schneider-Hirsch S, Reinhardt S, Benavente R, Maelicke A.

FEBS Lett. 1998 Nov 20;439(3):208-14.

43.

Expression and renaturation of the N-terminal extracellular domain of torpedo nicotinic acetylcholine receptor alpha-subunit.

Schrattenholz A, Pfeiffer S, Pejovic V, Rudolph R, Godovac-Zimmermann J, Maelicke A.

J Biol Chem. 1998 Dec 4;273(49):32393-9.

44.

Incorporation of the acetylcholine receptor dimer from Torpedo californica in a peptide supported lipid membrane investigated by surface plasmon and fluorescence spectroscopy.

Schmidt EK, Liebermann T, Kreiter M, Jonczyk A, Naumann R, Offenhäusser A, Neumann E, Kukol A, Maelicke A, Knoll W.

Biosens Bioelectron. 1998 Sep 15;13(6):585-91.

PMID:
9828354
45.

Neuronal nicotinic receptors in the locust Locusta migratoria. Cloning and expression.

Hermsen B, Stetzer E, Thees R, Heiermann R, Schrattenholz A, Ebbinghaus U, Kretschmer A, Methfessel C, Reinhardt S, Maelicke A.

J Biol Chem. 1998 Jul 17;273(29):18394-404.

46.

Cell fate specification in an in vitro model of neural development.

Jostock R, Rentrop M, Maelicke A.

Eur J Cell Biol. 1998 May;76(1):63-76.

PMID:
9650784
47.

Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons.

Alkondon M, Pereira EF, Cortes WS, Maelicke A, Albuquerque EX.

Eur J Neurosci. 1997 Dec;9(12):2734-42.

PMID:
9517478
48.

Cloning of the human NCNF gene.

Schneider-Hirsch S, Bauer UM, Heiermann R, Rentrop M, Maelicke A.

J Recept Signal Transduct Res. 1998 Jan;18(1):1-13.

PMID:
9493564
49.

Retinoic acid induces apoptosis-associated neural differentiation of a murine teratocarcinoma cell line.

Herget T, Specht H, Esdar C, Oehrlein SA, Maelicke A.

J Neurochem. 1998 Jan;70(1):47-58.

50.

De novo acquisition of neuronal polarity in retinoic acid-induced embryonal carcinoma cells.

Berger C, Reinhardt S, Rentrop M, Bachmann M, Weiser T, Link E, Wienrich M, Jahn R, Maelicke A.

Eur J Cell Biol. 1997 Nov;74(3):230-45.

PMID:
9402471

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