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Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica.

Nakada-Tsukui K, Watanabe N, Maehama T, Nozaki T.

Front Cell Infect Microbiol. 2019 Jun 6;9:150. doi: 10.3389/fcimb.2019.00150. eCollection 2019. Review.


MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner.

Kato W, Nishio M, To Y, Togashi H, Mak TW, Takada H, Ohga S, Maehama T, Suzuki A.

Genes Cells. 2019 Jul;24(7):485-495. doi: 10.1111/gtc.12704. Epub 2019 May 24.


Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency.

Nishio M, Miyachi Y, Otani J, Tane S, Omori H, Ueda F, Togashi H, Sasaki T, Mak TW, Nakao K, Fujita Y, Nishina H, Maehama T, Suzuki A.

FASEB J. 2019 Apr;33(4):5548-5560. doi: 10.1096/fj.201802005R. Epub 2019 Jan 14.


Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.

Goto H, Nishio M, To Y, Oishi T, Miyachi Y, Maehama T, Nishina H, Akiyama H, Mak TW, Makii Y, Saito T, Yasoda A, Tsumaki N, Suzuki A.

Development. 2018 Mar 16;145(6). pii: dev159244. doi: 10.1242/dev.159244.


Comparison of the digene hybrid capture 2 and Roche cobas 4800 HPV tests for detection of CIN2+ in a referral population in Japan.

Sasagawa T, Maehama T, Osaka Y, Sakamoto J, Shibata T, Fujita S, Takakura M, Takagi H.

J Med Virol. 2018 May;90(5):972-980. doi: 10.1002/jmv.25025. Epub 2018 Jan 31.


MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation.

Otsubo K, Goto H, Nishio M, Kawamura K, Yanagi S, Nishie W, Sasaki T, Maehama T, Nishina H, Mimori K, Nakano T, Shimizu H, Mak TW, Nakao K, Nakanishi Y, Suzuki A.

Oncogene. 2017 Jul 20;36(29):4201-4211. doi: 10.1038/onc.2017.58. Epub 2017 Mar 27.


Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway.

Nishio M, Maehama T, Goto H, Nakatani K, Kato W, Omori H, Miyachi Y, Togashi H, Shimono Y, Suzuki A.

Genes Cells. 2017 Jan;22(1):6-31. doi: 10.1111/gtc.12461. Review.


Targeting the Hippo signalling pathway for cancer treatment.

Nakatani K, Maehama T, Nishio M, Goto H, Kato W, Omori H, Miyachi Y, Togashi H, Shimono Y, Suzuki A.

J Biochem. 2017 Mar 1;161(3):237-244. doi: 10.1093/jb/mvw074. Review.


Population-based study for human papillomavirus (HPV) infection in young women in Japan: A multicenter study by the Japanese human papillomavirus disease education research survey group (J-HERS).

Sasagawa T, Maehama T, Ideta K, Irie T; Fujiko Itoh J-HERS Study Group.

J Med Virol. 2016 Feb;88(2):324-35. doi: 10.1002/jmv.24323.


Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein.

Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K.

J Biol Chem. 2014 Jul 25;289(30):20802-12.


Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.

Kukimoto I, Maehama T, Sekizuka T, Ogasawara Y, Kondo K, Kusumoto-Matsuo R, Mori S, Ishii Y, Takeuchi T, Yamaji T, Takeuchi F, Hanada K, Kuroda M.

PLoS One. 2013 Nov 13;8(11):e80583. doi: 10.1371/journal.pone.0080583. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/524fa93c-e77c-4c3d-bf6e-763a5b057409.


A class II phosphoinositide 3-kinase plays an indispensable role in hepatitis C virus replication.

Maehama T, Fukasawa M, Date T, Wakita T, Hanada K.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):150-6. doi: 10.1016/j.bbrc.2013.09.048. Epub 2013 Sep 18.


PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression.

Uchi R, Kogo R, Kawahara K, Sudo T, Yokobori T, Eguchi H, Sugimachi K, Maehama T, Mori M, Suzuki A, Komune S, Mimori K.

Br J Cancer. 2013 Oct 15;109(8):2199-206. doi: 10.1038/bjc.2013.561. Epub 2013 Sep 17.


Capturing the mammalian Hippo: elucidating its role in cancer.

Nishio M, Otsubo K, Maehama T, Mimori K, Suzuki A.

Cancer Sci. 2013 Oct;104(10):1271-7. doi: 10.1111/cas.12227. Epub 2013 Aug 7.


A new PICTure of nucleolar stress.

Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, Maehama T, Sasaki T, Mimori K, Mori M.

Cancer Sci. 2012 Apr;103(4):632-7. doi: 10.1111/j.1349-7006.2012.02219.x. Epub 2012 Mar 8. Review.


Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.

Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A.

Nat Med. 2011 Jul 31;17(8):944-51. doi: 10.1038/nm.2392.


Impaired coronary flow reserve in obstructive sleep apnea and its improvement after continuous positive airway pressure therapy: a transthoracic Doppler echocardiographic study.

Obase K, Okura H, Mouri K, Maehama T, Hayashida A, Watanabe N, Neishi Y, Kawamoto T, Oka M, Yoshida K.

J Echocardiogr. 2011 Jun;9(2):59-63. doi: 10.1007/s12574-010-0074-5. Epub 2010 Dec 8.


Relationship between arterial and fibrous cap remodeling: a serial three-vessel intravascular ultrasound and optical coherence tomography study.

Yamada R, Okura H, Kume T, Saito K, Miyamoto Y, Imai K, Tsuchiya T, Maehama T, Okahashi N, Obase K, Hayashida A, Neishi Y, Kawamoto T, Yoshida K.

Circ Cardiovasc Interv. 2010 Oct;3(5):484-90. doi: 10.1161/CIRCINTERVENTIONS.109.928911. Epub 2010 Aug 24.


Usefulness of CHADS2 score to predict C-reactive protein, left atrial blood stasis, and prognosis in patients with nonrheumatic atrial fibrillation.

Maehama T, Okura H, Imai K, Yamada R, Obase K, Saito K, Hayashida A, Neishi Y, Kawamoto T, Yoshida K.

Am J Cardiol. 2010 Aug 15;106(4):535-8. doi: 10.1016/j.amjcard.2010.03.067.


An improved method for cell-to-cell transmission of infectious prion.

Tanaka M, Hara H, Nishina H, Hanada K, Hagiwara K, Maehama T.

Biochem Biophys Res Commun. 2010 Jul 2;397(3):505-8. doi: 10.1016/j.bbrc.2010.05.143. Epub 2010 May 31.


Systemic inflammation and left atrial thrombus in patients with non-rheumatic atrial fibrillation.

Maehama T, Okura H, Imai K, Saito K, Yamada R, Koyama T, Hayashida A, Neishi Y, Kawamoto T, Yoshida K.

J Cardiol. 2010 Jul;56(1):118-24. doi: 10.1016/j.jjcc.2010.03.006. Epub 2010 May 13.


Diagnosis of myocardial viability by fluorodeoxyglucose distribution at the border zone of a low uptake region.

Toyota E, Sone T, Yoshikawa K, Mimura H, Hayashida A, Wada N, Obase K, Imai K, Saito K, Maehama T, Fukunaga M, Yoshida K.

Yonsei Med J. 2010 Mar;51(2):178-86. doi: 10.3349/ymj.2010.51.2.178. Epub 2010 Feb 12.


Quantitative measurements of aortic valve coaptation by three-dimensional transesophageal echocardiography in patients with aortic regurgitation without primary leaflet disease.

Imai K, Watanabe N, Saito K, Hayashida A, Maehama T, Miyamoto Y, Kawamoto T, Neishi Y, Okura H, Yoshida K.

J Echocardiogr. 2010 Mar;8(1):7-13. doi: 10.1007/s12574-009-0028-y. Epub 2009 Nov 14.


Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells.

Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F.

Mol Biol Cell. 2009 Dec;20(24):5156-65. doi: 10.1091/mbc.E09-08-0692.


Sinus of Valsalva dilates disproportionately in aortic root aneurysm with moderate to severe aortic regurgitation: quantitative assessment by transesophageal echocardiography.

Imai K, Watanabe N, Hayashida A, Obase K, Maehama T, Saito K, Kawamoto T, Neishi Y, Okura H, Yoshida K.

J Echocardiogr. 2009 Sep;7(3):41-7. doi: 10.1007/s12574-009-0012-6. Epub 2009 Jul 2.


Comprehensive evaluation of left ventricular strain using speckle tracking echocardiography in normal adults: comparison of three-dimensional and two-dimensional approaches.

Saito K, Okura H, Watanabe N, Hayashida A, Obase K, Imai K, Maehama T, Kawamoto T, Neishi Y, Yoshida K.

J Am Soc Echocardiogr. 2009 Sep;22(9):1025-30. doi: 10.1016/j.echo.2009.05.021. Epub 2009 Jun 24.


RalA functions as an indispensable signal mediator for the nutrient-sensing system.

Maehama T, Tanaka M, Nishina H, Murakami M, Kanaho Y, Hanada K.

J Biol Chem. 2008 Dec 12;283(50):35053-9. doi: 10.1074/jbc.M805822200. Epub 2008 Oct 23.


[Primary diffuse large B-cell lymphoma of the uterine cervix--a case report].

Okudaira T, Nagasaki A, Miyagi T, Nakazato T, Taira N, Kudaka W, Maehama T, Takasu N.

Gan To Kagaku Ryoho. 2008 Aug;35(8):1423-5. Japanese.


S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.

Malchinkhuu E, Sato K, Maehama T, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Y, Kurose H, Okajima F.

Biochem Biophys Res Commun. 2008 Feb 22;366(4):963-8. Epub 2007 Dec 26.


PTEN: its deregulation and tumorigenesis.

Maehama T.

Biol Pharm Bull. 2007 Sep;30(9):1624-7. Review.


Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation.

Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T.

Mol Biol Cell. 2006 Nov;17(11):4888-95. Epub 2006 Sep 13.


Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development.

Suzuki T, Kanai Y, Hara T, Sasaki J, Sasaki T, Kohara M, Maehama T, Taya C, Shitara H, Yonekawa H, Frohman MA, Yokozeki T, Kanaho Y.

Mol Cell Biol. 2006 Aug;26(16):6149-56.


A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases.

Nigorikawa K, Yoshikawa K, Sasaki T, Iida E, Tsukamoto M, Murakami H, Maehama T, Hazeki K, Hazeki O.

Mol Pharmacol. 2006 Sep;70(3):1143-9. Epub 2006 Jun 27.


[Regulation of the lipid phosphatase PTEN].

Maehama T.

Seikagaku. 2006 Feb;78(2):133-7. Review. Japanese. No abstract available.


The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.

Miyazaki H, Yamazaki M, Watanabe H, Maehama T, Yokozeki T, Kanaho Y.

FEBS Lett. 2005 Dec 19;579(30):6834-8. Epub 2005 Nov 28.


Profiling of proteins associated with cisplatin resistance in ovarian cancer cells.

Zhu K, Fukasawa I, Fujinoki M, Furuno M, Inaba F, Yamazaki T, Kamemori T, Kousaka N, Ota Y, Hayashi M, Maehama T, Inaba N.

Int J Gynecol Cancer. 2005 Sep-Oct;15(5):747-54.


Inhibitory effects of herbal drugs on the growth of human ovarian cancer cell lines through the induction of apoptosis.

Zhu K, Fukasawa I, Furuno M, Inaba F, Yamazaki T, Kamemori T, Kousaka N, Ota Y, Hayashi M, Maehama T, Inaba N.

Gynecol Oncol. 2005 May;97(2):405-9.


Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.

Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, Chiba T, Maehama T, Hamada K, Kishimoto H, Frohman MA, Tanaka K, Penninger JM, Yonekawa H, Suzuki A, Kanaho Y.

J Exp Med. 2005 Mar 21;201(6):859-70. Epub 2005 Mar 14.


Concurrent chemoradiotherapy using high-dose-rate intracavitary brachytherapy for uterine cervical cancer.

Toita T, Moromizato H, Ogawa K, Kakinohana Y, Maehama T, Kanazawa K, Murayama S.

Gynecol Oncol. 2005 Mar;96(3):665-70.


Persistence of human papillomavirus infection as a predictor for recurrence in carcinoma of the cervix after radiotherapy.

Nagai Y, Toma T, Moromizato H, Maehama T, Asato T, Kariya K, Kanazawa K.

Am J Obstet Gynecol. 2004 Dec;191(6):1907-13.


Production of research-grade antibody by in vivo electroporation of DNA-encoding target protein.

Okahara F, Itoh K, Ebihara M, Kobayashi M, Maruyama H, Kanaho Y, Maehama T.

Anal Biochem. 2005 Jan 1;336(1):138-40. No abstract available.


Human T cell leukemia virus-1 in pregnancy.

Maehama T.

Int J Gynaecol Obstet. 2004 Dec;87(3):247-8. No abstract available.


Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

Okahara F, Ikawa H, Kanaho Y, Maehama T.

J Biol Chem. 2004 Oct 29;279(44):45300-3. Epub 2004 Sep 7.


Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells.

Watanabe H, Yokozeki T, Yamazaki M, Miyazaki H, Sasaki T, Maehama T, Itoh K, Frohman MA, Kanaho Y.

J Biol Chem. 2004 Sep 3;279(36):37870-7. Epub 2004 Jun 29.


Suppression of a phosphatidylinositol 3-kinase signal by a specific spliced variant of Drosophila PTEN.

Maehama T, Kosaka N, Okahara F, Takeuchi K, Umeda M, Dixon JE, Kanaho Y.

FEBS Lett. 2004 May 7;565(1-3):43-7.


A large case-control study of cervical cancer risk associated with human papillomavirus infection in Japan, by nucleotide sequencing-based genotyping.

Asato T, Maehama T, Nagai Y, Kanazawa K, Uezato H, Kariya K.

J Infect Dis. 2004 May 15;189(10):1829-32. Epub 2004 Apr 26.


The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover.

Maehama T, Okahara F, Kanaho Y.

Biochem Soc Trans. 2004 Apr;32(Pt 2):343-7. Review.


Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons.

Watanabe H, Yamazaki M, Miyazaki H, Arikawa C, Itoh K, Sasaki T, Maehama T, Frohman MA, Kanaho Y.

J Neurochem. 2004 Apr;89(1):142-51.


A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi.

Merlot S, Meili R, Pagliarini DJ, Maehama T, Dixon JE, Firtel RA.

J Biol Chem. 2003 Oct 10;278(41):39866-73. Epub 2003 Jul 23.

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