Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 86

1.

Correction to: Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets.

Goehring I, Sauter NS, Catchpole G, Assmann A, Shu L, Zien KS, Moehlig M, Pfeiffer AFH, Oberholzer J, Willmitzer L, Spranger J, Maedler K.

Diabetologia. 2019 Mar;62(3):553-554. doi: 10.1007/s00125-018-4717-9.

PMID:
30635678
2.

TLR4 triggered complex inflammation in human pancreatic islets.

He W, Rebello O, Savino R, Terracciano R, Schuster-Klein C, Guardiola B, Maedler K.

Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):86-97. doi: 10.1016/j.bbadis.2018.09.030. Epub 2018 Oct 1.

PMID:
30287405
3.

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response.

Gorrepati KDD, Lupse B, Annamalai K, Yuan T, Maedler K, Ardestani A.

iScience. 2018 Mar 23;1:72-86. doi: 10.1016/j.isci.2018.02.003. Epub 2018 Mar 23.

4.

mTORC1 and IRS1: Another Deadly Kiss.

Ardestani A, Maedler K.

Trends Endocrinol Metab. 2018 Nov;29(11):737-739. doi: 10.1016/j.tem.2018.07.003. Epub 2018 Aug 3. Review.

PMID:
30082207
5.

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism.

Ardestani A, Lupse B, Maedler K.

Trends Endocrinol Metab. 2018 Jul;29(7):492-509. doi: 10.1016/j.tem.2018.04.006. Epub 2018 May 5. Review.

PMID:
29739703
6.

An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis.

Gorrepati KDD, He W, Lupse B, Yuan T, Maedler K, Ardestani A.

Int J Mol Sci. 2018 Mar 24;19(4). pii: E975. doi: 10.3390/ijms19040975.

7.

mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function.

Yuan T, Lupse B, Maedler K, Ardestani A.

J Mol Biol. 2018 Mar 30;430(7):904-918. doi: 10.1016/j.jmb.2018.02.013. Epub 2018 Feb 23. Review.

PMID:
29481838
8.

Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4.

He W, Yuan T, Choezom D, Hunkler H, Annamalai K, Lupse B, Maedler K.

Sci Rep. 2018 Feb 9;8(1):2767. doi: 10.1038/s41598-018-20909-w.

9.

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells.

Ardestani A, Lupse B, Kido Y, Leibowitz G, Maedler K.

Cell Metab. 2018 Feb 6;27(2):314-331. doi: 10.1016/j.cmet.2017.11.004. Epub 2017 Dec 21. Review.

10.

The Hippo Signaling Pathway in Pancreatic β-Cells: Functions and Regulations.

Ardestani A, Maedler K.

Endocr Rev. 2018 Feb 1;39(1):21-35. doi: 10.1210/er.2017-00167. Review.

PMID:
29053790
11.

mTORC in β cells: more Than Only Recognizing Comestibles.

Maedler K, Ardestani A.

J Cell Biol. 2017 Jul 3;216(7):1883-1885. doi: 10.1083/jcb.201704179. Epub 2017 Jun 12.

12.

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K.

Sci Rep. 2017 Apr 5;7:45319. doi: 10.1038/srep45319.

13.

Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets.

Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY.

J Clin Invest. 2017 Apr 3;127(4):1589. doi: 10.1172/JCI92172. Epub 2017 Apr 3. No abstract available.

14.

Statement of Retraction. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets.

Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K.

Diabetes. 2017 Jun;66(6):1729-1730. doi: 10.2337/db17-rt06a. Epub 2017 Mar 29. No abstract available.

15.

Pancreatic β-cell rescue in diabetes by targeting Merlin.

Yuan T, Maedler K, Ardestani A.

Expert Rev Endocrinol Metab. 2017 Mar;12(2):97-99. doi: 10.1080/17446651.2017.1294484. Epub 2017 Feb 16. No abstract available.

PMID:
30063428
16.

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes.

Busse N, Paroni F, Richardson SJ, Laiho JE, Oikarinen M, Frisk G, Hyöty H, de Koning E, Morgan NG, Maedler K.

Oncotarget. 2017 Feb 21;8(8):12620-12636. doi: 10.18632/oncotarget.14896.

17.

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes.

Yuan T, Rafizadeh S, Gorrepati KD, Lupse B, Oberholzer J, Maedler K, Ardestani A.

Diabetologia. 2017 Apr;60(4):668-678. doi: 10.1007/s00125-016-4188-9. Epub 2016 Dec 21.

PMID:
28004151
18.

Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells.

Yuan T, Rafizadeh S, Azizi Z, Lupse B, Gorrepati KDD, Awal S, Oberholzer J, Maedler K, Ardestani A.

JCI Insight. 2016 Nov 3;1(18):e86326. doi: 10.1172/jci.insight.86326.

19.

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes.

Shah P, Lueschen N, Ardestani A, Oberholzer J, Olerud J, Carlsson PO, Maedler K.

PLoS One. 2016 Sep 12;11(9):e0161834. doi: 10.1371/journal.pone.0161834. eCollection 2016.

20.

Enhanced cell adhesion on bioinert ceramics mediated by the osteogenic cell membrane enzyme alkaline phosphatase.

Aminian A, Shirzadi B, Azizi Z, Maedler K, Volkmann E, Hildebrand N, Maas M, Treccani L, Rezwan K.

Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:184-94. doi: 10.1016/j.msec.2016.06.056. Epub 2016 Jun 17.

PMID:
27612703
21.

Evaluation of Existing Methods for Human Blood mRNA Isolation and Analysis for Large Studies.

Meyer A, Paroni F, Günther K, Dharmadhikari G, Ahrens W, Kelm S, Maedler K.

PLoS One. 2016 Aug 30;11(8):e0161778. doi: 10.1371/journal.pone.0161778. eCollection 2016.

22.

Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein-Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722; DOI: 10.2337/db05-1430.

Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

Diabetes. 2016 Aug;65(8):2462. doi: 10.2337/db16-ec08a. No abstract available. Update in: Diabetes. 2018 Nov;67(11):2479-2480.

23.
24.

β-MSCs: successful fusion of MSCs with β-cells results in a β-cell like phenotype.

Azizi Z, Lange C, Paroni F, Ardestani A, Meyer A, Wu Y, Zander AR, Westenfelder C, Maedler K.

Oncotarget. 2016 Aug 2;7(31):48963-48977. doi: 10.18632/oncotarget.10214.

25.

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes.

Ardestani A, Maedler K.

Diabetologia. 2016 Sep;59(9):1843-9. doi: 10.1007/s00125-016-3892-9. Epub 2016 Apr 6. Review.

PMID:
27053234
26.

Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2.

Yuan T, Gorrepati KD, Maedler K, Ardestani A.

Cell Death Dis. 2016 Feb 18;7:e2107. doi: 10.1038/cddis.2016.21. No abstract available.

27.

Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.

Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E.

Cell Signal. 2016 Apr;28(4):272-83. doi: 10.1016/j.cellsig.2016.01.002. Epub 2016 Jan 9.

PMID:
26776303
28.

Erratum to: Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival.

Glas R, Sauter NS, Schulthess FT, Shu L, Oberholzer J, Maedler K.

Diabetologia. 2015 Sep;58(9):2201. doi: 10.1007/s00125-015-3681-x. No abstract available.

29.

Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry.

Oetjen J, Veselkov K, Watrous J, McKenzie JS, Becker M, Hauberg-Lotte L, Kobarg JH, Strittmatter N, Mróz AK, Hoffmann F, Trede D, Palmer A, Schiffler S, Steinhorst K, Aichler M, Goldin R, Guntinas-Lichius O, von Eggeling F, Thiele H, Maedler K, Walch A, Maass P, Dorrestein PC, Takats Z, Alexandrov T.

Gigascience. 2015 May 4;4:20. doi: 10.1186/s13742-015-0059-4. eCollection 2015.

30.

Manganese-mediated MRI signals correlate with functional β-cell mass during diabetes progression.

Meyer A, Stolz K, Dreher W, Bergemann J, Holebasavanahalli Thimmashetty V, Lueschen N, Azizi Z, Khobragade V, Maedler K, Kuestermann E.

Diabetes. 2015 Jun;64(6):2138-47. doi: 10.2337/db14-0864. Epub 2015 Mar 24.

31.

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.

Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K.

Hum Mol Genet. 2015 May 15;24(10):3004. doi: 10.1093/hmg/ddv075. Epub 2015 Mar 8.

32.

Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies.

Zhao G, Dharmadhikari G, Maedler K, Meyer-Hermann M.

PLoS Comput Biol. 2014 Aug 28;10(8):e1003798. doi: 10.1371/journal.pcbi.1003798. eCollection 2014 Aug.

33.

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6.

Nackiewicz D, Dan M, He W, Kim R, Salmi A, Rütti S, Westwell-Roper C, Cunningham A, Speck M, Schuster-Klein C, Guardiola B, Maedler K, Ehses JA.

Diabetologia. 2014 Aug;57(8):1645-54. doi: 10.1007/s00125-014-3249-1. Epub 2014 May 12.

PMID:
24816367
34.

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.

Ardestani A, Paroni F, Azizi Z, Kaur S, Khobragade V, Yuan T, Frogne T, Tao W, Oberholzer J, Pattou F, Conte JK, Maedler K.

Nat Med. 2014 Apr;20(4):385-397. doi: 10.1038/nm.3482. Epub 2014 Mar 16.

35.

The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization.

Shah P, Ardestani A, Dharmadhikari G, Laue S, Schumann DM, Kerr-Conte J, Pattou F, Klein T, Maedler K.

J Clin Endocrinol Metab. 2013 Jul;98(7):E1163-72. doi: 10.1210/jc.2013-1029. Epub 2013 Apr 30.

PMID:
23633194
36.

Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression.

Hoffmeister A, Tuennemann J, Sommerer I, Mössner J, Rittger A, Schleinitz D, Kratzsch J, Rosendahl J, Klöting N, Stahl T, Rossner S, Paroni F, Maedler K, Kovacs P, Blüher M.

Obesity (Silver Spring). 2013 Dec;21(12):E626-33. doi: 10.1002/oby.20482. Epub 2013 Jul 5.

37.

The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion.

Spinnler R, Gorski T, Stolz K, Schuster S, Garten A, Beck-Sickinger AG, Engelse MA, de Koning EJ, Körner A, Kiess W, Maedler K.

PLoS One. 2013;8(1):e54106. doi: 10.1371/journal.pone.0054106. Epub 2013 Jan 16.

38.

Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.

Sahin H, Borkham-Kamphorst E, do O NT, Berres ML, Kaldenbach M, Schmitz P, Weiskirchen R, Liedtke C, Streetz KL, Maedler K, Trautwein C, Wasmuth HE.

Hepatology. 2013 Feb;57(2):797-805. doi: 10.1002/hep.26069. Epub 2013 Jan 8.

PMID:
22996399
39.

TCF7L2 promotes beta cell regeneration in human and mouse pancreas.

Shu L, Zien K, Gutjahr G, Oberholzer J, Pattou F, Kerr-Conte J, Maedler K.

Diabetologia. 2012 Dec;55(12):3296-307. doi: 10.1007/s00125-012-2693-z. Epub 2012 Sep 4.

PMID:
22945304
40.

Imaging of the β-cells of the islets of Langerhans.

Malaisse WJ, Maedler K.

Diabetes Res Clin Pract. 2012 Oct;98(1):11-8. doi: 10.1016/j.diabres.2012.07.001. Epub 2012 Jul 31. Review.

PMID:
22854107
41.

COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways.

Boutant M, Ramos OH, Tourrel-Cuzin C, Movassat J, Ilias A, Vallois D, Planchais J, Pégorier JP, Schuit F, Petit PX, Bossard P, Maedler K, Grapin-Botton A, Vasseur-Cognet M.

PLoS One. 2012;7(1):e30847. doi: 10.1371/journal.pone.0030847. Epub 2012 Jan 24.

42.

TOSO promotes β-cell proliferation and protects from apoptosis.

Dharmadhikari G, Mühle M, Schulthess FT, Laue S, Oberholzer J, Pattou F, Kerr-Conte J, Maedler K.

Mol Metab. 2012 Aug 17;1(1-2):70-8. doi: 10.1016/j.molmet.2012.08.006. eCollection 2012.

43.

Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets.

Goehring I, Sauter NS, Catchpole G, Assmann A, Shu L, Zien KS, Moehlig M, Pfeiffer AF, Oberholzer J, Willmitzer L, Spranger J, Maedler K.

Diabetologia. 2011 Oct;54(10):2584-94. doi: 10.1007/s00125-011-2249-7. Epub 2011 Jul 28. Erratum in: Diabetologia. 2019 Jan 11;:.

PMID:
21796486
44.

Interleukin-targeted therapy for metabolic syndrome and type 2 diabetes.

Maedler K, Dharmadhikari G, Schumann DM, Størling J.

Handb Exp Pharmacol. 2011;(203):257-78. doi: 10.1007/978-3-642-17214-4_11. Review. Erratum in: Handb Exp Pharmacol. 2011;203:E1..

PMID:
21484575
45.

Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.

Ardestani A, Sauter NS, Paroni F, Dharmadhikari G, Cho JH, Lupi R, Marchetti P, Oberholzer J, Conte JK, Maedler K.

J Biol Chem. 2011 May 13;286(19):17144-55. doi: 10.1074/jbc.M110.210526. Epub 2011 Mar 10. Retraction in: Ardestani A, Sauter NS, Paroni F, Dharmadhikari G, Cho JH, Lupi R, Marchetti P, Oberholzer J, Kerr Conte J, Maedler K. J Biol Chem. 2015 Nov 13;290(46):27532.

46.

TCF7L2 splice variants have distinct effects on beta-cell turnover and function.

Le Bacquer O, Shu L, Marchand M, Neve B, Paroni F, Kerr Conte J, Pattou F, Froguel P, Maedler K.

Hum Mol Genet. 2011 May 15;20(10):1906-15. doi: 10.1093/hmg/ddr072. Epub 2011 Feb 28.

PMID:
21357677
47.

Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus--an adaptive response to hyperglycaemia?

Hansen AM, Bödvarsdottir TB, Nordestgaard DN, Heller RS, Gotfredsen CF, Maedler K, Fels JJ, Holst JJ, Karlsen AE.

Diabetologia. 2011 Jun;54(6):1379-87. doi: 10.1007/s00125-011-2080-1. Epub 2011 Feb 25.

PMID:
21347622
48.

CXCL10- a path to β-cell death.

Paroni F, Domsgen E, Maedler K.

Islets. 2009 Nov-Dec;1(3):256-9. doi: 10.4161/isl.1.3.9110.

PMID:
21099280
49.

Efficient gene delivery and silencing of mouse and human pancreatic islets.

Lefebvre B, Vandewalle B, Longue J, Moerman E, Lukowiak B, Gmyr V, Maedler K, Kerr-conte J, Pattou F.

BMC Biotechnol. 2010 Mar 30;10:28. doi: 10.1186/1472-6750-10-28.

50.

XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model.

Owyang AM, Maedler K, Gross L, Yin J, Esposito L, Shu L, Jadhav J, Domsgen E, Bergemann J, Lee S, Kantak S.

Endocrinology. 2010 Jun;151(6):2515-27. doi: 10.1210/en.2009-1124. Epub 2010 Mar 23.

PMID:
20332197

Supplemental Content

Loading ...
Support Center