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Items: 1 to 50 of 133

1.

SIMON, an Automated Machine Learning System, Reveals Immune Signatures of Influenza Vaccine Responses.

Tomic A, Tomic I, Rosenberg-Hasson Y, Dekker CL, Maecker HT, Davis MM.

J Immunol. 2019 Jun 14. pii: ji1900033. doi: 10.4049/jimmunol.1900033. [Epub ahead of print]

PMID:
31201239
2.

Getting the Most from Your High-Dimensional Cytometry Data.

Olsen LR, Pedersen CB, Leipold MD, Maecker HT.

Immunity. 2019 Mar 19;50(3):535-536. doi: 10.1016/j.immuni.2019.02.015. No abstract available.

PMID:
30893579
3.

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring.

Alpert A, Pickman Y, Leipold M, Rosenberg-Hasson Y, Ji X, Gaujoux R, Rabani H, Starosvetsky E, Kveler K, Schaffert S, Furman D, Caspi O, Rosenschein U, Khatri P, Dekker CL, Maecker HT, Davis MM, Shen-Orr SS.

Nat Med. 2019 Mar;25(3):487-495. doi: 10.1038/s41591-019-0381-y. Epub 2019 Mar 6.

PMID:
30842675
4.

Penalized Supervised Star Plots: Example Application in Influenza-Specific CD4+ T Cells.

Holmes TH, Subrahmanyam PB, Wang W, Maecker HT.

Viral Immunol. 2019 Mar;32(2):102-109. doi: 10.1089/vim.2018.0046. Epub 2019 Jan 30. Erratum in: Viral Immunol. 2019 May;32(4):195.

PMID:
30698511
5.

Mycophenolate mofetil reduces STAT3 phosphorylation in systemic lupus erythematosus patients.

Slight-Webb S, Guthridge JM, Chakravarty EF, Chen H, Lu R, Macwana S, Bean K, Maecker HT, Utz PJ, James JA.

JCI Insight. 2019 Jan 24;4(2). pii: 124575. doi: 10.1172/jci.insight.124575. [Epub ahead of print]

6.

Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.

Crosby EJ, Gwin W, Blackwell K, Marcom PK, Chang S, Maecker HT, Broadwater G, Hyslop T, Kim S, Rogatko A, Lubkov V, Snyder JC, Osada T, Hobeika AC, Morse MA, Lyerly HK, Hartman ZC.

Clin Cancer Res. 2019 May 1;25(9):2725-2736. doi: 10.1158/1078-0432.CCR-18-3102. Epub 2019 Jan 11.

PMID:
30635338
7.

Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy.

Luo G, Ambati A, Lin L, Bonvalet M, Partinen M, Ji X, Maecker HT, Mignot EJ.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12323-E12332. doi: 10.1073/pnas.1818150116. Epub 2018 Dec 12.

8.

Diminished B-Cell Response After Repeat Influenza Vaccination.

Sanyal M, Holmes TH, Maecker HT, Albrecht RA, Dekker CL, He XS, Greenberg HB.

J Infect Dis. 2019 Apr 19;219(10):1586-1595. doi: 10.1093/infdis/jiy685. Erratum in: J Infect Dis. 2019 Apr 19;219(10):1683.

PMID:
30496437
9.

Differences in multiple immune parameters between Indian and U.S. infants.

Rathore DK, Holmes TH, Nadeau KC, Mittal P, Batra A, Rosenberg-Hasson Y, Sopory S, Gupta R, Chellani HK, Aggarwal KC, Bal V, Natchu UCM, Bhatnagar S, Tavassoli M, Lyell DJ, Rath S, Wadhwa N, Maecker HT.

PLoS One. 2018 Nov 16;13(11):e0207297. doi: 10.1371/journal.pone.0207297. eCollection 2018. Erratum in: PLoS One. 2019 Mar 28;14(3):e0214749.

10.

The anatomy of single cell mass cytometry data.

Olsen LR, Leipold MD, Pedersen CB, Maecker HT.

Cytometry A. 2019 Feb;95(2):156-172. doi: 10.1002/cyto.a.23621. Epub 2018 Oct 2. Review.

PMID:
30277658
11.

Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin.

Plugis NM, Weng N, Zhao Q, Palanski BA, Maecker HT, Habtezion A, Khosla C.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8781-8786. doi: 10.1073/pnas.1805288115. Epub 2018 Aug 13.

12.

Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults.

Lingblom CMD, Kowli S, Swaminathan N, Maecker HT, Lambert SL.

J Transl Med. 2018 Jun 5;16(1):153. doi: 10.1186/s12967-018-1528-1.

13.

Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients.

Subrahmanyam PB, Dong Z, Gusenleitner D, Giobbie-Hurder A, Severgnini M, Zhou J, Manos M, Eastman LM, Maecker HT, Hodi FS.

J Immunother Cancer. 2018 Mar 6;6(1):18. doi: 10.1186/s40425-018-0328-8.

14.

Comparison of CyTOF assays across sites: Results of a six-center pilot study.

Leipold MD, Obermoser G, Fenwick C, Kleinstuber K, Rashidi N, McNevin JP, Nau AN, Wagar LE, Rozot V, Davis MM, DeRosa S, Pantaleo G, Scriba TJ, Walker BD, Olsen LR, Maecker HT.

J Immunol Methods. 2018 Feb;453:37-43. doi: 10.1016/j.jim.2017.11.008. Epub 2017 Nov 23.

15.

Reply to Roerink et al: Methods for recruitment, serum separation, and storage were the same for patients and controls.

Montoya JG, Maecker HT, Rosenberg-Hasson Y, Davis MM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9436. doi: 10.1073/pnas.1714692114. Epub 2017 Oct 30. No abstract available.

16.

Multiparameter Intracellular Cytokine Staining.

Lovelace P, Maecker HT.

Methods Mol Biol. 2018;1678:151-166. doi: 10.1007/978-1-4939-7346-0_9.

PMID:
29071680
17.

Mass Cytometry Assays for Antigen-Specific T Cells Using CyTOF.

Lin D, Maecker HT.

Methods Mol Biol. 2018;1678:37-47. doi: 10.1007/978-1-4939-7346-0_3.

18.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.

19.

CyTOF Measurement of Immunocompetence Across Major Immune Cell Types.

Subrahmanyam PB, Maecker HT.

Curr Protoc Cytom. 2017 Oct 2;82:9.54.1-9.54.12. doi: 10.1002/cpcy.27.

20.

Cytokine signature associated with disease severity in chronic fatigue syndrome patients.

Montoya JG, Holmes TH, Anderson JN, Maecker HT, Rosenberg-Hasson Y, Valencia IJ, Chu L, Younger JW, Tato CM, Davis MM.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7150-E7158. doi: 10.1073/pnas.1710519114. Epub 2017 Jul 31.

21.

Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation.

Karnell FG, Lin D, Motley S, Duhen T, Lim N, Campbell DJ, Turka LA, Maecker HT, Harris KM.

Clin Exp Immunol. 2017 Sep;189(3):268-278. doi: 10.1111/cei.12985. Epub 2017 Jun 7.

22.

Systems approach to uncover signaling networks in primary immunodeficiency diseases.

Choi J, Fernandez R, Maecker HT, Butte MJ.

J Allergy Clin Immunol. 2017 Sep;140(3):881-884.e8. doi: 10.1016/j.jaci.2017.03.025. Epub 2017 Apr 13. No abstract available.

23.

Opening the Door on the CMV Immune Response in Aging.

Maecker HT.

J Infect Dis. 2017 Apr 15;215(8):1179-1180. doi: 10.1093/infdis/jix081. No abstract available.

PMID:
28199686
24.

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans.

Shen-Orr SS, Furman D, Kidd BA, Hadad F, Lovelace P, Huang YW, Rosenberg-Hasson Y, Mackey S, Grisar FA, Pickman Y, Maecker HT, Chien YH, Dekker CL, Wu JC, Butte AJ, Davis MM.

Cell Syst. 2016 Oct 26;3(4):374-384.e4. doi: 10.1016/j.cels.2016.09.009. Epub 2016 Oct 13.

25.

A Prospective Clinical Trial Combining Radiation Therapy With Systemic Immunotherapy in Metastatic Melanoma.

Hiniker SM, Reddy SA, Maecker HT, Subrahmanyam PB, Rosenberg-Hasson Y, Swetter SM, Saha S, Shura L, Knox SJ.

Int J Radiat Oncol Biol Phys. 2016 Nov 1;96(3):578-88. doi: 10.1016/j.ijrobp.2016.07.005. Epub 2016 Jul 15.

26.

Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis.

Mukai K, Gaudenzio N, Gupta S, Vivanco N, Bendall SC, Maecker HT, Chinthrajah RS, Tsai M, Nadeau KC, Galli SJ.

J Allergy Clin Immunol. 2017 Mar;139(3):889-899.e11. doi: 10.1016/j.jaci.2016.04.060. Epub 2016 Jul 15.

27.

Wild immunology assessed by multidimensional mass cytometry.

Japp AS, Hoffmann K, Schlickeiser S, Glauben R, Nikolaou C, Maecker HT, Braun J, Matzmohr N, Sawitzki B, Siegmund B, Radbruch A, Volk HD, Frentsch M, Kunkel D, Thiel A.

Cytometry A. 2017 Jan;91(1):85-95. doi: 10.1002/cyto.a.22906. Epub 2016 Jul 12.

28.

Immune Profiles to Predict Response to Desensitization Therapy in Highly HLA-Sensitized Kidney Transplant Candidates.

Yabu JM, Siebert JC, Maecker HT.

PLoS One. 2016 Apr 14;11(4):e0153355. doi: 10.1371/journal.pone.0153355. eCollection 2016.

29.

Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity.

Slight-Webb S, Lu R, Ritterhouse LL, Munroe ME, Maecker HT, Fathman CG, Utz PJ, Merrill JT, Guthridge JM, James JA.

Arthritis Rheumatol. 2016 Oct;68(10):2492-502. doi: 10.1002/art.39706.

30.

Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets.

Ryan JF, Hovde R, Glanville J, Lyu SC, Ji X, Gupta S, Tibshirani RJ, Jay DC, Boyd SD, Chinthrajah RS, Davis MM, Galli SJ, Maecker HT, Nadeau KC.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1286-95. doi: 10.1073/pnas.1520180113. Epub 2016 Jan 25.

31.

Novel technologies and emerging biomarkers for personalized cancer immunotherapy.

Yuan J, Hegde PS, Clynes R, Foukas PG, Harari A, Kleen TO, Kvistborg P, Maccalli C, Maecker HT, Page DB, Robins H, Song W, Stack EC, Wang E, Whiteside TL, Zhao Y, Zwierzina H, Butterfield LH, Fox BA.

J Immunother Cancer. 2016 Jan 19;4:3. doi: 10.1186/s40425-016-0107-3. eCollection 2016. Review.

32.

Predictors of clinical response to immunotherapy with or without radiotherapy.

Hiniker SM, Maecker HT, Knox SJ.

J Radiat Oncol. 2015;4:339-345. Epub 2015 Sep 19. Review.

33.

Multiparameter Phenotyping of Human PBMCs Using Mass Cytometry.

Leipold MD, Newell EW, Maecker HT.

Methods Mol Biol. 2015;1343:81-95. doi: 10.1007/978-1-4939-2963-4_7.

34.

Immune monitoring technology primer: flow and mass cytometry.

Maecker HT, Harari A.

J Immunother Cancer. 2015 Sep 15;3:44. doi: 10.1186/s40425-015-0085-x. eCollection 2015. No abstract available.

35.

Platinum-conjugated antibodies for application in mass cytometry.

Mei HE, Leipold MD, Maecker HT.

Cytometry A. 2016 Mar;89(3):292-300. doi: 10.1002/cyto.a.22778. Epub 2015 Sep 10.

36.

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging.

Whiting CC, Siebert J, Newman AM, Du HW, Alizadeh AA, Goronzy J, Weyand CM, Krishnan E, Fathman CG, Maecker HT.

PLoS One. 2015 Jul 21;10(7):e0133627. doi: 10.1371/journal.pone.0133627. eCollection 2015.

37.

Algorithmic Tools for Mining High-Dimensional Cytometry Data.

Chester C, Maecker HT.

J Immunol. 2015 Aug 1;195(3):773-9. doi: 10.4049/jimmunol.1500633. Review.

38.

Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy.

Nair N, Mei HE, Chen SY, Hale M, Nolan GP, Maecker HT, Genovese M, Fathman CG, Whiting CC.

Arthritis Res Ther. 2015 May 18;17:127. doi: 10.1186/s13075-015-0644-z. Review.

39.

Thinking outside the gate: single-cell assessments in multiple dimensions.

Kvistborg P, Gouttefangeas C, Aghaeepour N, Cazaly A, Chattopadhyay PK, Chan C, Eckl J, Finak G, Hadrup SR, Maecker HT, Maurer D, Mosmann T, Qiu P, Scheuermann RH, Welters MJ, Ferrari G, Brinkman RR, Britten CM.

Immunity. 2015 Apr 21;42(4):591-2. doi: 10.1016/j.immuni.2015.04.006. No abstract available.

40.

Cytomegalovirus infection enhances the immune response to influenza.

Furman D, Jojic V, Sharma S, Shen-Orr SS, Angel CJ, Onengut-Gumuscu S, Kidd BA, Maecker HT, Concannon P, Dekker CL, Thomas PG, Davis MM.

Sci Transl Med. 2015 Apr 1;7(281):281ra43. doi: 10.1126/scitranslmed.aaa2293.

41.

Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry.

Mei HE, Leipold MD, Schulz AR, Chester C, Maecker HT.

J Immunol. 2015 Feb 15;194(4):2022-31. doi: 10.4049/jimmunol.1402661. Epub 2015 Jan 21.

42.

Variation in the human immune system is largely driven by non-heritable influences.

Brodin P, Jojic V, Gao T, Bhattacharya S, Angel CJ, Furman D, Shen-Orr S, Dekker CL, Swan GE, Butte AJ, Maecker HT, Davis MM.

Cell. 2015 Jan 15;160(1-2):37-47. doi: 10.1016/j.cell.2014.12.020.

43.

Intracellular Cytokine Staining on PBMCs Using CyTOF™ Mass Cytometry.

Lin D, Gupta S, Maecker HT.

Bio Protoc. 2015 Jan 5;5(1). pii: e1370. doi: 10.21769/BioProtoc.1370.

44.

Phenotyping of Live Human PBMC using CyTOF™ Mass Cytometry.

Leipold MD, Maecker HT.

Bio Protoc. 2015;5(2). pii: e1382. Epub 2015 Jan 20.

45.

mTOR inhibition improves immune function in the elderly.

Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB.

Sci Transl Med. 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892.

PMID:
25540326
46.

flowCL: ontology-based cell population labelling in flow cytometry.

Courtot M, Meskas J, Diehl AD, Droumeva R, Gottardo R, Jalali A, Taghiyar MJ, Maecker HT, McCoy JP, Ruttenberg A, Scheuermann RH, Brinkman RR.

Bioinformatics. 2015 Apr 15;31(8):1337-9. doi: 10.1093/bioinformatics/btu807. Epub 2014 Dec 6.

47.

The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors.

O'Gorman WE, Huang H, Wei YL, Davis KL, Leipold MD, Bendall SC, Kidd BA, Dekker CL, Maecker HT, Chien YH, Davis MM.

Vaccine. 2014 Oct 14;32(45):5989-97. doi: 10.1016/j.vaccine.2014.07.115. Epub 2014 Sep 6.

48.

IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes.

Rodriguez-Pla A, Patel P, Maecker HT, Rossello-Urgell J, Baldwin N, Bennett L, Cantrell V, Baisch J, Punaro M, Gotte A, Nassi L, Wright T, Palucka AK, Banchereau J, Pascual V.

J Immunol. 2014 Jun 15;192(12):5586-98. doi: 10.4049/jimmunol.1301319. Epub 2014 May 14.

49.

Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls.

Ritterhouse LL, Lu R, Shah HB, Robertson JM, Fife DA, Maecker HT, Du H, Fathman CG, Chakravarty EF, Scofield RH, Kamen DL, Guthridge JM, James JA.

PLoS One. 2014 Apr 11;9(4):e94500. doi: 10.1371/journal.pone.0094500. eCollection 2014.

50.

Effects of serum and plasma matrices on multiplex immunoassays.

Rosenberg-Hasson Y, Hansmann L, Liedtke M, Herschmann I, Maecker HT.

Immunol Res. 2014 May;58(2-3):224-33. doi: 10.1007/s12026-014-8491-6.

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