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Items: 1 to 50 of 196

1.

Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A Multicenter Phase II Study.

Khodadoust MS, Rook AH, Porcu P, Foss F, Moskowitz AJ, Shustov A, Shanbhag S, Sokol L, Fling SP, Ramchurren N, Pierce R, Davis A, Shine R, Li S, Fong S, Kim J, Yang Y, Blumenschein WM, Yearley JH, Das B, Patidar R, Datta V, Cantu E, McCutcheon JN, Karlovich C, Williams PM, Subrahmanyam PB, Maecker HT, Horwitz SM, Sharon E, Kohrt HE, Cheever MA, Kim YH.

J Clin Oncol. 2019 Sep 18:JCO1901056. doi: 10.1200/JCO.19.01056. [Epub ahead of print]

PMID:
31532724
2.

Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study.

Chinthrajah RS, Purington N, Andorf S, Long A, O'Laughlin KL, Lyu SC, Manohar M, Boyd SD, Tibshirani R, Maecker H, Plaut M, Mukai K, Tsai M, Desai M, Galli SJ, Nadeau KC.

Lancet. 2019 Sep 12. pii: S0140-6736(19)31793-3. doi: 10.1016/S0140-6736(19)31793-3. [Epub ahead of print]

PMID:
31522849
3.

Guidelines for Gating Flow Cytometry Data for Immunological Assays.

Staats J, Divekar A, McCoy JP Jr, Maecker HT.

Methods Mol Biol. 2019;2032:81-104. doi: 10.1007/978-1-4939-9650-6_5.

PMID:
31522414
4.

High-Parameter Immune Profiling with CyTOF.

Sahaf B, Rahman A, Maecker HT, Bendall SC.

Methods Mol Biol. 2020;2055:351-368. doi: 10.1007/978-1-4939-9773-2_16.

PMID:
31502160
5.

Reversal of epigenetic aging and immunosenescent trends in humans.

Fahy GM, Brooke RT, Watson JP, Good Z, Vasanawala SS, Maecker H, Leipold MD, Lin DTS, Kobor MS, Horvath S.

Aging Cell. 2019 Sep 8:e13028. doi: 10.1111/acel.13028. [Epub ahead of print]

6.

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy.

Hartmann FJ, Babdor J, Gherardini PF, Amir ED, Jones K, Sahaf B, Marquez DM, Krutzik P, O'Donnell E, Sigal N, Maecker HT, Meyer E, Spitzer MH, Bendall SC.

Cell Rep. 2019 Jul 16;28(3):819-831.e4. doi: 10.1016/j.celrep.2019.06.049.

7.

SIMON, an Automated Machine Learning System, Reveals Immune Signatures of Influenza Vaccine Responses.

Tomic A, Tomic I, Rosenberg-Hasson Y, Dekker CL, Maecker HT, Davis MM.

J Immunol. 2019 Aug 1;203(3):749-759. doi: 10.4049/jimmunol.1900033. Epub 2019 Jun 14.

8.

Cytokine expression in Treponema pallidum infection.

Kojima N, Siebert JC, Maecker H, Rosenberg-Hasson Y, Leon SR, Vargas SK, Konda KA, Caceres CF, Klausner JD.

J Transl Med. 2019 Jun 11;17(1):196. doi: 10.1186/s12967-019-1947-7.

9.

Getting the Most from Your High-Dimensional Cytometry Data.

Olsen LR, Pedersen CB, Leipold MD, Maecker HT.

Immunity. 2019 Mar 19;50(3):535-536. doi: 10.1016/j.immuni.2019.02.015. No abstract available.

PMID:
30893579
10.

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring.

Alpert A, Pickman Y, Leipold M, Rosenberg-Hasson Y, Ji X, Gaujoux R, Rabani H, Starosvetsky E, Kveler K, Schaffert S, Furman D, Caspi O, Rosenschein U, Khatri P, Dekker CL, Maecker HT, Davis MM, Shen-Orr SS.

Nat Med. 2019 Mar;25(3):487-495. doi: 10.1038/s41591-019-0381-y. Epub 2019 Mar 6.

11.

Penalized Supervised Star Plots: Example Application in Influenza-Specific CD4+ T Cells.

Holmes TH, Subrahmanyam PB, Wang W, Maecker HT.

Viral Immunol. 2019 Mar;32(2):102-109. doi: 10.1089/vim.2018.0046. Epub 2019 Jan 30. Erratum in: Viral Immunol. 2019 May;32(4):195.

PMID:
30698511
12.

Mycophenolate mofetil reduces STAT3 phosphorylation in systemic lupus erythematosus patients.

Slight-Webb S, Guthridge JM, Chakravarty EF, Chen H, Lu R, Macwana S, Bean K, Maecker HT, Utz PJ, James JA.

JCI Insight. 2019 Jan 24;4(2). pii: 124575. doi: 10.1172/jci.insight.124575. [Epub ahead of print]

13.

Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.

Crosby EJ, Gwin W, Blackwell K, Marcom PK, Chang S, Maecker HT, Broadwater G, Hyslop T, Kim S, Rogatko A, Lubkov V, Snyder JC, Osada T, Hobeika AC, Morse MA, Lyerly HK, Hartman ZC.

Clin Cancer Res. 2019 May 1;25(9):2725-2736. doi: 10.1158/1078-0432.CCR-18-3102. Epub 2019 Jan 11.

PMID:
30635338
14.

Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy.

Luo G, Ambati A, Lin L, Bonvalet M, Partinen M, Ji X, Maecker HT, Mignot EJ.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12323-E12332. doi: 10.1073/pnas.1818150116. Epub 2018 Dec 12.

15.

Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy.

Wright BL, Fernandez-Becker NQ, Kambham N, Purington N, Tupa D, Zhang W, Rank MA, Kita H, Shim KP, Bunning BJ, Doyle AD, Jacobsen EA, Boyd SD, Tsai M, Maecker H, Manohar M, Galli SJ, Nadeau KC, Chinthrajah RS.

Front Immunol. 2018 Nov 22;9:2624. doi: 10.3389/fimmu.2018.02624. eCollection 2018.

16.

Diminished B-Cell Response After Repeat Influenza Vaccination.

Sanyal M, Holmes TH, Maecker HT, Albrecht RA, Dekker CL, He XS, Greenberg HB.

J Infect Dis. 2019 Apr 19;219(10):1586-1595. doi: 10.1093/infdis/jiy685. Erratum in: J Infect Dis. 2019 Apr 19;219(10):1683.

PMID:
30496437
17.

Differences in multiple immune parameters between Indian and U.S. infants.

Rathore DK, Holmes TH, Nadeau KC, Mittal P, Batra A, Rosenberg-Hasson Y, Sopory S, Gupta R, Chellani HK, Aggarwal KC, Bal V, Natchu UCM, Bhatnagar S, Tavassoli M, Lyell DJ, Rath S, Wadhwa N, Maecker HT.

PLoS One. 2018 Nov 16;13(11):e0207297. doi: 10.1371/journal.pone.0207297. eCollection 2018. Erratum in: PLoS One. 2019 Mar 28;14(3):e0214749.

18.

The anatomy of single cell mass cytometry data.

Olsen LR, Leipold MD, Pedersen CB, Maecker HT.

Cytometry A. 2019 Feb;95(2):156-172. doi: 10.1002/cyto.a.23621. Epub 2018 Oct 2. Review.

PMID:
30277658
19.

Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin.

Plugis NM, Weng N, Zhao Q, Palanski BA, Maecker HT, Habtezion A, Khosla C.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8781-8786. doi: 10.1073/pnas.1805288115. Epub 2018 Aug 13.

20.

JAK-STAT signaling is activated in the kidney and peripheral blood cells of patients with focal segmental glomerulosclerosis.

Tao J, Mariani L, Eddy S, Maecker H, Kambham N, Mehta K, Hartman J, Wang W, Kretzler M, Lafayette RA.

Kidney Int. 2018 Oct;94(4):795-808. doi: 10.1016/j.kint.2018.05.022. Epub 2018 Aug 6.

21.

Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults.

Lingblom CMD, Kowli S, Swaminathan N, Maecker HT, Lambert SL.

J Transl Med. 2018 Jun 5;16(1):153. doi: 10.1186/s12967-018-1528-1.

22.

Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients.

Subrahmanyam PB, Dong Z, Gusenleitner D, Giobbie-Hurder A, Severgnini M, Zhou J, Manos M, Eastman LM, Maecker HT, Hodi FS.

J Immunother Cancer. 2018 Mar 6;6(1):18. doi: 10.1186/s40425-018-0328-8.

23.

Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Moneghetti KJ, Skhiri M, Contrepois K, Kobayashi Y, Maecker H, Davis M, Snyder M, Haddad F, Montoya JG.

Sci Rep. 2018 Feb 9;8(1):2779. doi: 10.1038/s41598-018-20941-w.

24.

Food allergy and omics.

Dhondalay GK, Rael E, Acharya S, Zhang W, Sampath V, Galli SJ, Tibshirani R, Boyd SD, Maecker H, Nadeau KC, Andorf S.

J Allergy Clin Immunol. 2018 Jan;141(1):20-29. doi: 10.1016/j.jaci.2017.11.007. Review.

PMID:
29307411
25.

Comparison of CyTOF assays across sites: Results of a six-center pilot study.

Leipold MD, Obermoser G, Fenwick C, Kleinstuber K, Rashidi N, McNevin JP, Nau AN, Wagar LE, Rozot V, Davis MM, DeRosa S, Pantaleo G, Scriba TJ, Walker BD, Olsen LR, Maecker HT.

J Immunol Methods. 2018 Feb;453:37-43. doi: 10.1016/j.jim.2017.11.008. Epub 2017 Nov 23.

26.

Reply to Roerink et al: Methods for recruitment, serum separation, and storage were the same for patients and controls.

Montoya JG, Maecker HT, Rosenberg-Hasson Y, Davis MM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9436. doi: 10.1073/pnas.1714692114. Epub 2017 Oct 30. No abstract available.

27.

Multiparameter Intracellular Cytokine Staining.

Lovelace P, Maecker HT.

Methods Mol Biol. 2018;1678:151-166. doi: 10.1007/978-1-4939-7346-0_9.

PMID:
29071680
28.

Mass Cytometry Assays for Antigen-Specific T Cells Using CyTOF.

Lin D, Maecker HT.

Methods Mol Biol. 2018;1678:37-47. doi: 10.1007/978-1-4939-7346-0_3.

29.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.

30.

CyTOF Measurement of Immunocompetence Across Major Immune Cell Types.

Subrahmanyam PB, Maecker HT.

Curr Protoc Cytom. 2017 Oct 2;82:9.54.1-9.54.12. doi: 10.1002/cpcy.27.

31.

Cytokine signature associated with disease severity in chronic fatigue syndrome patients.

Montoya JG, Holmes TH, Anderson JN, Maecker HT, Rosenberg-Hasson Y, Valencia IJ, Chu L, Younger JW, Tato CM, Davis MM.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7150-E7158. doi: 10.1073/pnas.1710519114. Epub 2017 Jul 31.

32.

Continuous immunotypes describe human immune variation and predict diverse responses.

Kaczorowski KJ, Shekhar K, Nkulikiyimfura D, Dekker CL, Maecker H, Davis MM, Chakraborty AK, Brodin P.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6097-E6106. doi: 10.1073/pnas.1705065114. Epub 2017 Jul 10.

33.

Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures.

Nygaard UC, Li Z, Palys T, Jackson B, Subbiah M, Malipatlolla M, Sampath V, Maecker H, Karagas MR, Nadeau KC.

PLoS One. 2017 Jun 29;12(6):e0179606. doi: 10.1371/journal.pone.0179606. eCollection 2017.

34.

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

Gustafson CE, Qi Q, Hutter-Saunders J, Gupta S, Jadhav R, Newell E, Maecker H, Weyand CM, Goronzy JJ.

Front Immunol. 2017 Jun 14;8:692. doi: 10.3389/fimmu.2017.00692. eCollection 2017.

35.

Immunotherapy biomarkers 2016: overcoming the barriers.

Gulley JL, Berzofsky JA, Butler MO, Cesano A, Fox BA, Gnjatic S, Janetzki S, Kalavar S, Karanikas V, Khleif SN, Kirsch I, Lee PP, Maccalli C, Maecker H, Schlom J, Seliger B, Siebert J, Stroncek DF, Thurin M, Yuan J, Butterfield LH.

J Immunother Cancer. 2017 Mar 21;5(1):29. doi: 10.1186/s40425-017-0225-6.

36.

Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease.

Li X, Kuznetsova T, Cauwenberghs N, Wheeler M, Maecker H, Wu JC, Haddad F, Dai H.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7089-7094. doi: 10.1073/pnas.1621457114. Epub 2017 Jun 19.

37.

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis.

Moguche AO, Musvosvi M, Penn-Nicholson A, Plumlee CR, Mearns H, Geldenhuys H, Smit E, Abrahams D, Rozot V, Dintwe O, Hoff ST, Kromann I, Ruhwald M, Bang P, Larson RP, Shafiani S, Ma S, Sherman DR, Sette A, Lindestam Arlehamn CS, McKinney DM, Maecker H, Hanekom WA, Hatherill M, Andersen P, Scriba TJ, Urdahl KB.

Cell Host Microbe. 2017 Jun 14;21(6):695-706.e5. doi: 10.1016/j.chom.2017.05.012.

38.

Reconstitution of immune cell populations in multiple sclerosis patients after autologous stem cell transplantation.

Karnell FG, Lin D, Motley S, Duhen T, Lim N, Campbell DJ, Turka LA, Maecker HT, Harris KM.

Clin Exp Immunol. 2017 Sep;189(3):268-278. doi: 10.1111/cei.12985. Epub 2017 Jun 7.

39.

Systems approach to uncover signaling networks in primary immunodeficiency diseases.

Choi J, Fernandez R, Maecker HT, Butte MJ.

J Allergy Clin Immunol. 2017 Sep;140(3):881-884.e8. doi: 10.1016/j.jaci.2017.03.025. Epub 2017 Apr 13. No abstract available.

40.

Opening the Door on the CMV Immune Response in Aging.

Maecker HT.

J Infect Dis. 2017 Apr 15;215(8):1179-1180. doi: 10.1093/infdis/jix081. No abstract available.

PMID:
28199686
41.

Characterizing CD137 upregulation on NK cells in patients receiving monoclonal antibody therapy.

Makkouk A, Sundaram V, Chester C, Chang S, Colevas AD, Sunwoo JB, Maecker H, Desai M, Kohrt HE.

Ann Oncol. 2017 Feb 1;28(2):415-420. doi: 10.1093/annonc/mdw570.

42.

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans.

Shen-Orr SS, Furman D, Kidd BA, Hadad F, Lovelace P, Huang YW, Rosenberg-Hasson Y, Mackey S, Grisar FA, Pickman Y, Maecker HT, Chien YH, Dekker CL, Wu JC, Butte AJ, Davis MM.

Cell Syst. 2016 Oct 26;3(4):374-384.e4. doi: 10.1016/j.cels.2016.09.009. Epub 2016 Oct 13.

43.

Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals.

Qi Q, Cavanagh MM, Le Saux S, Wagar LE, Mackey S, Hu J, Maecker H, Swan GE, Davis MM, Dekker CL, Tian L, Weyand CM, Goronzy JJ.

PLoS Pathog. 2016 Oct 20;12(10):e1005892. doi: 10.1371/journal.ppat.1005892. eCollection 2016 Oct.

44.

Cytokine profiles in patients with toxoplasmic lymphadenitis in the setting of pregnancy.

Pomares C, Holmes TH, Estran R, Press CJ, Ramirez R, Talucod J, Maecker H, Rosenberg-Hasson Y, Montoya JG.

Cytokine. 2017 Feb;90:14-20. doi: 10.1016/j.cyto.2016.09.021. Epub 2016 Oct 13.

PMID:
27744174
45.

A Prospective Clinical Trial Combining Radiation Therapy With Systemic Immunotherapy in Metastatic Melanoma.

Hiniker SM, Reddy SA, Maecker HT, Subrahmanyam PB, Rosenberg-Hasson Y, Swetter SM, Saha S, Shura L, Knox SJ.

Int J Radiat Oncol Biol Phys. 2016 Nov 1;96(3):578-88. doi: 10.1016/j.ijrobp.2016.07.005. Epub 2016 Jul 15.

46.

Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis.

Mukai K, Gaudenzio N, Gupta S, Vivanco N, Bendall SC, Maecker HT, Chinthrajah RS, Tsai M, Nadeau KC, Galli SJ.

J Allergy Clin Immunol. 2017 Mar;139(3):889-899.e11. doi: 10.1016/j.jaci.2016.04.060. Epub 2016 Jul 15.

47.

Cytokine-stimulated Phosphoflow of PBMC Using CyTOF Mass Cytometry.

Fernandez R, Maecker H.

Bio Protoc. 2015 Jun 5;5(11). pii: e1496.

48.

Wild immunology assessed by multidimensional mass cytometry.

Japp AS, Hoffmann K, Schlickeiser S, Glauben R, Nikolaou C, Maecker HT, Braun J, Matzmohr N, Sawitzki B, Siegmund B, Radbruch A, Volk HD, Frentsch M, Kunkel D, Thiel A.

Cytometry A. 2017 Jan;91(1):85-95. doi: 10.1002/cyto.a.22906. Epub 2016 Jul 12.

49.

Cytokine-Stimulated Phosphoflow of Whole Blood Using CyTOF Mass Cytometry.

Fernandez R, Maecker H.

Bio Protoc. 2015 Jun 5;5(11). pii: e1495.

50.

Immune Profiles to Predict Response to Desensitization Therapy in Highly HLA-Sensitized Kidney Transplant Candidates.

Yabu JM, Siebert JC, Maecker HT.

PLoS One. 2016 Apr 14;11(4):e0153355. doi: 10.1371/journal.pone.0153355. eCollection 2016.

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