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Items: 1 to 50 of 122

1.

Liver Glutamate Dehydrogenase Controls Whole Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.

Karaca M, Martin-Levilain J, Grimaldi M, Li L, Dizin E, Emre Y, Maechler P.

Diabetes. 2018 Jul 12. pii: db171561. doi: 10.2337/db17-1561. [Epub ahead of print]

PMID:
30002133
2.

Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected myocardial infarction.

Cupa J, Strebel I, Badertscher P, Abächerli R, Twerenbold R, Schumacher L, Boeddinghaus J, Nestelberger T, Maechler P, Kozhuharov N, Rubini Giménez M, Wildi K, du Fay de Lavallaz J, Sabti Z, Sazgary L, Puelacher C, Mueller D, Bianci C, Miró Ò, Fuenzalida C, Calderón S, Martín-Sánchez FJ, Lopez Iglesias S, Morawiec B, Kawecki D, Parenica J, I Keller D, Geigy N, Osswald S, Mueller C, Reichlin T.

Cardiol J. 2018 Apr 3. doi: 10.5603/CJ.a2018.0033. [Epub ahead of print]

3.

Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction.

Lander SS, Khan U, Lewandowski N, Chakraborty D, Provenzano FA, Mingote S, Chornyy S, Frigerio F, Maechler P, Kaphzan H, Small SA, Rayport S, Gaisler-Salomon I.

Schizophr Bull. 2018 Feb 20. doi: 10.1093/schbul/sby011. [Epub ahead of print]

PMID:
29471549
4.

Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions.

Kaczmarek P, Skrzypski M, Pruszynska-Oszmalek E, Sassek M, Kolodziejski PA, Billert M, Szczepankiewicz D, Wojciechowicz T, Maechler P, Nowak KW, Strowski MZ.

J Physiol Pharmacol. 2017 Oct;68(5):669-681.

5.

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

Dalmas E, Lehmann FM, Dror E, Wueest S, Thienel C, Borsigova M, Stawiski M, Traunecker E, Lucchini FC, Dapito DH, Kallert SM, Guigas B, Pattou F, Kerr-Conte J, Maechler P, Girard JP, Konrad D, Wolfrum C, Böni-Schnetzler M, Finke D, Donath MY.

Immunity. 2017 Nov 21;47(5):928-942.e7. doi: 10.1016/j.immuni.2017.10.015.

PMID:
29166590
6.

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.

Grimaldi M, Karaca M, Latini L, Brioudes E, Schalch T, Maechler P.

Hum Mol Genet. 2017 Sep 15;26(18):3453-3465. doi: 10.1093/hmg/ddx213.

PMID:
28911206
7.

Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity.

Li N, Karaca M, Maechler P.

Redox Biol. 2017 Oct;13:541-549. doi: 10.1016/j.redox.2017.07.012. Epub 2017 Jul 21.

8.

Glutamate pathways of the beta-cell and the control of insulin secretion.

Maechler P.

Diabetes Res Clin Pract. 2017 Sep;131:149-153. doi: 10.1016/j.diabres.2017.07.009. Epub 2017 Jul 12. Review.

PMID:
28743063
9.

Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression.

Brun J, Berthou F, Trajkovski M, Maechler P, Foti M, Bonnet N.

Diabetes. 2017 Oct;66(10):2541-2554. doi: 10.2337/db17-0116. Epub 2017 Jul 7.

10.

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

Hohnholt MC, Andersen VH, Andersen JV, Christensen SK, Karaca M, Maechler P, Waagepetersen HS.

J Cereb Blood Flow Metab. 2017 Jan 1:271678X17714680. doi: 10.1177/0271678X17714680. [Epub ahead of print]

PMID:
28621566
11.

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

Pournourmohammadi S, Grimaldi M, Stridh MH, Lavallard V, Waagepetersen HS, Wollheim CB, Maechler P.

Int J Biochem Cell Biol. 2017 Jul;88:220-225. doi: 10.1016/j.biocel.2017.01.012. Epub 2017 Jan 27.

PMID:
28137482
12.

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells.

Schmidt SF, Madsen JG, Frafjord KØ, Poulsen Ll, Salö S, Boergesen M, Loft A, Larsen BD, Madsen MS, Holst JJ, Maechler P, Dalgaard LT, Mandrup S.

Cell Rep. 2016 Aug 30;16(9):2359-72. doi: 10.1016/j.celrep.2016.07.063. Epub 2016 Aug 18.

13.

Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.

Klee P, Bosco D, Guérardel A, Somm E, Toulotte A, Maechler P, Schwitzgebel VM.

Endocrinology. 2016 Oct;157(10):3800-3808. Epub 2016 Jul 29.

PMID:
27471776
14.

Channels and transporters in cell metabolism.

Sonveaux P, Maechler P, Martinou JC.

Biochim Biophys Acta. 2016 Oct;1863(10):2359-61. doi: 10.1016/j.bbamcr.2016.06.001. Epub 2016 Jun 3. No abstract available.

15.

The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.

Vetterli L, Carobbio S, Frigerio F, Karaca M, Maechler P.

J Biol Chem. 2016 Jun 17;291(25):13063-75. doi: 10.1074/jbc.M115.707448. Epub 2016 May 2.

16.

Beta-cell mitochondrial carriers and the diabetogenic stress response.

Brun T, Maechler P.

Biochim Biophys Acta. 2016 Oct;1863(10):2540-9. doi: 10.1016/j.bbamcr.2016.03.012. Epub 2016 Mar 12. Review.

17.

Design and performance of an ultra-flexible two-photon microscope for in vivo research.

Mayrhofer JM, Haiss F, Haenni D, Weber S, Zuend M, Barrett MJ, Ferrari KD, Maechler P, Saab AS, Stobart JL, Wyss MT, Johannssen H, Osswald H, Palmer LM, Revol V, Schuh CD, Urban C, Hall A, Larkum ME, Rutz-Innerhofer E, Zeilhofer HU, Ziegler U, Weber B.

Biomed Opt Express. 2015 Oct 2;6(11):4228-37. doi: 10.1364/BOE.6.004228. eCollection 2015 Nov 1.

18.

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

Karaca M, Frigerio F, Migrenne S, Martin-Levilain J, Skytt DM, Pajecka K, Martin-del-Rio R, Gruetter R, Tamarit-Rodriguez J, Waagepetersen HS, Magnan C, Maechler P.

Cell Rep. 2015 Oct 13;13(2):365-75. doi: 10.1016/j.celrep.2015.09.003. Epub 2015 Oct 1.

19.

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes.

Lukowski SW, Fish RJ, Martin-Levilain J, Gonelle-Gispert C, Bühler LH, Maechler P, Dermitzakis ET, Neerman-Arbez M.

Data Brief. 2015 Jun 10;4:226-8. doi: 10.1016/j.dib.2015.05.023. eCollection 2015 Sep.

20.

Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets.

Brun T, Li N, Jourdain AA, Gaudet P, Duhamel D, Meyer J, Bosco D, Maechler P.

Hum Mol Genet. 2015 Sep 15;24(18):5270-84. doi: 10.1093/hmg/ddv247. Epub 2015 Jun 29.

PMID:
26123492
21.

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes.

Lukowski SW, Fish RJ, Martin-Levilain J, Gonelle-Gispert C, Bühler LH, Maechler P, Dermitzakis ET, Neerman-Arbez M.

Genomics. 2015 Aug;106(2):107-15. doi: 10.1016/j.ygeno.2015.05.001. Epub 2015 May 12.

22.

Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

Wollheim CB, Maechler P.

Nat Med. 2015 Apr;21(4):310-1. doi: 10.1038/nm.3835. No abstract available.

PMID:
25849270
23.

Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.

Aragón F, Karaca M, Novials A, Maldonado R, Maechler P, Rubí B.

Biochim Biophys Acta. 2015 Feb;1850(2):343-51. doi: 10.1016/j.bbagen.2014.11.005. Epub 2014 Nov 8.

PMID:
25445712
24.

Postmortem examination of patient H.M.'s brain based on histological sectioning and digital 3D reconstruction.

Annese J, Schenker-Ahmed NM, Bartsch H, Maechler P, Sheh C, Thomas N, Kayano J, Ghatan A, Bresler N, Frosch MP, Klaming R, Corkin S.

Nat Commun. 2014;5:3122. doi: 10.1038/ncomms4122.

25.

Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids.

Brun T, Scarcia P, Li N, Gaudet P, Duhamel D, Palmieri F, Maechler P.

PLoS One. 2013 Dec 12;8(12):e82364. doi: 10.1371/journal.pone.0082364. eCollection 2013.

26.

A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets.

Sileno S, D'Oria V, Stucchi R, Alessio M, Petrini S, Bonetto V, Maechler P, Bertuzzi F, Grasso V, Paolella K, Barbetti F, Massa O.

J Proteomics. 2014 Jan 16;96:314-27. doi: 10.1016/j.jprot.2013.11.011. Epub 2013 Nov 27.

27.

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

Supale S, Thorel F, Merkwirth C, Gjinovci A, Herrera PL, Scorrano L, Meda P, Langer T, Maechler P.

Diabetes. 2013 Oct;62(10):3488-99. doi: 10.2337/db13-0152. Epub 2013 Jul 17.

28.

Mitochondrial function and insulin secretion.

Maechler P.

Mol Cell Endocrinol. 2013 Oct 15;379(1-2):12-8. doi: 10.1016/j.mce.2013.06.019. Epub 2013 Jun 20. Review.

PMID:
23792187
29.

Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.

Karaca M, Maechler P.

Neurochem Res. 2014;39(3):456-9. doi: 10.1007/s11064-013-1041-0. Epub 2013 Apr 18. Review.

PMID:
23595828
30.

Hepatic glucose sensing is required to preserve β cell glucose competence.

Seyer P, Vallois D, Poitry-Yamate C, Schütz F, Metref S, Tarussio D, Maechler P, Staels B, Lanz B, Grueter R, Decaris J, Turner S, da Costa A, Preitner F, Minehira K, Foretz M, Thorens B.

J Clin Invest. 2013 Apr;123(4):1662-76. doi: 10.1172/JCI65538. Epub 2013 Mar 15.

31.

Mitochondrial signal transduction in pancreatic β-cells.

Maechler P.

Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):739-52. doi: 10.1016/j.beem.2012.07.003. Epub 2012 Aug 18. Review.

PMID:
23168276
32.

Mitochondria in endocrinology.

Maechler P.

Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):709-10. doi: 10.1016/j.beem.2012.08.001. Epub 2012 Sep 3. No abstract available.

PMID:
23168273
33.

Automated determination of axonal orientation in the deep white matter of the human brain.

Bartsch H, Maechler P, Annese J.

Brain Connect. 2012;2(5):284-90. doi: 10.1089/brain.2012.0096.

34.

Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?

Li N, Stojanovski S, Maechler P.

Oxid Med Cell Longev. 2012;2012:740849. doi: 10.1155/2012/740849. Epub 2012 Sep 16. Review.

35.

NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.

Li N, Li B, Brun T, Deffert-Delbouille C, Mahiout Z, Daali Y, Ma XJ, Krause KH, Maechler P.

Diabetes. 2012 Nov;61(11):2842-50. doi: 10.2337/db12-0009. Epub 2012 Aug 28.

36.

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.

Frigerio F, Karaca M, De Roo M, Mlynárik V, Skytt DM, Carobbio S, Pajęcka K, Waagepetersen HS, Gruetter R, Muller D, Maechler P.

J Neurochem. 2012 Nov;123(3):342-8. doi: 10.1111/j.1471-4159.2012.07933.x. Epub 2012 Sep 28.

37.

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.

Vetterli L, Carobbio S, Pournourmohammadi S, Martin-Del-Rio R, Skytt DM, Waagepetersen HS, Tamarit-Rodriguez J, Maechler P.

Mol Biol Cell. 2012 Oct;23(19):3851-62. doi: 10.1091/mbc.E11-08-0676. Epub 2012 Aug 8.

38.

Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB.

Zhang Y, Zhen W, Maechler P, Liu D.

J Nutr Biochem. 2013 Apr;24(4):638-46. doi: 10.1016/j.jnutbio.2012.03.008. Epub 2012 Jul 21.

39.

Mitochondrial dysfunction in pancreatic β cells.

Supale S, Li N, Brun T, Maechler P.

Trends Endocrinol Metab. 2012 Sep;23(9):477-87. doi: 10.1016/j.tem.2012.06.002. Epub 2012 Jul 4. Review.

PMID:
22766318
40.

Procyanidins modify insulinemia by affecting insulin production and degradation.

Castell-Auví A, Cedó L, Pallarès V, Blay MT, Pinent M, Motilva MJ, Garcia-Vallvé S, Pujadas G, Maechler P, Ardévol A.

J Nutr Biochem. 2012 Dec;23(12):1565-72. doi: 10.1016/j.jnutbio.2011.10.010. Epub 2012 Mar 22.

PMID:
22444499
41.

Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.

Russo L, Marsella C, Nardo G, Massignan T, Alessio M, Piermarini E, La Rosa S, Finzi G, Bonetto V, Bertuzzi F, Maechler P, Massa O.

Acta Diabetol. 2013 Feb;50(1):61-72. doi: 10.1007/s00592-012-0381-6. Epub 2012 Mar 3.

PMID:
22382775
42.

Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells.

Račková L, Cumaoğlu A, Bağrıacık EU, Štefek M, Maechler P, Karasu Ç.

Med Chem. 2011 Nov;7(6):711-7.

PMID:
22313311
43.

From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis.

Karaca M, Frigerio F, Maechler P.

Neurochem Int. 2011 Sep;59(4):510-7. doi: 10.1016/j.neuint.2011.03.024. Epub 2011 May 12. Review.

PMID:
21600947
45.

Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells.

Cumaoğlu A, Rackova L, Stefek M, Kartal M, Maechler P, Karasu C.

Acta Biochim Pol. 2011;58(1):45-50. Epub 2011 Mar 7.

46.

Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats.

Auer VJ, Bucher J, Schremmer-Danninger E, Paulmurugan R, Maechler P, Reiser MF, Stangl MJ, Berger F.

Curr Pharm Biotechnol. 2011 Apr;12(4):488-96.

PMID:
21342106
47.

ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.

Boergesen M, Poulsen Ll, Schmidt SF, Frigerio F, Maechler P, Mandrup S.

J Biol Chem. 2011 Apr 15;286(15):13214-25. doi: 10.1074/jbc.M110.215467. Epub 2011 Jan 31.

48.

A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes.

Casimir M, de Andrade PB, Gjinovci A, Montani JP, Maechler P, Dulloo AG.

Nutr Metab (Lond). 2011 Jan 18;8(1):2. doi: 10.1186/1743-7075-8-2.

49.

Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.

Vetterli L, Brun T, Giovannoni L, Bosco D, Maechler P.

J Biol Chem. 2011 Feb 25;286(8):6049-60. doi: 10.1074/jbc.M110.176842. Epub 2010 Dec 16.

50.

Minireview: new roles for peripheral dopamine on metabolic control and tumor growth: let's seek the balance.

Rubí B, Maechler P.

Endocrinology. 2010 Dec;151(12):5570-81. doi: 10.1210/en.2010-0745. Epub 2010 Nov 3. Review.

PMID:
21047943

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