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Items: 36

1.

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer.

Zhang H, Pandey S, Travers M, Sun H, Morton G, Madzo J, Chung W, Khowsathit J, Perez-Leal O, Barrero CA, Merali C, Okamoto Y, Sato T, Pan J, Garriga J, Bhanu NV, Simithy J, Patel B, Huang J, Raynal NJ, Garcia BA, Jacobson MA, Kadoch C, Merali S, Zhang Y, Childers W, Abou-Gharbia M, Karanicolas J, Baylin SB, Zahnow CA, Jelinek J, Graña X, Issa JJ.

Cell. 2018 Nov 15;175(5):1244-1258.e26. doi: 10.1016/j.cell.2018.09.051. Epub 2018 Oct 25.

PMID:
30454645
2.

Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1.

Hulse M, Caruso LB, Madzo J, Tan Y, Johnson S, Tempera I.

PLoS Pathog. 2018 Nov 5;14(11):e1007394. doi: 10.1371/journal.ppat.1007394. eCollection 2018 Nov.

3.

PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type.

Lupey-Green LN, Caruso LB, Madzo J, Martin KA, Tan Y, Hulse M, Tempera I.

J Virol. 2018 Aug 29;92(18). pii: e00755-18. doi: 10.1128/JVI.00755-18. Print 2018 Sep 15.

4.

TET1-Mediated Hypomethylation Activates Oncogenic Signaling in Triple-Negative Breast Cancer.

Good CR, Panjarian S, Kelly AD, Madzo J, Patel B, Jelinek J, Issa JJ.

Cancer Res. 2018 Aug 1;78(15):4126-4137. doi: 10.1158/0008-5472.CAN-17-2082. Epub 2018 Jun 11.

PMID:
29891505
5.

Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion.

Garriga J, Laumet G, Chen SR, Zhang Y, Madzo J, Issa JJ, Pan HL, Jelinek J.

J Neurosci. 2018 Jul 4;38(27):6090-6101. doi: 10.1523/JNEUROSCI.2616-17.2018. Epub 2018 Jun 6.

6.

Demethylator phenotypes in acute myeloid leukemia.

Kelly AD, Madzo J, Madireddi P, Kropf P, Good CR, Jelinek J, Issa JJ.

Leukemia. 2018 Oct;32(10):2178-2188. doi: 10.1038/s41375-018-0084-2. Epub 2018 Mar 7.

7.

Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity.

He S, Liu Y, Meng L, Sun H, Wang Y, Ji Y, Purushe J, Chen P, Li C, Madzo J, Issa JP, Soboloff J, Reshef R, Moore B, Gattinoni L, Zhang Y.

Nat Commun. 2017 Dec 14;8(1):2125. doi: 10.1038/s41467-017-02187-8.

8.

Digital Restriction Enzyme Analysis of Methylation (DREAM).

Jelinek J, Lee JT, Cesaroni M, Madzo J, Liang S, Lu Y, Issa JJ.

Methods Mol Biol. 2018;1708:247-265. doi: 10.1007/978-1-4939-7481-8_13.

PMID:
29224148
9.

Caloric restriction delays age-related methylation drift.

Maegawa S, Lu Y, Tahara T, Lee JT, Madzo J, Liang S, Jelinek J, Colman RJ, Issa JJ.

Nat Commun. 2017 Sep 14;8(1):539. doi: 10.1038/s41467-017-00607-3.

10.

Sex chromosomes drive gene expression and regulatory dimorphisms in mouse embryonic stem cells.

Werner RJ, Schultz BM, Huhn JM, Jelinek J, Madzo J, Engel N.

Biol Sex Differ. 2017 Aug 17;8(1):28. doi: 10.1186/s13293-017-0150-x.

11.

A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.

Good CR, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, Issa JJ.

Nucleic Acids Res. 2017 Aug 21;45(14):8269-8281. doi: 10.1093/nar/gkx435.

12.

Transcriptional Selectivity of Epigenetic Therapy in Cancer.

Sato T, Cesaroni M, Chung W, Panjarian S, Tran A, Madzo J, Okamoto Y, Zhang H, Chen X, Jelinek J, Issa JJ.

Cancer Res. 2017 Jan 15;77(2):470-481. doi: 10.1158/0008-5472.CAN-16-0834. Epub 2016 Nov 22.

13.

DREAM: A Simple Method for DNA Methylation Profiling by High-throughput Sequencing.

Jelinek J, Madzo J.

Methods Mol Biol. 2016;1465:111-27. doi: 10.1007/978-1-4939-4011-0_10.

PMID:
27581143
14.

Corrigendum: TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer.

Chapman CG, Mariani CJ, Wu F, Meckel K, Butun F, Chuang A, Madzo J, Bissonnette MB, Kwon JH, Godley LA.

Sci Rep. 2016 Apr 28;6:24963. doi: 10.1038/srep24963. No abstract available.

15.

TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer.

Chapman CG, Mariani CJ, Wu F, Meckel K, Butun F, Chuang A, Madzo J, Bissonette MB, Kwon JH, Godley LA.

Sci Rep. 2015 Dec 3;5:17568. doi: 10.1038/srep17568. Erratum in: Sci Rep. 2016 Apr 28;6:24963.

16.

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estecio MR, Godley LA, Issa JP.

Cancer Res. 2015 Jul 15;75(14):2833-43. doi: 10.1158/0008-5472.CAN-14-0739. Epub 2015 May 13.

17.

A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia.

Odenike O, Halpern A, Godley LA, Madzo J, Karrison T, Green M, Fulton N, Mattison RJ, Yee KW, Bennett M, Koval G, Malnassy G, Larson RA, Ratain MJ, Stock W.

Invest New Drugs. 2015 Apr;33(2):371-9. doi: 10.1007/s10637-014-0194-2. Epub 2014 Dec 9.

18.

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.

Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X, Daniels D, Dai Q, Ciminio L, Aifantis I, He C, Fuks F, Tallman MS, Ferrando A, Nimer S, Paietta E, Thompson CB, Licht JD, Mason CE, Godley LA, Melnick A, Figueroa ME, Levine RL.

Cell Rep. 2014 Dec 11;9(5):1841-1855. doi: 10.1016/j.celrep.2014.11.004. Epub 2014 Dec 4.

19.

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.

Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LA.

Cell Rep. 2014 Jun 12;7(5):1343-1352. doi: 10.1016/j.celrep.2014.04.040. Epub 2014 May 15.

20.

Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.

Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LA.

Cell Rep. 2014 Jan 16;6(1):231-244. doi: 10.1016/j.celrep.2013.11.044. Epub 2013 Dec 27.

21.

Alterations of 5-hydroxymethylcytosine in human cancers.

Mariani CJ, Madzo J, Moen EL, Yesilkanal A, Godley LA.

Cancers (Basel). 2013 Jun 25;5(3):786-814. doi: 10.3390/cancers5030786.

22.

Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.

Madzo J, Vasanthakumar A, Godley LA.

Semin Hematol. 2013 Jan;50(1):61-9. doi: 10.1053/j.seminhematol.2013.01.004. Review.

PMID:
23507484
23.

Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia.

Churpek JE, Nickels E, Marquez R, Rojek K, Liu B, Lorenz R, Lepore J, Madzo J, Wickrema A, Artz AS, van Besien K, Godley LA.

Blood. 2012 Dec 20;120(26):5247-9. doi: 10.1182/blood-2012-09-457945. No abstract available.

24.

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao X, Perna F, Pandey S, Madzo J, Song C, Dai Q, He C, Ibrahim S, Beran M, Zavadil J, Nimer SD, Melnick A, Godley LA, Aifantis I, Levine RL.

Cancer Cell. 2011 Jul 12;20(1):11-24. doi: 10.1016/j.ccr.2011.06.001. Epub 2011 Jun 30.

25.

ETV6/RUNX1 (TEL/AML1) is a frequent prenatal first hit in childhood leukemia.

Zuna J, Madzo J, Krejci O, Zemanova Z, Kalinova M, Muzikova K, Zapotocky M, Starkova J, Hrusak O, Horak J, Trka J.

Blood. 2011 Jan 6;117(1):368-9; author reply 370-1. doi: 10.1182/blood-2010-09-309070. No abstract available.

26.

Revealing the role of TEL/AML1 for leukemic cell survival by RNAi-mediated silencing.

Zaliova M, Madzo J, Cario G, Trka J.

Leukemia. 2011 Feb;25(2):313-20. doi: 10.1038/leu.2010.277. Epub 2010 Nov 26.

PMID:
21109770
27.

Identification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder.

Churpek JE, Garcia JS, Madzo J, Jackson SA, Onel K, Godley LA.

Leuk Lymphoma. 2010 Oct;51(10):1931-5. doi: 10.3109/10428194.2010.503821. No abstract available.

PMID:
20846103
28.

The identification of (ETV6)/RUNX1-regulated genes in lymphopoiesis using histone deacetylase inhibitors in ETV6/RUNX1-positive lymphoid leukemic cells.

Starkova J, Madzo J, Cario G, Kalina T, Ford A, Zaliova M, Hrusak O, Trka J.

Clin Cancer Res. 2007 Mar 15;13(6):1726-35. Epub 2007 Feb 26.

29.

Prenatal origin of childhood AML occurs less frequently than in childhood ALL.

Burjanivova T, Madzo J, Muzikova K, Meyer C, Schneider B, Votava F, Marschalek R, Stary J, Trka J, Zuna J.

BMC Cancer. 2006 Apr 21;6:100.

30.

TEL/AML1 and immunoreceptor gene rearrangements-which comes first?

Zuna J, Krejci O, Madzo J, Fronkova E, Sramkova L, Hrusak O, Kalina T, Vaskova M, Stary J, Trka J; Czech Paediatric Haematology Working Group (CPH).

Leuk Res. 2005 Jun;29(6):633-9. Epub 2005 Jan 18.

PMID:
15863202
31.

TEL/AML 1 real-time quantitative reverse transcriptase PCR can complement minimal residual disease assessment in childhood ALL.

Fronkova E, Madzo J, Zuna J, Reznickova L, Muzikova K, Hrusak O, Stary J, Trka J.

Leukemia. 2005 Jul;19(7):1296-7. No abstract available.

PMID:
15858617
32.

Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens.

Kalina T, Vaskova M, Mejstrikova E, Madzo J, Trka J, Stary J, Hrusak O.

BMC Cancer. 2005 Apr 12;5:38.

33.

Upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells.

Krejci O, Starkova J, Otova B, Madzo J, Kalinova M, Hrusak O, Trka J.

Leukemia. 2004 Mar;18(3):434-41.

PMID:
14724653
34.
35.

Temperature non-homogeneity in rapid airflow-based cycler significantly affects real-time PCR.

Zuna J, Muzikova K, Madzo J, Krejci O, Trka J.

Biotechniques. 2002 Sep;33(3):508, 510, 512. No abstract available.

36.

Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry.

Trka J, Kalinová M, Hrusák O, Zuna J, Krejcí O, Madzo J, Sedlácek P, Vávra V, Michalová K, Jarosová M, Starý J; For Czech Paediatric Haematology Working Group.

Leukemia. 2002 Jul;16(7):1381-9.

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