Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 86

1.

Effectiveness of implementation strategies for the improvement of guideline and protocol adherence in emergency care: a systematic review.

Ebben RHA, Siqeca F, Madsen UR, Vloet LCM, van Achterberg T.

BMJ Open. 2018 Nov 25;8(11):e017572. doi: 10.1136/bmjopen-2017-017572.

2.

Age and health-related quality of life, general self-efficacy, and functional level 12 months following dysvascular major lower limb amputation: a prospective longitudinal study.

Madsen UR, Baath C, Berthelsen CB, Hommel A.

Disabil Rehabil. 2018 Jun 29:1-10. doi: 10.1080/09638288.2018.1480668. [Epub ahead of print]

PMID:
29961340
3.

A prospective study of short-term functional outcome after dysvascular major lower limb amputation.

Madsen UR, Bååth C, Berthelsen CB, Hommel A.

Int J Orthop Trauma Nurs. 2018 Feb;28:22-29. doi: 10.1016/j.ijotn.2017.08.001. Epub 2017 Aug 12.

4.

Systematic review describing the effect of early mobilisation after dysvascular major lower limb amputations.

Madsen UR, Hommel A, Berthelsen CB, Bååth C.

J Clin Nurs. 2017 Nov;26(21-22):3286-3297. doi: 10.1111/jocn.13716. Epub 2017 Feb 21. Review.

PMID:
28042882
5.

Pendulating-A grounded theory explaining patients' behavior shortly after having a leg amputated due to vascular disease.

Madsen UR, Hommel A, Bååth C, Berthelsen CB.

Int J Qual Stud Health Well-being. 2016 Sep 16;11:32739. doi: 10.3402/qhw.v11.32739. eCollection 2016.

6.

Comparing three different approaches to the measurement of needs concerning fatigue in patients with advanced cancer.

Madsen UR, Groenvold M, Petersen MA, Johnsen AT.

Qual Life Res. 2015 Sep;24(9):2231-8. doi: 10.1007/s11136-015-0962-2. Epub 2015 Mar 18.

PMID:
25784562
7.

Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK binding sites.

Sköld N, Nielsen B, Olsen J, Han L, Olsen L, Madsen U, Kristensen JL, Pickering DS, Johansen TN.

Bioorg Med Chem. 2014 Oct 1;22(19):5368-77. doi: 10.1016/j.bmc.2014.07.045. Epub 2014 Aug 2.

PMID:
25172149
8.

Analogues of 3-hydroxyisoxazole-containing glutamate receptor ligands based on the 3-hydroxypyrazole-moiety: design, synthesis and pharmacological characterization.

Jørgensen L, Nielsen B, Pickering DS, Kristensen AS, Frydenvang K, Madsen U, Clausen RP.

Neurochem Res. 2014 Oct;39(10):1895-905. doi: 10.1007/s11064-014-1332-0. Epub 2014 May 22.

PMID:
24848194
9.

Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.

Mølck C, Harpsøe K, Gloriam DE, Clausen RP, Madsen U, Pedersen LØ, Jimenez HN, Nielsen SM, Mathiesen JM, Bräuner-Osborne H.

Mol Pharmacol. 2012 Nov;82(5):929-37. doi: 10.1124/mol.112.078808. Epub 2012 Aug 16.

PMID:
22899869
10.

Structure-activity relationships for negative allosteric mGluR5 modulators.

Kaae BH, Harpsøe K, Kvist T, Mathiesen JM, Mølck C, Gloriam D, Jimenez HN, Uberti MA, Nielsen SM, Nielsen B, Bräuner-Osborne H, Sauerberg P, Clausen RP, Madsen U.

ChemMedChem. 2012 Mar 5;7(3):440-51. doi: 10.1002/cmdc.201100578. Epub 2012 Jan 20.

PMID:
22267204
11.

Cognitive enhancing effects of an AMPA receptor positive modulator on place learning in mice.

Malá H, Chen Y, Worm VH, Kure J, Kaae BH, Madsen U, Badolo L, Pickering DS, Mogensen J.

Behav Brain Res. 2012 Jan 1;226(1):18-25. doi: 10.1016/j.bbr.2011.08.036. Epub 2011 Sep 1.

PMID:
21906629
12.

Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors.

Pinto A, Conti P, Grazioso G, Tamborini L, Madsen U, Nielsen B, De Micheli C.

Eur J Med Chem. 2011 Feb;46(2):787-93. doi: 10.1016/j.ejmech.2010.12.020. Epub 2010 Dec 23.

PMID:
21220180
13.

Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators.

Pøhlsgaard J, Frydenvang K, Madsen U, Kastrup JS.

Neuropharmacology. 2011 Jan;60(1):135-50. doi: 10.1016/j.neuropharm.2010.08.004. Epub 2010 Aug 14. Review.

PMID:
20713069
14.

Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization.

Conti P, Pinto A, Tamborini L, Madsen U, Nielsen B, Bräuner-Osborne H, Hansen KB, Landucci E, Pellegrini-Giampietro DE, De Sarro G, Donato Di Paola E, De Micheli C.

ChemMedChem. 2010 Sep 3;5(9):1465-75. doi: 10.1002/cmdc.201000184.

PMID:
20665761
15.

[Influence of the reimbursement scheme on the consumption of drugs].

Madsen UK.

Ugeskr Laeger. 2009 Mar 2;171(10):783-6. Danish.

PMID:
19265600
16.

Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.

Pinto A, Conti P, De Amici M, Tamborini L, Madsen U, Nielsen B, Christesen T, Bräuner-Osborne H, De Micheli C.

J Med Chem. 2008 Apr 10;51(7):2311-5. doi: 10.1021/jm701394a. Epub 2008 Mar 14.

PMID:
18338843
17.

Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites.

Kaae BH, Harpsøe K, Kastrup JS, Sanz AC, Pickering DS, Metzler B, Clausen RP, Gajhede M, Sauerberg P, Liljefors T, Madsen U.

Chem Biol. 2007 Nov;14(11):1294-303.

18.

Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.

Hald H, Naur P, Pickering DS, Sprogøe D, Madsen U, Timmermann DB, Ahring PK, Liljefors T, Schousboe A, Egebjerg J, Gajhede M, Kastrup JS.

J Biol Chem. 2007 Aug 31;282(35):25726-36. Epub 2007 Jun 20.

19.

Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.

Jørgensen CG, Bräuner-Osborne H, Nielsen B, Kehler J, Clausen RP, Krogsgaard-Larsen P, Madsen U.

Bioorg Med Chem. 2007 May 15;15(10):3524-38. Epub 2007 Mar 3.

PMID:
17376693
20.

Synthesis and pharmacological evaluation of novel conformationally constrained homologues of glutamic acid.

Conti P, Caligiuri A, Pinto A, Roda G, Tamborini L, Nielsen B, Madsen U, Frydenvang K, Colombo A, De Micheli C.

Eur J Med Chem. 2007 Aug;42(8):1059-68. Epub 2007 Jan 27.

PMID:
17346858
21.

Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid.

Jørgensen CG, Clausen RP, Hansen KB, Bräuner-Osborne H, Nielsen B, Metzler B, Kehler J, Krogsgaard-Larsen P, Madsen U.

Org Biomol Chem. 2007 Feb 7;5(3):463-71. Erratum in: Org Biomol Chem. 2007 Mar 7;5(5):848. Metzler, Birgitte Bjørn [corrected to Metzler, Bjørn].

PMID:
17340770
22.

Synthesis of novel N1-substituted bicyclic pyrazole amino acids and evaluation of their interaction with glutamate receptors.

Conti P, Grazioso G, di Ventimiglia SJ, Pinto A, Roda G, Madsen U, Bräuner-Osborne H, Nielsen B, Costagli C, Galli A.

Chem Biodivers. 2005 Jun;2(6):748-57.

PMID:
17192018
23.

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.

Conti P, De Amici M, Grazioso G, Roda G, Pinto A, Hansen KB, Nielsen B, Madsen U, Bräuner-Osborne H, Egebjerg J, Vestri V, Pellegrini-Giampietro DE, Sibille P, Acher FC, De Micheli C.

J Med Chem. 2005 Oct 6;48(20):6315-25.

PMID:
16190758
24.

Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.

Frølund B, Greenwood JR, Holm MM, Egebjerg J, Madsen U, Nielsen B, Bräuner-Osborne H, Stensbøl TB, Krogsgaard-Larsen P.

Bioorg Med Chem. 2005 Sep 15;13(18):5391-8.

PMID:
16043357
25.
26.

Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids.

Meyer U, Bisel P, Bräuner-Osborne H, Madsen U, Höfner G, Wanner KT, Frahm AW.

Chirality. 2005 Feb;17(2):99-107.

PMID:
15660439
27.

Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.

Valgeirsson J, Nielsen EO, Peters D, Mathiesen C, Kristensen AS, Madsen U.

J Med Chem. 2004 Dec 30;47(27):6948-57.

PMID:
15615543
28.

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists.

Conti P, De Amici M, Grazioso G, Roda G, Barberis Negra FF, Nielsen B, Stensbøl TB, Madsen U, Bräuner-Osborne H, Frydenvang K, De Sarro G, Toma L, De Micheli C.

J Med Chem. 2004 Dec 30;47(27):6740-8.

PMID:
15615523
29.

Analogues of homoibotenic acid show potent and selective activity following sensitisation by quisqualic acid.

Vestergaard HT, Vogensen SB, Madsen U, Ebert B.

Eur J Pharmacol. 2004 Mar 19;488(1-3):101-9.

PMID:
15044041
30.

Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.

Hermit MB, Greenwood JR, Nielsen B, Bunch L, Jørgensen CG, Vestergaard HT, Stensbøl TB, Sanchez C, Krogsgaard-Larsen P, Madsen U, Bräuner-Osborne H.

Eur J Pharmacol. 2004 Feb 23;486(3):241-50.

PMID:
14985045
31.

2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.

Valgeirsson J, Nielsen EØ, Peters D, Varming T, Mathiesen C, Kristensen AS, Madsen U.

J Med Chem. 2003 Dec 18;46(26):5834-43.

PMID:
14667236
32.

Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues.

Valgeirsson J, Christensen JK, Kristensen AS, Pickering DS, Nielsen B, Fischer CH, Bräuner-Osborne H, Nielsen EØ, Krogsgaard-Larsen P, Madsen U.

Bioorg Med Chem. 2003 Oct 1;11(20):4341-9.

PMID:
13129570
33.

Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.

Conti P, De Amici M, Joppolo Di Ventimiglia S, Stensbøl TB, Madsen U, Bräuner-Osborne H, Russo E, De Sarro G, Bruno G, De Micheli C.

J Med Chem. 2003 Jul 3;46(14):3102-8.

PMID:
12825948
34.

Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).

Bjerrum EJ, Kristensen AS, Pickering DS, Greenwood JR, Nielsen B, Liljefors T, Schousboe A, Bräuner-Osborne H, Madsen U.

J Med Chem. 2003 May 22;46(11):2246-9.

PMID:
12747796
35.

Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.

Bunch L, Liljefors T, Greenwood JR, Frydenvang K, Bräuner-Osborne H, Krogsgaard-Larsen P, Madsen U.

J Org Chem. 2003 Feb 21;68(4):1489-95.

PMID:
12585893
36.

Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.

Johansen TN, Greenwood JR, Frydenvang K, Madsen U, Krogsgaard-Larsen P.

Chirality. 2003 Feb;15(2):167-79. Review.

PMID:
12520509
37.

Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.

Conti P, De Amici M, Bräuner-Osborne H, Madsen U, Toma L, De Micheli C.

Farmaco. 2002 Nov;57(11):889-95.

PMID:
12484537
38.

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors.

Johansen TN, Janin YL, Nielsen B, Frydenvang K, Bräuner-Osborne H, Stensbøl TB, Vogensen SB, Madsen U, Krogsgaard-Larsen P.

Bioorg Med Chem. 2002 Jul;10(7):2259-66.

PMID:
11983523
39.

Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs.

Guldbrandt M, Johansen TN, Frydenvang K, Bräuner-Osborne H, Stensbøl TB, Nielsen B, Karla R, Santi F, Krogsgaard-Larsen P, Madsen U.

Chirality. 2002 May 5;14(4):351-63.

PMID:
11968078
40.

The AMPA receptor binding site: focus on agonists and competitive antagonists.

Stensbøl TB, Madsen U, Krogsgaard-Larsen P.

Curr Pharm Des. 2002;8(10):857-72. Review.

PMID:
11945136
41.
42.

Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.

Kromann H, Sløk FA, Stensbøl TB, Bräuner-Osborne H, Madsen U, Krogsgaard-Larsen P.

J Med Chem. 2002 Feb 14;45(4):988-91.

PMID:
11831912
43.

Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology.

Stensbøl TB, Uhlmann P, Morel S, Eriksen BL, Felding J, Kromann H, Hermit MB, Greenwood JR, Braüner-Osborne H, Madsen U, Junager F, Krogsgaard-Larsen P, Begtrup M, Vedsø P.

J Med Chem. 2002 Jan 3;45(1):19-31.

PMID:
11754576
44.

Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.

Johansen TN, Stensbøl TB, Nielsen B, Vogensen SB, Frydenvang K, Sløk FA, Bräüner-Osborne H, Madsen U, Krogsgaard-Larsen P.

Chirality. 2001;13(9):523-32.

PMID:
11579444
45.

Inhibitors of AMPA and kainate receptors.

Madsen U, Stensbøl TB, Krogsgaard-Larsen P.

Curr Med Chem. 2001 Sep;8(11):1291-301. Review.

PMID:
11562267
46.

Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol.

Bunch L, Norrby PO, Frydenvang K, Krogsgaard-Larsen P, Madsen U.

Org Lett. 2001 Feb 8;3(3):433-5.

PMID:
11428032
47.

Synthesis and receptor binding affinity of new selective GluR5 ligands.

Bunch L, Johansen TH, Bräuner-Osborne H, Stensbøl TB, Johansen TN, Krogsgaard-Larsen P, Madsen U.

Bioorg Med Chem. 2001 Apr;9(4):875-9.

PMID:
11354670
48.

Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.

Madsen U, Bräuner-Osborne H, Frydenvang K, Hvene L, Johansen TN, Nielsen B, Sánchez C, Stensbøl TB, Bischoff F, Krogsgaard-Larsen P.

J Med Chem. 2001 Mar 29;44(7):1051-9.

PMID:
11297452
49.

Structural determinants for AMPA agonist activity of aryl or heteroaryl substituted AMPA analogues. Synthesis and pharmacology.

Sørensen US, Falch E, Stensbøl TB, Jaroszewski JW, Madsen U, Krogsgaard-Larsen P.

Arch Pharm (Weinheim). 2001 Feb;334(2):62-8.

PMID:
11268776
50.

Structural determinants of AMPA agonist activity in analogues of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid: synthesis and pharmacology.

Bang-Andersen B, Ahmadian H, Lenz SM, Stensbøl TB, Madsen U, Bøgesø KP, Krogsgaard-Larsen P.

J Med Chem. 2000 Dec 14;43(25):4910-8.

PMID:
11124000

Supplemental Content

Loading ...
Support Center