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Items: 1 to 50 of 110

1.

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.

Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T.

Mol Metab. 2018 Feb;8:144-157. doi: 10.1016/j.molmet.2017.12.007. Epub 2017 Dec 19.

2.

Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation.

Larger E, Wewer Albrechtsen NJ, Hansen LH, Gelling RW, Capeau J, Deacon CF, Madsen OD, Yakushiji F, De Meyts P, Holst JJ, Nishimura E.

Endocrinol Diabetes Metab Case Rep. 2016;2016. pii: 16-0081. Epub 2016 Nov 21.

3.

Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.

Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroquí L, Thévenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P.

Cell. 2017 Jan 12;168(1-2):73-85.e11. doi: 10.1016/j.cell.2016.11.002. Epub 2016 Dec 1.

4.

Revisiting the immunocytochemical detection of Neurogenin 3 expression in mouse and man.

Honoré C, Rescan C, Hald J, McGrath PS, Petersen MB, Hansson M, Klein T, Østergaard S, Wells JM, Madsen OD.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:10-22. doi: 10.1111/dom.12718. Review.

PMID:
27615127
5.

Xenotropic retrovirus Bxv1 in human pancreatic β cell lines.

Kirkegaard JS, Ravassard P, Ingvarsen S, Diedisheim M, Bricout-Neveu E, Grønborg M, Frogne T, Scharfmann R, Madsen OD, Rescan C, Albagli O.

J Clin Invest. 2016 Mar 1;126(3):1109-13. doi: 10.1172/JCI83573. Epub 2016 Feb 22.

6.

Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.

Horn S, Kirkegaard JS, Hoelper S, Seymour PA, Rescan C, Nielsen JH, Madsen OD, Jensen JN, Krüger M, Grønborg M, Ahnfelt-Rønne J.

Mol Endocrinol. 2016 Jan;30(1):133-43. doi: 10.1210/me.2015-1208. Epub 2015 Dec 9.

7.

Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.

Modi H, Jacovetti C, Tarussio D, Metref S, Madsen OD, Zhang FP, Rantakari P, Poutanen M, Nef S, Gorman T, Regazzi R, Thorens B.

Diabetes. 2015 Dec;64(12):4148-57. doi: 10.2337/db14-1735. Epub 2015 Sep 17.

8.

Analysis artefacts of the INS-IGF2 fusion transcript.

Wernersson R, Frogne T, Rescan C, Hansson L, Bruun C, Grønborg M, Jensen JN, Madsen OD.

BMC Mol Biol. 2015 Jul 29;16:13. doi: 10.1186/s12867-015-0042-8.

9.

Betatrophin.

Ahnfelt-Rønne J, Madsen OD.

Islets. 2014;6(2):e28686. doi: 10.4161/isl.28686.

10.

Beta cell workshop 2013 Kyoto.

Heller RS, Madsen OD, Nielsen JH.

Islets. 2013 May-Jun;5(3):107-10. doi: 10.4161/isl.25290. Epub 2013 Jun 11. Review.

PMID:
23756674
11.

Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas.

Van de Casteele M, Leuckx G, Baeyens L, Cai Y, Yuchi Y, Coppens V, De Groef S, Eriksson M, Svensson C, Ahlgren U, Ahnfelt-Rønne J, Madsen OD, Waisman A, Dor Y, Jensen JN, Heimberg H.

Cell Death Dis. 2013 Mar 7;4:e523. doi: 10.1038/cddis.2013.52.

12.

A new view of the beta cell.

Ahnfelt-Rønne J, Hecksher-Sørensen J, Schäffer L, Madsen OD.

Diabetologia. 2012 Sep;55(9):2316-8. doi: 10.1007/s00125-012-2609-y. Epub 2012 Jul 18. No abstract available.

PMID:
22801902
13.

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.

Ahnfelt-Rønne J, Jørgensen MC, Klinck R, Jensen JN, Füchtbauer EM, Deering T, MacDonald RJ, Wright CV, Madsen OD, Serup P.

Development. 2012 Jan;139(1):33-45. doi: 10.1242/dev.071761. Epub 2011 Nov 17.

14.

Pancreatic islet and progenitor cell surface markers with cell sorting potential.

Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Rønne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD.

Diabetologia. 2012 Jan;55(1):154-65. doi: 10.1007/s00125-011-2295-1. Epub 2011 Sep 23.

PMID:
21947380
15.

Foetal proglucagon processing in relation to adult appetite control: lessons from a transplantable rat glucagonoma with severe anorexia.

Jensen PB, Larsen PJ, Karlsen C, Jensen HI, Holst JJ, Madsen OD.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:60-8. doi: 10.1111/j.1463-1326.2011.01439.x. Review.

PMID:
21824258
16.

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1.

Torekov SS, Ma L, Grarup N, Hartmann B, Hainerová IA, Kielgast U, Kissow H, Rosenkilde M; GIANT Consortium, Lebl J, Witte DR, Jørgensen T, Sandbaek A, Lauritzen T, Madsen OD, Wang J, Linneberg A, Madsbad S, Holst JJ, Hansen T, Pedersen O.

Diabetologia. 2011 Nov;54(11):2820-31. doi: 10.1007/s00125-011-2265-7. Epub 2011 Aug 7.

PMID:
21822931
17.

Intracranial ectopic pancreatic tissue.

Heller RS, Tsugu H, Nabeshima K, Madsen OD.

Islets. 2010 Mar-Apr;2(2):65-71. doi: 10.4161/isl.2.2.10580.

PMID:
21099298
18.

[From stem cells to functional beta cells in type 1 diabetes].

Engberg N, Hansson M, Madsen OD.

Ugeskr Laeger. 2010 Sep 20;172(38):2608-12. Review. Danish.

PMID:
20920405
19.

Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels.

Galbo T, Pedersen IL, Fløyel T, Bang-Berthelsen CH, Serup P, Madsen OD, Hald J.

Eur J Histochem. 2010 Apr 15;54(2):e19.

20.

Pluripotent stem cells, a potential source of beta-cells for diabetes therapy.

Hansson M, Madsen OD.

Curr Opin Investig Drugs. 2010 Apr;11(4):417-25. Review.

PMID:
20336589
21.

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A.

Cell. 2009 Aug 7;138(3):449-62. doi: 10.1016/j.cell.2009.05.035.

22.

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.

Holst B, Egerod KL, Jin C, Petersen PS, Østergaard MV, Hald J, Sprinkel AM, Størling J, Mandrup-Poulsen T, Holst JJ, Thams P, Orskov C, Wierup N, Sundler F, Madsen OD, Schwartz TW.

Endocrinology. 2009 Jun;150(6):2577-85. doi: 10.1210/en.2008-1250. Epub 2009 Feb 12.

23.

The morphology of islets of Langerhans is only mildly affected by the lack of Pdx-1 in the pancreas of adult Meriones jirds.

Gustavsen CR, Chevret P, Krasnov B, Mowlavi G, Madsen OD, Heller RS.

Gen Comp Endocrinol. 2008 Nov-Dec;159(2-3):241-9. doi: 10.1016/j.ygcen.2008.08.017. Epub 2008 Sep 23.

PMID:
18845151
24.

Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction.

Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS.

Pancreas. 2009 Jan;38(1):36-48. doi: 10.1097/MPA.0b013e3181816547.

PMID:
18665014
25.

Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development.

Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD.

J Histochem Cytochem. 2008 Jun;56(6):587-95. doi: 10.1369/jhc.2008.950675. Epub 2008 Mar 17.

26.

Specificity of four monoclonal anti-NKx6-1 antibodies.

Klinck R, Serup P, Madsen OD, Jørgensen MC.

J Histochem Cytochem. 2008 Apr;56(4):415-24. doi: 10.1369/jhc.7A7350.2008. Epub 2008 Jan 22.

27.

An illustrated review of early pancreas development in the mouse.

Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J.

Endocr Rev. 2007 Oct;28(6):685-705. Epub 2007 Sep 19. Review.

PMID:
17881611
28.

Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'.

Madsen OD.

C R Biol. 2007 Jun-Jul;330(6-7):534-7. Epub 2007 Apr 24. Review.

29.

An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.

Ahnfelt-Rønne J, Jørgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J.

J Histochem Cytochem. 2007 Sep;55(9):925-30. Epub 2007 May 3.

PMID:
17478445
30.

Towards cell therapy for diabetes.

Madsen OD, Serup P.

Nat Biotechnol. 2006 Dec;24(12):1481-3. No abstract available.

PMID:
17160042
31.

Association between neuromedin U gene variants and overweight and obesity.

Hainerová I, Torekov SS, Ek J, Finková M, Borch-Johnsen K, Jørgensen T, Madsen OD, Lebl J, Hansen T, Pedersen O.

J Clin Endocrinol Metab. 2006 Dec;91(12):5057-63. Epub 2006 Sep 19.

PMID:
16984985
32.

Stem cells and diabetes treatment.

Madsen OD.

APMIS. 2005 Nov-Dec;113(11-12):858-75. Review.

PMID:
16480455
33.

Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1.

Pedersen IL, Klinck R, Hecksher-Sorensen J, Zahn S, Madsen OD, Serup P, Jorgensen MC.

J Histochem Cytochem. 2006 May;54(5):567-74. Epub 2006 Jan 9.

PMID:
16401696
34.

Genetic determinants of pancreatic epsilon-cell development.

Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P.

Dev Biol. 2005 Oct 1;286(1):217-24.

35.

Evidence of an association between the Arg72 allele of the peptide YY and increased risk of type 2 diabetes.

Torekov SS, Larsen LH, Glümer C, Borch-Johnsen K, Jørgensen T, Holst JJ, Madsen OD, Hansen T, Pedersen O.

Diabetes. 2005 Jul;54(7):2261-5.

36.

EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade.

Rescan C, Le Bras S, Lefebvre VH, Frandsen U, Klein T, Foschi M, Pipeleers DG, Scharfmann R, Madsen OD, Heimberg H.

Lab Invest. 2005 Jan;85(1):65-74.

37.

The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity.

Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB 3rd, Madsen OD, Serup P.

Dev Biol. 2004 Apr 1;268(1):123-34.

38.

Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas.

Heller RS, Klein T, Ling Z, Heimberg H, Katoh M, Madsen OD, Serup P.

Gene Expr. 2003;11(3-4):141-7.

39.

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.

Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J.

Dev Biol. 2003 Aug 15;260(2):426-37.

40.

Nestin is expressed in vascular endothelial cells in the adult human pancreas.

Klein T, Ling Z, Heimberg H, Madsen OD, Heller RS, Serup P.

J Histochem Cytochem. 2003 Jun;51(6):697-706.

PMID:
12754281
41.
42.

Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas.

Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P.

Diabetes. 2001 Jul;50(7):1553-61.

43.

Islet and stem cell transplantation for treating diabetes.

Serup P, Madsen OD, Mandrup-Poulsen T.

BMJ. 2001 Jan 6;322(7277):29-32. Review. No abstract available.

44.

Pax4 represses pancreatic glucagon gene expression.

Petersen HV, Jørgensen MC, Andersen FG, Jensen J, F-Nielsen T, Jørgensen R, Madsen OD, Serup P.

Mol Cell Biol Res Commun. 2000 Apr;3(4):249-54.

PMID:
10891400
45.

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P.

Diabetes. 2000 Feb;49(2):163-76.

PMID:
10868931
46.

Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.

Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP.

Mol Cell Biol. 2000 Jun;20(12):4445-54.

47.

Human islets in mixed islet grafts protect mouse pancreatic beta-cells from alloxan toxicity.

Tyrberg B, Eizirik DL, Marklund SL, Olejnicka B, Madsen OD, Andersson A.

Pharmacol Toxicol. 1999 Dec;85(6):269-75.

PMID:
10628902
48.

Control of endodermal endocrine development by Hes-1.

Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD.

Nat Genet. 2000 Jan;24(1):36-44.

PMID:
10615124
49.

Beta-cell maturation leads to in vitro sensitivity to cytotoxins.

Nielsen K, Karlsen AE, Deckert M, Madsen OD, Serup P, Mandrup-Poulsen T, Nerup J.

Diabetes. 1999 Dec;48(12):2324-32.

PMID:
10580420
50.

Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1.

Jørgensen MC, Vestergård Petersen H, Ericson J, Madsen OD, Serup P.

FEBS Lett. 1999 Nov 19;461(3):287-94.

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