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Portable normothermic ex-vivo lung perfusion, ventilation, and functional assessment with the Organ Care System on donor lung use for transplantation from extended-criteria donors (EXPAND): a single-arm, pivotal trial.

Loor G, Warnecke G, Villavicencio MA, Smith MA, Kukreja J, Ardehali A, Hartwig M, Daneshmand MA, Hertz MI, Huddleston S, Haverich A, Madsen JC, Van Raemdonck D.

Lancet Respir Med. 2019 Aug 1. pii: S2213-2600(19)30200-0. doi: 10.1016/S2213-2600(19)30200-0. [Epub ahead of print]


Plasmacytoid dendritic cell driven induction of Tregs is strain-specific and correlates with spontaneous acceptance of kidney allografts.

Oh NA, O'Shea T, Ndishabandi DK, Yuan Q, Hong S, Gans J, Ge J, Gibney S, Chase C, Yang C, Rosales I, Shinoda K, Drew B, Kojima L, Russell PS, Madsen JC, Colvin RB, Alessandrini A.

Transplantation. 2019 Jul 15. doi: 10.1097/TP.0000000000002867. [Epub ahead of print]


Translational impact of NIH-funded nonhuman primate research in transplantation.

Knechtle SJ, Shaw JM, Hering BJ, Kraemer K, Madsen JC.

Sci Transl Med. 2019 Jul 10;11(500). pii: eaau0143. doi: 10.1126/scitranslmed.aau0143. Review.


Erythropoietin inhibits SGK1-dependent TH17 induction and TH17-dependent kidney disease.

Donadei C, Angeletti A, Cantarelli C, D'Agati VD, La Manna G, Fiaccadori E, Horwitz JK, Xiong H, Guglielmo C, Hartzell S, Madsen JC, Maggiore U, Heeger PS, Cravedi P.

JCI Insight. 2019 Apr 23;5. pii: 127428. doi: 10.1172/jci.insight.127428.


Early immune biomarkers and intermediate-term outcomes after heart transplantation: Results of Clinical Trials in Organ Transplantation-18.

Stehlik J, Armstrong B, Baran DA, Bridges ND, Chandraker A, Gordon R, De Marco T, Givertz MM, Heroux A, Iklé D, Hunt J, Kfoury AG, Madsen JC, Morrison Y, Feller E, Pinney S, Tripathi S, Heeger PS, Starling RC.

Am J Transplant. 2019 May;19(5):1518-1528. doi: 10.1111/ajt.15218. Epub 2019 Jan 22.


Why some organ allografts are tolerated better than others: new insights for an old question.

Hull TD, Benichou G, Madsen JC.

Curr Opin Organ Transplant. 2019 Feb;24(1):49-57. doi: 10.1097/MOT.0000000000000594.


Maintaining T cell tolerance of alloantigens: Lessons from animal studies.

Robinson KA, Orent W, Madsen JC, Benichou G.

Am J Transplant. 2018 Aug;18(8):1843-1856. doi: 10.1111/ajt.14984. Review.


Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates.

Wang Z, Louras NJ, Lellouch AG, Pratts SG, Zhang H, Wang H, Huang CA, Cetrulo CL Jr, Madsen JC, Sachs DH, Wang Z.

Mol Oncol. 2018 Aug;12(8):1374-1382. doi: 10.1002/1878-0261.12331. Epub 2018 Jul 3.


Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study.

Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A.

Lancet Respir Med. 2018 May;6(5):357-367. doi: 10.1016/S2213-2600(18)30136-X. Epub 2018 Apr 9. Erratum in: Lancet Respir Med. 2018 Jun;6(6):e27.


The effects of brain death and ischemia on tolerance induction are organ-specific.

Michel SG, Madariaga MLL, LaMuraglia GM 2nd, Villani V, Sekijima M, Farkash EA, Colvin RB, Sachs DH, Yamada K, Rosengard BR, Allan JS, Madsen JC.

Am J Transplant. 2018 May;18(5):1262-1269. doi: 10.1111/ajt.14674. Epub 2018 Mar 5.


Preclinical and clinical studies for transplant tolerance via the mixed chimerism approach.

Sasaki H, Oura T, Spitzer TR, Chen YB, Madsen JC, Allan J, Sachs DH, Cosimi AB, Kawai T.

Hum Immunol. 2018 May;79(5):258-265. doi: 10.1016/j.humimm.2017.11.008. Epub 2017 Nov 22. Review.


Advances in the immunology of heart transplantation.

Madsen JC.

J Heart Lung Transplant. 2017 Dec;36(12):1299-1305. doi: 10.1016/j.healun.2017.10.003. Epub 2017 Oct 20. Review. No abstract available.


Prevalence of polyreactive innate clones among graft--infiltrating B cells in human cardiac allograft vasculopathy.

Chatterjee D, Moore C, Gao B, Clerkin KJ, See SB, Shaked D, Rogers K, Nunez S, Veras Y, Addonizio L, Givertz MM, Naka Y, Mancini D, Vasilescu R, Marboe C, Restaino S, Madsen JC, Zorn E.

J Heart Lung Transplant. 2018 Mar;37(3):385-393. doi: 10.1016/j.healun.2017.09.011. Epub 2017 Sep 28.


Ontak-like human IL-2 fusion toxin.

Wang Z, Zheng Q, Zhang H, Bronson RT, Madsen JC, Sachs DH, Huang CA, Wang Z.

J Immunol Methods. 2017 Sep;448:51-58. doi: 10.1016/j.jim.2017.05.008. Epub 2017 May 24.


The human thymus perivascular space is a functional niche for viral-specific plasma cells.

Nuñez S, Moore C, Gao B, Rogers K, Hidalgo Y, Del Nido PJ, Restaino S, Naka Y, Bhagat G, Madsen JC, Bono MR, Zorn E.

Sci Immunol. 2016 Dec;1(6). pii: eaah4447. doi: 10.1126/sciimmunol.aah4447. Epub 2016 Dec 23.


Diphtheria toxin-based anti-human CD19 immunotoxin for targeting human CD19+ tumors.

Zheng Q, Wang Z, Zhang H, Huang Q, Madsen JC, Sachs DH, Huang CA, Wang Z.

Mol Oncol. 2017 May;11(5):584-594. doi: 10.1002/1878-0261.12056. Epub 2017 Apr 4.


Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival.

Purroy C, Fairchild RL, Tanaka T, Baldwin WM 3rd, Manrique J, Madsen JC, Colvin RB, Alessandrini A, Blazar BR, Fribourg M, Donadei C, Maggiore U, Heeger PS, Cravedi P.

J Am Soc Nephrol. 2017 Aug;28(8):2377-2392. doi: 10.1681/ASN.2016101100. Epub 2017 Mar 16.


Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin.

Wang Z, Navarro-Alvarez N, Shah JA, Zhang H, Huang Q, Zheng Q, Madsen JC, Sachs DH, Huang CA, Wang Z.

Vet Immunol Immunopathol. 2016 Dec;182:150-158. doi: 10.1016/j.vetimm.2016.10.014. Epub 2016 Oct 29.


Long-Term Outcome in Levothyroxine Treated Patients With Subclinical Hypothyroidism and Concomitant Heart Disease.

Andersen MN, Olsen AS, Madsen JC, Kristensen SL, Faber J, Torp-Pedersen C, Gislason GH, Selmer C.

J Clin Endocrinol Metab. 2016 Nov;101(11):4170-4177. Epub 2016 Aug 29.


Hyponatremia, all-cause mortality, and risk of cancer diagnoses in the primary care setting: A large population study.

Selmer C, Madsen JC, Torp-Pedersen C, Gislason GH, Faber J.

Eur J Intern Med. 2016 Dec;36:36-43. doi: 10.1016/j.ejim.2016.07.028. Epub 2016 Aug 13.


Induced regulatory T cells in allograft tolerance via transient mixed chimerism.

Hotta K, Aoyama A, Oura T, Yamada Y, Tonsho M, Huh KH, Kawai K, Schoenfeld D, Allan JS, Madsen JC, Benichou G, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T.

JCI Insight. 2016 Jul 7;1(10). pii: e86419.


Natural IgM Blockade Limits Infarct Expansion and Left Ventricular Dysfunction in a Swine Myocardial Infarct Model.

Sihag S, Haas MS, Kim KM, Guerrero JL, Beaudoin J, Alicot EM, Schuerpf F, Gottschall JD, Puro RJ, Madsen JC, Sachs DH, Newman W, Carroll MC, Allan JS.

Circ Cardiovasc Interv. 2016 Jan;9(1):e002547. doi: 10.1161/CIRCINTERVENTIONS.115.002547.


Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin.

Wang Z, Pratts SG, Zhang H, Spencer PJ, Yu R, Tonsho M, Shah JA, Tanabe T, Powell HR, Huang CA, Madsen JC, Sachs DH, Wang Z.

Mol Oncol. 2016 Apr;10(4):553-65. doi: 10.1016/j.molonc.2015.11.008. Epub 2015 Nov 19.


Organ Transplant Tolerance for Children; in Sight for Some.

Alexander SI, Madsen JC.

J Pediatr. 2016 Jan;168:232-5. doi: 10.1016/j.jpeds.2015.10.042. Epub 2015 Nov 12. No abstract available.


A novel approach to measuring cell-mediated lympholysis using quantitative flow and imaging cytometry.

La Muraglia GM 2nd, O'Neil MJ, Madariaga ML, Michel SG, Mordecai KS, Allan JS, Madsen JC, Hanekamp IM, Preffer FI.

J Immunol Methods. 2015 Dec;427:85-93. doi: 10.1016/j.jim.2015.10.005. Epub 2015 Oct 26.


Effects of Lung Cotransplantation on Cardiac Allograft Tolerance Across a Full Major Histocompatibility Complex Barrier in Miniature Swine.

Madariaga ML, Spencer PJ, Michel SG, La Muraglia GM 2nd, O'Neil MJ, Mannon EC, Leblang C, Rosales IA, Colvin RB, Sachs DH, Allan JS, Madsen JC.

Am J Transplant. 2016 Mar;16(3):979-86. doi: 10.1111/ajt.13489. Epub 2015 Oct 15.


Twelve-Hour Hypothermic Machine Perfusion for Donor Heart Preservation Leads to Improved Ultrastructural Characteristics Compared to Conventional Cold Storage.

Michel SG, La Muraglia GM 2nd, Madariaga ML, Titus JS, Selig MK, Farkash EA, Allan JS, Anderson LM, Madsen JC.

Ann Transplant. 2015 Aug 11;20:461-8. doi: 10.12659/AOT.893784.


Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys.

Yamada Y, Nadazdin O, Boskovic S, Lee S, Zorn E, Smith RN, Colvin RB, Madsen JC, Cosimi AB, Kawai T, Benichou G.

Am J Transplant. 2015 Dec;15(12):3055-66. doi: 10.1111/ajt.13382. Epub 2015 Jul 17.


Organ-specific differences in achieving tolerance.

Madariaga ML, Kreisel D, Madsen JC.

Curr Opin Organ Transplant. 2015 Aug;20(4):392-9. doi: 10.1097/MOT.0000000000000206. Review.


Levothyroxine Substitution in Patients with Subclinical Hypothyroidism and the Risk of Myocardial Infarction and Mortality.

Andersen MN, Olsen AM, Madsen JC, Faber J, Torp-Pedersen C, Gislason GH, Selmer C.

PLoS One. 2015 Jun 12;10(6):e0129793. doi: 10.1371/journal.pone.0129793. eCollection 2015.


Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4(+) cells in vivo.

Wang Z, Wei M, Zhang H, Chen H, Germana S, Huang CA, Madsen JC, Sachs DH, Wang Z.

Mol Oncol. 2015 Aug;9(7):1458-70. doi: 10.1016/j.molonc.2015.04.004. Epub 2015 Apr 25.


Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism.

Tonsho M, Lee S, Aoyama A, Boskovic S, Nadazdin O, Capetta K, Smith RN, Colvin RB, Sachs DH, Cosimi AB, Kawai T, Madsen JC, Benichou G, Allan JS.

Am J Transplant. 2015 Aug;15(8):2231-9. doi: 10.1111/ajt.13274. Epub 2015 Apr 22.


Kidney-induced cardiac allograft tolerance in miniature swine is dependent on MHC-matching of donor cardiac and renal parenchyma.

Madariaga ML, Michel SG, La Muraglia GM 2nd, Sekijima M, Villani V, Leonard DA, Powell HJ, Kurtz JM, Farkash EA, Colvin RB, Allan JS, Cetrulo CL Jr, Huang CA, Sachs DH, Yamada K, Madsen JC.

Am J Transplant. 2015 Jun;15(6):1580-90. doi: 10.1111/ajt.13131. Epub 2015 Mar 30.


Long-term lung transplantation in nonhuman primates.

Aoyama A, Tonsho M, Ng CY, Lee S, Millington T, Nadazdin O, Wain JC, Cosimi AB, Sachs DH, Smith RN, Colvin RB, Kawai T, Madsen JC, Benichou G, Allan JS.

Am J Transplant. 2015 May;15(5):1415-20. doi: 10.1111/ajt.13130. Epub 2015 Mar 13.


Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts.

Madariaga MLL, Shanmugarajah K, Michel SG, Villani V, Muraglia GM 2nd, Torabi R, Leonard DA, Randolph MA, Colvin RB, Yamada K, Madsen JC, Cetrulo CL Jr, Sachs DH.

Transplantation. 2015 Aug;99(8):1590-1597. doi: 10.1097/TP.0000000000000681.


Recipient-matching of Passenger Leukocytes Prolongs Survival of Donor Lung Allografts in Miniature Swine.

Madariaga ML, Michel SG, La Muraglia GM 2nd, Sihag S, Leonard DA, Farkash EA, Colvin RB, Cetrulo CL Jr, Huang CA, Sachs DH, Madsen JC, Allan JS.

Transplantation. 2015 Jul;99(7):1372-8. doi: 10.1097/TP.0000000000000676.


Chronic restraint stress increases the protein expression of VEGF and its receptor VEGFR-2 in the prefrontal cortex.

Elfving B, Jakobsen JL, Madsen JC, Wegener G, Müller HK.

Synapse. 2015 Apr;69(4):190-4. doi: 10.1002/syn.21808. Epub 2015 Feb 19.


Use of CTLA4Ig for induction of mixed chimerism and renal allograft tolerance in nonhuman primates.

Yamada Y, Ochiai T, Boskovic S, Nadazdin O, Oura T, Schoenfeld D, Cappetta K, Smith RN, Colvin RB, Madsen JC, Sachs DH, Benichou G, Cosimi AB, Kawai T.

Am J Transplant. 2014 Dec;14(12):2704-12. doi: 10.1111/ajt.12936. Epub 2014 Nov 13.


Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy.

Hirohashi T, Chase CM, DellaPelle P, Sebastian D, Farkesh E, Colvin RB, Russell PS, Alessandrini A, Madsen JC.

Transplantation. 2014 Oct 27;98(8):828-34. doi: 10.1097/TP.0000000000000329.


Depletion of foxp3(+) T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism.

Shinoda K, Akiyoshi T, Chase CM, Farkash EA, Ndishabandi DK, Raczek CM, Sebastian DP, Pelle PD, Russell PS, Madsen JC, Colvin RB, Alessandrini A.

Am J Transplant. 2014 Oct;14(10):2263-2274. doi: 10.1111/ajt.12851. Epub 2014 Aug 25.


Diphtheria toxin-based recombinant murine IL-2 fusion toxin for depleting murine regulatory T cells in vivo.

Wei M, Marino J, Trowell A, Zhang H, Stromp Peraino J, Rajasekera PV, Madsen JC, Sachs DH, Huang CA, Benichou G, Wang Z.

Protein Eng Des Sel. 2014 Sep;27(9):289-95. doi: 10.1093/protein/gzu034.


Preservation of donor hearts using hypothermic oxygenated perfusion.

Michel SG, La Muraglia GM 2nd, Madariaga ML, Titus JS, Selig MK, Farkash EA, Allan JS, Anderson LM, Madsen JC.

Ann Transplant. 2014 Aug 20;19:409-16. doi: 10.12659/AOT.890797.


Tolerance: one transplant for life.

Kawai T, Leventhal J, Madsen JC, Strober S, Turka LA, Wood KJ.

Transplantation. 2014 Jul 27;98(2):117-21. doi: 10.1097/TP.0000000000000260.


Heart transplantation: challenges facing the field.

Tonsho M, Michel S, Ahmed Z, Alessandrini A, Madsen JC.

Cold Spring Harb Perspect Med. 2014 May 1;4(5). pii: a015636. doi: 10.1101/cshperspect.a015636. Review.


Subclinical and overt thyroid dysfunction and risk of all-cause mortality and cardiovascular events: a large population study.

Selmer C, Olesen JB, Hansen ML, von Kappelgaard LM, Madsen JC, Hansen PR, Pedersen OD, Faber J, Torp-Pedersen C, Gislason GH.

J Clin Endocrinol Metab. 2014 Jul;99(7):2372-82. doi: 10.1210/jc.2013-4184. Epub 2014 Mar 21.


Diphtheria toxin-based bivalent human IL-2 fusion toxin with improved efficacy for targeting human CD25(+) cells.

Peraino JS, Zhang H, Rajasekera PV, Wei M, Madsen JC, Sachs DH, Huang CA, Wang Z.

J Immunol Methods. 2014 Mar;405:57-66. doi: 10.1016/j.jim.2014.01.008. Epub 2014 Jan 24.


Successful right ventricular mechanical support after combined heart-liver transplantation.

Fitzsimons MG, Ichinose F, Vagefi PA, Markmann JF, Pierce ET, MacGillivray TE, Hertl M, Gauran C, Madsen JC, Baker J.

J Cardiothorac Vasc Anesth. 2014 Dec;28(6):1583-5. doi: 10.1053/j.jvca.2013.10.013. Epub 2014 Jan 24. No abstract available.


Predictors of survival to orthotopic heart transplant in patients with light chain amyloidosis.

Gray Gilstrap L, Niehaus E, Malhotra R, Ton VK, Watts J, Seldin DC, Madsen JC, Semigran MJ.

J Heart Lung Transplant. 2014 Feb;33(2):149-56. doi: 10.1016/j.healun.2013.09.004. Epub 2013 Nov 5.


Induction of cardiac allograft tolerance across a full MHC barrier in miniature swine by donor kidney cotransplantation.

Madariaga ML, Michel SG, Tasaki M, Villani V, La Muraglia GM 2nd, Sihag S, Gottschall J, Farkash EA, Shimizu A, Allan JS, Sachs DH, Yamada K, Madsen JC.

Am J Transplant. 2013 Oct;13(10):2558-66. doi: 10.1111/ajt.12423. Epub 2013 Aug 22.

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