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Intestinal sensing and handling of dietary lipids in gastric bypass-operated patients and matched controls.

Martinussen C, Dirksen C, Bojsen-Møller KN, Svane MS, Carlsson ER, Hartmann B, Clausen TR, Veedfald S, Kristiansen VB, Rehfeld JF, Hansen HS, Holst JJ, Madsbad S.

Am J Clin Nutr. 2020 Jan 1;111(1):28-41. doi: 10.1093/ajcn/nqz272.


Liraglutide reduces hyperglycaemia and body weight in overweight, dysregulated insulin-pump-treated patients with type 1 diabetes: The Lira Pump trial-a randomized, double-blinded, placebo-controlled trial.

Dejgaard TF, Schmidt S, Frandsen CS, Vistisen D, Madsbad S, Andersen HU, Nørgaard K.

Diabetes Obes Metab. 2019 Nov 6. doi: 10.1111/dom.13911. [Epub ahead of print]


Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet.

Jensen SBK, Lundgren JR, Janus C, Juhl CR, Olsen LM, Rosenkilde M, Holst JJ, Stallknecht BM, Madsbad S, Torekov SS.

BMJ Open. 2019 Nov 2;9(11):e031431. doi: 10.1136/bmjopen-2019-031431.


Sustained Improvements in Glucose Metabolism Late After Roux-En-Y Gastric Bypass Surgery in Patients with and Without Preoperative Diabetes.

Jørgensen NB, Bojsen-Møller KN, Dirksen C, Martinussen C, Svane MS, Kristiansen VB, Holst JJ, Madsbad S.

Sci Rep. 2019 Oct 22;9(1):15154. doi: 10.1038/s41598-019-51516-y.


[The glucagon-like peptide-1 receptor-agonist semaglutide].

Boje AD, Juhl CR, Torekov SS, Madsbad S.

Ugeskr Laeger. 2019 Oct 7;181(41). pii: V03190155. Danish.


Impact of baseline characteristics and beta-cell function on the efficacy and safety of subcutaneous once-weekly semaglutide: A patient-level, pooled analysis of the SUSTAIN 1-5 trials.

Aroda VR, Capehorn MS, Chaykin L, Frias JP, Lausvig NL, Macura S, Lüdemann J, Madsbad S, Rosenstock J, Tabak O, Tadayon S, Bain SC.

Diabetes Obes Metab. 2019 Oct 13. doi: 10.1111/dom.13896. [Epub ahead of print]


Phosphatidylcholine and its relation to apolipoproteins A-1 and B changes after Roux-en-Y gastric bypass: a cohort study.

Carlsson ER, Allin KH, Madsbad S, Fenger M.

Lipids Health Dis. 2019 Sep 5;18(1):169. doi: 10.1186/s12944-019-1111-7.


Adults with pathogenic MC4R mutations have increased final height and thereby increased bone mass.

Iepsen EW, Zhang J, Hollensted M, Madsbad S, Hansen T, Holst JJ, Jørgensen NR, Holm JC, Torekov SS.

J Bone Miner Metab. 2020 Jan;38(1):117-125. doi: 10.1007/s00774-019-01034-8. Epub 2019 Aug 30.


Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle.

Han X, Møller LLV, De Groote E, Bojsen-Møller KN, Davey J, Henríquez-Olguin C, Li Z, Knudsen JR, Jensen TE, Madsbad S, Gregorevic P, Richter EA, Sylow L.

J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1241-1257. doi: 10.1002/jcsm.12474. Epub 2019 Aug 11.


A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial.

Skytte MJ, Samkani A, Petersen AD, Thomsen MN, Astrup A, Chabanova E, Frystyk J, Holst JJ, Thomsen HS, Madsbad S, Larsen TM, Haugaard SB, Krarup T.

Diabetologia. 2019 Nov;62(11):2066-2078. doi: 10.1007/s00125-019-4956-4. Epub 2019 Jul 23.


Liraglutide in combination with metformin may improve the atherogenic lipid profile and decrease C-reactive protein level in statin treated obese patients with coronary artery disease and newly diagnosed type 2 diabetes: A randomized trial.

Anholm C, Kumarathurai P, Pedersen LR, Samkani A, Walzem RL, Nielsen OW, Kristiansen OP, Fenger M, Madsbad S, Sajadieh A, Haugaard SB.

Atherosclerosis. 2019 Sep;288:60-66. doi: 10.1016/j.atherosclerosis.2019.07.007. Epub 2019 Jul 5.


Pros and cons of Roux en-Y gastric bypass surgery in obese patients with type 2 diabetes.

Justinussen T, Madsbad S, Holst JJ, Bojsen-Møller KN.

Expert Rev Endocrinol Metab. 2019 Jul;14(4):243-257. doi: 10.1080/17446651.2019.1628639. Epub 2019 Jun 19.


Cardiovascular risk reduction with once-weekly semaglutide in subjects with type 2 diabetes: a post hoc analysis of gender, age, and baseline CV risk profile in the SUSTAIN 6 trial.

Leiter LA, Bain SC, Hramiak I, Jódar E, Madsbad S, Gondolf T, Hansen T, Holst I, Lingvay I.

Cardiovasc Diabetol. 2019 Jun 6;18(1):73. doi: 10.1186/s12933-019-0871-8.


Liraglutide improves the beta-cell function without increasing insulin secretion during a mixed meal in patients, who exhibit well-controlled type 2 diabetes and coronary artery disease.

Anholm C, Kumarathurai P, Jürs A, Pedersen LR, Nielsen OW, Kristiansen OP, Fenger M, Holst JJ, Madsbad S, Sajadieh A, Haugaard SB.

Diabetol Metab Syndr. 2019 May 31;11:42. doi: 10.1186/s13098-019-0438-6. eCollection 2019.


GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men.

Skov-Jeppesen K, Svane MS, Martinussen C, Gabe MBN, Gasbjerg LS, Veedfald S, Bojsen-Møller KN, Madsbad S, Holst JJ, Rosenkilde MM, Hartmann B.

Bone. 2019 Aug;125:178-185. doi: 10.1016/j.bone.2019.05.014. Epub 2019 May 15.


Liraglutide for the prevention of major adverse cardiovascular events in diabetic patients.

Madsbad S.

Expert Rev Cardiovasc Ther. 2019 May;17(5):377-387. doi: 10.1080/14779072.2019.1615444. Epub 2019 May 17. Review.


Effect of liraglutide on estimates of lipolysis and lipid oxidation in obese patients with stable coronary artery disease and newly diagnosed type 2 diabetes: A randomized trial.

Anholm C, Kumarathurai P, Samkani A, Pedersen LR, Boston RC, Nielsen OW, Kristiansen OP, Fenger M, Madsbad S, Sajadieh A, Haugaard SB.

Diabetes Obes Metab. 2019 Aug;21(8):2012-2016. doi: 10.1111/dom.13761. Epub 2019 May 29.


Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes.

Hansen CS, Frandsen CS, Fleischer J, Vistisen D, Holst JJ, Tarnow L, Knop FK, Madsbad S, Andersen HU, Dejgaard TF.

Front Endocrinol (Lausanne). 2019 Apr 12;10:242. doi: 10.3389/fendo.2019.00242. eCollection 2019.


Genetic Determinants of Weight Loss After Bariatric Surgery.

Aasbrenn M, Schnurr TM, Have CT, Svendstrup M, Hansen DL, Worm D, Balslev-Harder M, Hollensted M, Grarup N, Burgdorf KS, Vestergaard H, Pedersen O, Sørensen TIA, Fenger M, Madsbad S, Hansen T.

Obes Surg. 2019 Aug;29(8):2554-2561. doi: 10.1007/s11695-019-03878-5.


Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus.

Madsen KS, Kähler P, Kähler LKA, Madsbad S, Gnesin F, Metzendorf MI, Richter B, Hemmingsen B.

Cochrane Database Syst Rev. 2019 Apr 18;4:CD012368. doi: 10.1002/14651858.CD012368.pub2.


Bariatric surgery-which procedure is the optimal choice?

Madsbad S, Holst JJ.

Lancet. 2019 Mar 30;393(10178):1263-1264. doi: 10.1016/S0140-6736(19)30489-1. Epub 2019 Mar 6. No abstract available.


Augmented GLP-1 Secretion as Seen After Gastric Bypass May Be Obtained by Delaying Carbohydrate Digestion.

Martinussen C, Bojsen-Møller KN, Dirksen C, Svane MS, Kristiansen VB, Hartmann B, Holst JJ, Madsbad S.

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3233-3244. doi: 10.1210/jc.2018-02661.


Extracellular Fluid Volume Expansion Uncovers a Natriuretic Action of GLP-1: A Functional GLP-1-Renal Axis in Man.

Asmar A, Cramon PK, Simonsen L, Asmar M, Sorensen CM, Madsbad S, Moro C, Hartmann B, Jensen BL, Holst JJ, Bülow J.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2509-2519. doi: 10.1210/jc.2019-00004.


Effect of liraglutide on body weight and microvascular function in non-diabetic overweight women with coronary microvascular dysfunction.

Suhrs HE, Raft KF, Bové K, Madsbad S, Holst JJ, Zander M, Prescott E.

Int J Cardiol. 2019 May 15;283:28-34. doi: 10.1016/j.ijcard.2018.12.005. Epub 2019 Jan 2.


Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.

Svane MS, Bojsen-Møller KN, Martinussen C, Dirksen C, Madsen JL, Reitelseder S, Holm L, Rehfeld JF, Kristiansen VB, van Hall G, Holst JJ, Madsbad S.

Gastroenterology. 2019 May;156(6):1627-1641.e1. doi: 10.1053/j.gastro.2019.01.262. Epub 2019 Feb 8.


The effect of DPP-4-protected GLP-1 (7-36) on coronary microvascular function in obese adults.

Nilsson M, Bové KB, Suhrs E, Hermann T, Madsbad S, Holst JJ, Prescott E, Zander M.

Int J Cardiol Heart Vasc. 2019 Jan 29;22:139-144. doi: 10.1016/j.ijcha.2019.01.004. eCollection 2019 Mar.


Effect of bariatric surgery on plasma GDF15 in humans.

Kleinert M, Bojsen-Møller KN, Jørgensen NB, Svane MS, Martinussen C, Kiens B, Wojtaszewski JFP, Madsbad S, Richter EA, Clemmensen C.

Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E615-E621. doi: 10.1152/ajpendo.00010.2019. Epub 2019 Feb 5.


Metabolic Health in Severely Obese Subjects: A Descriptive Study.

Worm D, Madsbad S, Hansen DL.

Metab Syndr Relat Disord. 2019 Mar;17(2):115-119. doi: 10.1089/met.2018.0083. Epub 2019 Jan 16.


Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery.

Kandel D, Bojsen-Møller KN, Svane MS, Samkani A, Astrup A, Holst JJ, Madsbad S, Krarup T.

Am J Clin Nutr. 2019 Aug 1;110(2):296-304. doi: 10.1093/ajcn/nqy310.


The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial.

Samkani A, Skytte MJ, Anholm C, Astrup A, Deacon CF, Holst JJ, Madsbad S, Boston R, Krarup T, Haugaard SB.

Lipids Health Dis. 2018 Dec 27;17(1):295. doi: 10.1186/s12944-018-0953-8.


Molecular Mechanisms in Skeletal Muscle Underlying Insulin Resistance in Women Who Are Lean With Polycystic Ovary Syndrome.

Hansen SL, Svendsen PF, Jeppesen JF, Hoeg LD, Andersen NR, Kristensen JM, Nilas L, Lundsgaard AM, Wojtaszewski JFP, Madsbad S, Kiens B.

J Clin Endocrinol Metab. 2019 May 1;104(5):1841-1854. doi: 10.1210/jc.2018-01771.


Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery.

Wewer Albrechtsen NJ, Geyer PE, Doll S, Treit PV, Bojsen-Møller KN, Martinussen C, Jørgensen NB, Torekov SS, Meier F, Niu L, Santos A, Keilhauer EC, Holst JJ, Madsbad S, Mann M.

Cell Syst. 2018 Dec 26;7(6):601-612.e3. doi: 10.1016/j.cels.2018.10.012. Epub 2018 Dec 5.


Cholecystokinin secretion is suppressed by glucagon-like peptide-1: clue to the mechanism of the adverse gallbladder events of GLP-1-derived drugs.

Rehfeld JF, Knop FK, Asmar A, Madsbad S, Holst JJ, Asmar M.

Scand J Gastroenterol. 2018 Dec;53(12):1429-1432. doi: 10.1080/00365521.2018.1530297. Epub 2018 Nov 19.


[Successful treatment of KCNJ11 neonatal diabetes without insulin].

Gade-Rasmussen B, Madsbad S, Svane MS, Martinussen C, Hansen T.

Ugeskr Laeger. 2018 Nov 12;180(46). pii: V08180547. Danish.


Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations-Role of Carbohydrate and Energy Availability.

Bojsen-Møller KN, Lundsgaard AM, Madsbad S, Kiens B, Holst JJ.

Diabetes. 2018 Nov;67(11):2129-2136. doi: 10.2337/db18-0539. Review.


Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects.

Samkani A, Skytte MJ, Thomsen MN, Astrup A, Deacon CF, Holst JJ, Madsbad S, Rehfeld JF, Krarup T, Haugaard SB.

Nutrients. 2018 Sep 12;10(9). pii: E1285. doi: 10.3390/nu10091285.


The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial.

Nordklint AK, Almdal TP, Vestergaard P, Lundby-Christensen L, Boesgaard TW, Breum L, Gade-Rasmussen B, Sneppen SB, Gluud C, Hemmingsen B, Jensen T, Krarup T, Madsbad S, Mathiesen ER, Perrild H, Tarnow L, Thorsteinsson B, Vestergaard H, Lund SS, Eiken P.

Osteoporos Int. 2018 Nov;29(11):2517-2526. doi: 10.1007/s00198-018-4637-z. Epub 2018 Jul 19.


Non-insulin pharmacological therapies for treating type 1 diabetes.

Frandsen CS, Dejgaard TF, Madsbad S, Holst JJ.

Expert Opin Pharmacother. 2018 Jun;19(9):947-960. doi: 10.1080/14656566.2018.1483339. Review.


Preoperative High-Dose Methylprednisolone and Glycemic Control Early After Total Hip and Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.

Lindberg-Larsen V, Kehlet H, Bagger J, Madsbad S.

Anesth Analg. 2018 Oct;127(4):906-913. doi: 10.1213/ANE.0000000000003591.


Changes in Serum Sphingomyelin After Roux-en-Y Gastric Bypass Surgery Are Related to Diabetes Status.

Carlsson ER, Grundtvig JLG, Madsbad S, Fenger M.

Front Endocrinol (Lausanne). 2018 Apr 25;9:172. doi: 10.3389/fendo.2018.00172. eCollection 2018.


Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist.

Iepsen EW, Zhang J, Thomsen HS, Hansen EL, Hollensted M, Madsbad S, Hansen T, Holst JJ, Holm JC, Torekov SS.

Cell Metab. 2018 Jul 3;28(1):23-32.e3. doi: 10.1016/j.cmet.2018.05.008. Epub 2018 May 31.


Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss.

Holst JJ, Madsbad S, Bojsen-Møller KN, Svane MS, Jørgensen NB, Dirksen C, Martinussen C.

Surg Obes Relat Dis. 2018 May;14(5):708-714. doi: 10.1016/j.soard.2018.03.003. Epub 2018 Mar 8.


A carbohydrate-reduced high-protein diet acutely decreases postprandial and diurnal glucose excursions in type 2 diabetes patients.

Samkani A, Skytte MJ, Kandel D, Kjaer S, Astrup A, Deacon CF, Holst JJ, Madsbad S, Rehfeld JF, Haugaard SB, Krarup T.

Br J Nutr. 2018 Apr;119(8):910-917. doi: 10.1017/S0007114518000521.


Erratum to semaglutide seems to be more effective the other GLP-1Ras.

Holst JJ, Madsbad S.

Ann Transl Med. 2018 Feb;6(3):74. doi: 10.21037/atm.2018.01.20.


Systems Signatures Reveal Unique Remission-path of Type 2 Diabetes Following Roux-en-Y Gastric Bypass Surgery.

Li QR, Wang ZM, Wewer Albrechtsen NJ, Wang DD, Su ZD, Gao XF, Wu QQ, Zhang HP, Zhu L, Li RX, Jacobsen S, Jørgensen NB, Dirksen C, Bojsen-Møller KN, Petersen JS, Madsbad S, Clausen TR, Diderichsen B, Chen LN, Holst JJ, Zeng R, Wu JR.

EBioMedicine. 2018 Feb;28:234-240. doi: 10.1016/j.ebiom.2018.01.018. Epub 2018 Feb 2.


Effects of Preceding Ethanol Intake on Glucose Response to Low-Dose Glucagon in Individuals With Type 1 Diabetes: A Randomized, Placebo-Controlled, Crossover Study.

Ranjan A, Nørgaard K, Tetzschner R, Steineck IIK, Clausen TR, Holst JJ, Madsbad S, Schmidt S.

Diabetes Care. 2018 Apr;41(4):797-806. doi: 10.2337/dc17-1458. Epub 2018 Jan 22.


Semaglutide seems to be more effective the other GLP-1Ras.

Holst JJ, Madsbad S.

Ann Transl Med. 2017 Dec;5(24):505. doi: 10.21037/atm.2017.11.10. No abstract available. Erratum in: Ann Transl Med. 2018 Feb;6(3):74.


Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB.

Engelbrechtsen L, Lundgren J, Wewer Albrechtsen NJ, Mahendran Y, Iepsen EW, Finocchietto P, Jonsson AE, Madsbad S, Holst JJ, Vestergaard H, Hansen T, Torekov SS.

Obes Sci Pract. 2017 Nov 21;3(4):425-433. doi: 10.1002/osp4.133. eCollection 2017 Dec.


Instrumentalization of Eating Improves Weight Loss Maintenance in Obesity.

Christensen BJ, Iepsen EW, Lundgren J, Holm L, Madsbad S, Holst JJ, Torekov SS.

Obes Facts. 2017;10(6):633-647. doi: 10.1159/000481138. Epub 2017 Dec 6.


Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.

Wewer Albrechtsen NJ, Kuhre RE, Hornburg D, Jensen CZ, Hornum M, Dirksen C, Svane M, Gasbjerg LS, Jørgensen NB, Gabe MN, Balk-Møller E, Albrechtsen R, Winther-Sørensen M, Galsgaard KD, Meissner F, Jorsal T, Lund A, Vilsbøll T, Eliasen R, Bojsen-Møller KN, Idorn T, Deacon CF, Knop FK, Rosenkilde MM, Hartmann B, Feldt-Rasmussen B, Mann M, Madsbad S, Holst JJ.

Cell Rep. 2017 Nov 7;21(6):1452-1460. doi: 10.1016/j.celrep.2017.10.034.

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