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Items: 1 to 50 of 109

1.

The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania.

Pawar H, Puri M, Fischer Weinberger R, Madhubala R, Zilberstein D.

PLoS Negl Trop Dis. 2019 Apr 24;13(4):e0007304. doi: 10.1371/journal.pntd.0007304. eCollection 2019 Apr.

2.

A Plant like Cytochrome P450 Subfamily CYP710C1 Gene in Leishmania donovani Encodes Sterol C-22 Desaturase and its Over-expression Leads to Resistance to Amphotericin B.

Bansal R, Sen SS, Muthuswami R, Madhubala R.

PLoS Negl Trop Dis. 2019 Apr 3;13(4):e0007260. doi: 10.1371/journal.pntd.0007260. eCollection 2019 Apr.

3.

Leishmania donovani Parasites Are Inhibited by the Benzoxaborole AN2690 Targeting Leucyl-tRNA Synthetase.

Manhas R, Tandon S, Sen SS, Tiwari N, Munde M, Madhubala R.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00079-18. doi: 10.1128/AAC.00079-18. Print 2018 Sep.

4.

Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target.

Chadha S, Vijayan R, Gupta S, Munde M, Gourinath S, Madhubala R.

PLoS Negl Trop Dis. 2018 Jun 13;12(6):e0006575. doi: 10.1371/journal.pntd.0006575. eCollection 2018 Jun.

5.

Genetic Validation of Leishmania donovani Lysyl-tRNA Synthetase Shows that It Is Indispensable for Parasite Growth and Infectivity.

Chadha S, Mallampudi NA, Mohapatra DK, Madhubala R.

mSphere. 2017 Aug 30;2(4). pii: e00340-17. doi: 10.1128/mSphereDirect.00340-17. eCollection 2017 Jul-Aug.

6.

The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity.

Mittal N, Muthuswami R, Madhubala R.

PLoS Negl Trop Dis. 2017 May 11;11(5):e0005590. doi: 10.1371/journal.pntd.0005590. eCollection 2017 May.

7.

MicroRNA expression profiling of Leishmania donovani-infected host cells uncovers the regulatory role of MIR30A-3p in host autophagy.

Singh AK, Pandey RK, Shaha C, Madhubala R.

Autophagy. 2016 Oct 2;12(10):1817-1831. Epub 2016 Jul 26.

8.

Twin Attributes of Tyrosyl-tRNA Synthetase of Leishmania donovani: A HOUSEKEEPING PROTEIN TRANSLATION ENZYME AND A MIMIC OF HOST CHEMOKINE.

Anand S, Madhubala R.

J Biol Chem. 2016 Aug 19;291(34):17754-71. doi: 10.1074/jbc.M116.727107. Epub 2016 Jul 5.

9.

Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase.

Manhas R, Gowri VS, Madhubala R.

J Biol Chem. 2016 Jan 15;291(3):1203-20. doi: 10.1074/jbc.M115.695007. Epub 2015 Nov 19.

11.

Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window.

Singh AK, Pandey RK, Siqueira-Neto JL, Kwon YJ, Freitas-Junior LH, Shaha C, Madhubala R.

Infect Immun. 2015 May;83(5):1853-68. doi: 10.1128/IAI.02833-14. Epub 2015 Feb 17.

12.

Cryptosporidium parvum has an active hypusine biosynthesis pathway.

Mittal N, Morada M, Tripathi P, Gowri VS, Mandal S, Quirch A, Park MH, Yarlett N, Madhubala R.

Mol Biochem Parasitol. 2014 Jun;195(1):14-22. doi: 10.1016/j.molbiopara.2014.05.005. Epub 2014 Jun 2.

13.

Leishmania genome analysis and high-throughput immunological screening identifies tuzin as a novel vaccine candidate against visceral leishmaniasis.

Lakshmi BS, Wang R, Madhubala R.

Vaccine. 2014 Jun 24;32(30):3816-22. doi: 10.1016/j.vaccine.2014.04.088. Epub 2014 May 9.

PMID:
24814525
14.

A quantitative proteomic screen to identify potential drug resistance mechanism in ╬▒-difluoromethylornithine (DFMO) resistant Leishmania donovani.

Singh AK, Roberts S, Ullman B, Madhubala R.

J Proteomics. 2014 May 6;102:44-59. doi: 10.1016/j.jprot.2014.02.030. Epub 2014 Mar 12.

PMID:
24631822
15.

Identification and functional characterization of a novel bacterial type asparagine synthetase A: a tRNA synthetase paralog from Leishmania donovani.

Manhas R, Tripathi P, Khan S, Sethu Lakshmi B, Lal SK, Gowri VS, Sharma A, Madhubala R.

J Biol Chem. 2014 Apr 25;289(17):12096-108. doi: 10.1074/jbc.M114.554642. Epub 2014 Mar 7.

16.

Deletion of Vitamin C biosynthesis enzyme, Arabino-1, 4-lactone oxidase in Leishmania donovani results in increased pro-inflammatory responses from host immune cells.

Manhas R, Anand S, Tripathi P, Madhubala R.

Mol Microbiol. 2014 Mar;91(6):1227-39. doi: 10.1111/mmi.12530. Epub 2014 Feb 21.

17.

Influence of Bacillus spp. strains on seedling growth and physiological parameters of sorghum under moisture stress conditions.

Grover M, Madhubala R, Ali SZ, Yadav SK, Venkateswarlu B.

J Basic Microbiol. 2014 Sep;54(9):951-61. doi: 10.1002/jobm.201300250. Epub 2013 Sep 11.

PMID:
24027209
18.

Structural insight into DFMO resistant ornithine decarboxylase from Entamoeba histolytica: an inkling to adaptive evolution.

Preeti, Tapas S, Kumar P, Madhubala R, Tomar S.

PLoS One. 2013;8(1):e53397. doi: 10.1371/journal.pone.0053397. Epub 2013 Jan 11.

19.

Visceral and post-Kala-Azar dermal leishmaniasis isolates show significant difference in their in vitro drug susceptibility pattern.

Mishra J, Madhubala R, Singh S.

Parasitol Res. 2013 Mar;112(3):1001-9. doi: 10.1007/s00436-012-3222-1. Epub 2012 Dec 18.

PMID:
23242321
20.

Unique posttranslational modifications in eukaryotic translation factors and their roles in protozoan parasite viability and pathogenesis.

Mittal N, Subramanian G, B├╝tikofer P, Madhubala R.

Mol Biochem Parasitol. 2013 Jan;187(1):21-31. doi: 10.1016/j.molbiopara.2012.11.001. Epub 2012 Nov 28. Review.

PMID:
23201129
21.

Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from Leishmania major.

Gowri VS, Ghosh I, Sharma A, Madhubala R.

BMC Genomics. 2012 Nov 14;13:621. doi: 10.1186/1471-2164-13-621.

22.
23.

A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani.

Chawla B, Kumar RR, Tyagi N, Subramanian G, Srinivasan N, Park MH, Madhubala R.

PLoS One. 2012;7(3):e33138. doi: 10.1371/journal.pone.0033138. Epub 2012 Mar 16.

24.

Biochemical, mutational and in silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica.

Preeti, Tapas S, Kumar P, Madhubala R, Tomar S.

PLoS Negl Trop Dis. 2012;6(2):e1559. doi: 10.1371/journal.pntd.0001559. Epub 2012 Feb 28.

25.

Paromomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycin -susceptible -resistant Leishmania donovani.

Chawla B, Jhingran A, Panigrahi A, Stuart KD, Madhubala R.

PLoS One. 2011;6(10):e26660. doi: 10.1371/journal.pone.0026660. Epub 2011 Oct 27.

26.

Characterization of Leishmania donovani aquaporins shows presence of subcellular aquaporins similar to tonoplast intrinsic proteins of plants.

Biyani N, Mandal S, Seth C, Saint M, Natarajan K, Ghosh I, Madhubala R.

PLoS One. 2011;6(9):e24820. doi: 10.1371/journal.pone.0024820. Epub 2011 Sep 28.

27.

[Leishmania donovani: structural insignt in the recognition of C-methylated analogues of spermidine as natural polyamine].

Mandal S, Khomutov MA, Simonian AP, Kochetkov SN, Madhubala R.

Mol Biol (Mosk). 2011 Jul-Aug;45(4):673-8. Russian.

PMID:
21954600
28.

Leishmania donovani encodes a functional enzyme involved in vitamin C biosynthesis: arabino-1,4-lactone oxidase.

Biyani N, Madhubala R.

Mol Biochem Parasitol. 2011 Dec;180(2):76-85. doi: 10.1016/j.molbiopara.2011.08.005. Epub 2011 Sep 3.

PMID:
21907739
29.

Differential expression of proteins in antimony-susceptible and -resistant isolates of Leishmania donovani.

Biyani N, Singh AK, Mandal S, Chawla B, Madhubala R.

Mol Biochem Parasitol. 2011 Oct;179(2):91-9. doi: 10.1016/j.molbiopara.2011.06.004. Epub 2011 Jun 25.

PMID:
21736901
30.

Drug targets in Leishmania.

Chawla B, Madhubala R.

J Parasit Dis. 2010 Apr;34(1):1-13. doi: 10.1007/s12639-010-0006-3. Epub 2010 Oct 8.

31.

Novel arylimidamides for treatment of visceral leishmaniasis.

Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA.

Antimicrob Agents Chemother. 2010 Jun;54(6):2507-16. doi: 10.1128/AAC.00250-10. Epub 2010 Apr 5.

32.

Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India.

Mandal S, Maharjan M, Singh S, Chatterjee M, Madhubala R.

J Antimicrob Chemother. 2010 Mar;65(3):496-507. doi: 10.1093/jac/dkp468. Epub 2010 Jan 12.

PMID:
20067981
33.

Novel convenient synthesis of biologically active esters of hydroxylamine.

Khomutov MA, Mandal S, Weisell J, Saxena N, Simonian AR, Vepsalainen J, Madhubala R, Kochetkov SN.

Amino Acids. 2010 Feb;38(2):509-17. doi: 10.1007/s00726-009-0410-0. Epub 2009 Dec 8.

PMID:
19997759
35.

Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani.

Chawla B, Jhingran A, Singh S, Tyagi N, Park MH, Srinivasan N, Roberts SC, Madhubala R.

J Biol Chem. 2010 Jan 1;285(1):453-63. doi: 10.1074/jbc.M109.048850. Epub 2009 Oct 30.

36.

Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification.

Chauhan SC, Madhubala R.

PLoS One. 2009 Aug 27;4(8):e6805. doi: 10.1371/journal.pone.0006805.

37.

High-throughput screening of amastigotes of Leishmania donovani clinical isolates against drugs using a colorimetric beta-lactamase assay.

Mandal S, Maharjan M, Ganguly S, Chatterjee M, Singh S, Buckner FS, Madhubala R.

Indian J Exp Biol. 2009 Jun;47(6):475-9.

38.

Paromomycin: uptake and resistance in Leishmania donovani.

Jhingran A, Chawla B, Saxena S, Barrett MP, Madhubala R.

Mol Biochem Parasitol. 2009 Apr;164(2):111-7. doi: 10.1016/j.molbiopara.2008.12.007. Epub 2008 Dec 25.

39.

Glyoxalase pathway of trypanosomatid parasites: a promising chemotherapeutic target.

Chauhan SC, Padmanabhan PK, Madhubala R.

Curr Drug Targets. 2008 Nov;9(11):957-65. Review.

PMID:
18991608
40.

A glutathione-specific aldose reductase of Leishmania donovani and its potential implications for methylglyoxal detoxification pathway.

Rath J, Gowri VS, Chauhan SC, Padmanabhan PK, Srinivasan N, Madhubala R.

Gene. 2009 Jan 15;429(1-2):1-9. doi: 10.1016/j.gene.2008.09.037. Epub 2008 Oct 15.

PMID:
18983902
41.

Novel agmatine analogue, gamma-guanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels.

Singh S, Jhingran A, Sharma A, Simonian AR, Soininen P, Vepsalainen J, Khomutov AR, Madhubala R.

Biochem Biophys Res Commun. 2008 Oct 10;375(1):168-72. doi: 10.1016/j.bbrc.2008.07.143. Epub 2008 Aug 8.

PMID:
18692480
42.

Role of aquaglyceroporin (AQP1) gene and drug uptake in antimony-resistant clinical isolates of Leishmania donovani.

Maharjan M, Singh S, Chatterjee M, Madhubala R.

Am J Trop Med Hyg. 2008 Jul;79(1):69-75.

PMID:
18606765
43.

Characterization and localization of ORFF gene from the LD1 locus of Leishmania donovani.

Jain M, Madhubala R.

Gene. 2008 Jun 15;416(1-2):1-10. doi: 10.1016/j.gene.2008.01.011. Epub 2008 Jan 26.

PMID:
18423903
44.

Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme.

Jhingran A, Padmanabhan PK, Singh S, Anamika K, Bakre AA, Bhattacharya S, Bhattacharya A, Srinivasan N, Madhubala R.

PLoS Negl Trop Dis. 2008 Jan 2;2(1):e115. doi: 10.1371/journal.pntd.0000115.

45.

Sodium sulphite enhances RNA isolation and sensitivity of Cucumber mosaic virus detection by RT-PCR in black pepper.

Siju S, Madhubala R, Bhat AI.

J Virol Methods. 2007 Apr;141(1):107-10. Epub 2007 Feb 2.

PMID:
17275931
46.

Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.

Mukherjee A, Padmanabhan PK, Singh S, Roy G, Girard I, Chatterjee M, Ouellette M, Madhubala R.

J Antimicrob Chemother. 2007 Feb;59(2):204-11. Epub 2007 Jan 9.

PMID:
17213267
47.

Antileishmanial effect of 3-aminooxy-1-aminopropane is due to polyamine depletion.

Singh S, Mukherjee A, Khomutov AR, Persson L, Heby O, Chatterjee M, Madhubala R.

Antimicrob Agents Chemother. 2007 Feb;51(2):528-34. Epub 2006 Nov 13.

48.

Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis.

Tewary P, Saxena S, Madhubala R.

Vaccine. 2006 Mar 20;24(13):2409-16. Epub 2005 Dec 12.

PMID:
16413950
49.

The sterol-binding antibiotic nystatin inhibits entry of non-opsonized Leishmania donovani into macrophages.

Tewary P, Veena K, Pucadyil TJ, Chattopadhyay A, Madhubala R.

Biochem Biophys Res Commun. 2006 Jan 13;339(2):661-6. Epub 2005 Nov 18.

PMID:
16310160
50.

Glyoxalase I from Leishmania donovani: a potential target for anti-parasite drug.

Padmanabhan PK, Mukherjee A, Singh S, Chattopadhyaya S, Gowri VS, Myler PJ, Srinivasan N, Madhubala R.

Biochem Biophys Res Commun. 2005 Dec 2;337(4):1237-48. Epub 2005 Oct 7.

PMID:
16236261

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