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Items: 11

1.

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A.

Rivero-Ríos P, Romo-Lozano M, Madero-Pérez J, Thomas AP, Biosa A, Greggio E, Hilfiker S.

J Biol Chem. 2019 Mar 29;294(13):4738-4758. doi: 10.1074/jbc.RA118.005008. Epub 2019 Feb 1.

2.

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A.

Madero-Pérez J, Fernández B, Lara Ordóñez AJ, Fdez E, Lobbestael E, Baekelandt V, Hilfiker S.

Front Mol Neurosci. 2018 Nov 13;11:417. doi: 10.3389/fnmol.2018.00417. eCollection 2018.

3.

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S.

Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y.

4.

Two-Pore Channels and Parkinson's Disease: Where's the Link?

Rivero-Ríos P, Fernández B, Madero-Pérez J, Lozano MR, Hilfiker S.

Messenger (Los Angel). 2016 Jun 1;5(1-2):67-75. doi: 10.1166/msr.2016.1051.

5.

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.

Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Madero-Pérez J, Gonnelli A, Drouyer M, Chartier-Harlin MC, Taymans JM, Bubacco L, Greggio E, Hilfiker S.

Hum Mol Genet. 2017 Jul 15;26(14):2747-2767. doi: 10.1093/hmg/ddx161.

6.

Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Romo Lozano M, Rivero-Ríos P, Hilfiker S.

Biochem Soc Trans. 2017 Feb 8;45(1):147-154. doi: 10.1042/BST20160392. Review.

PMID:
28202668
7.

LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.

Blanca Ramírez M, Madero-Perez J, Rivero-Rios P, Martinez-Salvador M, Lara Ordonez AJ, Fernandez B, Fdez E, Hilfiker S.

Curr Protein Pept Sci. 2017;18(7):677-686. doi: 10.2174/1389203717666160311121748. Review.

PMID:
26965688
8.

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.

Rivero-Ríos P, Madero-Pérez J, Fernández B, Hilfiker S.

Curr Neuropharmacol. 2016;14(3):238-49. Review.

9.

Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.

Rivero-Ríos P, Gómez-Suaga P, Fernández B, Madero-Pérez J, Schwab AJ, Ebert AD, Hilfiker S.

Biochem Soc Trans. 2015 Jun;43(3):390-5. doi: 10.1042/BST20140301.

PMID:
26009181
10.

Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease.

Gómez-Suaga P, Fdez E, Fernández B, Martínez-Salvador M, Blanca Ramírez M, Madero-Pérez J, Rivero-Ríos P, Fuentes JM, Hilfiker S.

Neuropharmacology. 2014 Oct;85:45-56. doi: 10.1016/j.neuropharm.2014.05.020. Epub 2014 May 24. Review.

PMID:
24863040
11.

[Percutaneous tracheostomy in ventilated patients].

Madero Pérez J, Vidal Tegedor B, Abizanda Campos R, Cubedo Bort M, Alvaro Sánchez R, Micó Gómez M.

Med Intensiva. 2007 Apr;31(3):120-5. Spanish.

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