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Items: 23


Investigating the Detrimental Effects of Low Pressure Plasma Sterilization on the Survival of Bacillus subtilis Spores Using Live Cell Microscopy.

Fuchs FM, Raguse M, Fiebrandt M, Madela K, Awakowicz P, Laue M, Stapelmann K, Moeller R.

J Vis Exp. 2017 Nov 30;(129). doi: 10.3791/56666.


Easy and low-cost stable positioning of suspension cells during live-cell imaging.

Ivanusic D, Madela K, Denner J.

J Biol Methods. 2017 Oct 17;4(4):e80. doi: 10.14440/jbm.2017.203. eCollection 2017.


Identification of Differentially Expressed Genes during Bacillus subtilis Spore Outgrowth in High-Salinity Environments Using RNA Sequencing.

Nagler K, Krawczyk AO, De Jong A, Madela K, Hoffmann T, Laue M, Kuipers OP, Bremer E, Moeller R.

Front Microbiol. 2016 Oct 6;7:1564. eCollection 2016.


Improvement of Biological Indicators by Uniformly Distributing Bacillus subtilis Spores in Monolayers To Evaluate Enhanced Spore Decontamination Technologies.

Raguse M, Fiebrandt M, Stapelmann K, Madela K, Laue M, Lackmann JW, Thwaite JE, Setlow P, Awakowicz P, Moeller R.

Appl Environ Microbiol. 2016 Jan 22;82(7):2031-2038. doi: 10.1128/AEM.03934-15.


Three-Dimensional Imaging of CD63 Recruitment at the Virological Synapse: HIV-1.

Ivanusic D, Madela K, Laue M, Denner J.

AIDS Res Hum Retroviruses. 2015 Jun;31(6):579-80. doi: 10.1089/AID.2014.0252. Epub 2015 May 11. No abstract available.


A simple procedure to analyze positions of interest in infectious cell cultures by correlative light and electron microscopy.

Madela K, Banhart S, Zimmermann A, Piesker J, Bannert N, Laue M.

Methods Cell Biol. 2014;124:93-110. doi: 10.1016/B978-0-12-801075-4.00005-7.


Visualization of HIV-1 budding structures.

Ivanusic D, Madela K, Laue M, Denner J.

AIDS Res Hum Retroviruses. 2014 Oct;30(10):945-6. doi: 10.1089/AID.2014.0228. No abstract available.


Improved plaque assay identifies a novel anti-Chlamydia ceramide derivative with altered intracellular localization.

Banhart S, Saied EM, Martini A, Koch S, Aeberhard L, Madela K, Arenz C, Heuer D.

Antimicrob Agents Chemother. 2014 Sep;58(9):5537-46. doi: 10.1128/AAC.03457-14. Epub 2014 Jul 7.


Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.

McGuigan C, Bourdin C, Derudas M, Hamon N, Hinsinger K, Kandil S, Madela K, Meneghesso S, Pertusati F, Serpi M, Slusarczyk M, Chamberlain S, Kolykhalov A, Vernachio J, Vanpouille C, Introini A, Margolis L, Balzarini J.

Eur J Med Chem. 2013;70:326-40. doi: 10.1016/j.ejmech.2013.09.047. Epub 2013 Oct 9.


Synthesis of phosphoramidate prodrugs: ProTide approach.

Serpi M, Madela K, Pertusati F, Slusarczyk M.

Curr Protoc Nucleic Acid Chem. 2013 Jun;Chapter 15:Unit15.5. doi: 10.1002/0471142700.nc1505s53.


Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs.

Madela K, McGuigan C.

Future Med Chem. 2012 Apr;4(5):625-50. doi: 10.4155/fmc.12.10. Review.


Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents.

McGuigan C, Madela K, Aljarah M, Bourdin C, Arrica M, Barrett E, Jones S, Kolykhalov A, Bleiman B, Bryant KD, Ganguly B, Gorovits E, Henson G, Hunley D, Hutchins J, Muhammad J, Obikhod A, Patti J, Walters CR, Wang J, Vernachio J, Ramamurty CV, Battina SK, Chamberlain S.

J Med Chem. 2011 Dec 22;54(24):8632-45. doi: 10.1021/jm2011673. Epub 2011 Nov 16.


Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.

McGuigan C, Madela K, Aljarah M, Gilles A, Battina SK, Ramamurty CV, Srinivas Rao C, Vernachio J, Hutchins J, Hall A, Kolykhalov A, Henson G, Chamberlain S.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):6007-12. doi: 10.1016/j.bmcl.2011.06.013. Epub 2011 Aug 17.


INX-08189, a phosphoramidate prodrug of 6-O-methyl-2'-C-methyl guanosine, is a potent inhibitor of hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties.

Vernachio JH, Bleiman B, Bryant KD, Chamberlain S, Hunley D, Hutchins J, Ames B, Gorovits E, Ganguly B, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters CR, Wang J, Williams K, Patti JM, Henson G, Madela K, Aljarah M, Gilles A, McGuigan C.

Antimicrob Agents Chemother. 2011 May;55(5):1843-51. doi: 10.1128/AAC.01335-10. Epub 2011 Feb 28.


Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus.

McGuigan C, Madela K, Aljarah M, Gilles A, Brancale A, Zonta N, Chamberlain S, Vernachio J, Hutchins J, Hall A, Ames B, Gorovits E, Ganguly B, Kolykhalov A, Wang J, Muhammad J, Patti JM, Henson G.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4850-4. doi: 10.1016/j.bmcl.2010.06.094. Epub 2010 Jun 20.


Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.

J Med Chem. 2010 Jul 8;53(13):4949-57. doi: 10.1021/jm1003792.


The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

McGuigan C, Perrone P, Madela K, Neyts J.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4316-20. doi: 10.1016/j.bmcl.2009.05.122. Epub 2009 Jun 10.


Role of galectin-3 in prion infections of the CNS.

Mok SW, Riemer C, Madela K, Hsu DK, Liu FT, Gültner S, Heise I, Baier M.

Biochem Biophys Res Commun. 2007 Aug 3;359(3):672-8. Epub 2007 Jun 4.


Propagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters.

Kratzel C, Mai J, Madela K, Beekes M, Krüger D.

Vet Res. 2007 Jan-Feb;38(1):127-39. Epub 2006 Dec 21.


Transcriptional activity of the host-interaction locus and a putative pilin gene of Bdellovibrio bacteriovorus in the predatory life cycle.

Schwudke D, Bernhardt A, Beck S, Madela K, Linscheid MW, Appel B, Strauch E.

Curr Microbiol. 2005 Nov;51(5):310-6. Epub 2005 Sep 29.


Characterization of enterocoliticin, a phage tail-like bacteriocin, and its effect on pathogenic Yersinia enterocolitica strains.

Strauch E, Kaspar H, Schaudinn C, Dersch P, Madela K, Gewinner C, Hertwig S, Wecke J, Appel B.

Appl Environ Microbiol. 2001 Dec;67(12):5634-42.


A novel technique for monitoring the development of bacterial biofilms in human periodontal pockets.

Wecke J, Kersten T, Madela K, Moter A, Göbel UB, Friedmann A, Bernimoulin J.

FEMS Microbiol Lett. 2000 Oct 1;191(1):95-101.


[Use of phototherapy for in newborns with pathologic jaundice].

Komar-Szymborska M, Szymborski J, Madeła K, Bajkacz M.

Wiad Lek. 1994 Apr;47(7-8):284-7. Polish.


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