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Laparoscopic hysterectomy as optimal approach for 5400 grams uterus with associated polycythemia: A case report.

Macciò A, Chiappe G, Lavra F, Sanna E, Nieddu R, Madeddu C.

World J Clin Cases. 2019 Oct 6;7(19):3027-3032. doi: 10.12998/wjcc.v7.i19.3027.


Systemic therapy for the treatment of endometrial cancer.

Neri M, Peiretti M, Melis GB, Piras B, Vallerino V, Paoletti AM, Madeddu C, Scartozzi M, Mais V.

Expert Opin Pharmacother. 2019 Nov;20(16):2019-2032. doi: 10.1080/14656566.2019.1654996. Epub 2019 Aug 26.


The mechanism of cancer cell death by PARP inhibitors goes beyond DNA damage alone.

Macciò A, Madeddu C.

Int J Cancer. 2019 Nov 1;145(9):2594-2596. doi: 10.1002/ijc.32392. Epub 2019 May 16. No abstract available.


Next generation sequencing driven successful combined treatment with laparoscopic surgery and immunotherapy for relapsed stage IVB cervical and synchronous stage IV lung cancer.

Madeddu C, Kotsonis P, Lavra F, Chiappe G, Melis L, Mura E, Scartozzi M, Macciò A.

Oncotarget. 2019 Mar 12;10(21):2012-2021. doi: 10.18632/oncotarget.26769. eCollection 2019 Mar 12.


Editorial: Biological Mechanism-Based and Patient-Centered Management of Cancer-Related Symptoms and Syndromes.

Macciò A, Busquets S, Madeddu C, Argilés JM.

Front Physiol. 2018 Dec 18;9:1819. doi: 10.3389/fphys.2018.01819. eCollection 2018. No abstract available.


Pathogenesis and Treatment Options of Cancer Related Anemia: Perspective for a Targeted Mechanism-Based Approach.

Madeddu C, Gramignano G, Astara G, Demontis R, Sanna E, Atzeni V, Macciò A.

Front Physiol. 2018 Sep 20;9:1294. doi: 10.3389/fphys.2018.01294. eCollection 2018. Review.


Future Prospects for PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Patients With Sarcomas.

Macciò A, Madeddu C.

JAMA Oncol. 2018 Aug 1;4(8):1134. doi: 10.1001/jamaoncol.2018.0875. No abstract available.


Microenvironmental M1 tumor-associated macrophage polarization influences cancer-related anemia in advanced ovarian cancer: key role of interleukin-6.

Madeddu C, Gramignano G, Kotsonis P, Coghe F, Atzeni V, Scartozzi M, Macciò A.

Haematologica. 2018 Sep;103(9):e388-e391. doi: 10.3324/haematol.2018.191551. Epub 2018 Apr 19. No abstract available.


Correction: Energy expenditure in caving.

Antoni G, Marini E, Curreli N, Tuveri V, Comandini O, Cabras S, Gabba S, Madeddu C, Crisafulli A, Rinaldi AC.

PLoS One. 2018 Apr 13;13(4):e0196028. doi: 10.1371/journal.pone.0196028. eCollection 2018.


Feasibility and safety of total laparoscopic hysterectomy for huge uteri without the use of uterine manipulator: description of emblematic cases.

Macciò A, Madeddu C, Kotsonis P, Chiappe G, Lavra F, Collu I, Demontis R.

Gynecol Surg. 2018;15(1):6. doi: 10.1186/s10397-018-1037-5. Epub 2018 Feb 26.


Abdominal leiomyosarcomatosis after surgery with external morcellation for occult smooth muscle tumors of uncertain malignant potential: A case report.

Macciò A, Chiappe G, Kotsonis P, Lavra F, Serra M, Demontis R, Madeddu C.

Int J Surg Case Rep. 2017;38:107-110. doi: 10.1016/j.ijscr.2017.07.020. Epub 2017 Jul 19.


Antimicrobial sulfonamides clear latent Kaposi sarcoma herpesvirus infection and impair MDM2-p53 complex formation.

Angius F, Piras E, Uda S, Madeddu C, Serpe R, Bigi R, Chen W, Dittmer DP, Pompei R, Ingianni A.

J Antibiot (Tokyo). 2017 Aug;70(9):962-966. doi: 10.1038/ja.2017.67. Epub 2017 Jun 14.


Laparoscopic removal of a very large uterus weighting 5320 g is feasible and safe: a case report.

Macciò A, Kotsonis P, Lavra F, Chiappe G, Sanna D, Zamboni F, Madeddu C.

BMC Surg. 2017 May 4;17(1):50. doi: 10.1186/s12893-017-0248-4.


Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link?

Pani F, Massidda M, Pusceddu V, Puzzoni M, Massa E, Madeddu C, Scartozzi M, Mariotti S.

Eur J Endocrinol. 2017 Jul;177(1):85-92. doi: 10.1530/EJE-17-0231. Epub 2017 May 3.


Validation of the CAchexia SCOre (CASCO). Staging Cancer Patients: The Use of miniCASCO as a Simplified Tool.

Argilés JM, Betancourt A, Guàrdia-Olmos J, Peró-Cebollero M, López-Soriano FJ, Madeddu C, Serpe R, Busquets S.

Front Physiol. 2017 Feb 17;8:92. doi: 10.3389/fphys.2017.00092. eCollection 2017.


Energy expenditure in caving.

Antoni G, Marini E, Curreli N, Tuveri V, Comandini O, Cabras S, Gabba S, Madeddu C, Crisafulli A, Rinaldi AC.

PLoS One. 2017 Feb 3;12(2):e0170853. doi: 10.1371/journal.pone.0170853. eCollection 2017. Erratum in: PLoS One. 2018 Apr 13;13(4):e0196028.


[Cancer cachexia assessment: new tools for oncologists.]

Serpe R, Demurtas L, Puzzoni M, Madeddu C, Scartozzi M.

Recenti Prog Med. 2016 Oct;107(10):515-524. doi: 10.1701/2454.25702. Review. Italian.


Pathophysiology of cardiotoxicity induced by nonanthracycline chemotherapy.

Madeddu C, Deidda M, Piras A, Cadeddu C, Demurtas L, Puzzoni M, Piscopo G, Scartozzi M, Mercuro G.

J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1 Special issue on Cardiotoxicity from Antiblastic Drugs and Cardioprotection:e12-e18. Review.


Combined laparoscopic excisional surgery for synchronous endometrial and rectal adenocarcinoma in an obese woman.

Macciò A, Lavra F, Chiappe G, Kotsonis P, Sollai G, Zamboni F, Madeddu C.

J Obstet Gynaecol. 2016 Nov;36(8):1012-1015. Epub 2016 Oct 18. No abstract available.


Timing of the negative effects of trastuzumab on cardiac mechanics after anthracycline chemotherapy.

Cadeddu C, Piras A, Dessì M, Madeddu C, Mantovani G, Scartozzi M, Hagendorff A, Colonna P, Mercuro G.

Int J Cardiovasc Imaging. 2017 Feb;33(2):197-207. doi: 10.1007/s10554-016-0987-9. Epub 2016 Oct 1.


α2A adrenergic receptors highly expressed in mesoprefrontal dopamine neurons.

Castelli MP, Spiga S, Perra A, Madeddu C, Mulas G, Ennas MG, Gessa GL.

Neuroscience. 2016 Sep 22;332:130-9. doi: 10.1016/j.neuroscience.2016.06.037. Epub 2016 Jun 27.


Long-Term Survival in a Patient With Abdominal Sarcomatosis From Uterine Leiomyosarcoma: Role of Repeated Laparoscopic Surgery in Treatment and Follow-Up.

Macciò A, Kotsonis P, Chiappe G, Melis L, Zamboni F, Madeddu C.

J Minim Invasive Gynecol. 2016 Sep-Oct;23(6):1003-8. doi: 10.1016/j.jmig.2016.05.005. Epub 2016 May 24.


Pathophysiology of cardiotoxicity induced by nonanthracycline chemotherapy.

Madeddu C, Deidda M, Piras A, Cadeddu C, Demurtas L, Puzzoni M, Piscopo G, Scartozzi M, Mercuro G.

J Cardiovasc Med (Hagerstown). 2016 May;17 Suppl 1:S12-8. doi: 10.2459/JCM.0000000000000376. Review.


The role of "closed abdomen" hyperthermic intraperitoneal chemotherapy (HIPEC) in the palliative treatment of neoplastic ascites from peritoneal carcinomatosis: report of a single-center experience.

Orgiano L, Pani F, Astara G, Madeddu C, Marini S, Manca A, Mantovani G.

Support Care Cancer. 2016 Oct;24(10):4293-9. doi: 10.1007/s00520-016-3262-7. Epub 2016 May 12.


Surgical outcome and complications of total laparoscopic hysterectomy for very large myomatous uteri in relation to uterine weight: a prospective study in a continuous series of 461 procedures.

Macciò A, Chiappe G, Kotsonis P, Nieddu R, Lavra F, Serra M, Onnis P, Sollai G, Zamboni F, Madeddu C.

Arch Gynecol Obstet. 2016 Sep;294(3):525-31. doi: 10.1007/s00404-016-4075-0. Epub 2016 Mar 25.


High-density lipoprotein contribute to G0-G1/S transition in Swiss NIH/3T3 fibroblasts.

Angius F, Spolitu S, Uda S, Deligia S, Frau A, Banni S, Collu M, Accossu S, Madeddu C, Serpe R, Batetta B.

Sci Rep. 2015 Dec 7;5:17812. doi: 10.1038/srep17812.


Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent.

Frau L, Costa G, Porceddu PF, Khairnar A, Castelli MP, Ennas MG, Madeddu C, Wardas J, Morelli M.

J Neurochem. 2016 Jan;136(1):148-62. doi: 10.1111/jnc.13377. Epub 2015 Nov 6.


Muscle wasting as main evidence of energy impairment in cancer cachexia: future therapeutic approaches.

Madeddu C, Mantovani G, Gramignano G, Astara G, Macciò A.

Future Oncol. 2015 Oct;11(19):2697-2710. doi: 10.2217/fon.15.195. Epub 2015 Sep 17.


Advances in pharmacologic strategies for cancer cachexia.

Madeddu C, Mantovani G, Gramignano G, Macciò A.

Expert Opin Pharmacother. 2015;16(14):2163-77. doi: 10.1517/14656566.2015.1079621. Epub 2015 Sep 2. Review.


A Multitargeted Treatment Approach for Anemia and Cachexia in Metastatic Castration-Resistant Prostate Cancer.

Macciò A, Gramignano G, Madeddu C.

J Pain Symptom Manage. 2015 Aug;50(2):e1-4. doi: 10.1016/j.jpainsymman.2015.04.014. Epub 2015 May 21. No abstract available.


Cardioprotection by gene therapy: A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology.

Madonna R, Cadeddu C, Deidda M, Giricz Z, Madeddu C, Mele D, Monte I, Novo G, Pagliaro P, Pepe A, Spallarossa P, Tocchetti CG, Varga ZV, Zito C, Geng YJ, Mercuro G, Ferdinandy P.

Int J Cardiol. 2015 Jul 15;191:203-10. doi: 10.1016/j.ijcard.2015.04.232. Epub 2015 May 1. Review.


Endodontic infection and endothelial dysfunction are associated with different mechanisms in men and women.

Cotti E, Zedda A, Deidda M, Piras A, Flore G, Ideo F, Madeddu C, Pau VM, Mercuro G.

J Endod. 2015 May;41(5):594-600. doi: 10.1016/j.joen.2015.01.037. Epub 2015 Mar 19.


Surprising results of a supportive integrated therapy in myelofibrosis.

Macciò A, Gramignano G, Madeddu C.

Nutrition. 2015 Jan;31(1):239-43. doi: 10.1016/j.nut.2014.07.016. Epub 2014 Aug 6.


Role of inflammation and oxidative stress in post-menopausal oestrogen-dependent breast cancer.

Madeddu C, Gramignano G, Floris C, Murenu G, Sollai G, Macciò A.

J Cell Mol Med. 2014 Dec;18(12):2519-29. doi: 10.1111/jcmm.12413. Epub 2014 Oct 22.


The role of inflammation, iron, and nutritional status in cancer-related anemia: results of a large, prospective, observational study.

Macciò A, Madeddu C, Gramignano G, Mulas C, Tanca L, Cherchi MC, Floris C, Omoto I, Barracca A, Ganz T.

Haematologica. 2015 Jan;100(1):124-32. doi: 10.3324/haematol.2014.112813. Epub 2014 Sep 19.


Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats.

Melis M, Sagheddu C, De Felice M, Casti A, Madeddu C, Spiga S, Muntoni AL, Mackie K, Marsicano G, Colombo G, Castelli MP, Pistis M.

J Neurosci. 2014 Sep 17;34(38):12716-24. doi: 10.1523/JNEUROSCI.1844-14.2014.


Ovarian hyperstimulation in premenopausal women during adjuvant tamoxifen treatment for endocrine-dependent breast cancer: A report of two cases.

Madeddu C, Gramignano G, Kotsonis P, Paribello F, Macciò A.

Oncol Lett. 2014 Sep;8(3):1279-1282. Epub 2014 Jul 4.


Large twisted ovarian fibroma associated with Meigs' syndrome, abdominal pain and severe anemia treated by laparoscopic surgery.

Macciò A, Madeddu C, Kotsonis P, Pietrangeli M, Paoletti AM.

BMC Surg. 2014 Jun 24;14:38. doi: 10.1186/1471-2482-14-38.


Δ9-tetrahydrocannabinol prevents methamphetamine-induced neurotoxicity.

Castelli MP, Madeddu C, Casti A, Casu A, Casti P, Scherma M, Fattore L, Fadda P, Ennas MG.

PLoS One. 2014 May 20;9(5):e98079. doi: 10.1371/journal.pone.0098079. eCollection 2014.


Successful laparoscopic management of a giant ovarian cyst.

Macciò A, Madeddu C, Kotsonis P, Pietrangeli M, Paoletti AM.

J Obstet Gynaecol. 2014 Oct;34(7):651-2. doi: 10.3109/01443615.2014.902432. Epub 2014 Apr 30. No abstract available.


Treatment of irradiated expanders: protective lipofilling allows immediate prosthetic breast reconstruction in the setting of postoperative radiotherapy.

Ribuffo D, Atzeni M, Guerra M, Bucher S, Politi C, Deidda M, Atzori F, Dessi M, Madeddu C, Lay G.

Aesthetic Plast Surg. 2013 Dec;37(6):1146-52. doi: 10.1007/s00266-013-0221-2. Epub 2013 Oct 10.


The role of interleukin-6 in the evolution of ovarian cancer: clinical and prognostic implications--a review.

Macciò A, Madeddu C.

J Mol Med (Berl). 2013 Dec;91(12):1355-68. doi: 10.1007/s00109-013-1080-7. Epub 2013 Sep 21. Review.


Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome.

Mantovani G, Madeddu C, Macciò A.

Drug Des Devel Ther. 2013 Aug 12;7:645-56. doi: 10.2147/DDDT.S39771. eCollection 2013. Retraction in: Drug Des Devel Ther. 2013;7:1385.


Cisplatin : an old drug with a newfound efficacy -- from mechanisms of action to cytotoxicity.

Macciò A, Madeddu C.

Expert Opin Pharmacother. 2013 Sep;14(13):1839-57. doi: 10.1517/14656566.2013.813934. Epub 2013 Jul 22. Review.


Long-term, up to 18 months, protective effects of the angiotensin II receptor blocker telmisartan on Epirubin-induced inflammation and oxidative stress assessed by serial strain rate.

Dessì M, Madeddu C, Piras A, Cadeddu C, Antoni G, Mercuro G, Mantovani G.

Springerplus. 2013 Apr 30;2(1):198. doi: 10.1186/2193-1801-2-198. Print 2013 Dec.


PPARα regulates cholinergic-driven activity of midbrain dopamine neurons via a novel mechanism involving α7 nicotinic acetylcholine receptors.

Melis M, Scheggi S, Carta G, Madeddu C, Lecca S, Luchicchi A, Cadeddu F, Frau R, Fattore L, Fadda P, Ennas MG, Castelli MP, Fratta W, Schilstrom B, Banni S, De Montis MG, Pistis M.

J Neurosci. 2013 Apr 3;33(14):6203-11. doi: 10.1523/JNEUROSCI.4647-12.2013.


Management of anemia of inflammation in the elderly.

Macciò A, Madeddu C.

Anemia. 2012;2012:563251. doi: 10.1155/2012/563251. Epub 2012 Oct 3.


Current pharmacotherapy options for cancer anorexia and cachexia.

Macciò A, Madeddu C, Mantovani G.

Expert Opin Pharmacother. 2012 Dec;13(17):2453-72. doi: 10.1517/14656566.2012.734297. Epub 2012 Oct 17. Review.


Long-term protective effects of the angiotensin receptor blocker telmisartan on epirubicin-induced inflammation, oxidative stress and myocardial dysfunction.

Dessì M, Piras A, Madeddu C, Cadeddu C, Deidda M, Massa E, Antoni G, Mantovani G, Mercuro G.

Exp Ther Med. 2011 Sep;2(5):1003-1009. Epub 2011 Jun 30.


Multitargeted treatment of cancer cachexia.

Madeddu C, Maccio A, Mantovani G.

Crit Rev Oncog. 2012;17(3):305-14. Review.


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