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Items: 22


Assessment of tumor redox status through (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid positron emission tomography imaging of system xc- activity.

McCormick PN, Greenwood HE, Glaser M, Maddocks ODK, Gendron T, Sander K, Gowrishankar G, Hoehne A, Zhang T, Shuhendler AJ, Lewis DY, Berndt M, Koglin N, Lythgoe MF, Gambhir SS, Årstad E, Witney TH.

Cancer Res. 2018 Nov 6. pii: canres.2634.2018. doi: 10.1158/0008-5472.CAN-18-2634. [Epub ahead of print]


A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila.

Scopelliti A, Bauer C, Yu Y, Zhang T, Kruspig B, Murphy DJ, Vidal M, Maddocks ODK, Cordero JB.

Cell Metab. 2018 Oct 15. pii: S1550-4131(18)30629-6. doi: 10.1016/j.cmet.2018.09.021. [Epub ahead of print]


Direct Estimation of Metabolic Flux by Heavy Isotope Labeling Simultaneous with Pathway Inhibition: Metabolic Flux Inhibition Assay.

Zhang T, Labuschagne CF, Vousden KH, Maddocks ODK.

Methods Mol Biol. 2019;1862:109-119. doi: 10.1007/978-1-4939-8769-6_8.


Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH.

Nature. 2017 Aug 2;548(7665):122. doi: 10.1038/nature23471.


Serine and Functional Metabolites in Cancer.

Newman AC, Maddocks ODK.

Trends Cell Biol. 2017 Sep;27(9):645-657. doi: 10.1016/j.tcb.2017.05.001. Epub 2017 Jun 7. Review.


Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.

Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI.

J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31.


One-carbon metabolism in cancer.

Newman AC, Maddocks ODK.

Br J Cancer. 2017 Jun 6;116(12):1499-1504. doi: 10.1038/bjc.2017.118. Epub 2017 May 4. Review.


Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH.

Nature. 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056. Erratum in: Nature. 2017 Aug 2;548(7665):122.


Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.

Maddocks OD, Labuschagne CF, Adams PD, Vousden KH.

Mol Cell. 2016 Jan 21;61(2):210-21. doi: 10.1016/j.molcel.2015.12.014. Epub 2016 Jan 7.


Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.

Carroll B, Maetzel D, Maddocks OD, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI.

Elife. 2016 Jan 7;5. pii: e11058. doi: 10.7554/eLife.11058.


PHD1 regulates p53-mediated colorectal cancer chemoresistance.

Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M.

EMBO Mol Med. 2015 Oct;7(10):1350-65. doi: 10.15252/emmm.201505492.


A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM.

Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Review.


Localization of NADPH production: a wheel within a wheel.

Maddocks OD, Labuschagne CF, Vousden KH.

Mol Cell. 2014 Jul 17;55(2):158-60. doi: 10.1016/j.molcel.2014.07.001. Erratum in: Mol Cell. 2014 Nov 20;56(4):608.


Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

Labuschagne CF, van den Broek NJ, Mackay GM, Vousden KH, Maddocks OD.

Cell Rep. 2014 May 22;7(4):1248-58. doi: 10.1016/j.celrep.2014.04.045. Epub 2014 May 10.


iRFP is a sensitive marker for cell number and tumor growth in high-throughput systems.

Hock AK, Lee P, Maddocks OD, Mason SM, Blyth K, Vousden KH.

Cell Cycle. 2014;13(2):220-6. doi: 10.4161/cc.26985. Epub 2013 Oct 31.


Metabolic regulation by p53 family members.

Berkers CR, Maddocks OD, Cheung EC, Mor I, Vousden KH.

Cell Metab. 2013 Nov 5;18(5):617-33. doi: 10.1016/j.cmet.2013.06.019. Epub 2013 Aug 15. Review.


An Escherichia coli effector protein promotes host mutation via depletion of DNA mismatch repair proteins.

Maddocks OD, Scanlon KM, Donnenberg MS.

MBio. 2013 Jun 18;4(3):e00152-13. doi: 10.1128/mBio.00152-13.


Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Maddocks OD, Berkers CR, Mason SM, Zheng L, Blyth K, Gottlieb E, Vousden KH.

Nature. 2013 Jan 24;493(7433):542-6. doi: 10.1038/nature11743. Epub 2012 Dec 16.


Serine is a natural ligand and allosteric activator of pyruvate kinase M2.

Chaneton B, Hillmann P, Zheng L, Martin ACL, Maddocks ODK, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O'Reilly M, Gottlieb E.

Nature. 2012 Nov 15;491(7424):458-462. doi: 10.1038/nature11540. Epub 2012 Oct 14. Erratum in: Nature. 2013 Apr 18;496(7445):386.


Metabolic regulation by p53.

Maddocks OD, Vousden KH.

J Mol Med (Berl). 2011 Mar;89(3):237-45. doi: 10.1007/s00109-011-0735-5. Epub 2011 Feb 23. Review. Erratum in: J Mol Med. 2011 May;89(5):531.


Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans.

Maddocks OD, Short AJ, Donnenberg MS, Bader S, Harrison DJ.

PLoS One. 2009;4(5):e5517. doi: 10.1371/journal.pone.0005517. Epub 2009 May 13.


Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).

Patek CE, Brownstein DG, Fleming S, Wroe C, Rose L, Webb A, Berry RL, Devenney PS, Walker M, Maddocks OD, Lawrence NJ, Harrison DJ, Wood KM, Miles CG, Hooper ML.

Transgenic Res. 2008 Jun;17(3):459-75. Epub 2007 Nov 27.


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