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Items: 11

1.

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).

Wehn PM, Rizzi JP, Dixon DD, Grina JA, Schlachter ST, Wang B, Xu R, Yang H, Du X, Han G, Wang K, Cao Z, Cheng T, Czerwinski RM, Goggin BS, Huang H, Halfmann MM, Maddie MA, Morton EL, Olive SR, Tan H, Xie S, Wong T, Josey JA, Wallace EM.

J Med Chem. 2018 Nov 8;61(21):9691-9721. doi: 10.1021/acs.jmedchem.8b01196. Epub 2018 Oct 18.

PMID:
30289716
2.

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.

Wallace EM, Rizzi JP, Han G, Wehn PM, Cao Z, Du X, Cheng T, Czerwinski RM, Dixon DD, Goggin BS, Grina JA, Halfmann MM, Maddie MA, Olive SR, Schlachter ST, Tan H, Wang B, Wang K, Xie S, Xu R, Yang H, Josey JA.

Cancer Res. 2016 Sep 15;76(18):5491-500. doi: 10.1158/0008-5472.CAN-16-0473. Epub 2016 Sep 6.

3.

Deletion of the pro-apoptotic endoplasmic reticulum stress response effector CHOP does not result in improved locomotor function after severe contusive spinal cord injury.

Ohri SS, Maddie MA, Zhang Y, Shields CB, Hetman M, Whittemore SR.

J Neurotrauma. 2012 Feb 10;29(3):579-88. doi: 10.1089/neu.2011.1940. Epub 2011 Nov 21.

4.

Attenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury.

Ohri SS, Maddie MA, Zhao Y, Qiu MS, Hetman M, Whittemore SR.

Glia. 2011 Oct;59(10):1489-502. doi: 10.1002/glia.21191. Epub 2011 Jun 2.

5.

Angiogenic potential of microvessel fragments is independent of the tissue of origin and can be influenced by the cellular composition of the implants.

Nunes SS, Krishnan L, Gerard CS, Dale JR, Maddie MA, Benton RL, Hoying JB.

Microcirculation. 2010 Oct;17(7):557-67. doi: 10.1111/j.1549-8719.2010.00052.x.

6.

Rescuing vasculature with intravenous angiopoietin-1 and alpha v beta 3 integrin peptide is protective after spinal cord injury.

Han S, Arnold SA, Sithu SD, Mahoney ET, Geralds JT, Tran P, Benton RL, Maddie MA, D'Souza SE, Whittemore SR, Hagg T.

Brain. 2010 Apr;133(Pt 4):1026-42. doi: 10.1093/brain/awq034. Erratum in: Brain. 2011 May;134(Pt 5):1575.

7.

Transcriptional activation of endothelial cells by TGFβ coincides with acute microvascular plasticity following focal spinal cord ischaemia/reperfusion injury.

Benton RL, Maddie MA, Dincman TA, Hagg T, Whittemore SR.

ASN Neuro. 2009 Aug 26;1(3). pii: e00015. doi: 10.1042/AN20090008.

8.
9.

ADAM8 is selectively up-regulated in endothelial cells and is associated with angiogenesis after spinal cord injury in adult mice.

Mahoney ET, Benton RL, Maddie MA, Whittemore SR, Hagg T.

J Comp Neurol. 2009 Jan 10;512(2):243-55. doi: 10.1002/cne.21902.

10.

Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury.

Benton RL, Maddie MA, Worth CA, Mahoney ET, Hagg T, Whittemore SR.

J Cereb Blood Flow Metab. 2008 Nov;28(11):1771-85. doi: 10.1038/jcbfm.2008.76. Epub 2008 Jul 9.

11.

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