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Items: 31


Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine.

Gachechiladze M, Tichý T, Kolek V, Grygárková I, Klein J, Mgebrishvili G, Kharaishvili G, Janíková M, Smičková P, Cierna L, Pitson S, Maddelein ML, Cuvillier O, Škarda J.

Oncol Lett. 2019 Aug;18(2):1259-1266. doi: 10.3892/ol.2019.10447. Epub 2019 Jun 7.


Pharmacomodulation on Gold-NHC complexes for anticancer applications - is lipophilicity the key point?

Zhang C, Maddelein ML, Wai-Yin Sun R, Gornitzka H, Cuvillier O, Hemmert C.

Eur J Med Chem. 2018 Sep 5;157:320-332. doi: 10.1016/j.ejmech.2018.07.070. Epub 2018 Aug 2.


Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain.

Dominguez G, Maddelein ML, Pucelle M, Nicaise Y, Maurage CA, Duyckaerts C, Cuvillier O, Delisle MB.

Acta Neuropathol Commun. 2018 Apr 3;6(1):25. doi: 10.1186/s40478-018-0527-z.


Discovery of novel inhibitors of amyloid β-peptide 1-42 aggregation.

López LC, Dos-Reis S, Espargaró A, Carrodeguas JA, Maddelein ML, Ventura S, Sancho J.

J Med Chem. 2012 Nov 26;55(22):9521-30. doi: 10.1021/jm301186p. Epub 2012 Oct 22.


The mechanism of prion inhibition by HET-S.

Greenwald J, Buhtz C, Ritter C, Kwiatkowski W, Choe S, Maddelein ML, Ness F, Cescau S, Soragni A, Leitz D, Saupe SJ, Riek R.

Mol Cell. 2010 Jun 25;38(6):889-99. doi: 10.1016/j.molcel.2010.05.019.


Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity.

Perrone L, Mothes E, Vignes M, Mockel A, Figueroa C, Miquel MC, Maddelein ML, Faller P.

Chembiochem. 2010 Jan 4;11(1):110-8. doi: 10.1002/cbic.200900474.


A non-Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast.

Taneja V, Maddelein ML, Talarek N, Saupe SJ, Liebman SW.

Mol Cell. 2007 Jul 6;27(1):67-77.


Prion and non-prion amyloids of the HET-s prion forming domain.

Sabaté R, Baxa U, Benkemoun L, Sánchez de Groot N, Coulary-Salin B, Maddelein ML, Malato L, Ventura S, Steven AC, Saupe SJ.

J Mol Biol. 2007 Jul 20;370(4):768-83. Epub 2007 May 22.


Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide.

Gomez-Brouchet A, Pchejetski D, Brizuela L, Garcia V, Altié MF, Maddelein ML, Delisle MB, Cuvillier O.

Mol Pharmacol. 2007 Aug;72(2):341-9. Epub 2007 May 23.


Infectious fold and amyloid propagation in Podospora anserina.

Maddelein ML.

Prion. 2007 Jan-Mar;1(1):44-7. Epub 2007 Jan 28. Review.


Methods for the in vivo and in vitro analysis of [Het-s] prion infectivity.

Benkemoun L, Sabaté R, Malato L, Dos Reis S, Dalstra H, Saupe SJ, Maddelein ML.

Methods. 2006 May;39(1):61-7.


Correlation of structural elements and infectivity of the HET-s prion.

Ritter C, Maddelein ML, Siemer AB, Lührs T, Ernst M, Meier BH, Saupe SJ, Riek R.

Nature. 2005 Jun 9;435(7043):844-8.


Amyloid aggregates of the HET-s prion protein are infectious.

Maddelein ML, Dos Reis S, Duvezin-Caubet S, Coulary-Salin B, Saupe SJ.

Proc Natl Acad Sci U S A. 2002 May 28;99(11):7402-7.


In vivo aggregation of the HET-s prion protein of the fungus Podospora anserina.

Coustou-Linares V, Maddelein ML, Bégueret J, Saupe SJ.

Mol Microbiol. 2001 Dec;42(5):1325-35.


A novel Rtg2p activity regulates nitrogen catabolism in yeast.

Pierce MM, Maddelein ML, Roberts BT, Wickner RB.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13213-8. Epub 2001 Oct 30.


[URE3] and [PSI] are prions of yeast and evidence for new fungal prions.

Masison DC, Edskes HK, Maddelein ML, Taylor KL, Wickner RB.

Curr Issues Mol Biol. 2000 Apr;2(2):51-9. Review.


Yeast prions act as genes composed of self-propagating protein amyloids.

Wickner RB, Taylor KL, Edskes HK, Maddelein ML, Moriyama H, Roberts BT.

Adv Protein Chem. 2001;57:313-34. Review. No abstract available.


Prions of yeast from cytoplasmic genes to heritable amyloidosis.

Wickner RB, Edskes HK, Taylor KL, Maddelein ML, Moriyama H, Tibor Roberts B.

Methods Mol Med. 2001;59:237-67. doi: 10.1385/1-59259-134-5:237.


Prions of yeast as heritable amyloidoses.

Wickner RB, Taylor KL, Edskes HK, Maddelein ML, Moriyama H, Roberts BT.

J Struct Biol. 2000 Jun;130(2-3):310-22. Review.


Prions: Portable prion domains.

Wickner RB, Taylor KL, Edskes HK, Maddelein ML.

Curr Biol. 2000 May 4;10(9):R335-7. Review.


Prions in Saccharomyces and Podospora spp.: protein-based inheritance.

Wickner RB, Taylor KL, Edskes HK, Maddelein ML, Moriyama H, Roberts BT.

Microbiol Mol Biol Rev. 1999 Dec;63(4):844-61, table of contents. Review.


Two prion-inducing regions of Ure2p are nonoverlapping.

Maddelein ML, Wickner RB.

Mol Cell Biol. 1999 Jun;19(6):4516-24.


Prions of yeast and fungi. Proteins as genetic material.

Wickner RB, Edskes HK, Maddelein ML, Taylor KL, Moriyama H.

J Biol Chem. 1999 Jan 8;274(2):555-8. Review. No abstract available.


The prion model for [URE3] of yeast: spontaneous generation and requirements for propagation.

Masison DC, Maddelein ML, Wickner RB.

Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12503-8.


Preamylopectin Processing: A Mandatory Step for Starch Biosynthesis in Plants.

Mouille G, Maddelein ML, Libessart N, Talaga P, Decq A, Delrue B, Ball S.

Plant Cell. 1996 Aug;8(8):1353-1366.


Prions of yeast, [PSI] and [URE3], as models for neurodegenerative diseases.

Wickner RB, Masison DC, Edskes HK, Maddelein ML.

Cold Spring Harb Symp Quant Biol. 1996;61:541-50. Review. No abstract available.


Storage, Photosynthesis, and Growth: The Conditional Nature of Mutations Affecting Starch Synthesis and Structure in Chlamydomonas.

Libessart N, Maddelein ML, Koornhuyse N, Decq A, Delrue B, Mouille G, D'Hulst C, Ball S.

Plant Cell. 1995 Aug;7(8):1117-1127.


Toward an understanding of the biogenesis of the starch granule. Determination of granule-bound and soluble starch synthase functions in amylopectin synthesis.

Maddelein ML, Libessart N, Bellanger F, Delrue B, D'Hulst C, Van den Koornhuyse N, Fontaine T, Wieruszeski JM, Decq A, Ball S.

J Biol Chem. 1994 Oct 7;269(40):25150-7.


Toward an understanding of the biogenesis of the starch granule. Evidence that Chlamydomonas soluble starch synthase II controls the synthesis of intermediate size glucans of amylopectin.

Fontaine T, D'Hulst C, Maddelein ML, Routier F, Pépin TM, Decq A, Wieruszeski JM, Delrue B, Van den Koornhuyse N, Bossu JP, et al.

J Biol Chem. 1993 Aug 5;268(22):16223-30.


Waxy Chlamydomonas reinhardtii: monocellular algal mutants defective in amylose biosynthesis and granule-bound starch synthase activity accumulate a structurally modified amylopectin.

Delrue B, Fontaine T, Routier F, Decq A, Wieruszeski JM, Van Den Koornhuyse N, Maddelein ML, Fournet B, Ball S.

J Bacteriol. 1992 Jun;174(11):3612-20.

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