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Items: 31


Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation.

Yombo DJK, Mentink-Kane MM, Wilson MS, Wynn TA, Madala SK.

J Biol Chem. 2019 Oct 11;294(41):15082-15094. doi: 10.1074/jbc.RA119.009145. Epub 2019 Aug 20.


Dysregulation of Mesenchymal Cell Survival Pathways in Severe Fibrotic Lung Disease: The Effect of Nintedanib Therapy.

Kasam RK, Reddy GB, Jegga AG, Madala SK.

Front Pharmacol. 2019 May 17;10:532. doi: 10.3389/fphar.2019.00532. eCollection 2019.


Longitudinal free-breathing MRI measurement of murine lung physiology in a progressive model of lung fibrosis.

Guo J, Hardie WD, Cleveland ZI, Davidson C, Xu X, Madala SK, Woods JC.

J Appl Physiol (1985). 2019 Apr 1;126(4):1138-1149. doi: 10.1152/japplphysiol.00993.2018. Epub 2019 Feb 7.


New therapeutics based on emerging concepts in pulmonary fibrosis.

Sontake V, Gajjala PR, Kasam RK, Madala SK.

Expert Opin Ther Targets. 2019 Jan;23(1):69-81. doi: 10.1080/14728222.2019.1552262. Epub 2018 Nov 28. Review.


Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease.

Sontake V, Kasam RK, Sinner D, Korfhagen TR, Reddy GB, White ES, Jegga AG, Madala SK.

JCI Insight. 2018 Aug 23;3(16). pii: 121252. doi: 10.1172/jci.insight.121252. eCollection 2018 Aug 23.


Subacute TGFβ expression drives inflammation, goblet cell hyperplasia, and pulmonary function abnormalities in mice with effects dependent on CFTR function.

Kramer EL, Hardie WD, Madala SK, Davidson C, Clancy JP.

Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L456-L465. doi: 10.1152/ajplung.00530.2017. Epub 2018 Jun 7.


Extracellular small heat shock proteins: exosomal biogenesis and function.

Reddy VS, Madala SK, Trinath J, Reddy GB.

Cell Stress Chaperones. 2018 May;23(3):441-454. doi: 10.1007/s12192-017-0856-z. Epub 2017 Oct 30. Review.


Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers.

Wang Y, Yella J, Chen J, McCormack FX, Madala SK, Jegga AG.

BMC Pulm Med. 2017 Oct 20;17(1):133. doi: 10.1186/s12890-017-0472-9.


Repetitive intradermal bleomycin injections evoke T-helper cell 2 cytokine-driven pulmonary fibrosis.

Singh B, Kasam RK, Sontake V, Wynn TA, Madala SK.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L796-L806. doi: 10.1152/ajplung.00184.2017. Epub 2017 Aug 3.


Hsp90 regulation of fibroblast activation in pulmonary fibrosis.

Sontake V, Wang Y, Kasam RK, Sinner D, Reddy GB, Naren AP, McCormack FX, White ES, Jegga AG, Madala SK.

JCI Insight. 2017 Feb 23;2(4):e91454. doi: 10.1172/jci.insight.91454.


Correction: IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.

Singh B, Jegga AG, Shanmukhappa KS, Edukulla R, Khurana Hershey GK, Medvedovic M, Dillon SR, Madala SK.

PLoS One. 2017 Jan 23;12(1):e0170446. doi: 10.1371/journal.pone.0170446. eCollection 2017.


IL-31-Driven Skin Remodeling Involves Epidermal Cell Proliferation and Thickening That Lead to Impaired Skin-Barrier Function.

Singh B, Jegga AG, Shanmukhappa KS, Edukulla R, Khurana Hershey GH, Medvedovic M, Dillon SR, Madala SK.

PLoS One. 2016 Aug 24;11(8):e0161877. doi: 10.1371/journal.pone.0161877. eCollection 2016. Erratum in: PLoS One. 2017 Jan 23;12 (1):e0170446. Khurana, Gurjit H [corrected to Khurana Hershey, Gurjit H].


Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis.

Madala SK, Sontake V, Edukulla R, Davidson CR, Schmidt S, Hardie WD.

Am J Respir Cell Mol Biol. 2016 Dec;55(6):792-803.


Mechanisms of Lung Fibrosis Resolution.

Glasser SW, Hagood JS, Wong S, Taype CA, Madala SK, Hardie WD.

Am J Pathol. 2016 May;186(5):1066-77. doi: 10.1016/j.ajpath.2016.01.018. Epub 2016 Mar 25. Review.


p70 ribosomal S6 kinase regulates subpleural fibrosis following transforming growth factor-α expression in the lung.

Madala SK, Thomas G, Edukulla R, Davidson C, Schmidt S, Schehr A, Hardie WD.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15;310(2):L175-86. doi: 10.1152/ajplung.00063.2015. Epub 2015 Nov 13.


Fibrocytes Regulate Wilms Tumor 1-Positive Cell Accumulation in Severe Fibrotic Lung Disease.

Sontake V, Shanmukhappa SK, DiPasquale BA, Reddy GB, Medvedovic M, Hardie WD, White ES, Madala SK.

J Immunol. 2015 Oct 15;195(8):3978-91. doi: 10.4049/jimmunol.1500963. Epub 2015 Sep 14.


Cardiac metabolic pathways affected in the mouse model of barth syndrome.

Huang Y, Powers C, Madala SK, Greis KD, Haffey WD, Towbin JA, Purevjav E, Javadov S, Strauss AW, Khuchua Z.

PLoS One. 2015 Jun 1;10(6):e0128561. doi: 10.1371/journal.pone.0128561. eCollection 2015.


Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression.

Edukulla R, Singh B, Jegga AG, Sontake V, Dillon SR, Madala SK.

J Biol Chem. 2015 May 22;290(21):13510-20. doi: 10.1074/jbc.M114.622126. Epub 2015 Apr 6.


Reply: tissue fibrocytes are a subpopulation of macrophages.

Madala SK.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):138. doi: 10.1165/rcmb.2014-0218LE. No abstract available.


Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.

Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L726-35. doi: 10.1152/ajplung.00357.2013. Epub 2014 Feb 7.


Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

Madala SK, Edukulla R, Phatak M, Schmidt S, Davidson C, Acciani TH, Korfhagen TR, Medvedovic M, Lecras TD, Wagner K, Hardie WD.

PLoS One. 2014 Jan 27;9(1):e86536. doi: 10.1371/journal.pone.0086536. eCollection 2014.


Bone marrow-derived stromal cells are invasive and hyperproliferative and alter transforming growth factor-α-induced pulmonary fibrosis.

Madala SK, Edukulla R, Schmidt S, Davidson C, Ikegami M, Hardie WD.

Am J Respir Cell Mol Biol. 2014 Apr;50(4):777-86. doi: 10.1165/rcmb.2013-0042OC.


Resistin-like molecule α1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis.

Madala SK, Edukulla R, Davis KR, Schmidt S, Davidson C, Kitzmiller JA, Hardie WD, Korfhagen TR.

Respir Res. 2012 Jun 22;13:51. doi: 10.1186/1465-9921-13-51.


MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation.

Madala SK, Schmidt S, Davidson C, Ikegami M, Wert S, Hardie WD.

Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8. doi: 10.1165/rcmb.2011-0237OC. Epub 2011 Oct 20.


Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2.

Mentink-Kane MM, Cheever AW, Wilson MS, Madala SK, Beers LM, Ramalingam TR, Wynn TA.

Gastroenterology. 2011 Dec;141(6):2200-9. doi: 10.1053/j.gastro.2011.08.008. Epub 2011 Aug 22.


Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice.

Madala SK, Maxfield MD, Davidson CR, Schmidt SM, Garry D, Ikegami M, Hardie WD, Glasser SW.

Pulm Med. 2011;2011:653524. doi: 10.1155/2011/653524. Epub 2011 Mar 21.


Quantitative assessment of macrophage functions in repair and fibrosis.

Wynn TA, Barron L, Thompson RW, Madala SK, Wilson MS, Cheever AW, Ramalingam T.

Curr Protoc Immunol. 2011 Apr;Chapter 14:Unit14.22. doi: 10.1002/0471142735.im1422s93.


Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis.

Madala SK, Dolan MA, Sharma D, Ramalingam TR, Wilson MS, Mentink-Kane MM, Masison DC, Wynn TA.

Proteins. 2011 Jan;79(1):282-93. doi: 10.1002/prot.22881.


Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity.

Wilson MS, Ramalingam TR, Rivollier A, Shenderov K, Mentink-Kane MM, Madala SK, Cheever AW, Artis D, Kelsall BL, Wynn TA.

Gastroenterology. 2011 Jan;140(1):254-64. doi: 10.1053/j.gastro.2010.09.047. Epub 2010 Oct 14.


Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis.

Madala SK, Pesce JT, Ramalingam TR, Wilson MS, Minnicozzi S, Cheever AW, Thompson RW, Mentink-Kane MM, Wynn TA.

J Immunol. 2010 Apr 1;184(7):3955-63. doi: 10.4049/jimmunol.0903008. Epub 2010 Feb 24.


Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent.

Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA.

J Exp Med. 2010 Mar 15;207(3):535-52. doi: 10.1084/jem.20092121. Epub 2010 Feb 22.

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