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Items: 33


Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance.

Kulkoyluoglu-Cotul E, Smith BP, Wrobel K, Zhao YC, Chen KLA, Hieronymi K, Imir OB, Duong K, O'Callaghan C, Mehta A, Sahoo S, Haley B, Chang H, Landesman Y, Madak-Erdogan Z.

Cancers (Basel). 2019 Apr 4;11(4). pii: E479. doi: 10.3390/cancers11040479.


Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling.

Madak-Erdogan Z, Band S, Zhao YC, Smith BP, Kulkoyluoglu-Cotul E, Zuo Q, Santaliz Casiano A, Wrobel K, Rossi G, Smith RL, Kim SH, Katzenellenbogen JA, Johnson ML, Patel M, Marino N, Storniolo AMV, Flaws JA.

Cancer Res. 2019 May 15;79(10):2494-2510. doi: 10.1158/0008-5472.CAN-18-2849. Epub 2019 Mar 12.


Crosstalk between Estrogen Signaling and Breast Cancer Metabolism.

Kulkoyluoglu-Cotul E, Arca A, Madak-Erdogan Z.

Trends Endocrinol Metab. 2019 Jan;30(1):25-38. doi: 10.1016/j.tem.2018.10.006. Epub 2018 Nov 22. Review.


Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community.

Chen KLA, Liu X, Zhao YC, Hieronymi K, Rossi G, Auvil LS, Welge M, Bushell C, Smith RL, Carlson KE, Kim SH, Katzenellenbogen JA, Miller MJ, Madak-Erdogan Z.

Sci Rep. 2018 May 25;8(1):8166. doi: 10.1038/s41598-018-26506-1.


Urban Neighborhood and Residential Factors Associated with Breast Cancer in African American Women: a Systematic Review.

Smith BP, Madak-Erdogan Z.

Horm Cancer. 2018 Apr;9(2):71-81. doi: 10.1007/s12672-018-0325-x. Epub 2018 Feb 7.


Bazedoxifene and conjugated estrogen combination maintains metabolic homeostasis and benefits liver health.

Chen KLA, Zhao YC, Hieronymi K, Smith BP, Madak-Erdogan Z.

PLoS One. 2017 Dec 21;12(12):e0189911. doi: 10.1371/journal.pone.0189911. eCollection 2017.


Estrogens and female liver health.

Chen KL, Madak-Erdogan Z.

Steroids. 2018 May;133:38-43. doi: 10.1016/j.steroids.2017.10.015. Epub 2017 Nov 1. Review.


Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators.

Madak-Erdogan Z, Charn TH, Jiang Y, Liu ET, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Syst Biol. 2017 Apr 25;13(4):929. doi: 10.15252/msb.20177595. No abstract available.


Impact of Diet and Nutrition on Cancer Hallmarks.

Chen KL, Jung P, Kulkoyluoglu-Cotul E, Liguori C, Lumibao J, Mazewski C, Ranard K, Rowles JL 3rd, Wang Y, Xue L, Madak-Erdogan Z.

J Cancer Prev Curr Res. 2017;7(4). pii: 240. doi: 10.15406/jcpcr.2017.07.00240. Epub 2017 Feb 17.


Estrogen and Microbiota Crosstalk: Should We Pay Attention?

Chen KL, Madak-Erdogan Z.

Trends Endocrinol Metab. 2016 Nov;27(11):752-755. doi: 10.1016/j.tem.2016.08.001. Epub 2016 Aug 20.


Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.

Chambliss KL, Barrera J, Umetani M, Umetani J, Kim SH, Madak-Erdogan Z, Huang L, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW.

Endocrinology. 2016 Oct;157(10):3731-3741. Epub 2016 Aug 23.


Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells.

Gong P, Madak-Erdogan Z, Flaws JA, Shapiro DJ, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Cell Endocrinol. 2016 Dec 5;437:190-200. doi: 10.1016/j.mce.2016.08.025. Epub 2016 Aug 16.


ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization.

Wrobel K, Zhao YC, Kulkoyluoglu E, Chen KL, Hieronymi K, Holloway J, Li S, Ray T, Ray PS, Landesman Y, Lipka AE, Smith RL, Madak-Erdogan Z.

Mol Endocrinol. 2016 Oct;30(10):1029-1045. Epub 2016 Aug 17.


Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer.

Kulkoyluoglu E, Madak-Erdogan Z.

Steroids. 2016 Oct;114:41-47. doi: 10.1016/j.steroids.2016.06.007. Epub 2016 Jul 6. Review.


Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues.

Madak-Erdogan Z, Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen BS.

Sci Signal. 2016 May 24;9(429):ra53. doi: 10.1126/scisignal.aad8170.


Science Signaling podcast for 24 May 2016: Designer estrogens.

Katzenellenbogen BS, Katzenellenbogen JA, Madak-Erdogan Z, VanHook AM.

Sci Signal. 2016 May 24;9(429):pc12. doi: 10.1126/scisignal.aag1040.


Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer.

Zhao YC, Madak Erdogan Z.

J Vis Exp. 2016 Mar 17;(109). doi: 10.3791/53832.


Differential utilization of nuclear and extranuclear receptor signaling pathways in the actions of estrogens, SERMs, and a tissue-selective estrogen complex (TSEC).

Madak-Erdogan Z, Gong P, Katzenellenbogen BS.

J Steroid Biochem Mol Biol. 2016 Apr;158:198-206. doi: 10.1016/j.jsbmb.2015.12.008. Epub 2015 Dec 12.


Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland.

Madak-Erdogan Z, Gong P, Zhao YC, Xu L, Wrobel KU, Hartman JA, Wang M, Cam A, Iwaniec UT, Turner RT, Twaddle NC, Doerge DR, Khan IA, Katzenellenbogen JA, Katzenellenbogen BS, Helferich WG.

Mol Nutr Food Res. 2016 Feb;60(2):369-80. doi: 10.1002/mnfr.201500445. Epub 2015 Nov 10.


Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History.

Kim SH, Madak-Erdogan Z, Bae SC, Carlson KE, Mayne CG, Granick S, Katzenellenbogen BS, Katzenellenbogen JA.

J Am Chem Soc. 2015 Aug 19;137(32):10326-35. doi: 10.1021/jacs.5b05952. Epub 2015 Aug 10.


Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens.

Gong P, Madak-Erdogan Z, Li J, Cheng J, Greenlief CM, Helferich W, Katzenellenbogen JA, Katzenellenbogen BS.

Nucl Recept Signal. 2014 Sep 12;12:e001. doi: 10.1621/nrs.12001. eCollection 2014.


The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells.

Bergamaschi A, Madak-Erdogan Z, Kim YJ, Choi YL, Lu H, Katzenellenbogen BS.

Breast Cancer Res. 2014 Sep 12;16(5):436. doi: 10.1186/s13058-014-0436-4.


Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer.

Madak-Erdogan Z, Ventrella R, Petry L, Katzenellenbogen BS.

Mol Cancer Res. 2014 May;12(5):714-27. doi: 10.1158/1541-7786.MCR-13-0588. Epub 2014 Feb 6.


Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens.

Jiang Y, Gong P, Madak-Erdogan Z, Martin T, Jeyakumar M, Carlson K, Khan I, Smillie TJ, Chittiboyina AG, Rotte SC, Helferich WG, Katzenellenbogen JA, Katzenellenbogen BS.

FASEB J. 2013 Nov;27(11):4406-18. doi: 10.1096/fj.13-234617. Epub 2013 Jul 23.


Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators.

Madak-Erdogan Z, Charn TH, Jiang Y, Liu ET, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Syst Biol. 2013 Jun 18;9:676. doi: 10.1038/msb.2013.28. Erratum in: Mol Syst Biol. 2017 Apr 25;13(4):929.


A MicroRNA196a2* and TP63 circuit regulated by estrogen receptor-α and ERK2 that controls breast cancer proliferation and invasiveness properties.

Kim K, Madak-Erdogan Z, Ventrella R, Katzenellenbogen BS.

Horm Cancer. 2013 Apr;4(2):78-91. doi: 10.1007/s12672-012-0129-3. Epub 2012 Dec 19.


Macrophage-elicited loss of estrogen receptor-α in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus.

Stossi F, Madak-Erdoğan Z, Katzenellenbogen BS.

Oncogene. 2012 Apr 5;31(14):1825-34. doi: 10.1038/onc.2011.370. Epub 2011 Aug 22.


Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs.

Madak-Erdogan Z, Lupien M, Stossi F, Brown M, Katzenellenbogen BS.

Mol Cell Biol. 2011 Jan;31(1):226-36. doi: 10.1128/MCB.00821-10. Epub 2010 Oct 18.


Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice.

Chambliss KL, Wu Q, Oltmann S, Konaniah ES, Umetani M, Korach KS, Thomas GD, Mineo C, Yuhanna IS, Kim SH, Madak-Erdogan Z, Maggi A, Dineen SP, Roland CL, Hui DY, Brekken RA, Katzenellenbogen JA, Katzenellenbogen BS, Shaul PW.

J Clin Invest. 2010 Jul;120(7):2319-30. doi: 10.1172/JCI38291. Epub 2010 Jun 23.


Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1.

Stossi F, Madak-Erdogan Z, Katzenellenbogen BS.

Mol Cell Biol. 2009 Apr;29(7):1749-59. doi: 10.1128/MCB.01476-08. Epub 2009 Feb 2.


Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors.

Madak-Erdogan Z, Kieser KJ, Kim SH, Komm B, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Endocrinol. 2008 Sep;22(9):2116-27. doi: 10.1210/me.2008-0059. Epub 2008 Jul 10.


Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action.

Harrington WR, Kim SH, Funk CC, Madak-Erdogan Z, Schiff R, Katzenellenbogen JA, Katzenellenbogen BS.

Mol Endocrinol. 2006 Mar;20(3):491-502. Epub 2005 Nov 23.


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