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Research Culture and Reproducibility.

Munafò MR, Chambers CD, Collins AM, Fortunato L, Macleod MR.

Trends Cogn Sci. 2019 Dec 28. pii: S1364-6613(19)30290-6. doi: 10.1016/j.tics.2019.12.002. [Epub ahead of print]


Design of Meta-Analysis Studies.

Macleod MR, Tanriver-Ayder E, Hair K, Sena E.

Handb Exp Pharmacol. 2019 Oct 17. doi: 10.1007/164_2019_289. [Epub ahead of print]


Ischaemic stroke.

Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM, Donnan GA.

Nat Rev Dis Primers. 2019 Oct 10;5(1):70. doi: 10.1038/s41572-019-0118-8. Review.


The reproducibility opportunity.

Macleod MR.

Nat Hum Behav. 2018 Sep;2(9):616-617. doi: 10.1038/s41562-018-0398-0. No abstract available.


Designer Sinorhizobium meliloti strains and multi-functional vectors enable direct inter-kingdom DNA transfer.

Brumwell SL, MacLeod MR, Huang T, Cochrane RR, Meaney RS, Zamani M, Matysiakiewicz O, Dan KN, Janakirama P, Edgell DR, Charles TC, Finan TM, Karas BJ.

PLoS One. 2019 Jun 17;14(6):e0206781. doi: 10.1371/journal.pone.0206781. eCollection 2019. Erratum in: PLoS One. 2019 Jul 9;14(7):e0219562.


A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus).

Hair K, Macleod MR, Sena ES; IICARus Collaboration.

Res Integr Peer Rev. 2019 Jun 12;4:12. doi: 10.1186/s41073-019-0069-3. eCollection 2019.


Compressive Pressure Versus Time in Cauda Equina Syndrome: A Systematic Review and Meta-Analysis of Experimental Studies.

Pronin S, Koh CH, Bulovaite E, Macleod MR, Statham PF.

Spine (Phila Pa 1976). 2019 Sep 1;44(17):1238-1247. doi: 10.1097/BRS.0000000000003045.


Identifying stroke therapeutics from preclinical models: A protocol for a novel application of network meta-analysis.

Lalu MM, Fergusson DA, Cheng W, Avey MT, Corbett D, Dowlatshahi D, Macleod MR, Sena ES, Moher D, Shorr R, McCann SK, Gray LJ, Hill MD, O'Connor A, Thayer K, Haggar F, Dobriyal A, Chung HS, Welton NJ, Hutton B.

F1000Res. 2019 Jan 3;8:11. doi: 10.12688/f1000research.15869.1. eCollection 2019.


Machine learning algorithms for systematic review: reducing workload in a preclinical review of animal studies and reducing human screening error.

Bannach-Brown A, Przybyła P, Thomas J, Rice ASC, Ananiadou S, Liao J, Macleod MR.

Syst Rev. 2019 Jan 15;8(1):23. doi: 10.1186/s13643-019-0942-7.


PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. Rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment.

Reinink H, de Jonge JC, Bath PM, van de Beek D, Berge E, Borregaard S, Ciccone A, Csiba L, Demotes J, Dippel DW, Kõrv J, Kurkowska-Jastrzebska I, Lees KR, Macleod MR, Ntaios G, Randall G, Thomalla G, van der Worp HB.

Eur Stroke J. 2018 Sep;3(3):291-298. doi: 10.1177/2396987318772687. Epub 2018 Apr 30.


Transparency in the reporting of in vivo pre-clinical pain research: The relevance and implications of the ARRIVE (Animal Research: Reporting In Vivo Experiments) guidelines.

Rice ASC, Morland R, Huang W, Currie GL, Sena ES, Macleod MR.

Scand J Pain. 2013 Apr 1;4(2):58-62. doi: 10.1016/j.sjpain.2013.02.002.


Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30.


Effect size and statistical power in the rodent fear conditioning literature - A systematic review.

Carneiro CFD, Moulin TC, Macleod MR, Amaral OB.

PLoS One. 2018 Apr 26;13(4):e0196258. doi: 10.1371/journal.pone.0196258. eCollection 2018. Review.


NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons.

Antonic A, Dottori M, Macleod MR, Donnan GA, Howells DW.

J Stroke Cerebrovasc Dis. 2018 Aug;27(8):2158-2165. doi: 10.1016/j.jstrokecerebrovasdis.2018.03.015. Epub 2018 Apr 16.


A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models.

Jue TR, Sena ES, Macleod MR, McDonald KL, Hirst TC.

Oncotarget. 2018 Jan 29;9(13):11387-11401. doi: 10.18632/oncotarget.24334. eCollection 2018 Feb 16.


Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies.

Hooijmans CR, de Vries RBM, Ritskes-Hoitinga M, Rovers MM, Leeflang MM, IntHout J, Wever KE, Hooft L, de Beer H, Kuijpers T, Macleod MR, Sena ES, Ter Riet G, Morgan RL, Thayer KA, Rooney AA, Guyatt GH, Schünemann HJ, Langendam MW; GRADE Working Group.

PLoS One. 2018 Jan 11;13(1):e0187271. doi: 10.1371/journal.pone.0187271. eCollection 2018. Review.


Correction: D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices.

Sadigh-Eteghad S, Majdi A, McCann SK, Mahmoudi J, Vafaee MS, Macleod MR.

PLoS One. 2017 Dec 21;12(12):e0190328. doi: 10.1371/journal.pone.0190328. eCollection 2017.


Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke.

Winkel P, Bath PM, Gluud C, Lindschou J, van der Worp HB, Macleod MR, Szabo I, Durand-Zaleski I, Schwab S; EuroHYP-1 trial investigators.

Trials. 2017 Nov 29;18(1):573. doi: 10.1186/s13063-017-2302-z.


Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE.

Simonato M, Iyengar S, Brooks-Kayal A, Collins S, Depaulis A, Howells DW, Jensen F, Liao J, Macleod MR, Patel M, Potschka H, Walker M, Whittemore V, Sena ES.

Epilepsia. 2017 Nov;58 Suppl 4:68-77. doi: 10.1111/epi.13908.


Risk of bias reporting in the recent animal focal cerebral ischaemia literature.

Bahor Z, Liao J, Macleod MR, Bannach-Brown A, McCann SK, Wever KE, Thomas J, Ottavi T, Howells DW, Rice A, Ananiadou S, Sena E.

Clin Sci (Lond). 2017 Oct 12;131(20):2525-2532. doi: 10.1042/CS20160722. Print 2017 Oct 15. Review.


Standardized mean differences cause funnel plot distortion in publication bias assessments.

Zwetsloot PP, Van Der Naald M, Sena ES, Howells DW, IntHout J, De Groot JA, Chamuleau SA, MacLeod MR, Wever KE.

Elife. 2017 Sep 8;6. pii: e24260. doi: 10.7554/eLife.24260.


D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices.

Sadigh-Eteghad S, Majdi A, McCann SK, Mahmoudi J, Vafaee MS, Macleod MR.

PLoS One. 2017 Aug 30;12(8):e0184122. doi: 10.1371/journal.pone.0184122. eCollection 2017. Review. Erratum in: PLoS One. 2017 Dec 21;12 (12 ):e0190328.


Development of a psychological intervention for fatigue after stroke.

Wu S, Chalder T, Anderson KE, Gillespie D, Macleod MR, Mead GE.

PLoS One. 2017 Aug 17;12(8):e0183286. doi: 10.1371/journal.pone.0183286. eCollection 2017.


The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments).

Percie du Sert N, Alfieri A, Allan SM, Carswell HV, Deuchar GA, Farr TD, Flecknell P, Gallagher L, Gibson CL, Haley MJ, Macleod MR, McColl BW, McCabe C, Morancho A, Moon LD, O'Neill MJ, Pérez de Puig I, Planas A, Ragan CI, Rosell A, Roy LA, Ryder KO, Simats A, Sena ES, Sutherland BA, Tricklebank MD, Trueman RC, Whitfield L, Wong R, Macrae IM.

J Cereb Blood Flow Metab. 2017 Nov;37(11):3488-3517. doi: 10.1177/0271678X17709185. Epub 2017 Aug 11. Review.


Alpha Calcitonin Gene-Related Peptide Increases Cerebral Vessel Diameter in Animal Models of Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis.

Flynn LMC, Begg CJ, Macleod MR, Andrews PJD.

Front Neurol. 2017 Jul 25;8:357. doi: 10.3389/fneur.2017.00357. eCollection 2017. Review.


Increasing value and reducing waste in stroke research.

Berge E, Al-Shahi Salman R, van der Worp HB, Stapf C, Sandercock P, Sprigg N, Macleod MR, Kelly PJ, Nederkoorn PJ, Ford GA; European Stroke Organisation Trials Network Committee.

Lancet Neurol. 2017 May;16(5):399-408. doi: 10.1016/S1474-4422(17)30078-9. Review.


Improving our understanding of the in vivo modelling of psychotic disorders: A protocol for a systematic review and meta-analysis.

Bahor Z, Nunes-Fonseca C, Thomson LD, Sena ES, Macleod MR.

Evid Based Preclin Med. 2016 Dec;3(2):e00022. doi: 10.1002/ebm2.22. Epub 2017 Mar 17. Review.


Conjugal amyotrophic lateral sclerosis: a case report from Scotland.

Fernandes PM, Macleod MR, Bateman A, Abrahams S, Pal S.

BMC Neurol. 2017 Mar 29;17(1):64. doi: 10.1186/s12883-017-0847-9.


No publication without confirmation.

Mogil JS, Macleod MR.

Nature. 2017 Feb 22;542(7642):409-411. doi: 10.1038/542409a. No abstract available.


Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials.

Rewell SS, Churilov L, Sidon TK, Aleksoska E, Cox SF, Macleod MR, Howells DW.

PLoS One. 2017 Feb 9;12(2):e0171688. doi: 10.1371/journal.pone.0171688. eCollection 2017.


Hypothermia revisited: Impact of ischaemic duration and between experiment variability.

Rewell SS, Jeffreys AL, Sastra SA, Cox SF, Fernandez JA, Aleksoska E, van der Worp HB, Churilov L, Macleod MR, Howells DW.

J Cereb Blood Flow Metab. 2017 Oct;37(10):3380-3390. doi: 10.1177/0271678X16688704. Epub 2017 Jan 13.


Protocol for meta-analysis of temperature reduction in animal models of cardiac arrest.

Olai H, Thornéus G, Watson H, Macleod MR, Friberg H, Rhodes J, Nielsen N, Cronberg T, Deierborg T.

Evid Based Preclin Med. 2016 Aug;3(1):e00014. Epub 2016 May 3.


Multicenter Evaluation of Geometric Accuracy of MRI Protocols Used in Experimental Stroke.

Milidonis X, Lennen RJ, Jansen MA, Mueller S, Boehm-Sturm P, Holmes WM, Sena ES, Macleod MR, Marshall I.

PLoS One. 2016 Sep 7;11(9):e0162545. doi: 10.1371/journal.pone.0162545. eCollection 2016.


The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease.

Egan KJ, Vesterinen HM, McCann SK, Sena ES, MacLeod MR.

Evid Based Preclin Med. 2015 Aug;2(1):e00010. Epub 2015 Aug 11.


Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor Antagonist in Animal Models of Stroke: an Update.

McCann SK, Cramond F, Macleod MR, Sena ES.

Transl Stroke Res. 2016 Oct;7(5):395-406. doi: 10.1007/s12975-016-0489-z. Epub 2016 Aug 15. Review.


From a mouse: systematic analysis reveals limitations of experiments testing interventions in Alzheimer's disease mouse models.

Egan KJ, Vesterinen HM, Beglopoulos V, Sena ES, Macleod MR.

Evid Based Preclin Med. 2016 Aug;3(1):e00015. doi: 10.1002/ebm2.15. Epub 2016 Jul 22. Review.


Protocol for a Systematic Review of Effect Sizes and Statistical Power in the Rodent Fear Conditioning Literature.

Moulin TC, Carneiro CFD, Macleod MR, Amaral OB.

Evid Based Preclin Med. 2016 Jul 31;3(1). pii: e00016. doi: 10.1002/ebm2.16.


The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis.

Chen J, Yang C, Guo B, Sena ES, Macleod MR, Yuan Y, Hirst TC.

PLoS One. 2016 Jul 27;11(7):e0158240. doi: 10.1371/journal.pone.0158240. eCollection 2016. Review.


A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals.

Vandenberg LN, Ågerstrand M, Beronius A, Beausoleil C, Bergman Å, Bero LA, Bornehag CG, Boyer CS, Cooper GS, Cotgreave I, Gee D, Grandjean P, Guyton KZ, Hass U, Heindel JJ, Jobling S, Kidd KA, Kortenkamp A, Macleod MR, Martin OV, Norinder U, Scheringer M, Thayer KA, Toppari J, Whaley P, Woodruff TJ, Rudén C.

Environ Health. 2016 Jul 14;15(1):74. doi: 10.1186/s12940-016-0156-6. Review.


Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis.

Watzlawick R, Rind J, Sena ES, Brommer B, Zhang T, Kopp MA, Dirnagl U, Macleod MR, Howells DW, Schwab JM.

PLoS Biol. 2016 May 31;14(5):e1002468. doi: 10.1371/journal.pbio.1002468. eCollection 2016 May.


Cardiac Stem Cell Treatment in Myocardial Infarction: A Systematic Review and Meta-Analysis of Preclinical Studies.

Zwetsloot PP, Végh AM, Jansen of Lorkeers SJ, van Hout GP, Currie GL, Sena ES, Gremmels H, Buikema JW, Goumans MJ, Macleod MR, Doevendans PA, Chamuleau SA, Sluijter JP.

Circ Res. 2016 Apr 15;118(8):1223-32. doi: 10.1161/CIRCRESAHA.115.307676. Epub 2016 Feb 17. Review.


Corrigendum to 'Meta-analysis of data from animal studies: A practical guide': [Journal of Neuroscience Methods 221 (2014) 92-102].

Vesterinen HM, Sena ES, Egan KJ, Hirst TC, Churolov L, Currie GL, Antonic A, Howells DW, Macleod MR.

J Neurosci Methods. 2016 Feb 1;259:156. doi: 10.1016/j.jneumeth.2015.11.021. Epub 2015 Dec 12. No abstract available.


Correction: Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.

Macleod MR, Lawson McLean A, Kyriakopoulou A, Serghiou S, de Wilde A, Sherratt N, Hirst T, Hemblade R, Bahor Z, Nunes-Fonseca C, Potluru A, Thomson A, Baginskaite J, Egan K, Vesterinen H, Currie GL, Churilov L, Howells DW, Sena ES.

PLoS Biol. 2015 Nov 10;13(11):e1002301. doi: 10.1371/journal.pbio.1002301. eCollection 2015 Nov.


Translational failure of anti-inflammatory compounds for myocardial infarction: a meta-analysis of large animal models.

van Hout GP, Jansen of Lorkeers SJ, Wever KE, Sena ES, Kouwenberg LH, van Solinge WW, Macleod MR, Doevendans PA, Pasterkamp G, Chamuleau SA, Hoefer IE.

Cardiovasc Res. 2016 Feb 1;109(2):240-8. doi: 10.1093/cvr/cvv239. Epub 2015 Oct 20.


Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.

Macleod MR, Lawson McLean A, Kyriakopoulou A, Serghiou S, de Wilde A, Sherratt N, Hirst T, Hemblade R, Bahor Z, Nunes-Fonseca C, Potluru A, Thomson A, Baginskaite J, Egan K, Vesterinen H, Currie GL, Churilov L, Howells DW, Sena ES.

PLoS Biol. 2015 Oct 13;13(10):e1002273. doi: 10.1371/journal.pbio.1002273. eCollection 2015 Oct. Erratum in: PLoS Biol. 2015 Nov;13(11):e1002301. Baginskitae, Julija [corrected to Baginskaite, Julija].


Interventions for post-stroke fatigue.

Wu S, Kutlubaev MA, Chun HY, Cowey E, Pollock A, Macleod MR, Dennis M, Keane E, Sharpe M, Mead GE.

Cochrane Database Syst Rev. 2015 Jul 2;(7):CD007030. doi: 10.1002/14651858.CD007030.pub3. Review.


Increasing value and reducing waste in animal models of rheumatological disease.

Currie GL, Macleod MR.

Int J Rheum Dis. 2015 Jun;18(5):485-7. doi: 10.1111/1756-185X.12703. No abstract available.


Effect of endothelin receptor antagonists on clinically relevant outcomes after experimental subarachnoid hemorrhage: a systematic review and meta-analysis.

Laban KG, Vergouwen MD, Dijkhuizen RM, Sena ES, Macleod MR, Rinkel GJ, van der Worp HB.

J Cereb Blood Flow Metab. 2015 Jul;35(7):1085-9. doi: 10.1038/jcbfm.2015.89. Epub 2015 May 6. Review.


Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis.

Vesterinen HM, Connick P, Irvine CM, Sena ES, Egan KJ, Carmichael GG, Tariq A, Pavitt S, Chataway J, Macleod MR, Chandran S.

PLoS One. 2015 Apr 9;10(4):e0117705. doi: 10.1371/journal.pone.0117705. eCollection 2015.

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