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Items: 41


Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.

Stawarski M, Hernandez RX, Feghhi T, Borycz JA, Lu Z, Agarwal AB, Reihl KD, Tavora R, Lau AWC, Meinertzhagen IA, Renden R, Macleod GT.

J Neurosci. 2020 Feb 19;40(8):1611-1624. doi: 10.1523/JNEUROSCI.1774-19.2020. Epub 2020 Jan 21.


Endogenous Tagging Reveals Differential Regulation of Ca2+ Channels at Single Active Zones during Presynaptic Homeostatic Potentiation and Depression.

Gratz SJ, Goel P, Bruckner JJ, Hernandez RX, Khateeb K, Macleod GT, Dickman D, O'Connor-Giles KM.

J Neurosci. 2019 Mar 27;39(13):2416-2429. doi: 10.1523/JNEUROSCI.3068-18.2019. Epub 2019 Jan 28.


The application of 'kisser' probes for resolving the distribution and microenvironment of membrane proteins in situ.

Stawarski M, Justs KA, Hernandez RX, Macleod GT.

J Neurogenet. 2018 Sep;32(3):236-245. doi: 10.1080/01677063.2018.1503260. Epub 2018 Sep 3.


The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.

Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ.

Cell Rep. 2017 Dec 26;21(13):3794-3806. doi: 10.1016/j.celrep.2017.12.005.


Na+ /H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals.

Rossano AJ, Kato A, Minard KI, Romero MF, Macleod GT.

J Physiol. 2017 Feb 1;595(3):805-824. doi: 10.1113/JP273105. Epub 2016 Nov 13.


High-Probability Neurotransmitter Release Sites Represent an Energy-Efficient Design.

Lu Z, Chouhan AK, Borycz JA, Lu Z, Rossano AJ, Brain KL, Zhou Y, Meinertzhagen IA, Macleod GT.

Curr Biol. 2016 Oct 10;26(19):2562-2571. doi: 10.1016/j.cub.2016.07.032. Epub 2016 Sep 1.


A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.

Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K.

Neuron. 2014 Nov 19;84(4):764-77. doi: 10.1016/j.neuron.2014.09.030. Epub 2014 Oct 30.


The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.

Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H.

PLoS One. 2014 Jun 27;9(6):e100834. doi: 10.1371/journal.pone.0100834. eCollection 2014.


Expression of multiple transgenes from a single construct using viral 2A peptides in Drosophila.

Daniels RW, Rossano AJ, Macleod GT, Ganetzky B.

PLoS One. 2014 Jun 19;9(6):e100637. doi: 10.1371/journal.pone.0100637. eCollection 2014.


The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors.

Grygoruk A, Chen A, Martin CA, Lawal HO, Fei H, Gutierrez G, Biedermann T, Najibi R, Hadi R, Chouhan AK, Murphy NP, Schweizer FE, Macleod GT, Maidment NT, Krantz DE.

J Neurosci. 2014 May 14;34(20):6924-37. doi: 10.1523/JNEUROSCI.0694-14.2014.


Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice.

Sakellariou GK, Davis CS, Shi Y, Ivannikov MV, Zhang Y, Vasilaki A, Macleod GT, Richardson A, Van Remmen H, Jackson MJ, McArdle A, Brooks SV.

FASEB J. 2014 Apr;28(4):1666-81. doi: 10.1096/fj.13-240390. Epub 2013 Dec 30.


Mitochondrial free Ca²⁺ levels and their effects on energy metabolism in Drosophila motor nerve terminals.

Ivannikov MV, Macleod GT.

Biophys J. 2013 Jun 4;104(11):2353-61. doi: 10.1016/j.bpj.2013.03.064.


Genetically encoded pH-indicators reveal activity-dependent cytosolic acidification of Drosophila motor nerve termini in vivo.

Rossano AJ, Chouhan AK, Macleod GT.

J Physiol. 2013 Apr 1;591(7):1691-706. doi: 10.1113/jphysiol.2012.248377. Epub 2013 Jan 7.


Forward-filling of dextran-conjugated indicators for calcium imaging at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):791-6. doi: 10.1101/pdb.prot070094.


Topical application of indicators for calcium imaging at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):786-90. doi: 10.1101/pdb.prot070086.


Calcium imaging at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):758-66. doi: 10.1101/pdb.top070078.


Imaging and analysis of nonratiometric calcium indicators at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):802-9. doi: 10.1101/pdb.prot070110.


Direct injection of indicators for calcium imaging at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):797-801. doi: 10.1101/pdb.prot070102.


Cytosolic calcium coordinates mitochondrial energy metabolism with presynaptic activity.

Chouhan AK, Ivannikov MV, Lu Z, Sugimori M, Llinas RR, Macleod GT.

J Neurosci. 2012 Jan 25;32(4):1233-43. doi: 10.1523/JNEUROSCI.1301-11.2012.


Effects of diet on synaptic vesicle release in dynactin complex mutants: a mechanism for improved vitality during motor disease.

Rawson JM, Kreko T, Davison H, Mahoney R, Bokov A, Chang L, Gelfond J, Macleod GT, Eaton BA.

Aging Cell. 2012 Jun;11(3):418-27. doi: 10.1111/j.1474-9726.2012.00799.x. Epub 2012 Feb 22.


Differential control of presynaptic CaMKII activation and translocation to active zones.

Shakiryanova D, Morimoto T, Zhou C, Chouhan AK, Sigrist SJ, Nose A, Macleod GT, Deitcher DL, Levitan ES.

J Neurosci. 2011 Jun 22;31(25):9093-100. doi: 10.1523/JNEUROSCI.0550-11.2011.


Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.

George AA, Macleod GT, Zakon HH.

J Neurophysiol. 2011 Jul;106(1):319-31. doi: 10.1152/jn.00741.2010. Epub 2011 Apr 27.


Mitochondria: enigmatic stewards of the synaptic vesicle reserve pool.

Ivannikov MV, Harris KM, Macleod GT.

Front Synaptic Neurosci. 2010 Oct 4;2:145. doi: 10.3389/fnsyn.2010.00145. eCollection 2010. No abstract available.


Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport.

Russo GJ, Louie K, Wellington A, Macleod GT, Hu F, Panchumarthi S, Zinsmaier KE.

J Neurosci. 2009 Apr 29;29(17):5443-55. doi: 10.1523/JNEUROSCI.5417-08.2009.


Loading Drosophila nerve terminals with calcium indicators.

Rossano AJ, Macleod GT.

J Vis Exp. 2007;(6):250. doi: 10.3791/250. Epub 2007 Jul 30.


Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion.

Lagow RD, Bao H, Cohen EN, Daniels RW, Zuzek A, Williams WH, Macleod GT, Sutton RB, Zhang B.

PLoS Biol. 2007 Apr;5(4):e72. Erratum in: PLoS Biol. 2007 Jul;5(7):e175.


Synaptic homeostasis on the fast track.

Macleod GT, Zinsmaier KE.

Neuron. 2006 Nov 22;52(4):569-71. Review.


The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation.

Macleod GT, Chen L, Karunanithi S, Peloquin JB, Atwood HL, McRory JE, Zamponi GW, Charlton MP.

Eur J Neurosci. 2006 Jun;23(12):3230-44.


The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.

Guo X, Macleod GT, Wellington A, Hu F, Panchumarthi S, Schoenfield M, Marin L, Charlton MP, Atwood HL, Zinsmaier KE.

Neuron. 2005 Aug 4;47(3):379-93.


AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis.

Bao H, Daniels RW, MacLeod GT, Charlton MP, Atwood HL, Zhang B.

J Neurophysiol. 2005 Sep;94(3):1888-903. Epub 2005 May 11.


Synaptic vesicles: test for a role in presynaptic calcium regulation.

Macleod GT, Marin L, Charlton MP, Atwood HL.

J Neurosci. 2004 Mar 10;24(10):2496-505.


Single neuron activity in the Drosophila larval CNS detected with calcium indicators.

Macleod GT, Suster ML, Charlton MP, Atwood HL.

J Neurosci Methods. 2003 Aug 15;127(2):167-78.


Fast calcium signals in Drosophila motor neuron terminals.

Macleod GT, Hegström-Wojtowicz M, Charlton MP, Atwood HL.

J Neurophysiol. 2002 Nov;88(5):2659-63.


Quantal potential fields around individual active zones of amphibian motor-nerve terminals.

Bennett MR, Farnell L, Gibson WG, Macleod GT, Dickens P.

Biophys J. 2000 Mar;78(3):1106-18.


Quantal secretion and nerve-terminal cable properties at neuromuscular junctions in an amphibian (Bufo marinus).

Macleod GT, Farnell L, Gibson WG, Bennett MR.

J Neurophysiol. 1999 Mar;81(3):1135-46.


Probability of quantal secretion and the mobilization of vesicles at the active zones of endplates.

Macleod GT, Khurana V, Gibson WG, Bennett MR.

J Theor Biol. 1998 Apr 7;191(3):323-34.


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