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High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.

Youn JY, Dunham WH, Hong SJ, Knight JDR, Bashkurov M, Chen GI, Bagci H, Rathod B, MacLeod G, Eng SWM, Angers S, Morris Q, Fabian M, Côté JF, Gingras AC.

Mol Cell. 2018 Feb 1;69(3):517-532.e11. doi: 10.1016/j.molcel.2017.12.020. Epub 2018 Jan 25.


The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.

Ugur B, Bao H, Stawarski M, Duraine LR, Zuo Z, Lin YQ, Neely GG, Macleod GT, Chapman ER, Bellen HJ.

Cell Rep. 2017 Dec 26;21(13):3794-3806. doi: 10.1016/j.celrep.2017.12.005.


Na+ /H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals.

Rossano AJ, Kato A, Minard KI, Romero MF, Macleod GT.

J Physiol. 2017 Feb 1;595(3):805-824. doi: 10.1113/JP273105. Epub 2016 Nov 13.


High-Probability Neurotransmitter Release Sites Represent an Energy-Efficient Design.

Lu Z, Chouhan AK, Borycz JA, Lu Z, Rossano AJ, Brain KL, Zhou Y, Meinertzhagen IA, Macleod GT.

Curr Biol. 2016 Oct 10;26(19):2562-2571. doi: 10.1016/j.cub.2016.07.032. Epub 2016 Sep 1.


SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.

Chiu CWN, Monat C, Robitaille M, Lacomme M, Daulat AM, Macleod G, McNeill H, Cayouette M, Angers S.

Dev Cell. 2016 Jan 11;36(1):50-62. doi: 10.1016/j.devcel.2015.12.016.


High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, Durocher D, Angers S, Moffat J.

Cell. 2015 Dec 3;163(6):1515-26. doi: 10.1016/j.cell.2015.11.015. Epub 2015 Nov 25.


A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.

Wong CO, Chen K, Lin YQ, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K.

Neuron. 2014 Nov 19;84(4):764-77. doi: 10.1016/j.neuron.2014.09.030. Epub 2014 Oct 30.


The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.

Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H.

PLoS One. 2014 Jun 27;9(6):e100834. doi: 10.1371/journal.pone.0100834. eCollection 2014.


Expression of multiple transgenes from a single construct using viral 2A peptides in Drosophila.

Daniels RW, Rossano AJ, Macleod GT, Ganetzky B.

PLoS One. 2014 Jun 19;9(6):e100637. doi: 10.1371/journal.pone.0100637. eCollection 2014.


The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors.

Grygoruk A, Chen A, Martin CA, Lawal HO, Fei H, Gutierrez G, Biedermann T, Najibi R, Hadi R, Chouhan AK, Murphy NP, Schweizer FE, Macleod GT, Maidment NT, Krantz DE.

J Neurosci. 2014 May 14;34(20):6924-37. doi: 10.1523/JNEUROSCI.0694-14.2014.


Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.

Opaluch AM, Schneider M, Chiang CY, Nguyen QT, Maestre AM, Mulder LC, Secundino I, De Jesus PD, König R, Simon V, Nizet V, MacLeod G, Varmuza S, Fernandez-Sesma A, Chanda SK.

PLoS One. 2014 Feb 20;9(2):e89284. doi: 10.1371/journal.pone.0089284. eCollection 2014.


Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice.

Sakellariou GK, Davis CS, Shi Y, Ivannikov MV, Zhang Y, Vasilaki A, Macleod GT, Richardson A, Van Remmen H, Jackson MJ, McArdle A, Brooks SV.

FASEB J. 2014 Apr;28(4):1666-81. doi: 10.1096/fj.13-240390. Epub 2013 Dec 30.


PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.

MacLeod G, Shang P, Booth GT, Mastropaolo LA, Manafpoursakha N, Vogl AW, Varmuza S.

Reproduction. 2013 Nov 16;147(1):1-12. doi: 10.1530/REP-13-0224. Print 2014 Jan.


The application of proteomic approaches to the study of mammalian spermatogenesis and sperm function.

Macleod G, Varmuza S.

FEBS J. 2013 Nov;280(22):5635-51. doi: 10.1111/febs.12461. Epub 2013 Sep 2. Review.


Mitochondrial free Ca²⁺ levels and their effects on energy metabolism in Drosophila motor nerve terminals.

Ivannikov MV, Macleod GT.

Biophys J. 2013 Jun 4;104(11):2353-61. doi: 10.1016/j.bpj.2013.03.064.


Genetically encoded pH-indicators reveal activity-dependent cytosolic acidification of Drosophila motor nerve termini in vivo.

Rossano AJ, Chouhan AK, Macleod GT.

J Physiol. 2013 Apr 1;591(7):1691-706. doi: 10.1113/jphysiol.2012.248377. Epub 2013 Jan 7.


Drug safety awareness in New Zealand: public knowledge and preferred sources for information.

Brounéus F, Macleod G, Maclennan K, Parkin L, Paul C.

J Prim Health Care. 2012 Dec 1;4(4):288-93.


Tandem affinity purification in transgenic mouse embryonic stem cells identifies DDOST as a novel PPP1CC2 interacting protein.

MacLeod G, Varmuza S.

Biochemistry. 2012 Dec 4;51(48):9678-88. doi: 10.1021/bi3010158. Epub 2012 Nov 16.


Forward-filling of dextran-conjugated indicators for calcium imaging at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):791-6. doi: 10.1101/pdb.prot070094.


Topical application of indicators for calcium imaging at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):786-90. doi: 10.1101/pdb.prot070086.


Calcium imaging at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):758-66. doi: 10.1101/pdb.top070078.


Imaging and analysis of nonratiometric calcium indicators at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):802-9. doi: 10.1101/pdb.prot070110.


Direct injection of indicators for calcium imaging at the Drosophila larval neuromuscular junction.

Macleod GT.

Cold Spring Harb Protoc. 2012 Jul 1;2012(7):797-801. doi: 10.1101/pdb.prot070102.


Cytosolic calcium coordinates mitochondrial energy metabolism with presynaptic activity.

Chouhan AK, Ivannikov MV, Lu Z, Sugimori M, Llinas RR, Macleod GT.

J Neurosci. 2012 Jan 25;32(4):1233-43. doi: 10.1523/JNEUROSCI.1301-11.2012.


Effects of diet on synaptic vesicle release in dynactin complex mutants: a mechanism for improved vitality during motor disease.

Rawson JM, Kreko T, Davison H, Mahoney R, Bokov A, Chang L, Gelfond J, Macleod GT, Eaton BA.

Aging Cell. 2012 Jun;11(3):418-27. doi: 10.1111/j.1474-9726.2012.00799.x. Epub 2012 Feb 22.


Differential control of presynaptic CaMKII activation and translocation to active zones.

Shakiryanova D, Morimoto T, Zhou C, Chouhan AK, Sigrist SJ, Nose A, Macleod GT, Deitcher DL, Levitan ES.

J Neurosci. 2011 Jun 22;31(25):9093-100. doi: 10.1523/JNEUROSCI.0550-11.2011.


Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus.

George AA, Macleod GT, Zakon HH.

J Neurophysiol. 2011 Jul;106(1):319-31. doi: 10.1152/jn.00741.2010. Epub 2011 Apr 27.


New candidate targets of protein phosphatase-1c-gamma-2 in mouse testis revealed by a differential phosphoproteome analysis.

Henderson H, Macleod G, Hrabchak C, Varmuza S.

Int J Androl. 2011 Aug;34(4):339-51. doi: 10.1111/j.1365-2605.2010.01085.x. Epub 2010 Jul 1.


Mitochondria: enigmatic stewards of the synaptic vesicle reserve pool.

Ivannikov MV, Harris KM, Macleod GT.

Front Synaptic Neurosci. 2010 Oct 4;2:145. doi: 10.3389/fnsyn.2010.00145. eCollection 2010. No abstract available.


Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport.

Russo GJ, Louie K, Wellington A, Macleod GT, Hu F, Panchumarthi S, Zinsmaier KE.

J Neurosci. 2009 Apr 29;29(17):5443-55. doi: 10.1523/JNEUROSCI.5417-08.2009.


Identification of potentially damaging amino acid substitutions leading to human male infertility.

Kuzmin A, Jarvi K, Lo K, Spencer L, Chow GY, Macleod G, Wang Q, Varmuza S.

Biol Reprod. 2009 Aug;81(2):319-26. doi: 10.1095/biolreprod.109.076000. Epub 2009 Apr 15.


Loading Drosophila nerve terminals with calcium indicators.

Rossano AJ, Macleod GT.

J Vis Exp. 2007;(6):250. doi: 10.3791/250. Epub 2007 Jul 30.


Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion.

Lagow RD, Bao H, Cohen EN, Daniels RW, Zuzek A, Williams WH, Macleod GT, Sutton RB, Zhang B.

PLoS Biol. 2007 Apr;5(4):e72. Erratum in: PLoS Biol. 2007 Jul;5(7):e175.


Synaptic homeostasis on the fast track.

Macleod GT, Zinsmaier KE.

Neuron. 2006 Nov 22;52(4):569-71. Review.


The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation.

Macleod GT, Chen L, Karunanithi S, Peloquin JB, Atwood HL, McRory JE, Zamponi GW, Charlton MP.

Eur J Neurosci. 2006 Jun;23(12):3230-44.


The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.

Guo X, Macleod GT, Wellington A, Hu F, Panchumarthi S, Schoenfield M, Marin L, Charlton MP, Atwood HL, Zinsmaier KE.

Neuron. 2005 Aug 4;47(3):379-93.


AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis.

Bao H, Daniels RW, MacLeod GT, Charlton MP, Atwood HL, Zhang B.

J Neurophysiol. 2005 Sep;94(3):1888-903. Epub 2005 May 11.


Formulation and processing factors influencing the adhesion of film coats to tablet cores.

Khan H, Fell JT, Macleod GS.

Pharm Dev Technol. 2005;10(1):127-31.


Effect of punch tip geometry and embossment on the punch tip adherence of a model ibuprofen formulation.

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH, Dyas AM.

J Pharm Pharmacol. 2004 Jul;56(7):947-50.


Effect of lubricant type and concentration on the punch tip adherence of model ibuprofen formulations.

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH, Dyas AM.

J Pharm Pharmacol. 2004 Mar;56(3):299-305.


Synaptic vesicles: test for a role in presynaptic calcium regulation.

Macleod GT, Marin L, Charlton MP, Atwood HL.

J Neurosci. 2004 Mar 10;24(10):2496-505.


Mixing efficiency in side-vented coating equipment.

Smith GW, Macleod GS, Fell JT.

AAPS PharmSciTech. 2003;4(3):E37.


Effects of surface roughness and chrome plating of punch tips on the sticking tendencies of model ibuprofen formulations.

Roberts M, Ford JL, MacLeod GS, Fell JT, Smith GW, Rowe PH.

J Pharm Pharmacol. 2003 Sep;55(9):1223-8.


Single neuron activity in the Drosophila larval CNS detected with calcium indicators.

Macleod GT, Suster ML, Charlton MP, Atwood HL.

J Neurosci Methods. 2003 Aug 15;127(2):167-78.


Fast calcium signals in Drosophila motor neuron terminals.

Macleod GT, Hegström-Wojtowicz M, Charlton MP, Atwood HL.

J Neurophysiol. 2002 Nov;88(5):2659-63.


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