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Update from the laboratory: mechanistic studies of pathways of cancer-associated venous thrombosis using mouse models.

Hisada Y, Mackman N.

Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):182-186. doi: 10.1182/hematology.2019000025.


PKa (Plasma Kallikrein) Contributes to Coagulation in the Absence of FXI (Factor XI) by Activating FIX (Factor IX).

Visser M, van Oerle R, Ten Cate H, Laux V, Mackman N, Heitmeier S, Spronk HMH.

Arterioscler Thromb Vasc Biol. 2019 Nov 26:ATVBAHA119313503. doi: 10.1161/ATVBAHA.119.313503. [Epub ahead of print]


Eosinophils, atherosclerosis, and thrombosis.

Mackman N.

Blood. 2019 Nov 21;134(21):1781-1782. doi: 10.1182/blood.2019003027. No abstract available.


Increased circulating extracellular vesicle tissue factor activity during orthohantavirus infection is associated with intravascular coagulation.

Schmedes CM, Grover SP, Hisada YM, Goeijenbier M, Hultdin J, Nilsson S, Thunberg T, Ahlm C, Mackman N, Fors Connolly AM.

J Infect Dis. 2019 Nov 13. pii: jiz597. doi: 10.1093/infdis/jiz597. [Epub ahead of print]


Effect of blood flow on platelets, leukocytes, and extracellular vesicles in thrombosis of simulated neonatal extracorporeal circulation.

Meyer AD, Rishmawi AR, Kamucheka R, Lafleur C, Batchinsky AI, Mackman N, Cap AP.

J Thromb Haemost. 2019 Oct 19. doi: 10.1111/jth.14661. [Epub ahead of print]


How useful are ferric chloride models of arterial thrombosis?

Grover SP, Mackman N.

Platelets. 2019 Oct 13:1-7. doi: 10.1080/09537104.2019.1678119. [Epub ahead of print]


Cell type-specific mechanisms coupling protease-activated receptor-1 to infectious colitis pathogenesis.

Boucher AA, Rosenfeldt L, Mureb D, Shafer J, Sharma BK, Lane A, Crowther RR, McKell MC, Whitt J, Alenghat T, Qualls J, Antoniak S, Mackman N, Flick MJ, Steinbrecher KA, Palumbo JS.

J Thromb Haemost. 2019 Sep 20. doi: 10.1111/jth.14641. [Epub ahead of print]


Increasing the sensitivity of the human microvesicle tissue factor activity assay.

Vallier L, Bouriche T, Bonifay A, Judicone C, Bez J, Franco C, Guervilly C, Hisada Y, Mackman N, Houston R, Poncelet P, Dignat-George F, Lacroix R.

Thromb Res. 2019 Oct;182:64-74. doi: 10.1016/j.thromres.2019.07.011. Epub 2019 Jul 19.


Rivaroxaban does not affect growth of human pancreatic tumors in mice.

Maqsood A, Hisada Y, Garratt KB, Homeister J, Mackman N.

J Thromb Haemost. 2019 Dec;17(12):2169-2173. doi: 10.1111/jth.14604. Epub 2019 Aug 26.


Protease-activated receptor 4 protects mice from Coxsackievirus B3 and H1N1 influenza A virus infection.

Tatsumi K, Schmedes CM, Houston ER, Butler E, Mackman N, Antoniak S.

Cell Immunol. 2019 Oct;344:103949. doi: 10.1016/j.cellimm.2019.103949. Epub 2019 Jul 3.


Neutrophil Extracellular Traps: Villains and Targets in Arterial, Venous, and Cancer-Associated Thrombosis

Thålin C, Hisada Y, Lundström S, Mackman N, Wallén H.

Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1724-1738. doi: 10.1161/ATVBAHA.119.312463. Epub 2019 Jul 18.


Cancer cell-derived tissue factor-positive extracellular vesicles: biomarkers of thrombosis and survival.

Hisada Y, Mackman N.

Curr Opin Hematol. 2019 Sep;26(5):349-356. doi: 10.1097/MOH.0000000000000521.


Toward standardization of assays measuring extracellular vesicle-associated tissue factor activity.

Nieuwland R, Gardiner C, Dignat-George F, Mullier F, Mackman N, Woodhams B, Thaler J.

J Thromb Haemost. 2019 Aug;17(8):1261-1264. doi: 10.1111/jth.14481. Epub 2019 Jun 23. No abstract available.


Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells.

Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T, Schuster M, Wagner G, Rendeiro AF, Melki I, Kaun C, Wojta J, Bock C, Jilma B, Mackman N, Boilard E, Binder CJ.

Circ Res. 2019 Jun 21;125(1):43-52. doi: 10.1161/CIRCRESAHA.118.314601. Epub 2019 May 8. Erratum in: Circ Res. 2019 Oct 25;125(10):e93.


Tissue Factor and Cancer: Regulation, Tumor Growth, and Metastasis.

Hisada Y, Mackman N.

Semin Thromb Hemost. 2019 Jun;45(4):385-395. doi: 10.1055/s-0039-1687894. Epub 2019 May 16. Review.


Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis.

Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover SP, Zhang X, Li L, Xiang B, Shi J, Li XA, Daugherty A, Smyth SS, Kirchhofer D, Shiroishi T, Shao F, Mackman N, Wei Y, Li Z.

Immunity. 2019 Jun 18;50(6):1401-1411.e4. doi: 10.1016/j.immuni.2019.04.003. Epub 2019 May 7.


Patients with severe orthohantavirus cardiopulmonary syndrome due to Sin Nombre Virus infection have increased circulating extracellular vesicle tissue factor and an activated coagulation system.

Tatsumi K, Hisada Y, Connolly AF, Buranda T, Mackman N.

Thromb Res. 2019 Jul;179:31-33. doi: 10.1016/j.thromres.2019.04.032. Epub 2019 May 1. No abstract available.


Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors.

Hisada Y, Grover SP, Maqsood A, Houston R, Ay C, Noubouossie DF, Cooley BC, Wallén H, Key NS, Thålin C, Farkas ÁZ, Farkas VJ, Tenekedjiev K, Kolev K, Mackman N.

Haematologica. 2019 May 2. pii: haematol.2019.217083. doi: 10.3324/haematol.2019.217083. [Epub ahead of print]


Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity.

Zhang N, Czepielewski RS, Jarjour NN, Erlich EC, Esaulova E, Saunders BT, Grover SP, Cleuren AC, Broze GJ, Edelson BT, Mackman N, Zinselmeyer BH, Randolph GJ.

J Exp Med. 2019 Jun 3;216(6):1291-1300. doi: 10.1084/jem.20182024. Epub 2019 May 2.


Modulation of the mammalian coagulation system by venoms and other proteins from snakes, arthropods, nematodes and insects.

Sachetto ATA, Mackman N.

Thromb Res. 2019 Jun;178:145-154. doi: 10.1016/j.thromres.2019.04.019. Epub 2019 Apr 16. Review.


Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application.

Diaz JA, Saha P, Cooley B, Palmer OR, Grover SP, Mackman N, Wakefield TW, Henke PK, Smith A, Lal BK.

J Thromb Haemost. 2019 Apr;17(4):699-707. doi: 10.1111/jth.14413. Epub 2019 Mar 30.


Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine1.

McCann JV, Xiao L, Kim DJ, Khan OF, Kowalski PS, Anderson DG, Pecot CV, Azam SH, Parker JS, Tsai YS, Wolberg AS, Turner SD, Tatsumi K, Mackman N, Dudley AC.

J Clin Invest. 2019 Mar 11;130:1654-1670. doi: 10.1172/JCI123106. eCollection 2019 Mar 11.


Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice.

Posthuma JJ, Posma JJN, van Oerle R, Leenders P, van Gorp RH, Jaminon AMG, Mackman N, Heitmeier S, Schurgers LJ, Ten Cate H, Spronk HMH.

Sci Rep. 2019 Mar 7;9(1):3909. doi: 10.1038/s41598-019-40602-w.


Choosing a Mouse Model of Venous Thrombosis.

Diaz JA, Saha P, Cooley B, Palmer OR, Grover SP, Mackman N, Wakefield TW, Henke PK, Smith A, Lal BK.

Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):311-318. doi: 10.1161/ATVBAHA.118.311818.


A clinical practice-based evaluation of the RIETE score in predicting occult cancer in patients with venous thromboembolism.

Rosell A, Lundström S, Mackman N, Wallén H, Thålin C.

J Thromb Thrombolysis. 2019 Jul;48(1):111-118. doi: 10.1007/s11239-019-01822-z.


Intrinsic Pathway of Coagulation and Thrombosis.

Grover SP, Mackman N.

Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):331-338. doi: 10.1161/ATVBAHA.118.312130.


Measurement of tissue factor activity in extracellular vesicles from human plasma samples.

Hisada Y, Mackman N.

Res Pract Thromb Haemost. 2018 Nov 20;3(1):44-48. doi: 10.1002/rth2.12165. eCollection 2019 Jan.


Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases.

Posma JJ, Grover SP, Hisada Y, Owens AP 3rd, Antoniak S, Spronk HM, Mackman N.

Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):13-24. doi: 10.1161/ATVBAHA.118.311655. Review.


mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumors.

Lewis CS, Elnakat Thomas H, Orr-Asman MA, Green LC, Boody RE, Matiash K, Karve A, Hisada YM, Davis HW, Qi X, Mercer CA, Lucas FV, Aronow BJ, Mackman N, Versteeg HH, Bogdanov VY.

J Thromb Haemost. 2019 Jan;17(1):169-182. doi: 10.1111/jth.14342. Epub 2018 Dec 25.


Low extracellular vesicle-associated tissue factor activity in patients with persistent lupus anticoagulant and a history of thrombosis.

Hell L, Ay C, Posch F, Gebhart J, Koder S, Mackman N, Pabinger I, Thaler J.

Ann Hematol. 2019 Feb;98(2):313-319. doi: 10.1007/s00277-018-3544-x. Epub 2018 Nov 22.


Coagulation biomarkers and prediction of venous thromboembolism and survival in small cell lung cancer: A sub-study of RASTEN - A randomized trial with low molecular weight heparin.

Gezelius E, Flou Kristensen A, Bendahl PO, Hisada Y, Risom Kristensen S, Ek L, Bergman B, Wallberg M, Falkmer U, Mackman N, Pedersen S, Belting M.

PLoS One. 2018 Nov 9;13(11):e0207387. doi: 10.1371/journal.pone.0207387. eCollection 2018.


Reporting Sex and Sex Differences in Preclinical Studies.

Lu HS, Schmidt AM, Hegele RA, Mackman N, Rader DJ, Weber C, Daugherty A.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):e171-e184. doi: 10.1161/ATVBAHA.118.311717. No abstract available.


Neutrophils, NETs, and immunothrombosis.

Grover SP, Mackman N.

Blood. 2018 Sep 27;132(13):1360-1361. doi: 10.1182/blood-2018-08-868067. No abstract available.


The red blood cell death receptor and thrombosis.

Mackman N.

J Clin Invest. 2018 Aug 31;128(9):3747-3749. doi: 10.1172/JCI122881. Epub 2018 Aug 13.


Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity.

Antoniak S, Tatsumi K, Schmedes CM, Grover SP, Pawlinski R, Mackman N.

J Mol Cell Cardiol. 2018 Sep;122:80-87. doi: 10.1016/j.yjmcc.2018.08.008. Epub 2018 Aug 10.


The uremic solute-AHR-tissue factor axis in vascular cells, mouse models and thrombosis in chronic kidney disease patients.

Mackman N, Erlich JH.

Ann Transl Med. 2018 Jun;6(11):225. doi: 10.21037/atm.2018.04.27. No abstract available.


The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction.

Bode MF, Auriemma AC, Grover SP, Hisada Y, Rennie A, Bode WD, Vora R, Subramaniam S, Cooley B, Andrade-Gordon P, Antoniak S, Mackman N.

Thromb Res. 2018 Jul;167:128-134. doi: 10.1016/j.thromres.2018.05.015. Epub 2018 May 17.


Response by Daugherty et al to Letter Regarding Article, "Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Arteriosclerosis, Thrombosis, and Vascular Biology Council".

Daugherty A, Lu HS, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):e101-e102. doi: 10.1161/ATVBAHA.118.310988. No abstract available.


Tissue factor and oxidative stress.

Mackman N, Antoniak S.

Blood. 2018 May 10;131(19):2094-2095. doi: 10.1182/blood-2018-02-833673. No abstract available.


Extracellular vesicles exposing tissue factor for the prediction of venous thromboembolism in patients with cancer: A prospective cohort study.

van Es N, Hisada Y, Di Nisio M, Cesarman G, Kleinjan A, Mahé I, Otten HM, Kamphuisen PW, Berckmans RJ, Büller HR, Mackman N, Nieuwland R.

Thromb Res. 2018 Jun;166:54-59. doi: 10.1016/j.thromres.2018.04.009. Epub 2018 Apr 10.


PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in Mice.

Jones SM, Mann A, Conrad K, Saum K, Hall DE, McKinney LM, Robbins N, Thompson J, Peairs AD, Camerer E, Rayner KJ, Tranter M, Mackman N, Owens AP 3rd.

Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1271-1282. doi: 10.1161/ATVBAHA.117.310082. Epub 2018 Mar 29.


Platelet Signaling Pathways and New Inhibitors.

Grover SP, Bergmeier W, Mackman N.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):e28-e35. doi: 10.1161/ATVBAHA.118.310224. Review. No abstract available.


Comparison of microvesicle tissue factor activity in non-cancer severely ill patients and cancer patients.

Hisada Y, Thålin C, Lundström S, Wallén H, Mackman N.

Thromb Res. 2018 May;165:1-5. doi: 10.1016/j.thromres.2018.03.001. Epub 2018 Mar 7.


Correction: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.

Uderhardt S, Ackermann JA, Fillep T, Hammond VJ, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner KR, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz-Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins PW, Schabbauer G, Mackman N, Voehringer D, Nadler JL, Lee JJ, Massberg S, Rauh M, Kiechl S, Schett G, O'Donnell VB, Krönke G.

J Exp Med. 2018 Mar 5;215(3):1003. doi: 10.1084/jem.2016107002142018c. Epub 2018 Feb 20. No abstract available.


Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients.

Mackman N, Spronk HMH, Stouffer GA, Ten Cate H.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):726-732. doi: 10.1161/ATVBAHA.117.310048. Epub 2018 Feb 15. Review. No abstract available.


Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis.

Grover SP, Mackman N.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):709-725. doi: 10.1161/ATVBAHA.117.309846. Epub 2018 Feb 8. Review.


Androgen receptor dampens tissue factor expression via nuclear factor-κB and early growth response protein 1.

Hoesel B, Mussbacher M, Dikorman B, Salzmann M, Assinger A, Hell L, Thaler J, Basílio J, Moser B, Resch U, Paar H, Mackman N, Schmid JA.

J Thromb Haemost. 2018 Apr;16(4):749-758. doi: 10.1111/jth.13971. Epub 2018 Mar 13.


Distinct Pathogenesis of Pancreatic Cancer Microvesicle-Associated Venous Thrombosis Identifies New Antithrombotic Targets In Vivo.

Stark K, Schubert I, Joshi U, Kilani B, Hoseinpour P, Thakur M, Grünauer P, Pfeiler S, Schmidergall T, Stockhausen S, Bäumer M, Chandraratne S, von Brühl ML, Lorenz M, Coletti R, Reese S, Laitinen I, Wörmann SM, Algül H, Bruns CJ, Ware J, Mackman N, Engelmann B, Massberg S.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):772-786. doi: 10.1161/ATVBAHA.117.310262. Epub 2018 Feb 1.


Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis.

Spronk HMH, Padro T, Siland JE, Prochaska JH, Winters J, van der Wal AC, Posthuma JJ, Lowe G, d'Alessandro E, Wenzel P, Coenen DM, Reitsma PH, Ruf W, van Gorp RH, Koenen RR, Vajen T, Alshaikh NA, Wolberg AS, Macrae FL, Asquith N, Heemskerk J, Heinzmann A, Moorlag M, Mackman N, van der Meijden P, Meijers JCM, Heestermans M, Renné T, Dólleman S, Chayouâ W, Ariëns RAS, Baaten CC, Nagy M, Kuliopulos A, Posma JJ, Harrison P, Vries MJ, Crijns HJGM, Dudink EAMP, Buller HR, Henskens YMC, Själander A, Zwaveling S, Erküner O, Eikelboom JW, Gulpen A, Peeters FECM, Douxfils J, Olie RH, Baglin T, Leader A, Schotten U, Scaf B, van Beusekom HMM, Mosnier LO, van der Vorm L, Declerck P, Visser M, Dippel DWJ, Strijbis VJ, Pertiwi K, Ten Cate-Hoek AJ, Ten Cate H.

Thromb Haemost. 2018 Feb;118(2):229-250. doi: 10.1160/TH17-07-0492. Epub 2018 Jan 29.


Association of D-dimer with Plaque Characteristics and Plasma Biomarkers of Oxidation-Specific Epitopes in Stable Subjects with Coronary Artery Disease.

Kothari H, Nguyen AT, Yang X, Hisada Y, Tsimikas S, Mackman N, Taylor A, McNamara CA.

J Cardiovasc Transl Res. 2018 Jun;11(3):221-229. doi: 10.1007/s12265-018-9790-4. Epub 2018 Jan 17.


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