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Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo.

Liu Y, Given KS, Dickson EL, Owens GP, Macklin WB, Bennett JL.

Exp Neurol. 2019 Aug;318:32-41. doi: 10.1016/j.expneurol.2019.04.011. Epub 2019 Apr 25.


Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice.

Dingman AL, Rodgers KM, Dietz RM, Hickey SP, Frazier AP, Clevenger AC, Yonchek JC, Traystman RJ, Macklin WB, Herson PS.

Dev Neurosci. 2019 Mar 12:1-16. doi: 10.1159/000496200. [Epub ahead of print]


The Actin Cytoskeleton in Myelinating Cells.

Brown TL, Macklin WB.

Neurochem Res. 2019 Mar 7. doi: 10.1007/s11064-019-02753-0. [Epub ahead of print]


A novel myelin protein zero transgenic zebrafish designed for rapid readout of in vivo myelination.

Preston MA, Finseth LT, Bourne JN, Macklin WB.

Glia. 2019 Apr;67(4):650-667. doi: 10.1002/glia.23559. Epub 2019 Jan 9.


Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica.

Liu Y, Given KS, Owens GP, Macklin WB, Bennett JL.

Glia. 2018 Dec;66(12):2575-2588. doi: 10.1002/glia.23512. Epub 2018 Sep 21.


Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia.

Rodgers KM, Ahrendsen JT, Patsos OP, Strnad FA, Yonchek JC, Traystman RJ, Macklin WB, Herson PS.

Neuroscience. 2018 Jun 1;380:1-13. doi: 10.1016/j.neuroscience.2018.03.045. Epub 2018 Apr 9.


Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination.

Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH.

Front Mol Neurosci. 2018 Mar 15;11:57. doi: 10.3389/fnmol.2018.00057. eCollection 2018.


Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone.

Gould EA, Busquet N, Shepherd D, Dietz RM, Herson PS, Simoes de Souza FM, Li A, George NM, Restrepo D, Macklin WB.

Elife. 2018 Feb 13;7. pii: e34783. doi: 10.7554/eLife.34783.


Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke.

Orfila JE, Grewal H, Dietz RM, Strnad F, Shimizu T, Moreno M, Schroeder C, Yonchek J, Rodgers KM, Dingman A, Bernard TJ, Quillinan N, Macklin WB, Traystman RJ, Herson PS.

J Cereb Blood Flow Metab. 2019 Jun;39(6):1005-1014. doi: 10.1177/0271678X17750761. Epub 2017 Dec 28.


The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination.

Ahrendsen JT, Harlow DE, Finseth LT, Bourne JN, Hickey SP, Gould EA, Culp CM, Macklin WB.

J Neurosci. 2018 Jan 24;38(4):787-802. doi: 10.1523/JNEUROSCI.2864-16.2017. Epub 2017 Dec 7.


Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor.

Abi Ghanem C, Degerny C, Hussain R, Liere P, Pianos A, Tourpin S, Habert R, Macklin WB, Schumacher M, Ghoumari AM.

PLoS Genet. 2017 Nov 6;13(11):e1007049. doi: 10.1371/journal.pgen.1007049. eCollection 2017 Nov.


Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy.

Ryan DP, Gould EA, Seedorf GJ, Masihzadeh O, Abman SH, Vijayaraghavan S, Macklin WB, Restrepo D, Shepherd DP.

Nat Commun. 2017 Sep 20;8(1):612. doi: 10.1038/s41467-017-00514-7.


Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination.

McLane LE, Bourne JN, Evangelou AV, Khandker L, Macklin WB, Wood TL.

J Neurosci. 2017 Aug 2;37(31):7534-7546. doi: 10.1523/JNEUROSCI.3454-16.2017. Epub 2017 Jul 10.


Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination.

Liu Y, Given KS, Harlow DE, Matschulat AM, Macklin WB, Bennett JL, Owens GP.

Acta Neuropathol Commun. 2017 Mar 24;5(1):25. doi: 10.1186/s40478-017-0428-6.


Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle.

Hussain R, Macklin WB.

J Neurosci. 2017 Jan 11;37(2):397-412. doi: 10.1523/JNEUROSCI.2113-16.2016.


Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica.

Liu Y, Harlow DE, Given KS, Owens GP, Macklin WB, Bennett JL.

J Neuroinflammation. 2016 Dec 1;13(1):301.


Neuroprotection by central nervous system remyelination: Molecular, cellular, and functional considerations.

Verden D, Macklin WB.

J Neurosci Res. 2016 Dec;94(12):1411-1420. doi: 10.1002/jnr.23923. Epub 2016 Sep 12. Review.


Intravital assessment of myelin molecular order with polarimetric multiphoton microscopy.

Turcotte R, Rutledge DJ, Bélanger E, Dill D, Macklin WB, Côté DC.

Sci Rep. 2016 Aug 19;6:31685. doi: 10.1038/srep31685.


Juvenile striatal white matter is resistant to ischemia-induced damage.

Ahrendsen JT, Grewal HS, Hickey SP, Culp CM, Gould EA, Shimizu T, Strnad FA, Traystman RJ, Herson PS, Macklin WB.

Glia. 2016 Nov;64(11):1972-86. doi: 10.1002/glia.23036. Epub 2016 Jul 27.


A mouse model for testing remyelinating therapies.

Bai CB, Sun S, Roholt A, Benson E, Edberg D, Medicetty S, Dutta R, Kidd G, Macklin WB, Trapp B.

Exp Neurol. 2016 Sep;283(Pt A):330-40. doi: 10.1016/j.expneurol.2016.06.033. Epub 2016 Jul 3.


Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence.

Li Y, Dunphy JM, Pedraza CE, Lynch CR, Cardona SM, Macklin WB, Lynch WP.

J Virol. 2016 Jan 13;90(7):3385-99. doi: 10.1128/JVI.03156-15.


Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development.

Dai J, Bercury KK, Jin W, Macklin WB.

J Neurosci. 2015 Dec 2;35(48):15875-93. doi: 10.1523/JNEUROSCI.0882-15.2015.



Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI.

J Biol Chem. 2016 Jan 22;291(4):1957-73. doi: 10.1074/jbc.M115.668228. Epub 2015 Nov 30.


Olig1 function is required for oligodendrocyte differentiation in the mouse brain.

Dai J, Bercury KK, Ahrendsen JT, Macklin WB.

J Neurosci. 2015 Mar 11;35(10):4386-402. doi: 10.1523/JNEUROSCI.4962-14.2015.


Dynamics and mechanisms of CNS myelination.

Bercury KK, Macklin WB.

Dev Cell. 2015 Feb 23;32(4):447-58. doi: 10.1016/j.devcel.2015.01.016. Review.


A new model of cuprizone-mediated demyelination/remyelination.

Sachs HH, Bercury KK, Popescu DC, Narayanan SP, Macklin WB.

ASN Neuro. 2014 Sep 30;6(5). pii: 1759091414551955. doi: 10.1177/1759091414551955. Print 2014.


Zebrafish as a model to investigate CNS myelination.

Preston MA, Macklin WB.

Glia. 2015 Feb;63(2):177-93. doi: 10.1002/glia.22755. Epub 2014 Sep 27. Review.


Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation.

Dai J, Bercury KK, Macklin WB.

Glia. 2014 Dec;62(12):2096-109. doi: 10.1002/glia.22729. Epub 2014 Jul 25.


Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis.

Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh CM, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE.

Stem Cell Reports. 2014 May 15;2(6):825-37. doi: 10.1016/j.stemcr.2014.04.005. eCollection 2014 Jun 3.


Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis.

Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2349-55. doi: 10.1073/pnas.1406658111. Epub 2014 May 19.


Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.

Bercury KK, Dai J, Sachs HH, Ahrendsen JT, Wood TL, Macklin WB.

J Neurosci. 2014 Mar 26;34(13):4466-80. doi: 10.1523/JNEUROSCI.4314-13.2014.


Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination.

Wahl SE, McLane LE, Bercury KK, Macklin WB, Wood TL.

J Neurosci. 2014 Mar 26;34(13):4453-65. doi: 10.1523/JNEUROSCI.4311-13.2014.


Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.

Zhao X, Dai J, Ma Y, Mi Y, Cui D, Ju G, Macklin WB, Jin W.

Glia. 2014 Jun;62(6):914-26. doi: 10.1002/glia.22649. Epub 2014 Feb 25.


Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination.

Harlow DE, Saul KE, Culp CM, Vesely EM, Macklin WB.

J Neurosci. 2014 Jan 22;34(4):1333-43. doi: 10.1523/JNEUROSCI.2477-13.2014.


Inhibitors of myelination: ECM changes, CSPGs and PTPs.

Harlow DE, Macklin WB.

Exp Neurol. 2014 Jan;251:39-46. doi: 10.1016/j.expneurol.2013.10.017. Epub 2013 Nov 4.


Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity.

Jaini R, Popescu DC, Flask CA, Macklin WB, Tuohy VK.

J Neuroimmunol. 2013 Jun 15;259(1-2):37-46. doi: 10.1016/j.jneuroim.2013.03.012. Epub 2013 Apr 17.


Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors.

Dutta R, Chomyk AM, Chang A, Ribaudo MV, Deckard SA, Doud MK, Edberg DD, Bai B, Li M, Baranzini SE, Fox RJ, Staugaitis SM, Macklin WB, Trapp BD.

Ann Neurol. 2013 May;73(5):637-45. doi: 10.1002/ana.23860. Epub 2013 Apr 17.


mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.

Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB.

ASN Neuro. 2013 Mar 19;5(1):e00108. doi: 10.1042/AN20120092. Review.


The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination.

Hussain R, Ghoumari AM, Bielecki B, Steibel J, Boehm N, Liere P, Macklin WB, Kumar N, Habert R, Mhaouty-Kodja S, Tronche F, Sitruk-Ware R, Schumacher M, Ghandour MS.

Brain. 2013 Jan;136(Pt 1):132-46. doi: 10.1093/brain/aws284.


Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression.

Hu X, Schlanger R, He W, Macklin WB, Yan R.

FASEB J. 2013 May;27(5):1868-73. doi: 10.1096/fj.12-224212. Epub 2013 Jan 18.


Gene induction in mature oligodendrocytes with a PLP-tTA mouse line.

Inamura N, Sugio S, Macklin WB, Tomita K, Tanaka KF, Ikenaka K.

Genesis. 2012 May;50(5):424-8. doi: 10.1002/dvg.20808. Epub 2011 Dec 27.


Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors.

Hussain R, El-Etr M, Gaci O, Rakotomamonjy J, Macklin WB, Kumar N, Sitruk-Ware R, Schumacher M, Ghoumari AM.

Endocrinology. 2011 Oct;152(10):3820-31. doi: 10.1210/en.2011-1219. Epub 2011 Aug 9.


A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.

Zhao L, Spassieva SD, Jucius TJ, Shultz LD, Shick HE, Macklin WB, Hannun YA, Obeid LM, Ackerman SL.

PLoS Genet. 2011 May;7(5):e1002063. doi: 10.1371/journal.pgen.1002063. Epub 2011 May 19.


Longitudinal near-infrared imaging of myelination.

Wang C, Wu C, Popescu DC, Zhu J, Macklin WB, Miller RH, Wang Y.

J Neurosci. 2011 Feb 16;31(7):2382-90. doi: 10.1523/JNEUROSCI.2698-10.2011.


Visual abnormalities associated with enhanced optic nerve myelination.

Yu M, Narayanan SP, Wang F, Morse E, Macklin WB, Peachey NS.

Brain Res. 2011 Feb 16;1374:36-42. doi: 10.1016/j.brainres.2010.12.043. Epub 2010 Dec 21.


The myelin brake: when enough is enough.

Macklin WB.

Sci Signal. 2010 Sep 21;3(140):pe32. doi: 10.1126/scisignal.3140pe32.


Mutation in the myelin proteolipid protein gene alters BK and SK channel function in the caudal medulla.

Mayer CA, Macklin WB, Avishai N, Balan K, Wilson CG, Miller MJ.

Respir Physiol Neurobiol. 2009 Dec 31;169(3):303-14. doi: 10.1016/j.resp.2009.09.013. Epub 2009 Oct 4.


Neuronal expression of the proteolipid protein gene in the medulla of the mouse.

Miller MJ, Kangas CD, Macklin WB.

J Neurosci Res. 2009 Oct;87(13):2842-53. doi: 10.1002/jnr.22121.


Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

Narayanan SP, Flores AI, Wang F, Macklin WB.

J Neurosci. 2009 May 27;29(21):6860-70. doi: 10.1523/JNEUROSCI.0232-09.2009.

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