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Items: 1 to 50 of 307

1.

Fractal variability: an emergent property of complex dissipative systems.

Seely AJ, Macklem P.

Chaos. 2012 Mar;22(1):013108. doi: 10.1063/1.3675622.

PMID:
22462984
2.

Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside.

Seely AJ, Kauffman SA, Bates JH, Macklem PT, Suki B, Marshall JC, Batchinsky AI, Perez-Velazquez JL, Seiver A, McGregor C, Maksym G, Kamath MV, Similowski T, Buchman TG, Letellier C, Filoche M, Frasch MG, Straus C, Glass L, Godin PJ, Morris JA, Sow D, Nenadovic V, Arnold RC, Norris P, Moorman JR.

J Crit Care. 2011 Jun;26(3):325-7. doi: 10.1016/j.jcrc.2011.04.002. No abstract available.

PMID:
21616298
3.

Susceptibility to exacerbation in COPD.

Macklem PT.

N Engl J Med. 2010 Dec 30;363(27):2670; author reply 2671. doi: 10.1056/NEJMc1011871. No abstract available.

PMID:
21190466
4.

Concomitant ventilatory and circulatory functions of the diaphragm and abdominal muscles.

Aliverti A, Uva B, Laviola M, Bovio D, Lo Mauro A, Tarperi C, Colombo E, Loomas B, Pedotti A, Similowski T, Macklem PT.

J Appl Physiol (1985). 2010 Nov;109(5):1432-40. doi: 10.1152/japplphysiol.00576.2010. Epub 2010 Sep 2.

5.

Towards a definition of life.

Macklem PT, Seely A.

Perspect Biol Med. 2010 Summer;53(3):330-40. doi: 10.1353/pbm.0.0167.

PMID:
20639603
6.

Therapeutic implications of the pathophysiology of COPD.

Macklem PT.

Eur Respir J. 2010 Mar;35(3):676-80. doi: 10.1183/09031936.00120609. Review.

7.

Stephen Hales, an unrecognized giant of medicine.

Macklem PT.

Osler Libr Newsl. 2010;(114):1-4. No abstract available.

PMID:
21542394
8.

In memoriam: Jere Mead (1920-2009).

Macklem PT.

J Appl Physiol (1985). 2009 Dec;107(6):1679. doi: 10.1152/japplphysiol.01125.2009. Epub 2009 Oct 8. No abstract available.

9.

Quantification of trapped gas with CT and 3 He MR imaging in a porcine model of isolated airway obstruction.

Salito C, Aliverti A, Gierada DS, Deslée G, Pierce RA, Macklem PT, Woods JC.

Radiology. 2009 Nov;253(2):380-9. doi: 10.1148/radiol.2532081941. Epub 2009 Jul 31.

10.

The abdominal circulatory pump.

Aliverti A, Bovio D, Fullin I, Dellacà RL, Lo Mauro A, Pedotti A, Macklem PT.

PLoS One. 2009;4(5):e5550. doi: 10.1371/journal.pone.0005550. Epub 2009 May 14.

11.
12.

The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles.

Aliverti A, Macklem PT.

J Appl Physiol (1985). 2008 Aug;105(2):749-51; discussion 755-7. doi: 10.1152/japplphysiol.90336.2008. Epub 2008 Mar 20. No abstract available.

13.

Airway bypass improves the mechanical properties of explanted emphysematous lungs.

Choong CK, Macklem PT, Pierce JA, Das N, Lutey BA, Martinez CO, Cooper JD.

Am J Respir Crit Care Med. 2008 Nov 1;178(9):902-5. doi: 10.1164/rccm.200712-1832OC. Epub 2008 Jul 31.

14.

Dividing the FEV1 into its component parts.

Macklem PT, Irvin CG.

J Appl Physiol (1985). 2008 Jul;105(1):392; author reply 393. doi: 10.1152/japplphysiol.90489.2008. No abstract available.

15.

At Last! A Realistic Animal Model of Severe Asthma.

Macklem PT.

Am J Respir Crit Care Med. 2008 Feb 1;177(3):245-6. No abstract available.

PMID:
18246600
16.

Emergent phenomena and the secrets of life.

Macklem PT.

J Appl Physiol (1985). 2008 Jun;104(6):1844-6. doi: 10.1152/japplphysiol.00942.2007. Epub 2008 Jan 17. No abstract available.

17.

Chest wall dynamics and muscle recruitment during professional flute playing.

Cossette I, Monaco P, Aliverti A, Macklem PT.

Respir Physiol Neurobiol. 2008 Feb 1;160(2):187-95. Epub 2007 Sep 21.

PMID:
17977805
18.

Canada's contribution to respiratory physiology and pathophysiology.

Macklem PT.

Can Respir J. 2007 Oct;14(7):383-92. No abstract available.

19.

Commentary on "The role of the large airways on smooth muscle contraction in asthma".

Macklem P.

J Appl Physiol (1985). 2007 Oct;103(4):1459; author reply 1466. No abstract available.

20.

Percolation and phase transitions.

Fessler HE, Macklem PT.

Am J Respir Crit Care Med. 2007 Sep 15;176(6):530-1. No abstract available.

PMID:
17823359
21.

Bronchial thermoplasty.

Macklem PT.

N Engl J Med. 2007 Jun 28;356(26):2744; author reply 2745. No abstract available.

PMID:
17596611
22.

A human model of the pathophysiology of chronic obstructive pulmonary disease.

Aliverti A, Kayser B, Macklem PT.

Respirology. 2007 Jul;12(4):478-85. Review.

PMID:
17587412
23.

Transpleural ventilation of explanted human lungs.

Choong CK, Macklem PT, Pierce JA, Lefrak SS, Woods JC, Conradi MS, Yablonskiy DA, Hogg JC, Chino K, Cooper JD.

Thorax. 2007 Jul;62(7):623-30. Epub 2007 Apr 5.

24.

Oxygen kinetics and debt during recovery from expiratory flow-limited exercise in healthy humans.

Vogiatzis I, Zakynthinos S, Georgiadou O, Golemati S, Pedotti A, Macklem PT, Roussos C, Aliverti A.

Eur J Appl Physiol. 2007 Feb;99(3):265-74. Epub 2006 Dec 6.

25.

Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema.

Woods JC, Choong CK, Yablonskiy DA, Bentley J, Wong J, Pierce JA, Cooper JD, Macklem PT, Conradi MS, Hogg JC.

Magn Reson Med. 2006 Dec;56(6):1293-300.

26.

Exercise in COPD: damned if you do and damned if you don't.

Macklem PT.

Thorax. 2005 Nov;60(11):887-8. No abstract available.

27.

Influence of expiratory flow-limitation during exercise on systemic oxygen delivery in humans.

Aliverti A, Dellacà RL, Lotti P, Bertini S, Duranti R, Scano G, Heyman J, Lo Mauro A, Pedotti A, Macklem PT.

Eur J Appl Physiol. 2005 Oct;95(2-3):229-42. Epub 2005 Aug 5.

PMID:
16086145
28.

Long-range diffusion of hyperpolarized 3He in explanted normal and emphysematous human lungs via magnetization tagging.

Woods JC, Yablonskiy DA, Choong CK, Chino K, Pierce JA, Hogg JC, Bentley J, Cooper JD, Conradi MS, Macklem PT.

J Appl Physiol (1985). 2005 Nov;99(5):1992-7. Epub 2005 Jul 14.

29.

Complex systems and the technology of variability analysis.

Seely AJ, Macklem PT.

Crit Care. 2004 Dec;8(6):R367-84. Epub 2004 Sep 22. Review.

30.

The use and misuse of Penh in animal models of lung disease.

Bates J, Irvin C, Brusasco V, Drazen J, Fredberg J, Loring S, Eidelman D, Ludwig M, Macklem P, Martin J, Milic-Emili J, Hantos Z, Hyatt R, Lai-Fook S, Leff A, Solway J, Lutchen K, Suki B, Mitzner W, Paré P, Pride N, Sly P.

Am J Respir Cell Mol Biol. 2004 Sep;31(3):373-4. No abstract available.

PMID:
15317683
31.

Cell and molecular biology is not the only way to a better understanding of pathogenesis of lung disease.

Macklem PT.

Am J Respir Crit Care Med. 2004 Jul 1;170(1):ii-iii; author reply iv. No abstract available.

PMID:
15220132
32.

A century of the mechanics of breathing.

Macklem PT.

Am J Respir Crit Care Med. 2004 Jul 1;170(1):10-5. No abstract available.

PMID:
15220122
33.

Detection of expiratory flow limitation in COPD using the forced oscillation technique.

Dellacà RL, Santus P, Aliverti A, Stevenson N, Centanni S, Macklem PT, Pedotti A, Calverley PM.

Eur Respir J. 2004 Feb;23(2):232-40.

34.

Con: Greater funding of cell and molecular biology has not delivered what was promised to respiratory medicine.

Macklem PT.

Am J Respir Crit Care Med. 2004 Feb 15;169(4):438-9; discussion 439-40. No abstract available.

PMID:
14766660
35.

Breath-by-breath assessment of alveolar gas stores and exchange.

Aliverti A, Kayser B, Macklem PT.

J Appl Physiol (1985). 2004 Apr;96(4):1464-9. Epub 2003 Dec 2.

36.

The molecular-clinical divorce.

Macklem PT.

Am J Respir Crit Care Med. 2003 Aug 15;168(4):500. No abstract available.

PMID:
12912736
37.

Airway wall remodeling: friend or foe?

McParland BE, Macklem PT, Pare PD.

J Appl Physiol (1985). 2003 Jul;95(1):426-34. Review.

38.

Effects of rapid saline infusion on lung mechanics and airway responsiveness in humans.

Pellegrino R, Dellaca R, Macklem PT, Aliverti A, Bertini S, Lotti P, Agostoni P, Locatelli A, Brusasco V.

J Appl Physiol (1985). 2003 Aug;95(2):728-34. Epub 2003 May 2.

39.

Is cell and molecular biology divorcing from clinical practice?

Macklem PT.

Am J Respir Crit Care Med. 2003 May 1;167(9):1164-5. No abstract available.

PMID:
12714338
40.

Chest wall kinematic determinants of diaphragm length by optoelectronic plethysmography and ultrasonography.

Aliverti A, Ghidoli G, Dellacà RL, Pedotti A, Macklem PT.

J Appl Physiol (1985). 2003 Feb;94(2):621-30. Epub 2002 Oct 4.

41.

Phonospirometry for noninvasive measurement of ventilation: methodology and preliminary results.

Que CL, Kolmaga C, Durand LG, Kelly SM, Macklem PT.

J Appl Physiol (1985). 2002 Oct;93(4):1515-26.

42.

[A matter of life and death].

Macklem PT.

Rev Mal Respir. 2002 Apr;19(2 Pt1):135-9. French. No abstract available.

PMID:
12040310
43.

Respiratory muscle dynamics and control during exercise with externally imposed expiratory flow limitation.

Aliverti A, Iandelli I, Duranti R, Cala SJ, Kayser B, Kelly S, Misuri G, Pedotti A, Scano G, Sliwinski P, Yan S, Macklem PT.

J Appl Physiol (1985). 2002 May;92(5):1953-63.

44.

Determinants of exercise performance in normal men with externally imposed expiratory flow limitation.

Iandelli I, Aliverti A, Kayser B, Dellacà R, Cala SJ, Duranti R, Kelly S, Scano G, Sliwinski P, Yan S, Macklem PT, Pedotti A.

J Appl Physiol (1985). 2002 May;92(5):1943-52.

45.

Homeokinesis and short-term variability of human airway caliber.

Que CL, Kenyon CM, Olivenstein R, Macklem PT, Maksym GN.

J Appl Physiol (1985). 2001 Sep;91(3):1131-41.

46.

How and why exercise is impaired in COPD.

Aliverti A, Macklem PT.

Respiration. 2001;68(3):229-39. Review.

PMID:
11416240
47.

Respiratory parameters during professional flute playing.

Cossette I, Sliwinski P, Macklem PT.

Respir Physiol. 2000 Jun;121(1):33-44.

PMID:
10854621
48.

Deciphering the homeokinetic code of airway smooth muscle.

Que CL, Maksym G, Macklem PT.

Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 2):S161-3. Review. No abstract available.

PMID:
10712366
49.

Twitch transdiaphragmatic pressure depends critically on thoracoabdominal configuration.

Chen R, Kayser B, Yan S, Macklem PT.

J Appl Physiol (1985). 2000 Jan;88(1):54-60.

50.

Modified Campbell diagram to assess respiratory muscle action in speech.

Johnston S, Yan S, Sliwinski P, Macklem PT.

Respirology. 1999 Sep;4(3):213-22.

PMID:
10489662

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