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Evaluation, Validation, and Implementation of the Idylla System as Rapid Molecular Testing for Precision Medicine.

Huang H, Springborn S, Haug K, Bartow K, Samra H, Menon S, Mackinnon AC.

J Mol Diagn. 2019 Sep;21(5):862-872. doi: 10.1016/j.jmoldx.2019.05.007.


Antibiotic modulation of mucins in otitis media; should this change our approach to watchful waiting?

Hong W, Khampang P, Kerschner AR, Mackinnon AC, Yan K, Simpson PM, Kerschner JE.

Int J Pediatr Otorhinolaryngol. 2019 Oct;125:134-140. doi: 10.1016/j.ijporl.2019.07.002. Epub 2019 Jul 4.


Intrapulmonary Autoantibodies to HSP72 Are Associated with Improved Outcomes in IPF.

Mills R, Mathur A, Nicol LM, Walker JJ, Przybylski AA, Mackinnon AC, Howie SEM, Wallace WAH, Dransfield I, Hirani N.

J Immunol Res. 2019 Apr 11;2019:1845128. doi: 10.1155/2019/1845128. eCollection 2019.


MDM2 amplification and immunohistochemical expression in sarcomatoid renal cell carcinoma.

Suster D, Ronen S, Peterson JF, Mackinnon AC, Hes O, Suster S, Lin DI.

Hum Pathol. 2019 May;87:28-36. doi: 10.1016/j.humpath.2019.02.004. Epub 2019 Feb 28. French.


Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients.

Pabla S, Conroy JM, Nesline MK, Glenn ST, Papanicolau-Sengos A, Burgher B, Hagen J, Giamo V, Andreas J, Lenzo FL, Yirong W, Dy GK, Yau E, Early A, Chen H, Bshara W, Madden KG, Shirai K, Dragnev K, Tafe LJ, Marin D, Zhu J, Clarke J, Labriola M, McCall S, Zhang T, Zibelman M, Ghatalia P, Araujo-Fernandez I, Singavi A, George B, MacKinnon AC, Thompson J, Singh R, Jacob R, Dressler L, Steciuk M, Binns O, Kasuganti D, Shah N, Ernstoff M, Odunsi K, Kurzrock R, Gardner M, Galluzzi L, Morrison C.

J Immunother Cancer. 2019 Feb 1;7(1):27. doi: 10.1186/s40425-019-0506-3.


Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors.

Conroy JM, Pabla S, Nesline MK, Glenn ST, Papanicolau-Sengos A, Burgher B, Andreas J, Giamo V, Wang Y, Lenzo FL, Bshara W, Khalil M, Dy GK, Madden KG, Shirai K, Dragnev K, Tafe LJ, Zhu J, Labriola M, Marin D, McCall SJ, Clarke J, George DJ, Zhang T, Zibelman M, Ghatalia P, Araujo-Fernandez I, de la Cruz-Merino L, Singavi A, George B, MacKinnon AC, Thompson J, Singh R, Jacob R, Kasuganti D, Shah N, Day R, Galluzzi L, Gardner M, Morrison C.

J Immunother Cancer. 2019 Jan 24;7(1):18. doi: 10.1186/s40425-018-0489-5.


An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.

Vuong L, Kouverianou E, Rooney CM, McHugh BJ, Howie SEM, Gregory CD, Forbes SJ, Henderson NC, Zetterberg FR, Nilsson UJ, Leffler H, Ford P, Pedersen A, Gravelle L, Tantawi S, Schambye H, Sethi T, MacKinnon AC.

Cancer Res. 2019 Apr 1;79(7):1480-1492. doi: 10.1158/0008-5472.CAN-18-2244. Epub 2019 Jan 23.


Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer.

Xiong D, Wang Y, Singavi AK, Mackinnon AC, George B, You M.

iScience. 2018 Nov 30;9:258-277. doi: 10.1016/j.isci.2018.10.021. Epub 2018 Oct 25.


Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells.

Mon AM, MacKinnon AC Jr, Traktman P.

PLoS One. 2018 Sep 4;13(9):e0203397. doi: 10.1371/journal.pone.0203397. eCollection 2018.


Tubulopapillary adrenocortical adenoma in a patient with familial adenomatous polyposis: a morphologic, ultrastructural, and molecular study.

Huang H, Chang J, Rosati S, Geurts J, Mackinnon AC.

Hum Pathol. 2019 May;87:51-56. doi: 10.1016/j.humpath.2018.08.022. Epub 2018 Aug 31.


A Phase II Clinical Trial of Molecular Profiled Neoadjuvant Therapy for Localized Pancreatic Ductal Adenocarcinoma.

Tsai S, Christians KK, George B, Ritch PS, Dua K, Khan A, Mackinnon AC, Tolat P, Ahmad SA, Hall WA, Erickson BA, Evans DB.

Ann Surg. 2018 Oct;268(4):610-619. doi: 10.1097/SLA.0000000000002957.


Poorly Differentiated Nonkeratinizing Squamous Cell Carcinoma of the Thymus: Clinicopathologic and Molecular Genetic Study of 25 Cases.

Suster D, Pihan G, Mackinnon AC, Suster S.

Am J Surg Pathol. 2018 Sep;42(9):1224-1236. doi: 10.1097/PAS.0000000000001101.


Expression of PD-L1/PD-1 in lymphoepithelioma-like carcinoma of the thymus.

Suster D, Pihan G, Mackinnon AC, Suster S.

Mod Pathol. 2018 Dec;31(12):1801-1806. doi: 10.1038/s41379-018-0097-4. Epub 2018 Jul 4.


Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury.

Humphries DC, O'Neill S, Scholefield E, Dorward DA, Mackinnon AC, Rossi AG, Haslett C, Andrews PJD, Rhodes J, Dhaliwal K.

Crit Care Med. 2018 Sep;46(9):e937-e944. doi: 10.1097/CCM.0000000000003270.


Bronchiolar Adenoma: Expansion of the Concept of Ciliated Muconodular Papillary Tumors With Proposal for Revised Terminology Based on Morphologic, Immunophenotypic, and Genomic Analysis of 25 Cases.

Chang JC, Montecalvo J, Borsu L, Lu S, Larsen BT, Wallace WD, Sae-Ow W, Mackinnon AC, Kim HR, Bowman A, Sauter JL, Arcila ME, Ladanyi M, Travis WD, Rekhtman N.

Am J Surg Pathol. 2018 Aug;42(8):1010-1026. doi: 10.1097/PAS.0000000000001086.


A-C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions.

Hanson AM, Perera KLIS, Kim J, Pandey RK, Sweeney N, Lu X, Imhoff A, Mackinnon AC, Wargolet AJ, Van Hart RM, Frick KM, Donaldson WA, Sem DS.

J Med Chem. 2018 Jun 14;61(11):4720-4738. doi: 10.1021/acs.jmedchem.7b01601. Epub 2018 Jun 4.


Optimized b-value selection for the discrimination of prostate cancer grades, including the cribriform pattern, using diffusion weighted imaging.

Hurrell SL, McGarry SD, Kaczmarowski A, Iczkowski KA, Jacobsohn K, Hohenwalter MD, Hall WA, See WA, Banerjee A, Charles DK, Nevalainen MT, Mackinnon AC, LaViolette PS.

J Med Imaging (Bellingham). 2018 Jan;5(1):011004. doi: 10.1117/1.JMI.5.1.011004. Epub 2017 Oct 27.


αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.

Murray IR, Gonzalez ZN, Baily J, Dobie R, Wallace RJ, Mackinnon AC, Smith JR, Greenhalgh SN, Thompson AI, Conroy KP, Griggs DW, Ruminski PG, Gray GA, Singh M, Campbell MA, Kendall TJ, Dai J, Li Y, Iredale JP, Simpson H, Huard J, Péault B, Henderson NC.

Nat Commun. 2017 Oct 24;8(1):1118. doi: 10.1038/s41467-017-01097-z.


Evaluation of CD43 expression in non-hematopoietic malignancies.

Batdorf BH, Kroft SH, Hosking PR, Harrington AM, Mackinnon AC, Olteanu H.

Ann Diagn Pathol. 2017 Aug;29:23-27. doi: 10.1016/j.anndiagpath.2017.04.010. Epub 2017 Apr 26.


Immune Check Point Inhibition in Sarcomatoid Renal Cell Carcinoma: A New Treatment Paradigm.

Raychaudhuri R, Riese MJ, Bylow K, Burfeind J, Mackinnon AC, Tolat PP, Iczkowski KA, Kilari D.

Clin Genitourin Cancer. 2017 Oct;15(5):e897-e901. doi: 10.1016/j.clgc.2017.05.018. Epub 2017 May 25. No abstract available.


Cancer cell chemokines direct chemotaxis of activated stellate cells in pancreatic ductal adenocarcinoma.

Roy I, Boyle KA, Vonderhaar EP, Zimmerman NP, Gorse E, Mackinnon AC, Hwang RF, Franco-Barraza J, Cukierman E, Tsai S, Evans DB, Dwinell MB.

Lab Invest. 2017 Mar;97(3):302-317. doi: 10.1038/labinvest.2016.146. Epub 2017 Jan 16.


Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia.

Moore JK, MacKinnon AC, Man TY, Manning JR, Forbes SJ, Simpson KJ.

Aliment Pharmacol Ther. 2017 Feb;45(3):443-454. doi: 10.1111/apt.13878. Epub 2016 Nov 28.


A single center's approach to discriminating donor versus host origin of renal neoplasia in the allograft kidney.

Robin AJ, Cohen EP, Chongkrairatanakul T, Saad E, Mackinnon AC.

Ann Diagn Pathol. 2016 Aug;23:32-4. doi: 10.1016/j.anndiagpath.2016.05.004. Epub 2016 May 27.


The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases.

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL.

J Biol Chem. 2016 May 13;291(20):10948. doi: 10.1074/jbc.A115.696831. No abstract available.


The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL.

J Biol Chem. 2016 Mar 18;291(12):6534-45. doi: 10.1074/jbc.M115.696831. Epub 2016 Jan 26. Erratum in: J Biol Chem. 2016 May 13;291(20):10948.


Comparing gene expression data from formalin-fixed, paraffin embedded tissues and qPCR with that from snap-frozen tissue and microarrays for modeling outcomes of patients with ovarian carcinoma.

Bradley WH, Eng K, Le M, Mackinnon AC, Kendziorski C, Rader JS.

BMC Clin Pathol. 2015 Sep 24;15:17. doi: 10.1186/s12907-015-0017-1. eCollection 2015.


CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure.

Stutchfield BM, Antoine DJ, Mackinnon AC, Gow DJ, Bain CC, Hawley CA, Hughes MJ, Francis B, Wojtacha D, Man TY, Dear JW, Devey LR, Mowat AM, Pollard JW, Park BK, Jenkins SJ, Simpson KJ, Hume DA, Wigmore SJ, Forbes SJ.

Gastroenterology. 2015 Dec;149(7):1896-1909.e14. doi: 10.1053/j.gastro.2015.08.053. Epub 2015 Sep 5.


Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study.

Moore JK, Mackinnon AC, Wojtacha D, Pope C, Fraser AR, Burgoyne P, Bailey L, Pass C, Atkinson A, Mcgowan NW, Manson L, Turner ML, Campbell JD, Forbes SJ.

Cytotherapy. 2015 Nov;17(11):1604-16. doi: 10.1016/j.jcyt.2015.07.016. Epub 2015 Sep 3.


Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls.

Xia S, Huang CC, Le M, Dittmar R, Du M, Yuan T, Guo Y, Wang Y, Wang X, Tsai S, Suster S, Mackinnon AC, Wang L.

Lung Cancer. 2015 Oct;90(1):78-84. doi: 10.1016/j.lungcan.2015.07.002. Epub 2015 Jul 15.


Temporal expression of galectin-3 following myocardial infarction.

Milner TD, Viner AC, MacKinnon AC, Sethi T, Flapan AD.

Acta Cardiol. 2014 Dec;69(6):595-602.


Galectin-3 regulates hepatic progenitor cell expansion during liver injury.

Hsieh WC, Mackinnon AC, Lu WY, Jung J, Boulter L, Henderson NC, Simpson KJ, Schotanus B, Wojtacha D, Bird TG, Medine CN, Hay DC, Sethi T, Iredale JP, Forbes SJ.

Gut. 2015 Feb;64(2):312-21. doi: 10.1136/gutjnl-2013-306290. Epub 2014 May 16.


Depletion of M2-like tumor-associated macrophages delays cutaneous T-cell lymphoma development in vivo.

Wu X, Schulte BC, Zhou Y, Haribhai D, Mackinnon AC, Plaza JA, Williams CB, Hwang ST.

J Invest Dermatol. 2014 Nov;134(11):2814-2822. doi: 10.1038/jid.2014.206. Epub 2014 Apr 29.


Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori-positive and Helicobacter pylori-negative gastritis.

Villarreal-Calderon R, Luévano-González A, Aragón-Flores M, Zhu H, Yuan Y, Xiang Q, Yan B, Stoll KA, Cross JV, Iczkowski KA, Mackinnon AC Jr.

Ann Diagn Pathol. 2014 Jun;18(3):129-35. doi: 10.1016/j.anndiagpath.2014.02.003. Epub 2014 Feb 11.


CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis.

Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB, Dwinell MB.

PLoS One. 2014 Mar 4;9(3):e90400. doi: 10.1371/journal.pone.0090400. eCollection 2014.


Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury.

Tsuchiya A, Lu WY, Weinhold B, Boulter L, Stutchfield BM, Williams MJ, Guest RV, Minnis-Lyons SE, MacKinnon AC, Schwarzer D, Ichida T, Nomoto M, Aoyagi Y, Gerardy-Schahn R, Forbes SJ.

Hepatology. 2014 Nov;60(5):1727-40. doi: 10.1002/hep.27099. Epub 2014 Sep 29.


Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.

Kallis YN, Scotton CJ, Mackinnon AC, Goldin RD, Wright NA, Iredale JP, Chambers RC, Forbes SJ.

PLoS One. 2014 Jan 27;9(1):e86241. doi: 10.1371/journal.pone.0086241. eCollection 2014.


CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist.

Sarvi S, Mackinnon AC, Avlonitis N, Bradley M, Rintoul RC, Rassl DM, Wang W, Forbes SJ, Gregory CD, Sethi T.

Cancer Res. 2014 Mar 1;74(5):1554-65. doi: 10.1158/0008-5472.CAN-13-1541. Epub 2014 Jan 16.


Cribriform adenocarcinoma of the lung: clinicopathologic, immunohistochemical, and molecular analysis of 15 cases of a distinctive morphologic subtype of lung adenocarcinoma.

Mackinnon AC Jr, Luevano A, de Araujo LC, Rao N, Le M, Suster S.

Mod Pathol. 2014 Aug;27(8):1063-72. doi: 10.1038/modpathol.2013.227. Epub 2014 Jan 3.


The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer.

Hauser AD, Bergom C, Schuld NJ, Chen X, Lorimer EL, Huang J, Mackinnon AC, Williams CL.

Mol Cancer Res. 2014 Jan;12(1):130-42. doi: 10.1158/1541-7786.MCR-13-0362. Epub 2013 Nov 6.


Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death.

Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B.

BMC Cancer. 2013 Jun 13;13:285. doi: 10.1186/1471-2407-13-285.


Tracking in anatomic pathology.

Pantanowitz L, Mackinnon AC Jr, Sinard JH.

Arch Pathol Lab Med. 2013 Dec;137(12):1798-810. doi: 10.5858/arpa.2013-0125-SA. Epub 2013 May 1. Review.


Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice.

MacKinnon AC, Liu X, Hadoke PW, Miller MR, Newby DE, Sethi T.

Glycobiology. 2013 Jun;23(6):654-63. doi: 10.1093/glycob/cwt006. Epub 2013 Feb 19.


Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID).

Chase NM, Verbsky JW, Hintermeyer MK, Waukau JK, Tomita-Mitchell A, Casper JT, Singh S, Shahir KS, Tisol WB, Nugent ML, Rao RN, Mackinnon AC, Goodman LR, Simpson PM, Routes JM.

J Clin Immunol. 2013 Jan;33(1):30-9. doi: 10.1007/s10875-012-9755-3. Epub 2012 Aug 29.


Certification in molecular pathology in the United States: an update from the Association for Molecular Pathology Training and Education Committee.

Mackinnon AC Jr, Wang YL, Sahota A, Yeung CC, Weck KE.

J Mol Diagn. 2012 Nov;14(6):541-9. doi: 10.1016/j.jmoldx.2012.05.004. Epub 2012 Aug 24.


Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis.

Fons ME, Stein DJ, Patel A, Ferrer MS, Ammon H, Mackinnon AC, Komorowski RA, Yan BC.

Ann Diagn Pathol. 2013 Jun;17(3):291-4. doi: 10.1016/j.anndiagpath.2012.04.003. Epub 2012 Jun 1.


Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient.

Budzik JM, Hosseini M, Mackinnon AC Jr, Taxy JB.

Surg Infect (Larchmt). 2012 Jun;13(3):163-70. doi: 10.1089/sur.2011.012. Epub 2012 May 21. Review.


Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death.

Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B.

Cancer Res. 2012 May 15;72(10):2634-44. doi: 10.1158/0008-5472.CAN-11-3928. Epub 2012 Mar 19.


Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.

Mackinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, Delaine T, Simpson AJ, Forbes SJ, Hirani N, Gauldie J, Sethi T.

Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46. doi: 10.1164/rccm.201106-0965OC. Epub 2011 Nov 17.


Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.

Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, Phythian-Adams AT, van Rooijen N, Haslett C, Howie SE, Simpson AJ, Hirani N, Gauldie J, Iredale JP, Sethi T, Forbes SJ.

Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81. doi: 10.1164/rccm.201010-1719OC.


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