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Items: 1 to 50 of 387

1.

c-Jun N terminal kinase signaling pathways mediate cannabinoid tolerance in an agonist-specific manner.

Henderson-Redmond AN, Nealon CM, Davis BJ, Yuill MB, Sepulveda DE, Blanton HL, Piscura MK, Zee ML, Haskins CP, Marcus DJ, Mackie K, Guindon J, Morgan DJ.

Neuropharmacology. 2019 Nov 20:107847. doi: 10.1016/j.neuropharm.2019.107847. [Epub ahead of print]

PMID:
31758947
2.

Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of CB1 Receptor Positive Allosteric Modulators.

Garai S, Kulkarni PM, Schaffer PC, Leo L, Brandt AL, Zagzoog A, Black T, Lin X, Hurst DP, Janero DR, Abood ME, Zimmowitch A, Straiker A, Pertwee RG, Kelly M, Szczesniak AM, Denovan-Wright E, Mackie K, Hohmann A, Reggio PH, Laprairie RB, Thakur GA.

J Med Chem. 2019 Nov 22. doi: 10.1021/acs.jmedchem.9b01142. [Epub ahead of print]

PMID:
31756109
3.

Life-long epigenetic programming of cortical architecture by maternal 'Western' diet during pregnancy.

Cinquina V, Calvigioni D, Farlik M, Halbritter F, Fife-Gernedl V, Shirran SL, Fuszard MA, Botting CH, Poullet P, Piscitelli F, Máté Z, Szabó G, Yanagawa Y, Kasper S, Di Marzo V, Mackie K, McBain CJ, Bock C, Keimpema E, Harkany T.

Mol Psychiatry. 2019 Nov 18. doi: 10.1038/s41380-019-0580-4. [Epub ahead of print]

PMID:
31735910
4.

Efficacy of fenbendazole and ivermectin in treating gastrointestinal nematode infections in an Ontario cow-calf herd.

Mackie KG, Menzies PI, Bateman KG, Gordon JL.

Can Vet J. 2019 Nov;60(11):1213-1219.

PMID:
31692638
5.

Cannabinoid Exposure via Lactation in Rats Disrupts Perinatal Programming of the Gamma-Aminobutyric Acid Trajectory and Select Early-Life Behaviors.

Scheyer AF, Borsoi M, Wager-Miller J, Pelissier-Alicot AL, Murphy MN, Mackie K, Manzoni OJJ.

Biol Psychiatry. 2019 Sep 5. pii: S0006-3223(19)31662-2. doi: 10.1016/j.biopsych.2019.08.023. [Epub ahead of print]

PMID:
31653479
6.

Computer navigation of the glenoid component in reverse total shoulder arthroplasty: a clinical trial to evaluate the learning curve.

Wang AW, Hayes A, Gibbons R, Mackie KE.

J Shoulder Elbow Surg. 2019 Oct 21. pii: S1058-2746(19)30586-5. doi: 10.1016/j.jse.2019.08.012. [Epub ahead of print]

PMID:
31648783
7.

Activity following reverse total shoulder arthroplasty: What should surgeons be advising?

MacInnes SJ, Mackie KE, Titchener A, Gibbons R, Wang AW.

Shoulder Elbow. 2019 Jul;11(2 Suppl):4-15. doi: 10.1177/1758573218793648. Epub 2018 Aug 8. Review.

PMID:
31447940
8.

Feasibility of conducting an early pregnancy diet and lifestyle e-health intervention: the Pregnancy Lifestyle Activity Nutrition (PLAN) project.

Huang RC, Silva D, Beilin L, Neppe C, Mackie KE, Roffey E, Gibson LY, D'Vaz N, Christian H, Reid CM, Prescott SL.

J Dev Orig Health Dis. 2019 Aug 8:1-13. doi: 10.1017/S2040174419000400. [Epub ahead of print]

PMID:
31391133
9.

Inhibitory Control Deficits Associated with Upregulation of CB1R in the HIV-1 Tat Transgenic Mouse Model of Hand.

Jacobs IR, Xu C, Hermes DJ, League AF, Xu C, Nath B, Jiang W, Niphakis MJ, Cravatt BF, Mackie K, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska BM, Fitting S.

J Neuroimmune Pharmacol. 2019 Dec;14(4):661-678. doi: 10.1007/s11481-019-09867-w. Epub 2019 Aug 1.

10.

Chronic adolescent exposure to ∆9-tetrahydrocannabinol decreases NMDA current and extrasynaptic plasmalemmal density of NMDA GluN1 subunits in the prelimbic cortex of adult male mice.

Pickel VM, Bourie F, Chan J, Mackie K, Lane DA, Wang G.

Neuropsychopharmacology. 2020 Jan;45(2):374-383. doi: 10.1038/s41386-019-0466-9. Epub 2019 Jul 19.

PMID:
31323660
11.

Cannabinoid receptor-mediated modulation of inhibitory inputs to mitral cells in the main olfactory bulb.

Wang ZJ, Hu SS, Bradshaw HB, Sun L, Mackie K, Straiker A, Heinbockel T.

J Neurophysiol. 2019 Aug 1;122(2):749-759. doi: 10.1152/jn.00100.2018. Epub 2019 Jun 19.

PMID:
31215302
12.
13.

Noradrenergic depletion causes sex specific alterations in the endocannabinoid system in the Murine prefrontal cortex.

Urquhart MA, Ross JA, Reyes BAS, Nitikman M, Thomas SA, Mackie K, Van Bockstaele EJ.

Neurobiol Stress. 2019 Apr 10;10:100164. doi: 10.1016/j.ynstr.2019.100164. eCollection 2019 Feb.

14.

Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice.

Smoker MP, Mackie K, Lapish CC, Boehm SL 2nd.

Drug Alcohol Depend. 2019 Jun 1;199:106-115. doi: 10.1016/j.drugalcdep.2019.02.020. Epub 2019 Apr 17.

PMID:
31029878
15.

Ultrastructural localization of cannabinoid CB1 and mGluR5 receptors in the prefrontal cortex and amygdala.

Fitzgerald ML, Mackie K, Pickel VM.

J Comp Neurol. 2019 Nov 1;527(16):2730-2741. doi: 10.1002/cne.24704. Epub 2019 May 10.

PMID:
31008528
16.

Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea.

Murataeva N, Daily L, Taylor X, Dhopeshwarkar A, Hu SS, Miller S, McHugh D, Oehler O, Li S, Bonanno JA, Mackie K, Straiker A.

Cornea. 2019 Jul;38(7):905-913. doi: 10.1097/ICO.0000000000001934.

PMID:
30969262
17.

Measures of oxidative state are primarily driven by extrinsic factors in a long-distance migrant.

Bodey TW, Cleasby IR, Blount JD, Vigfusdottir F, Mackie K, Bearhop S.

Biol Lett. 2019 Jan 31;15(1):20180750. doi: 10.1098/rsbl.2018.0750.

PMID:
30958216
18.

Protective Effect of N-Arachidonoyl Glycine-GPR18 Signaling after Excitotoxical Lesion in Murine Organotypic Hippocampal Slice Cultures.

Grabiec U, Hohmann T, Ghadban C, Rothgänger C, Wong D, Antonietti A, Groth T, Mackie K, Dehghani F.

Int J Mol Sci. 2019 Mar 13;20(6). pii: E1266. doi: 10.3390/ijms20061266.

19.

GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation.

Korchynska S, Lutz MI, Borók E, Pammer J, Cinquina V, Fedirko N, Irving AJ, Mackie K, Harkany T, Keimpema E.

JCI Insight. 2019 Feb 21;4(4). pii: 122947. doi: 10.1172/jci.insight.122947. eCollection 2019 Feb 21.

20.

A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.

Hawken ER, Normandeau CP, Gardner Gregory J, Cécyre B, Bouchard JF, Mackie K, Dumont ÉC.

Neuropsychopharmacology. 2019 Jun;44(7):1274-1283. doi: 10.1038/s41386-018-0309-0. Epub 2019 Jan 7.

PMID:
30647449
21.

Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains.

Leishman E, Murphy MN, Murphy MI, Mackie K, Bradshaw HB.

Front Mol Neurosci. 2018 Nov 27;11:436. doi: 10.3389/fnmol.2018.00436. eCollection 2018.

22.

Cannabidiol's Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D.

Leishman E, Manchanda M, Thelen R, Miller S, Mackie K, Bradshaw HB.

Cannabis Cannabinoid Res. 2018 Nov 30;3(1):228-241. doi: 10.1089/can.2018.0031. eCollection 2018.

23.

Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal.

Li AL, Lin X, Dhopeshwarkar AS, Thomaz AC, Carey LM, Liu Y, Nikas SP, Makriyannis A, Mackie K, Hohmann AG.

Mol Pharmacol. 2019 Feb;95(2):155-168. doi: 10.1124/mol.118.113233. Epub 2018 Nov 30.

PMID:
30504240
24.

Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray.

Chen YH, Lee HJ, Lee MT, Wu YT, Lee YH, Hwang LL, Hung MS, Zimmer A, Mackie K, Chiou LC.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10720-E10729. doi: 10.1073/pnas.1807991115. Epub 2018 Oct 22.

25.

Sex-dependent effects of in utero cannabinoid exposure on cortical function.

Bara A, Manduca A, Bernabeu A, Borsoi M, Serviado M, Lassalle O, Murphy M, Wager-Miller J, Mackie K, Pelissier-Alicot AL, Trezza V, Manzoni OJ.

Elife. 2018 Sep 11;7. pii: e36234. doi: 10.7554/eLife.36234.

26.

( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.

Liu Y, Ji L, Eno M, Kudalkar S, Li AL, Schimpgen M, Benchama O, Morales P, Xu S, Hurst D, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis DP, Zhou H, Honrao C, Mackie K, Reggio P, Hohmann AG, Marnett LJ, Makriyannis A, Nikas SP.

J Med Chem. 2018 Oct 11;61(19):8639-8657. doi: 10.1021/acs.jmedchem.8b00611. Epub 2018 Sep 21.

PMID:
30196704
27.

Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS.

Hermes DJ, Xu C, Poklis JL, Niphakis MJ, Cravatt BF, Mackie K, Lichtman AH, Ignatowska-Jankowska BM, Fitting S.

Neuropharmacology. 2018 Oct;141:55-65. doi: 10.1016/j.neuropharm.2018.08.013. Epub 2018 Aug 13.

28.

Evaluation of Long-term Outcomes Following Plantar Fasciotomy.

Gibbons R, Mackie KE, Beveridge T, Hince D, Ammon P.

Foot Ankle Int. 2018 Nov;39(11):1312-1319. doi: 10.1177/1071100718788546. Epub 2018 Aug 1.

PMID:
30066576
29.

Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation.

Mulpuri Y, Marty VN, Munier JJ, Mackie K, Schmidt BL, Seltzman HH, Spigelman I.

Neuropharmacology. 2018 Sep 1;139:85-97. doi: 10.1016/j.neuropharm.2018.07.002. Epub 2018 Jul 5.

30.

Analysis of Endocannabinoid System in Rat Testis During the First Spermatogenetic Wave.

Migliaccio M, Ricci G, Suglia A, Manfrevola F, Mackie K, Fasano S, Pierantoni R, Chioccarelli T, Cobellis G.

Front Endocrinol (Lausanne). 2018 May 29;9:269. doi: 10.3389/fendo.2018.00269. eCollection 2018.

31.

Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure.

Miller S, Kulkarni S, Ciesielski A, Nikas SP, Mackie K, Makriyannis A, Straiker A.

Pharmaceuticals (Basel). 2018 May 22;11(2). pii: E50. doi: 10.3390/ph11020050.

32.

Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons.

Straiker A, Dvorakova M, Zimmowitch A, Mackie K.

Mol Pharmacol. 2018 Jul;94(1):743-748. doi: 10.1124/mol.118.111864. Epub 2018 Apr 18.

33.

Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).

Kasten CR, Zhang Y, Mackie K, Boehm SL 2nd.

Behav Genet. 2018 May;48(3):224-235. doi: 10.1007/s10519-018-9894-2. Epub 2018 Mar 17.

34.

Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.

Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ.

Biol Psychiatry. 2018 Aug 15;84(4):304-315. doi: 10.1016/j.biopsych.2017.11.036. Epub 2017 Dec 28.

35.

Δ9-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult.

Leishman E, Murphy M, Mackie K, Bradshaw HB.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 May;1863(5):479-492. doi: 10.1016/j.bbalip.2018.02.001. Epub 2018 Feb 8.

36.

GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage.

Sumida H, Lu E, Chen H, Yang Q, Mackie K, Cyster JG.

Sci Immunol. 2017 Dec 8;2(18). pii: eaao1135. doi: 10.1126/sciimmunol.aao1135.

37.

Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model.

Sepers MD, Smith-Dijak A, LeDue J, Kolodziejczyk K, Mackie K, Raymond LA.

J Neurosci. 2018 Jan 17;38(3):544-554. doi: 10.1523/JNEUROSCI.1739-17.2017. Epub 2017 Nov 30. Erratum in: J Neurosci. 2018 Aug 15;38(33):7364.

38.

Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence.

Lin X, Dhopeshwarkar AS, Huibregtse M, Mackie K, Hohmann AG.

Mol Pharmacol. 2018 Feb;93(2):49-62. doi: 10.1124/mol.117.109355. Epub 2017 Nov 30.

39.

Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

Westphal MV, Schafroth MA, Sarott RC, Imhof MA, Bold CP, Leippe P, Dhopeshwarkar A, Grandner JM, Katritch V, Mackie K, Trauner D, Carreira EM, Frank JA.

J Am Chem Soc. 2017 Dec 20;139(50):18206-18212. doi: 10.1021/jacs.7b06456. Epub 2017 Dec 12.

PMID:
29161035
40.

Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons.

Mitjavila J, Yin D, Kulkarni PM, Zanato C, Thakur GA, Ross R, Greig I, Mackie K, Straiker A.

Pharmacol Res. 2018 Mar;129:475-481. doi: 10.1016/j.phrs.2017.11.019. Epub 2017 Nov 20.

41.

Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Jourdan T, Park JK, Varga ZV, Pálóczi J, Coffey NJ, Rosenberg AZ, Godlewski G, Cinar R, Mackie K, Pacher P, Kunos G.

Diabetes Obes Metab. 2018 Mar;20(3):698-708. doi: 10.1111/dom.13150. Epub 2017 Dec 3.

PMID:
29106063
42.

Chronic Adolescent Δ9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment.

Murphy M, Mills S, Winstone J, Leishman E, Wager-Miller J, Bradshaw H, Mackie K.

Cannabis Cannabinoid Res. 2017 Sep 1;2(1):235-246. doi: 10.1089/can.2017.0034. eCollection 2017.

43.

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.

Slivicki RA, Xu Z, Kulkarni PM, Pertwee RG, Mackie K, Thakur GA, Hohmann AG.

Biol Psychiatry. 2018 Nov 15;84(10):722-733. doi: 10.1016/j.biopsych.2017.06.032. Epub 2017 Jul 8.

44.

Endocannabinoids exert CB1 receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein.

Xu C, Hermes DJ, Nwanguma B, Jacobs IR, Mackie K, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska B, Fitting S.

Mol Cell Neurosci. 2017 Sep;83:92-102. doi: 10.1016/j.mcn.2017.07.003. Epub 2017 Jul 19.

45.

Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse.

Ruehle S, Wager-Miller J, Straiker A, Farnsworth J, Murphy MN, Loch S, Monory K, Mackie K, Lutz B.

J Neurochem. 2017 Aug;142(4):521-533. doi: 10.1111/jnc.14099. Epub 2017 Jul 18.

46.

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner.

Miller S, Hu SS, Leishman E, Morgan D, Wager-Miller J, Mackie K, Bradshaw HB, Straiker A.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2930-2938. doi: 10.1167/iovs.16-21330.

47.

Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice.

Li AL, Carey LM, Mackie K, Hohmann AG.

J Pharmacol Exp Ther. 2017 Aug;362(2):296-305. doi: 10.1124/jpet.117.241901. Epub 2017 Jun 7.

48.

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.

Khurana L, Mackie K, Piomelli D, Kendall DA.

Neuropharmacology. 2017 Sep 15;124:3-12. doi: 10.1016/j.neuropharm.2017.05.018. Epub 2017 May 17. Review.

49.

Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.

Zhong H, Tong L, Gu N, Gao F, Lu Y, Xie RG, Liu J, Li X, Bergeron R, Pomeranz LE, Mackie K, Wang F, Luo CX, Ren Y, Wu SX, Xie Z, Xu L, Li J, Dong H, Xiong L, Zhang X.

J Clin Invest. 2017 Jun 1;127(6):2295-2309. doi: 10.1172/JCI91038. Epub 2017 May 2.

50.

Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice.

Carey LM, Gutierrez T, Deng L, Lee WH, Mackie K, Hohmann AG.

Sci Rep. 2017 Apr 20;7(1):944. doi: 10.1038/s41598-017-01062-2.

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