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Items: 1 to 50 of 368

1.

A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.

Hawken ER, Normandeau CP, Gardner Gregory J, Cécyre B, Bouchard JF, Mackie K, Dumont ÉC.

Neuropsychopharmacology. 2019 Jan 7. doi: 10.1038/s41386-018-0309-0. [Epub ahead of print]

PMID:
30647449
2.

Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains.

Leishman E, Murphy MN, Murphy MI, Mackie K, Bradshaw HB.

Front Mol Neurosci. 2018 Nov 27;11:436. doi: 10.3389/fnmol.2018.00436. eCollection 2018.

3.

Cannabidiol's Upregulation of N-acyl Ethanolamines in the Central Nervous System Requires N-acyl Phosphatidyl Ethanolamine-Specific Phospholipase D.

Leishman E, Manchanda M, Thelen R, Miller S, Mackie K, Bradshaw HB.

Cannabis Cannabinoid Res. 2018 Nov 30;3(1):228-241. doi: 10.1089/can.2018.0031. eCollection 2018.

4.

Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal.

Li AL, Lin X, Dhopeshwarkar AS, Thomaz AC, Carey LM, Liu Y, Nikas SP, Makriyannis A, Mackie K, Hohmann AG.

Mol Pharmacol. 2019 Feb;95(2):155-168. doi: 10.1124/mol.118.113233. Epub 2018 Nov 30.

PMID:
30504240
5.

Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray.

Chen YH, Lee HJ, Lee MT, Wu YT, Lee YH, Hwang LL, Hung MS, Zimmer A, Mackie K, Chiou LC.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10720-E10729. doi: 10.1073/pnas.1807991115. Epub 2018 Oct 22.

PMID:
30348772
6.

Sex-dependent effects of in utero cannabinoid exposure on cortical function.

Bara A, Manduca A, Bernabeu A, Borsoi M, Serviado M, Lassalle O, Murphy M, Wager-Miller J, Mackie K, Pelissier-Alicot AL, Trezza V, Manzoni OJ.

Elife. 2018 Sep 11;7. pii: e36234. doi: 10.7554/eLife.36234.

7.

( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.

Liu Y, Ji L, Eno M, Kudalkar S, Li AL, Schimpgen M, Benchama O, Morales P, Xu S, Hurst D, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis DP, Zhou H, Honrao C, Mackie K, Reggio P, Hohmann AG, Marnett LJ, Makriyannis A, Nikas SP.

J Med Chem. 2018 Oct 11;61(19):8639-8657. doi: 10.1021/acs.jmedchem.8b00611. Epub 2018 Sep 21.

PMID:
30196704
8.

Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS.

Hermes DJ, Xu C, Poklis JL, Niphakis MJ, Cravatt BF, Mackie K, Lichtman AH, Ignatowska-Jankowska BM, Fitting S.

Neuropharmacology. 2018 Oct;141:55-65. doi: 10.1016/j.neuropharm.2018.08.013. Epub 2018 Aug 13.

9.

Evaluation of Long-term Outcomes Following Plantar Fasciotomy.

Gibbons R, Mackie KE, Beveridge T, Hince D, Ammon P.

Foot Ankle Int. 2018 Nov;39(11):1312-1319. doi: 10.1177/1071100718788546. Epub 2018 Aug 1.

PMID:
30066576
10.

Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation.

Mulpuri Y, Marty VN, Munier JJ, Mackie K, Schmidt BL, Seltzman HH, Spigelman I.

Neuropharmacology. 2018 Sep 1;139:85-97. doi: 10.1016/j.neuropharm.2018.07.002. Epub 2018 Jul 5.

PMID:
29981335
11.

Analysis of Endocannabinoid System in Rat Testis During the First Spermatogenetic Wave.

Migliaccio M, Ricci G, Suglia A, Manfrevola F, Mackie K, Fasano S, Pierantoni R, Chioccarelli T, Cobellis G.

Front Endocrinol (Lausanne). 2018 May 29;9:269. doi: 10.3389/fendo.2018.00269. eCollection 2018.

12.

Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure.

Miller S, Kulkarni S, Ciesielski A, Nikas SP, Mackie K, Makriyannis A, Straiker A.

Pharmaceuticals (Basel). 2018 May 22;11(2). pii: E50. doi: 10.3390/ph11020050.

13.

Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons.

Straiker A, Dvorakova M, Zimmowitch A, Mackie K.

Mol Pharmacol. 2018 Jul;94(1):743-748. doi: 10.1124/mol.118.111864. Epub 2018 Apr 18.

PMID:
29669714
14.

Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).

Kasten CR, Zhang Y, Mackie K, Boehm SL 2nd.

Behav Genet. 2018 May;48(3):224-235. doi: 10.1007/s10519-018-9894-2. Epub 2018 Mar 17.

PMID:
29550900
15.

Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.

Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ.

Biol Psychiatry. 2018 Aug 15;84(4):304-315. doi: 10.1016/j.biopsych.2017.11.036. Epub 2017 Dec 28.

PMID:
29458998
16.

Δ9-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult.

Leishman E, Murphy M, Mackie K, Bradshaw HB.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 May;1863(5):479-492. doi: 10.1016/j.bbalip.2018.02.001. Epub 2018 Feb 8.

PMID:
29408467
17.

GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage.

Sumida H, Lu E, Chen H, Yang Q, Mackie K, Cyster JG.

Sci Immunol. 2017 Dec 8;2(18). pii: eaao1135. doi: 10.1126/sciimmunol.aao1135.

18.

Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model.

Sepers MD, Smith-Dijak A, LeDue J, Kolodziejczyk K, Mackie K, Raymond LA.

J Neurosci. 2018 Jan 17;38(3):544-554. doi: 10.1523/JNEUROSCI.1739-17.2017. Epub 2017 Nov 30.

19.

Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence.

Lin X, Dhopeshwarkar AS, Huibregtse M, Mackie K, Hohmann AG.

Mol Pharmacol. 2018 Feb;93(2):49-62. doi: 10.1124/mol.117.109355. Epub 2017 Nov 30.

20.

Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

Westphal MV, Schafroth MA, Sarott RC, Imhof MA, Bold CP, Leippe P, Dhopeshwarkar A, Grandner JM, Katritch V, Mackie K, Trauner D, Carreira EM, Frank JA.

J Am Chem Soc. 2017 Dec 20;139(50):18206-18212. doi: 10.1021/jacs.7b06456. Epub 2017 Dec 12.

PMID:
29161035
21.

Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons.

Mitjavila J, Yin D, Kulkarni PM, Zanato C, Thakur GA, Ross R, Greig I, Mackie K, Straiker A.

Pharmacol Res. 2018 Mar;129:475-481. doi: 10.1016/j.phrs.2017.11.019. Epub 2017 Nov 20.

PMID:
29158048
22.

Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Jourdan T, Park JK, Varga ZV, Pálóczi J, Coffey NJ, Rosenberg AZ, Godlewski G, Cinar R, Mackie K, Pacher P, Kunos G.

Diabetes Obes Metab. 2018 Mar;20(3):698-708. doi: 10.1111/dom.13150. Epub 2017 Dec 3.

PMID:
29106063
23.

Chronic Adolescent Δ9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment.

Murphy M, Mills S, Winstone J, Leishman E, Wager-Miller J, Bradshaw H, Mackie K.

Cannabis Cannabinoid Res. 2017 Sep 1;2(1):235-246. doi: 10.1089/can.2017.0034. eCollection 2017.

24.

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.

Slivicki RA, Xu Z, Kulkarni PM, Pertwee RG, Mackie K, Thakur GA, Hohmann AG.

Biol Psychiatry. 2018 Nov 15;84(10):722-733. doi: 10.1016/j.biopsych.2017.06.032. Epub 2017 Jul 8.

25.

Endocannabinoids exert CB1 receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein.

Xu C, Hermes DJ, Nwanguma B, Jacobs IR, Mackie K, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska B, Fitting S.

Mol Cell Neurosci. 2017 Sep;83:92-102. doi: 10.1016/j.mcn.2017.07.003. Epub 2017 Jul 19.

26.

Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse.

Ruehle S, Wager-Miller J, Straiker A, Farnsworth J, Murphy MN, Loch S, Monory K, Mackie K, Lutz B.

J Neurochem. 2017 Aug;142(4):521-533. doi: 10.1111/jnc.14099. Epub 2017 Jul 18.

27.

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner.

Miller S, Hu SS, Leishman E, Morgan D, Wager-Miller J, Mackie K, Bradshaw HB, Straiker A.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2930-2938. doi: 10.1167/iovs.16-21330.

28.

Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice.

Li AL, Carey LM, Mackie K, Hohmann AG.

J Pharmacol Exp Ther. 2017 Aug;362(2):296-305. doi: 10.1124/jpet.117.241901. Epub 2017 Jun 7.

29.

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.

Khurana L, Mackie K, Piomelli D, Kendall DA.

Neuropharmacology. 2017 Sep 15;124:3-12. doi: 10.1016/j.neuropharm.2017.05.018. Epub 2017 May 17. Review.

30.

Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.

Zhong H, Tong L, Gu N, Gao F, Lu Y, Xie RG, Liu J, Li X, Bergeron R, Pomeranz LE, Mackie K, Wang F, Luo CX, Ren Y, Wu SX, Xie Z, Xu L, Li J, Dong H, Xiong L, Zhang X.

J Clin Invest. 2017 Jun 1;127(6):2295-2309. doi: 10.1172/JCI91038. Epub 2017 May 2.

31.

Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice.

Carey LM, Gutierrez T, Deng L, Lee WH, Mackie K, Hohmann AG.

Sci Rep. 2017 Apr 20;7(1):944. doi: 10.1038/s41598-017-01062-2.

32.

Mice expressing a "hyper-sensitive" form of the CB1 cannabinoid receptor (CB1) show modestly enhanced alcohol preference and consumption.

Marcus DJ, Henderson-Redmond AN, Gonek M, Zee ML, Farnsworth JC, Amin RA, Andrews MJ, Davis BJ, Mackie K, Morgan DJ.

PLoS One. 2017 Apr 20;12(4):e0174826. doi: 10.1371/journal.pone.0174826. eCollection 2017.

33.

Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.

Cinar R, Gochuico BR, Iyer MR, Jourdan T, Yokoyama T, Park JK, Coffey NJ, Pri-Chen H, Szanda G, Liu Z, Mackie K, Gahl WA, Kunos G.

JCI Insight. 2017 Apr 20;2(8). pii: 92281. doi: 10.1172/jci.insight.92281. [Epub ahead of print]

34.

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.

Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S.

Nat Commun. 2017 Mar 28;8:14782. doi: 10.1038/ncomms14782.

35.

Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons.

Sousa-Valente J, Varga A, Torres-Perez JV, Jenes A, Wahba J, Mackie K, Cravatt B, Ueda N, Tsuboi K, Santha P, Jancso G, Tailor H, Avelino A, Nagy I.

J Comp Neurol. 2017 Jun 1;525(8):1778-1796. doi: 10.1002/cne.24154. Epub 2017 Mar 14.

36.

Climatic conditions produce contrasting influences on demographic traits in a long-distance Arctic migrant.

Cleasby IR, Bodey TW, Vigfusdottir F, McDonald JL, McElwaine G, Mackie K, Colhoun K, Bearhop S.

J Anim Ecol. 2017 Mar;86(2):285-295. doi: 10.1111/1365-2656.12623. Epub 2017 Jan 23.

PMID:
27973683
37.

Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists.

Dhopeshwarkar A, Murataeva N, Makriyannis A, Straiker A, Mackie K.

J Pharmacol Exp Ther. 2017 Feb;360(2):300-311. doi: 10.1124/jpet.116.236539. Epub 2016 Dec 7.

38.

Novel indole-based compounds that differentiate alkylindole-sensitive receptors from cannabinoid receptors and microtubules: Characterization of their activity on glioma cell migration.

Fung S, Xu C, Hamel E, Wager-Miller JB, Woodruff G, Miller A, Sanford C, Mackie K, Stella N.

Pharmacol Res. 2017 Jan;115:233-241. doi: 10.1016/j.phrs.2016.10.025. Epub 2016 Nov 8.

PMID:
27832960
39.

Matrix-Assisted Ionization on a Portable Mass Spectrometer: Analysis Directly from Biological and Synthetic Materials.

Devereaux ZJ, Reynolds CA, Fischer JL, Foley CD, DeLeeuw JL, Wager-Miller J, Narayan SB, Mackie K, Trimpin S.

Anal Chem. 2016 Nov 15;88(22):10831-10836. Epub 2016 Nov 3.

PMID:
26938428
40.

Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.

Chen J, Varga A, Selvarajah S, Jenes A, Dienes B, Sousa-Valente J, Kulik A, Veress G, Brain SD, Baker D, Urban L, Mackie K, Nagy I.

Sci Rep. 2016 Sep 22;6:33307. doi: 10.1038/srep33307.

41.

A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation.

Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G.

eNeuro. 2016 Aug 8;3(4). pii: ENEURO.0160-16.2016. doi: 10.1523/ENEURO.0160-16.2016. eCollection 2016 Jul-Aug.

42.

Mice Expressing a "Hyper-Sensitive" Form of the Cannabinoid Receptor 1 (CB1) Are Neither Obese Nor Diabetic.

Marcus DJ, Zee ML, Davis BJ, Haskins CP, Andrews MJ, Amin R, Henderson-Redmond AN, Mackie K, Czyzyk TA, Morgan DJ.

PLoS One. 2016 Aug 8;11(8):e0160462. doi: 10.1371/journal.pone.0160462. eCollection 2016.

43.

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.

Tung LW, Lu GL, Lee YH, Yu L, Lee HJ, Leishman E, Bradshaw H, Hwang LL, Hung MS, Mackie K, Zimmer A, Chiou LC.

Nat Commun. 2016 Jul 22;7:12199. doi: 10.1038/ncomms12199.

44.

Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells.

Wager-Miller J, Mackie K.

Methods Mol Biol. 2016;1412:255-66. doi: 10.1007/978-1-4939-3539-0_26.

PMID:
27245911
45.

Western Blotting of the Endocannabinoid System.

Wager-Miller J, Mackie K.

Methods Mol Biol. 2016;1412:247-54. doi: 10.1007/978-1-4939-3539-0_25.

PMID:
27245910
46.

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.

Pinheiro BS, Lemos C, Neutzling Kaufmann F, Marques JM, da Silva-Santos CS, Carvalho E, Mackie K, Rodrigues RJ, Cunha RA, Köfalvi A.

Brain Res Bull. 2016 Jun;124:222-30. doi: 10.1016/j.brainresbull.2016.05.009. Epub 2016 May 18.

PMID:
27208730
47.

Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway.

Dhopeshwarkar A, Mackie K.

J Pharmacol Exp Ther. 2016 Aug;358(2):342-51. doi: 10.1124/jpet.116.232561. Epub 2016 May 18.

48.

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.

Carey LM, Slivicki RA, Leishman E, Cornett B, Mackie K, Bradshaw H, Hohmann AG.

Mol Pain. 2016 May 13;12. pii: 1744806916649192. doi: 10.1177/1744806916649192. Print 2016.

49.

Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol.

Murataeva N, Dhopeshwarkar A, Yin D, Mitjavila J, Bradshaw H, Straiker A, Mackie K.

Pharmacol Res. 2016 Aug;110:173-180. doi: 10.1016/j.phrs.2016.04.015. Epub 2016 Apr 23.

50.

Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain.

Leishman E, Cornett B, Spork K, Straiker A, Mackie K, Bradshaw HB.

Pharmacol Res. 2016 Aug;110:159-172. doi: 10.1016/j.phrs.2016.04.020. Epub 2016 Apr 22.

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