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Items: 1 to 50 of 359

1.

Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation.

Mulpuri Y, Marty VN, Munier JJ, Mackie K, Schmidt BL, Seltzman HH, Spigelman I.

Neuropharmacology. 2018 Jul 5;139:85-97. doi: 10.1016/j.neuropharm.2018.07.002. [Epub ahead of print]

PMID:
29981335
2.

Analysis of Endocannabinoid System in Rat Testis During the First Spermatogenetic Wave.

Migliaccio M, Ricci G, Suglia A, Manfrevola F, Mackie K, Fasano S, Pierantoni R, Chioccarelli T, Cobellis G.

Front Endocrinol (Lausanne). 2018 May 29;9:269. doi: 10.3389/fendo.2018.00269. eCollection 2018.

3.

Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure.

Miller S, Kulkarni S, Ciesielski A, Nikas SP, Mackie K, Makriyannis A, Straiker A.

Pharmaceuticals (Basel). 2018 May 22;11(2). pii: E50. doi: 10.3390/ph11020050.

4.

Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons.

Straiker A, Dvorakova M, Zimmowitch A, Mackie K.

Mol Pharmacol. 2018 Jul;94(1):743-748. doi: 10.1124/mol.118.111864. Epub 2018 Apr 18.

PMID:
29669714
5.

Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).

Kasten CR, Zhang Y, Mackie K, Boehm SL 2nd.

Behav Genet. 2018 May;48(3):224-235. doi: 10.1007/s10519-018-9894-2. Epub 2018 Mar 17.

PMID:
29550900
6.

Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.

Shonesy BC, Parrish WP, Haddad HK, Stephenson JR, Báldi R, Bluett RJ, Marks CR, Centanni SW, Folkes OM, Spiess K, Augustin SM, Mackie K, Lovinger DM, Winder DG, Patel S, Colbran RJ.

Biol Psychiatry. 2017 Dec 28. pii: S0006-3223(17)32316-8. doi: 10.1016/j.biopsych.2017.11.036. [Epub ahead of print]

PMID:
29458998
7.

Δ9-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult.

Leishman E, Murphy M, Mackie K, Bradshaw HB.

Biochim Biophys Acta. 2018 May;1863(5):479-492. doi: 10.1016/j.bbalip.2018.02.001. Epub 2018 Feb 8.

PMID:
29408467
8.

GPR55 regulates intraepithelial lymphocyte migration dynamics and susceptibility to intestinal damage.

Sumida H, Lu E, Chen H, Yang Q, Mackie K, Cyster JG.

Sci Immunol. 2017 Dec 8;2(18). pii: eaao1135. doi: 10.1126/sciimmunol.aao1135.

9.

Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model.

Sepers MD, Smith-Dijak A, LeDue J, Kolodziejczyk K, Mackie K, Raymond LA.

J Neurosci. 2018 Jan 17;38(3):544-554. doi: 10.1523/JNEUROSCI.1739-17.2017. Epub 2017 Nov 30.

10.

Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence.

Lin X, Dhopeshwarkar AS, Huibregtse M, Mackie K, Hohmann AG.

Mol Pharmacol. 2018 Feb;93(2):49-62. doi: 10.1124/mol.117.109355. Epub 2017 Nov 30.

PMID:
29192123
11.

Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

Westphal MV, Schafroth MA, Sarott RC, Imhof MA, Bold CP, Leippe P, Dhopeshwarkar A, Grandner JM, Katritch V, Mackie K, Trauner D, Carreira EM, Frank JA.

J Am Chem Soc. 2017 Dec 20;139(50):18206-18212. doi: 10.1021/jacs.7b06456. Epub 2017 Dec 12.

PMID:
29161035
12.

Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons.

Mitjavila J, Yin D, Kulkarni PM, Zanato C, Thakur GA, Ross R, Greig I, Mackie K, Straiker A.

Pharmacol Res. 2018 Mar;129:475-481. doi: 10.1016/j.phrs.2017.11.019. Epub 2017 Nov 20.

PMID:
29158048
13.

Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Jourdan T, Park JK, Varga ZV, Pálóczi J, Coffey NJ, Rosenberg AZ, Godlewski G, Cinar R, Mackie K, Pacher P, Kunos G.

Diabetes Obes Metab. 2018 Mar;20(3):698-708. doi: 10.1111/dom.13150. Epub 2017 Dec 3.

PMID:
29106063
14.

Chronic Adolescent Δ9-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment.

Murphy M, Mills S, Winstone J, Leishman E, Wager-Miller J, Bradshaw H, Mackie K.

Cannabis Cannabinoid Res. 2017 Sep 1;2(1):235-246. doi: 10.1089/can.2017.0034. eCollection 2017.

15.

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence.

Slivicki RA, Xu Z, Kulkarni PM, Pertwee RG, Mackie K, Thakur GA, Hohmann AG.

Biol Psychiatry. 2017 Jul 8. pii: S0006-3223(17)31761-4. doi: 10.1016/j.biopsych.2017.06.032. [Epub ahead of print]

PMID:
28823711
16.

Endocannabinoids exert CB1 receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein.

Xu C, Hermes DJ, Nwanguma B, Jacobs IR, Mackie K, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska B, Fitting S.

Mol Cell Neurosci. 2017 Sep;83:92-102. doi: 10.1016/j.mcn.2017.07.003. Epub 2017 Jul 19.

17.

Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse.

Ruehle S, Wager-Miller J, Straiker A, Farnsworth J, Murphy MN, Loch S, Monory K, Mackie K, Lutz B.

J Neurochem. 2017 Aug;142(4):521-533. doi: 10.1111/jnc.14099. Epub 2017 Jul 18.

PMID:
28608535
18.

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner.

Miller S, Hu SS, Leishman E, Morgan D, Wager-Miller J, Mackie K, Bradshaw HB, Straiker A.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2930-2938. doi: 10.1167/iovs.16-21330.

19.

Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice.

Li AL, Carey LM, Mackie K, Hohmann AG.

J Pharmacol Exp Ther. 2017 Aug;362(2):296-305. doi: 10.1124/jpet.117.241901. Epub 2017 Jun 7.

PMID:
28592614
20.

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities.

Khurana L, Mackie K, Piomelli D, Kendall DA.

Neuropharmacology. 2017 Sep 15;124:3-12. doi: 10.1016/j.neuropharm.2017.05.018. Epub 2017 May 17. Review.

PMID:
28527758
21.

Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.

Zhong H, Tong L, Gu N, Gao F, Lu Y, Xie RG, Liu J, Li X, Bergeron R, Pomeranz LE, Mackie K, Wang F, Luo CX, Ren Y, Wu SX, Xie Z, Xu L, Li J, Dong H, Xiong L, Zhang X.

J Clin Invest. 2017 Jun 1;127(6):2295-2309. doi: 10.1172/JCI91038. Epub 2017 May 2.

22.

Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice.

Carey LM, Gutierrez T, Deng L, Lee WH, Mackie K, Hohmann AG.

Sci Rep. 2017 Apr 20;7(1):944. doi: 10.1038/s41598-017-01062-2.

23.

Mice expressing a "hyper-sensitive" form of the CB1 cannabinoid receptor (CB1) show modestly enhanced alcohol preference and consumption.

Marcus DJ, Henderson-Redmond AN, Gonek M, Zee ML, Farnsworth JC, Amin RA, Andrews MJ, Davis BJ, Mackie K, Morgan DJ.

PLoS One. 2017 Apr 20;12(4):e0174826. doi: 10.1371/journal.pone.0174826. eCollection 2017.

24.

Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.

Cinar R, Gochuico BR, Iyer MR, Jourdan T, Yokoyama T, Park JK, Coffey NJ, Pri-Chen H, Szanda G, Liu Z, Mackie K, Gahl WA, Kunos G.

JCI Insight. 2017 Apr 20;2(8). pii: 92281. doi: 10.1172/jci.insight.92281. [Epub ahead of print]

25.

Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.

Bluett RJ, Báldi R, Haymer A, Gaulden AD, Hartley ND, Parrish WP, Baechle J, Marcus DJ, Mardam-Bey R, Shonesy BC, Uddin MJ, Marnett LJ, Mackie K, Colbran RJ, Winder DG, Patel S.

Nat Commun. 2017 Mar 28;8:14782. doi: 10.1038/ncomms14782.

26.

Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons.

Sousa-Valente J, Varga A, Torres-Perez JV, Jenes A, Wahba J, Mackie K, Cravatt B, Ueda N, Tsuboi K, Santha P, Jancso G, Tailor H, Avelino A, Nagy I.

J Comp Neurol. 2017 Jun 1;525(8):1778-1796. doi: 10.1002/cne.24154. Epub 2017 Mar 14.

27.

Climatic conditions produce contrasting influences on demographic traits in a long-distance Arctic migrant.

Cleasby IR, Bodey TW, Vigfusdottir F, McDonald JL, McElwaine G, Mackie K, Colhoun K, Bearhop S.

J Anim Ecol. 2017 Mar;86(2):285-295. doi: 10.1111/1365-2656.12623. Epub 2017 Jan 23.

PMID:
27973683
28.

Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists.

Dhopeshwarkar A, Murataeva N, Makriyannis A, Straiker A, Mackie K.

J Pharmacol Exp Ther. 2017 Feb;360(2):300-311. doi: 10.1124/jpet.116.236539. Epub 2016 Dec 7.

29.

Novel indole-based compounds that differentiate alkylindole-sensitive receptors from cannabinoid receptors and microtubules: Characterization of their activity on glioma cell migration.

Fung S, Xu C, Hamel E, Wager-Miller JB, Woodruff G, Miller A, Sanford C, Mackie K, Stella N.

Pharmacol Res. 2017 Jan;115:233-241. doi: 10.1016/j.phrs.2016.10.025. Epub 2016 Nov 8.

PMID:
27832960
30.

Matrix-Assisted Ionization on a Portable Mass Spectrometer: Analysis Directly from Biological and Synthetic Materials.

Devereaux ZJ, Reynolds CA, Fischer JL, Foley CD, DeLeeuw JL, Wager-Miller J, Narayan SB, Mackie K, Trimpin S.

Anal Chem. 2016 Nov 15;88(22):10831-10836. Epub 2016 Nov 3.

PMID:
26938428
31.

Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk.

Chen J, Varga A, Selvarajah S, Jenes A, Dienes B, Sousa-Valente J, Kulik A, Veress G, Brain SD, Baker D, Urban L, Mackie K, Nagy I.

Sci Rep. 2016 Sep 22;6:33307. doi: 10.1038/srep33307.

32.

A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation.

Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G.

eNeuro. 2016 Aug 8;3(4). pii: ENEURO.0160-16.2016. doi: 10.1523/ENEURO.0160-16.2016. eCollection 2016 Jul-Aug.

33.

Mice Expressing a "Hyper-Sensitive" Form of the Cannabinoid Receptor 1 (CB1) Are Neither Obese Nor Diabetic.

Marcus DJ, Zee ML, Davis BJ, Haskins CP, Andrews MJ, Amin R, Henderson-Redmond AN, Mackie K, Czyzyk TA, Morgan DJ.

PLoS One. 2016 Aug 8;11(8):e0160462. doi: 10.1371/journal.pone.0160462. eCollection 2016.

34.

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.

Tung LW, Lu GL, Lee YH, Yu L, Lee HJ, Leishman E, Bradshaw H, Hwang LL, Hung MS, Mackie K, Zimmer A, Chiou LC.

Nat Commun. 2016 Jul 22;7:12199. doi: 10.1038/ncomms12199.

35.

Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells.

Wager-Miller J, Mackie K.

Methods Mol Biol. 2016;1412:255-66. doi: 10.1007/978-1-4939-3539-0_26.

PMID:
27245911
36.

Western Blotting of the Endocannabinoid System.

Wager-Miller J, Mackie K.

Methods Mol Biol. 2016;1412:247-54. doi: 10.1007/978-1-4939-3539-0_25.

PMID:
27245910
37.

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.

Pinheiro BS, Lemos C, Neutzling Kaufmann F, Marques JM, da Silva-Santos CS, Carvalho E, Mackie K, Rodrigues RJ, Cunha RA, Köfalvi A.

Brain Res Bull. 2016 Jun;124:222-30. doi: 10.1016/j.brainresbull.2016.05.009. Epub 2016 May 18.

PMID:
27208730
38.

Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway.

Dhopeshwarkar A, Mackie K.

J Pharmacol Exp Ther. 2016 Aug;358(2):342-51. doi: 10.1124/jpet.116.232561. Epub 2016 May 18.

39.

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.

Carey LM, Slivicki RA, Leishman E, Cornett B, Mackie K, Bradshaw H, Hohmann AG.

Mol Pain. 2016 May 13;12. pii: 1744806916649192. doi: 10.1177/1744806916649192. Print 2016.

40.

Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol.

Murataeva N, Dhopeshwarkar A, Yin D, Mitjavila J, Bradshaw H, Straiker A, Mackie K.

Pharmacol Res. 2016 Aug;110:173-180. doi: 10.1016/j.phrs.2016.04.015. Epub 2016 Apr 23.

41.

Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain.

Leishman E, Cornett B, Spork K, Straiker A, Mackie K, Bradshaw HB.

Pharmacol Res. 2016 Aug;110:159-172. doi: 10.1016/j.phrs.2016.04.020. Epub 2016 Apr 22.

42.

A broad-based study on hyphenating new ionization technologies with MS/MS for PTMs and tissue characterization.

Marshall DD, Inutan ED, Wang B, Liu CW, Thawoos S, Wager-Miller J, Mackie K, Trimpin S.

Proteomics. 2016 Jun;16(11-12):1695-706. doi: 10.1002/pmic.201500530.

PMID:
27093917
43.

Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor.

Delgado-Peraza F, Ahn KH, Nogueras-Ortiz C, Mungrue IN, Mackie K, Kendall DA, Yudowski GA.

Mol Pharmacol. 2016 Jun;89(6):618-29. doi: 10.1124/mol.115.103176. Epub 2016 Mar 23. Erratum in: Mol Pharmacol. 2016 Jul;90(1):62.

44.

Monoacylglycerol lipase inhibitors produce pro- or antidepressant responses via hippocampal CA1 GABAergic synapses.

Wang Y, Gu N, Duan T, Kesner P, Blaskovits F, Liu J, Lu Y, Tong L, Gao F, Harris C, Mackie K, Li J, Tan Q, Hill MN, Yuan Z, Zhang X.

Mol Psychiatry. 2017 Feb;22(2):215-226. doi: 10.1038/mp.2016.22. Epub 2016 Mar 22.

45.

Cannabinoids Occlude the HIV-1 Tat-Induced Decrease in GABAergic Neurotransmission in Prefrontal Cortex Slices.

Xu C, Hermes DJ, Mackie K, Lichtman AH, Ignatowska-Jankowska BM, Fitting S.

J Neuroimmune Pharmacol. 2016 Jun;11(2):316-31. doi: 10.1007/s11481-016-9664-y. Epub 2016 Mar 18.

46.

Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain.

Leishman E, Mackie K, Luquet S, Bradshaw HB.

Biochim Biophys Acta. 2016 Jun;1861(6):491-500. doi: 10.1016/j.bbalip.2016.03.003. Epub 2016 Mar 5.

47.

Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray.

Lee HJ, Chang LY, Ho YC, Teng SF, Hwang LL, Mackie K, Chiou LC.

Neuropharmacology. 2016 Jun;105:577-586. doi: 10.1016/j.neuropharm.2016.02.018. Epub 2016 Feb 18.

PMID:
26907809
48.

Role of GPR55 during Axon Growth and Target Innervation.

Cherif H, Argaw A, Cécyre B, Bouchard A, Gagnon J, Javadi P, Desgent S, Mackie K, Bouchard JF.

eNeuro. 2015 Nov 9;2(5). pii: ENEURO.0011-15.2015. doi: 10.1523/ENEURO.0011-15.2015. eCollection 2015 Sep-Oct.

49.

An Introduction to the Endogenous Cannabinoid System.

Lu HC, Mackie K.

Biol Psychiatry. 2016 Apr 1;79(7):516-25. doi: 10.1016/j.biopsych.2015.07.028. Epub 2015 Oct 30. Review.

50.

Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture.

Malenczyk K, Keimpema E, Piscitelli F, Calvigioni D, Björklund P, Mackie K, Di Marzo V, Hökfelt TG, Dobrzyn A, Harkany T.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6185-94. doi: 10.1073/pnas.1519040112. Epub 2015 Oct 22.

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