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Items: 1 to 50 of 119

1.

Associations between the radiographic appearance of vascular channels in proximal sesamoid bones, their microstructural characteristics and past racing performance in Thoroughbreds.

Lloyd KA, Ayodele BA, Hitchens PL, Beck C, Mackie EJ, Whitton RC.

Equine Vet J. 2020 Jan 28. doi: 10.1111/evj.13239. [Epub ahead of print]

PMID:
31991478
2.

Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone.

Vrahnas C, Blank M, Dite TA, Tatarczuch L, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Mackie EJ, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA.

Nat Commun. 2019 Nov 4;10(1):5073. doi: 10.1038/s41467-019-13040-5.

3.

Multidecadal observations of the Antarctic ice sheet from restored analog radar records.

Schroeder DM, Dowdeswell JA, Siegert MJ, Bingham RG, Chu W, MacKie EJ, Siegfried MR, Vega KI, Emmons JR, Winstein K.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18867-18873. doi: 10.1073/pnas.1821646116. Epub 2019 Sep 3.

4.

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs.

Gauci SJ, Golub SB, Tatarczuch L, Lee E, Chan D, Walsh NC, Little CB, Stanton H, Lokmic Z, Sims NA, Mackie EJ, Fosang AJ.

Matrix Biol. 2019 Oct;83:77-96. doi: 10.1016/j.matbio.2019.08.001. Epub 2019 Aug 2.

PMID:
31381970
5.

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone.

Vrahnas C, Blank M, Dite TA, Tatarczuch L, Ansari N, Crimeen-Irwin B, Nguyen H, Forwood MR, Hu Y, Ikegame M, Bambery KR, Petibois C, Mackie EJ, Tobin MJ, Smyth GK, Oakhill JS, Martin TJ, Sims NA.

Nat Commun. 2019 Jul 31;10(1):3436. doi: 10.1038/s41467-019-11373-9. Erratum in: Nat Commun. 2019 Nov 4;10(1):5073.

6.

Growth Plate Borderline Chondrocytes: A New Source of Metaphyseal Mesenchymal Precursors.

Mackie EJ.

J Bone Miner Res. 2019 Aug;34(8):1385-1386. doi: 10.1002/jbmr.3758. Epub 2019 Jul 22. No abstract available.

PMID:
31329317
7.

Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells.

Wasgewatte Wijesinghe DK, Mackie EJ, Pagel CN.

Skelet Muscle. 2019 Feb 26;9(1):6. doi: 10.1186/s13395-019-0190-5.

8.

Keratinocyte-specific ablation of protease-activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease.

Francis N, Ayodele BA, O'Brien-Simpson NM, Birchmeier W, Pike RN, Pagel CN, Mackie EJ.

Cell Microbiol. 2018 Nov;20(11):e12891. doi: 10.1111/cmi.12891. Epub 2018 Jul 31.

PMID:
30009515
9.

Subchondral bone microdamage accumulation in distal metacarpus of Thoroughbred racehorses.

Whitton RC, Ayodele BA, Hitchens PL, Mackie EJ.

Equine Vet J. 2018 Nov;50(6):766-773. doi: 10.1111/evj.12948. Epub 2018 May 12.

PMID:
29660153
10.

The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation.

Ayodele BA, Mirams M, Pagel CN, Mackie EJ.

Bone Rep. 2017 Aug 18;7:98-107. doi: 10.1016/j.bonr.2017.08.002. eCollection 2017 Dec.

11.

A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development.

Francis N, Every AL, Ayodele BA, Pike RN, Mackie EJ, Pagel CN.

Int J Biochem Cell Biol. 2017 Nov;92:95-103. doi: 10.1016/j.biocel.2017.09.015. Epub 2017 Sep 22.

PMID:
28951199
12.

Prevalence of subchondral bone pathological changes in the distal metacarpi/metatarsi of racing Thoroughbred horses.

Bani Hassan E, Mirams M, Mackie EJ, Whitton RC.

Aust Vet J. 2017 Oct;95(10):362-369. doi: 10.1111/avj.12628.

PMID:
28948629
13.

Correction: Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA.

Development. 2017 Feb 1;144(3):530. doi: 10.1242/dev.148460. No abstract available.

14.

The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts.

Petty SJ, Milligan CJ, Todaro M, Richards KL, Kularathna PK, Pagel CN, French CR, Hill-Yardin EL, O'Brien TJ, Wark JD, Mackie EJ, Petrou S.

Epilepsia. 2016 Sep;57(9):1398-405. doi: 10.1111/epi.13474. Epub 2016 Jul 21.

15.

Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification.

Tonna S, Poulton IJ, Taykar F, Ho PW, Tonkin B, Crimeen-Irwin B, Tatarczuch L, McGregor NE, Mackie EJ, Martin TJ, Sims NA.

Development. 2016 Feb 15;143(4):648-57. doi: 10.1242/dev.125625. Epub 2016 Jan 11. Erratum in: Development. 2017 Feb 1;144(3):530.

16.

Identification of novel osteochondrosis--Associated genes.

Mirams M, Ayodele BA, Tatarczuch L, Henson FM, Pagel CN, Mackie EJ.

J Orthop Res. 2016 Mar;34(3):404-11. doi: 10.1002/jor.23033. Epub 2015 Sep 8.

17.

Role of subchondral bone remodelling in collapse of the articular surface of Thoroughbred racehorses with palmar osteochondral disease.

Bani Hassan E, Mirams M, Ghasem-Zadeh A, Mackie EJ, Whitton RC.

Equine Vet J. 2016 Mar;48(2):228-33. doi: 10.1111/evj.12415. Epub 2015 Mar 12.

PMID:
25582246
18.

Tumour progression and cancer-induced pain: a role for protease-activated receptor-2?

Kularathna PK, Pagel CN, Mackie EJ.

Int J Biochem Cell Biol. 2014 Dec;57:149-56. doi: 10.1016/j.biocel.2014.10.026. Epub 2014 Oct 30. Review.

PMID:
25448411
19.

Thoroughbred horses in race training have lower levels of subchondral bone remodelling in highly loaded regions of the distal metacarpus compared to horses resting from training.

Holmes JM, Mirams M, Mackie EJ, Whitton RC.

Vet J. 2014 Dec;202(3):443-7. doi: 10.1016/j.tvjl.2014.09.010. Epub 2014 Sep 21.

PMID:
25296852
20.

EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis.

Tonna S, Takyar FM, Vrahnas C, Crimeen-Irwin B, Ho PW, Poulton IJ, Brennan HJ, McGregor NE, Allan EH, Nguyen H, Forwood MR, Tatarczuch L, Mackie EJ, Martin TJ, Sims NA.

FASEB J. 2014 Oct;28(10):4482-96. doi: 10.1096/fj.14-254300. Epub 2014 Jun 30. Erratum in: FASEB J. 2017 Mar;31(3):1249.

PMID:
24982128
21.

Can high-resolution peripheral quantitative computed tomography imaging of subchondral and cortical bone predict condylar fracture in Thoroughbred racehorses?

Trope GD, Ghasem-Zadeh A, Anderson GA, Mackie EJ, Whitton RC.

Equine Vet J. 2015 Jul;47(4):428-32. doi: 10.1111/evj.12312. Epub 2014 Sep 5.

PMID:
24964378
22.

Contractile properties of slow and fast skeletal muscles from protease activated receptor-1 null mice.

Sitparan PK, Pagel CN, Pinniger GJ, Yoo HJ, Mackie EJ, Bakker AJ.

Muscle Nerve. 2014 Dec;50(6):991-8. doi: 10.1002/mus.24256. Epub 2014 Oct 30.

PMID:
24692104
23.

Osteopontin, inflammation and myogenesis: influencing regeneration, fibrosis and size of skeletal muscle.

Pagel CN, Wasgewatte Wijesinghe DK, Taghavi Esfandouni N, Mackie EJ.

J Cell Commun Signal. 2014 Jun;8(2):95-103. doi: 10.1007/s12079-013-0217-3. Epub 2013 Dec 8.

24.

Hyaluronan synthesis and myogenesis: a requirement for hyaluronan synthesis during myogenic differentiation independent of pericellular matrix formation.

Hunt LC, Gorman C, Kintakas C, McCulloch DR, Mackie EJ, White JD.

J Biol Chem. 2013 May 3;288(18):13006-21. doi: 10.1074/jbc.M113.453209. Epub 2013 Mar 14.

25.

Thrombin inhibits osteoclast differentiation through a non-proteolytic mechanism.

Sivagurunathan S, Pagel CN, Loh LH, Wijeyewickrema LC, Pike RN, Mackie EJ.

J Mol Endocrinol. 2013 Apr 23;50(3):347-59. doi: 10.1530/JME-12-0177. Print 2013 Jun.

PMID:
23419317
26.

Exercise-induced inhibition of remodelling is focally offset with fatigue fracture in racehorses.

Whitton RC, Mirams M, Mackie EJ, Anderson GA, Seeman E.

Osteoporos Int. 2013 Jul;24(7):2043-8. doi: 10.1007/s00198-013-2291-z. Epub 2013 Feb 1.

PMID:
23371360
27.

Osteopontin deficiency delays inflammatory infiltration and the onset of muscle regeneration in a mouse model of muscle injury.

Uaesoontrachoon K, Wasgewatte Wijesinghe DK, Mackie EJ, Pagel CN.

Dis Model Mech. 2013 Jan;6(1):197-205. doi: 10.1242/dmm.009993. Epub 2012 Aug 23.

28.

Evaluation of antibodies directed against human protease-activated receptor-2.

Adams MN, Pagel CN, Mackie EJ, Hooper JD.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Sep;385(9):861-73. doi: 10.1007/s00210-012-0783-6. Epub 2012 Jul 31.

PMID:
22842724
29.

Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair.

Georgy SR, Pagel CN, Ghasem-Zadeh A, Zebaze RM, Pike RN, Sims NA, Mackie EJ.

Bone. 2012 Mar;50(3):704-12. doi: 10.1016/j.bone.2011.11.023. Epub 2011 Dec 7.

PMID:
22173052
30.

Transcriptional profiling of chondrodysplasia growth plate cartilage reveals adaptive ER-stress networks that allow survival but disrupt hypertrophy.

Cameron TL, Bell KM, Tatarczuch L, Mackie EJ, Rajpar MH, McDermott BT, Boot-Handford RP, Bateman JF.

PLoS One. 2011;6(9):e24600. doi: 10.1371/journal.pone.0024600. Epub 2011 Sep 15.

31.

The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification.

Mackie EJ, Tatarczuch L, Mirams M.

J Endocrinol. 2011 Nov;211(2):109-21. doi: 10.1530/JOE-11-0048. Epub 2011 Jun 3. Review.

PMID:
21642379
32.

Third metacarpal condylar fatigue fractures in equine athletes occur within previously modelled subchondral bone.

Whitton RC, Trope GD, Ghasem-Zadeh A, Anderson GA, Parkin TD, Mackie EJ, Seeman E.

Bone. 2010 Oct;47(4):826-31. doi: 10.1016/j.bone.2010.07.019. Epub 2010 Jul 24.

PMID:
20659599
33.

Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study.

Zebaze RM, Ghasem-Zadeh A, Bohte A, Iuliano-Burns S, Mirams M, Price RI, Mackie EJ, Seeman E.

Lancet. 2010 May 15;375(9727):1729-36. doi: 10.1016/S0140-6736(10)60320-0.

PMID:
20472174
34.

Identification of light and dark hypertrophic chondrocytes in mouse and rat chondrocyte pellet cultures.

Chen KS, Tatarczuch L, Ahmed Y, Huang HH, Mirams M, Pagel CN, Mackie EJ.

Tissue Cell. 2010 Apr;42(2):121-8. doi: 10.1016/j.tice.2010.02.003. Epub 2010 Mar 19.

PMID:
20303561
35.

Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics.

Wilson R, Diseberg AF, Gordon L, Zivkovic S, Tatarczuch L, Mackie EJ, Gorman JJ, Bateman JF.

Mol Cell Proteomics. 2010 Jun;9(6):1296-313. doi: 10.1074/mcp.M000014-MCP201. Epub 2010 Feb 26.

36.

Periostin expression distinguishes between light and dark hypertrophic chondrocytes.

Chen KS, Tatarczuch L, Mirams M, Ahmed YA, Pagel CN, Mackie EJ.

Int J Biochem Cell Biol. 2010 Jun;42(6):880-9. doi: 10.1016/j.biocel.2010.01.018. Epub 2010 Jan 18.

PMID:
20083223
37.

Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis.

Wong DM, Tam V, Lam R, Walsh KA, Tatarczuch L, Pagel CN, Reynolds EC, O'Brien-Simpson NM, Mackie EJ, Pike RN.

Infect Immun. 2010 Feb;78(2):629-38. doi: 10.1128/IAI.01019-09. Epub 2009 Nov 23.

38.

Proteinase-activated receptor-2 (PAR2) and mouse osteoblasts: regulation of cell function and lack of specificity of PAR2-activating peptides.

Georgy SR, Pagel CN, Wong DM, Sivagurunathan S, Loh LH, Myers DE, Hollenberg MD, Pike RN, Mackie EJ.

Clin Exp Pharmacol Physiol. 2010 Mar;37(3):328-36. doi: 10.1111/j.1440-1681.2009.05294.x. Epub 2009 Sep 21.

PMID:
19769607
39.

Protease-activated receptor-1 down-regulates the murine inflammatory and humoral response to Helicobacter pylori.

Wee JL, Chionh YT, Ng GZ, Harbour SN, Allison C, Pagel CN, Mackie EJ, Mitchell HM, Ferrero RL, Sutton P.

Gastroenterology. 2010 Feb;138(2):573-82. doi: 10.1053/j.gastro.2009.08.043. Epub 2009 Aug 23.

PMID:
19706295
40.

Thrombin-stimulated growth factor and cytokine expression in osteoblasts is mediated by protease-activated receptor-1 and prostanoids.

Pagel CN, Song SJ, Loh LH, Tudor EM, Murray-Rust TA, Pike RN, Mackie EJ.

Bone. 2009 May;44(5):813-21. doi: 10.1016/j.bone.2008.12.031. Epub 2009 Jan 15.

PMID:
19442625
41.

Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage.

Gauci SJ, Golub SB, Tutolo L, Little CB, Sims NA, Lee ER, Mackie EJ, Fosang AJ.

J Musculoskelet Neuronal Interact. 2008 Oct-Dec;8(4):308-10. Review. No abstract available.

42.

High molecular weight gingipains from Porphyromonas gingivalis induce cytokine responses from human macrophage-like cells via a nonproteolytic mechanism.

Fitzpatrick RE, Aprico A, Wijeyewickrema LC, Pagel CN, Wong DM, Potempa J, Mackie EJ, Pike RN.

J Innate Immun. 2009;1(2):109-17. doi: 10.1159/000181145. Epub 2008 Dec 2.

43.

Responses in vivo to purified poly(3-hydroxybutyrate-co-3-hydroxyvalerate) implanted in a murine tibial defect model.

Wu CA, Pettit AR, Toulson S, Gr√łndahl L, Mackie EJ, Cassady AI.

J Biomed Mater Res A. 2009 Dec;91(3):845-54. doi: 10.1002/jbm.a.32238.

PMID:
19065568
44.

Altered gene expression in early osteochondrosis lesions.

Mirams M, Tatarczuch L, Ahmed YA, Pagel CN, Jeffcott LB, Davies HM, Mackie EJ.

J Orthop Res. 2009 Apr;27(4):452-7. doi: 10.1002/jor.20761.

45.

The gingipains from Porphyromonas gingivalis do not directly induce osteoclast differentiation in primary mouse bone marrow cultures.

Fitzpatrick RE, Campbell PD, Sivagurunathan S, Pagel CN, Potempa J, Mackie EJ, Pike RN.

J Periodontal Res. 2009 Aug;44(4):565-7. doi: 10.1111/j.1600-0765.2008.01151.x. Epub 2008 Aug 19.

PMID:
18717779
46.

Osteopontin and skeletal muscle myoblasts: association with muscle regeneration and regulation of myoblast function in vitro.

Uaesoontrachoon K, Yoo HJ, Tudor EM, Pike RN, Mackie EJ, Pagel CN.

Int J Biochem Cell Biol. 2008;40(10):2303-14. doi: 10.1016/j.biocel.2008.03.020. Epub 2008 Apr 6.

PMID:
18490187
47.

Protease-activated receptors in the musculoskeletal system.

Mackie EJ, Loh LH, Sivagurunathan S, Uaesoontrachoon K, Yoo HJ, Wong D, Georgy SR, Pagel CN.

Int J Biochem Cell Biol. 2008;40(6-7):1169-84. doi: 10.1016/j.biocel.2007.12.003. Epub 2007 Dec 23. Review.

PMID:
18243039
48.

Hypertrophy and physiological death of equine chondrocytes in vitro.

Ahmed YA, Tatarczuch L, Pagel CN, Davies HM, Mirams M, Mackie EJ.

Equine Vet J. 2007 Nov;39(6):546-52.

PMID:
18065314
49.

Myoblasts isolated from hypertrophy-responsive callipyge muscles show altered growth rates and increased resistance to serum deprivation-induced apoptosis.

Lavulo LT, Uaesoontrachoon K, Mirams M, White JD, Cockett NE, Mackie EJ, Pagel CN.

Cells Tissues Organs. 2008;187(2):141-51. Epub 2007 Oct 23.

PMID:
17957094
50.

Endochondral ossification: how cartilage is converted into bone in the developing skeleton.

Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M.

Int J Biochem Cell Biol. 2008;40(1):46-62. Epub 2007 Jun 29. Review.

PMID:
17659995

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