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Items: 1 to 50 of 169

1.

Effects of increasing cannabis potency on adolescent health.

Wilson J, Freeman TP, Mackie CJ.

Lancet Child Adolesc Health. 2019 Feb;3(2):121-128. doi: 10.1016/S2352-4642(18)30342-0. Epub 2018 Dec 18. Review.

PMID:
30573419
2.

Involving people with lived experience in research on suicide prevention.

MacLean S, MacKie C, Hatcher S.

CMAJ. 2018 Nov 7;190(Suppl):S13-S14. doi: 10.1503/cmaj.180485. No abstract available.

3.

State-Identified Implementation Strategies to Increase Uptake of Immediate Postpartum Long-Acting Reversible Contraception Policies.

Kroelinger CD, Morgan IA, DeSisto CL, Estrich C, Waddell LF, Mackie C, Pliska E, Goodman DA, Cox S, Velonis A, Rankin KM.

J Womens Health (Larchmt). 2019 Mar;28(3):346-356. doi: 10.1089/jwh.2018.7083. Epub 2018 Nov 2.

4.

Fully anharmonic infrared cascade spectra of polycyclic aromatic hydrocarbons.

Mackie CJ, Chen T, Candian A, Lee TJ, Tielens AGGM.

J Chem Phys. 2018 Oct 7;149(13):134302. doi: 10.1063/1.5038725.

PMID:
30292208
5.

Antacid therapy for gastroesophageal reflux in preterm infants: a systematic review.

Dermyshi E, Mackie C, Kigozi P, Schoonakker B, Dorling J.

BMJ Paediatr Open. 2018 Jul 9;2(1):e000287. doi: 10.1136/bmjpo-2018-000287. eCollection 2018.

6.

Preclinical Bioavailability Strategy for Decisions on Clinical Drug Formulation Development: An In Depth Analysis.

Van den Bergh A, Van Hemelryck S, Bevernage J, Van Peer A, Brewster M, Mackie C, Mannaert E.

Mol Pharm. 2018 Jul 2;15(7):2633-2645. doi: 10.1021/acs.molpharmaceut.8b00172. Epub 2018 Jun 11.

PMID:
29799758
7.

Commentary on Salloum et al. (2018): Rethinking adolescent cannabis use and risk perception.

Freeman TP, Wilson J, Mackie C.

Addiction. 2018 Jun;113(6):1086-1087. doi: 10.1111/add.14212. No abstract available.

PMID:
29732700
8.

The anharmonic quartic force field infrared spectra of hydrogenated and methylated PAHs.

Mackie CJ, Candian A, Huang X, Maltseva E, Petrignani A, Oomens J, Buma WJ, Lee TJ, Tielens AGGM.

Phys Chem Chem Phys. 2018 Jan 3;20(2):1189-1197. doi: 10.1039/c7cp06546a.

PMID:
29242883
9.

Using a multi-state Learning Community as an implementation strategy for immediate postpartum long-acting reversible contraception.

DeSisto CL, Estrich C, Kroelinger CD, Goodman DA, Pliska E, Mackie CN, Waddell LF, Rankin KM.

Implement Sci. 2017 Nov 21;12(1):138. doi: 10.1186/s13012-017-0674-9.

10.

A qualitative study of a blended therapy using problem solving therapy with a customised smartphone app in men who present to hospital with intentional self-harm.

Mackie C, Dunn N, MacLean S, Testa V, Heisel M, Hatcher S.

Evid Based Ment Health. 2017 Nov;20(4):118-122. doi: 10.1136/eb-2017-102764. Epub 2017 Oct 13.

PMID:
29030503
11.

Oral bioavailability enhancement of flubendazole by developing nanofibrous solid dosage forms.

Vigh T, Démuth B, Balogh A, Galata DL, Van Assche I, Mackie C, Vialpando M, Van Hove B, Psathas P, Borbás E, Pataki H, Boeykens P, Marosi G, Verreck G, Nagy ZK.

Drug Dev Ind Pharm. 2017 Jul;43(7):1126-1133. doi: 10.1080/03639045.2017.1298121. Epub 2017 Mar 8.

PMID:
28274133
12.
13.

The anharmonic quartic force field infrared spectra of five non-linear polycyclic aromatic hydrocarbons: Benz[a]anthracene, chrysene, phenanthrene, pyrene, and triphenylene.

Mackie CJ, Candian A, Huang X, Maltseva E, Petrignani A, Oomens J, Mattioda AL, Buma WJ, Lee TJ, Tielens AG.

J Chem Phys. 2016 Aug 28;145(8):084313. doi: 10.1063/1.4961438.

PMID:
27586928
14.

Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).

Cid JM, Tresadern G, Vega JA, de Lucas AI, Del Cerro A, Matesanz E, Linares ML, García A, Iturrino L, Pérez-Benito L, Macdonald GJ, Oehlrich D, Lavreysen H, Peeters L, Ceusters M, Ahnaou A, Drinkenburg W, Mackie C, Somers M, Trabanco AA.

J Med Chem. 2016 Sep 22;59(18):8495-507. doi: 10.1021/acs.jmedchem.6b00913. Epub 2016 Sep 9.

PMID:
27579727
15.

Implementation of a structured hospital-wide morbidity and mortality rounds model.

Kwok ESH, Calder LA, Barlow-Krelina E, Mackie C, Seely AJE, Cwinn AA, Worthington JR, Frank JR.

BMJ Qual Saf. 2017 Jun;26(6):439-448. doi: 10.1136/bmjqs-2016-005459. Epub 2016 Jun 29.

PMID:
27358230
16.

Evaluation of Three Amorphous Drug Delivery Technologies to Improve the Oral Absorption of Flubendazole.

Vialpando M, Smulders S, Bone S, Jager C, Vodak D, Van Speybroeck M, Verheyen L, Backx K, Boeykens P, Brewster ME, Ceulemans J, Novoa de Armas H, Van Geel K, Kesselaers E, Hillewaert V, Lachau-Durand S, Meurs G, Psathas P, Van Hove B, Verreck G, Voets M, Weuts I, Mackie C.

J Pharm Sci. 2016 Sep;105(9):2782-2793. doi: 10.1016/j.xphs.2016.03.003. Epub 2016 Apr 22.

17.

Application of Implementation Science Methodology to Immediate Postpartum Long-Acting Reversible Contraception Policy Roll-Out Across States.

Rankin KM, Kroelinger CD, DeSisto CL, Pliska E, Akbarali S, Mackie CN, Goodman DA.

Matern Child Health J. 2016 Nov;20(Suppl 1):173-179.

18.

Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

Conde-Ceide S, Alcázar J, Alonso de Diego SA, López S, Martín-Martín ML, Martínez-Viturro CM, Pena MA, Tong HM, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Lindsley CW, Bartolomé-Nebreda JM.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434. doi: 10.1016/j.bmcl.2015.11.098. Epub 2015 Nov 28.

19.

The anharmonic quartic force field infrared spectra of three polycyclic aromatic hydrocarbons: Naphthalene, anthracene, and tetracene.

Mackie CJ, Candian A, Huang X, Maltseva E, Petrignani A, Oomens J, Buma WJ, Lee TJ, Tielens AG.

J Chem Phys. 2015 Dec 14;143(22):224314. doi: 10.1063/1.4936779.

PMID:
26671382
20.

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.

Malosh C, Turlington M, Bridges TM, Rook JM, Noetzel MJ, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martínez-Viturro CM, Piedrafita M, Sánchez-Casado MR, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5115-20. doi: 10.1016/j.bmcl.2015.10.009. Epub 2015 Oct 9.

21.

Many hands lighten the obesity load.

Sudicky A, Mackie C.

CMAJ. 2015 Sep 22;187(13):997. doi: 10.1503/cmaj.1150061. No abstract available.

22.

Genetic and Environmental Interplay in Adolescent Substance Use Disorders.

Hines LA, Morley KI, Mackie C, Lynskey M.

Curr Addict Rep. 2015 Jun;2(2):122-129.

23.

Criteria-Based Resource Allocation: A Tool to Improve Public Health Impact.

Graham JR, Mackie C.

J Public Health Manag Pract. 2016 Jul-Aug;22(4):E14-20. doi: 10.1097/PHH.0000000000000319.

PMID:
26247802
24.

Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound.

Zhou Y, Malosh C, Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Lavreysen H, Mackie C, Bridges TM, Daniels JS, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3515-9. doi: 10.1016/j.bmcl.2015.06.096. Epub 2015 Jul 4.

25.

Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.

Conde-Ceide S, Martínez-Viturro CM, Alcázar J, Garcia-Barrantes PM, Lavreysen H, Mackie C, Vinson PN, Rook JM, Bridges TM, Daniels JS, Megens A, Langlois X, Drinkenburg WH, Ahnaou A, Niswender CM, Jones CK, Macdonald GJ, Steckler T, Conn PJ, Stauffer SR, Bartolomé-Nebreda JM, Lindsley CW.

ACS Med Chem Lett. 2015 May 20;6(6):716-20. doi: 10.1021/acsmedchemlett.5b00181. eCollection 2015 Jun 11.

26.

Linear transformation of anharmonic molecular force constants between normal and Cartesian coordinates.

Mackie CJ, Candian A, Huang X, Lee TJ, Tielens AG.

J Chem Phys. 2015 Jun 28;142(24):244107. doi: 10.1063/1.4922891.

PMID:
26133410
27.

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.

Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN, Thompson AD, Byun N, Collier RL, Bubser M, Nedelcovych MT, Gould RW, Stauffer SR, Daniels JS, Niswender CM, Lavreysen H, Mackie C, Conde-Ceide S, Alcazar J, Bartolomé-Nebreda JM, Macdonald GJ, Talpos JC, Steckler T, Jones CK, Lindsley CW, Conn PJ.

Neuron. 2015 May 20;86(4):1029-1040. doi: 10.1016/j.neuron.2015.03.063. Epub 2015 Apr 30.

28.

Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor.

Lavreysen H, Ahnaou A, Drinkenburg W, Langlois X, Mackie C, Pype S, Lütjens R, Le Poul E, Trabanco AA, Nuñez JM.

Pharmacol Res Perspect. 2015 Feb;3(1):e00096. doi: 10.1002/prp2.96. Epub 2014 Dec 9.

29.

Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

Martín-Martín ML, Bartolomé-Nebreda JM, Conde-Ceide S, Alonso de Diego SA, López S, Martínez-Viturro CM, Tong HM, Lavreysen H, Macdonald GJ, Steckler T, Mackie C, Bridges TM, Daniels JS, Niswender CM, Noetzel MJ, Jones CK, Conn PJ, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1310-7. doi: 10.1016/j.bmcl.2015.01.038. Epub 2015 Jan 28.

30.

Molecular properties determining unbound intracellular and extracellular brain exposure of CNS drug candidates.

Loryan I, Sinha V, Mackie C, Van Peer A, Drinkenburg WH, Vermeulen A, Heald D, Hammarlund-Udenaes M, Wassvik CM.

Mol Pharm. 2015 Feb 2;12(2):520-32. doi: 10.1021/mp5005965. Epub 2014 Dec 26.

PMID:
25496026
31.

Discussion of papers: estimation of the height of complete groundwater drainage above mined longwall panels.

Mackie C.

Ground Water. 2014 Nov-Dec;52(6):825. doi: 10.1111/gwat.12268. Epub 2014 Oct 9. No abstract available.

PMID:
25302743
32.

Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.

Cid JM, Tresadern G, Duvey G, Lütjens R, Finn T, Rocher JP, Poli S, Vega JA, de Lucas AI, Matesanz E, Linares ML, Andrés JI, Alcazar J, Alonso JM, Macdonald GJ, Oehlrich D, Lavreysen H, Ahnaou A, Drinkenburg W, Mackie C, Pype S, Gallacher D, Trabanco AA.

J Med Chem. 2014 Aug 14;57(15):6495-512. doi: 10.1021/jm500496m. Epub 2014 Jul 28.

PMID:
25032784
33.

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.

Turlington M, Noetzel MJ, Bridges TM, Vinson PN, Steckler T, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Tong HM, Macdonald GJ, Daniels JS, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3641-6. doi: 10.1016/j.bmcl.2014.04.087. Epub 2014 May 2.

34.

Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₅).

Turlington M, Malosh C, Jacobs J, Manka JT, Noetzel MJ, Vinson PN, Jadhav S, Herman EJ, Lavreysen H, Mackie C, Bartolomé-Nebreda JM, Conde-Ceide S, Martín-Martín ML, Tong HM, López S, MacDonald GJ, Steckler T, Daniels JS, Weaver CD, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR.

J Med Chem. 2014 Jul 10;57(13):5620-37. doi: 10.1021/jm500259z. Epub 2014 Jun 25.

35.

Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery.

Loryan I, Sinha V, Mackie C, Van Peer A, Drinkenburg W, Vermeulen A, Morrison D, Monshouwer M, Heald D, Hammarlund-Udenaes M.

Pharm Res. 2014 Aug;31(8):2203-19. doi: 10.1007/s11095-014-1319-1. Epub 2014 Mar 13.

PMID:
24623476
36.

The importance of child car seats and current challenges with their use.

Young-Hoon KN, Mackie C.

Paediatr Child Health. 2012 Nov;17(9):483-4. No abstract available.

37.

Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.

Blobaum AL, Bridges TM, Byers FW, Turlington ML, Mattmann ME, Morrison RD, Mackie C, Lavreysen H, Bartolomé JM, Macdonald GJ, Steckler T, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR, Daniels JS.

Drug Metab Dispos. 2013 Dec;41(12):2066-75. doi: 10.1124/dmd.113.052662. Epub 2013 Sep 3.

38.

Two-year impact of personality-targeted, teacher-delivered interventions on youth internalizing and externalizing problems: a cluster-randomized trial.

O'Leary-Barrett M, Topper L, Al-Khudhairy N, Pihl RO, Castellanos-Ryan N, Mackie CJ, Conrod PJ.

J Am Acad Child Adolesc Psychiatry. 2013 Sep;52(9):911-20. doi: 10.1016/j.jaac.2013.05.020. Epub 2013 Jul 31.

PMID:
23972693
39.

N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.

Gregory KJ, Herman EJ, Ramsey AJ, Hammond AS, Byun NE, Stauffer SR, Manka JT, Jadhav S, Bridges TM, Weaver CD, Niswender CM, Steckler T, Drinkenburg WH, Ahnaou A, Lavreysen H, Macdonald GJ, Bartolomé JM, Mackie C, Hrupka BJ, Caron MG, Daigle TL, Lindsley CW, Conn PJ, Jones CK.

J Pharmacol Exp Ther. 2013 Nov;347(2):438-57. doi: 10.1124/jpet.113.206623. Epub 2013 Aug 21.

40.

Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.

Bartolomé-Nebreda JM, Conde-Ceide S, Delgado F, Iturrino L, Pastor J, Pena MÁ, Trabanco AA, Tresadern G, Wassvik CM, Stauffer SR, Jadhav S, Gogi K, Vinson PN, Noetzel MJ, Days E, Weaver CD, Lindsley CW, Niswender CM, Jones CK, Conn PJ, Rombouts F, Lavreysen H, Macdonald GJ, Mackie C, Steckler T.

J Med Chem. 2013 Sep 26;56(18):7243-59. doi: 10.1021/jm400650w. Epub 2013 Sep 4.

41.

Post processing of zone budgets to generate improved groundwater influx estimates associated with longwall mining.

Mackie CD.

Ground Water. 2014 Jul-Aug;52(4):613-7. doi: 10.1111/gwat.12097. Epub 2013 Jul 29.

PMID:
23895016
42.

The role of risk theory in rural maternity services planning.

Kornelsen J, Mackie C.

Rural Remote Health. 2013 Jan-Mar;13(1):2206. Epub 2013 Mar 12. No abstract available.

43.

Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping.

Van Vlaslaer A, Mortishire-Smith RJ, Mackie C, Langlois X, Schmidt ME.

EJNMMI Res. 2013 Feb 14;3(1):10. doi: 10.1186/2191-219X-3-10.

44.

Subchronic memantine induced concurrent functional disconnectivity and altered ultra-structural tissue integrity in the rodent brain: revealed by multimodal MRI.

Sekar S, Jonckers E, Verhoye M, Willems R, Veraart J, Van Audekerke J, Couto J, Giugliano M, Wuyts K, Dedeurwaerdere S, Sijbers J, Mackie C, Ver Donck L, Steckler T, Van der Linden A.

Psychopharmacology (Berl). 2013 Jun;227(3):479-91. doi: 10.1007/s00213-013-2966-3. Epub 2013 Jan 25.

PMID:
23354531
45.

Effectiveness of a selective, personality-targeted prevention program for adolescent alcohol use and misuse: a cluster randomized controlled trial.

Conrod PJ, O'Leary-Barrett M, Newton N, Topper L, Castellanos-Ryan N, Mackie C, Girard A.

JAMA Psychiatry. 2013 Mar;70(3):334-42. doi: 10.1001/jamapsychiatry.2013.651.

PMID:
23344135
46.

Adolescent bullying, cannabis use and emerging psychotic experiences: a longitudinal general population study.

Mackie CJ, O'Leary-Barrett M, Al-Khudhairy N, Castellanos-Ryan N, Struve M, Topper L, Conrod P.

Psychol Med. 2013 May;43(5):1033-44. doi: 10.1017/S003329171200205X. Epub 2012 Sep 7.

PMID:
23171473
47.

Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.

Rodriguez AL, Zhou Y, Williams R, Weaver CD, Vinson PN, Dawson ES, Steckler T, Lavreysen H, Mackie C, Bartolomé JM, Macdonald GJ, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7388-92. doi: 10.1016/j.bmcl.2012.10.068. Epub 2012 Oct 23.

48.

Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.

Cid JM, Tresadern G, Vega JA, de Lucas AI, Matesanz E, Iturrino L, Linares ML, Garcia A, Andrés JI, Macdonald GJ, Oehlrich D, Lavreysen H, Megens A, Ahnaou A, Drinkenburg W, Mackie C, Pype S, Gallacher D, Trabanco AA.

J Med Chem. 2012 Oct 25;55(20):8770-89. doi: 10.1021/jm3010724. Epub 2012 Oct 16.

PMID:
23072213
49.

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.

Manka JT, Vinson PN, Gregory KJ, Zhou Y, Williams R, Gogi K, Days E, Jadhav S, Herman EJ, Lavreysen H, Mackie C, Bartolomé JM, Macdonald GJ, Steckler T, Daniels JS, Weaver CD, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Stauffer SR.

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6481-5. doi: 10.1016/j.bmcl.2012.08.043. Epub 2012 Aug 24.

50.

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