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Exercise Intolerance in Anthracycline-Treated Breast Cancer Survivors: The Role of Skeletal Muscle Bioenergetics, Oxygenation, and Composition.

Beaudry RI, Kirkham AA, Thompson RB, Grenier JG, Mackey JR, Haykowsky MJ.

Oncologist. 2020 Jan 17. doi: 10.1634/theoncologist.2019-0777. [Epub ahead of print]


Chromophore selective multi-wavelength photoacoustic remote sensing of unstained human tissues.

Abbasi S, Le M, Sonier B, Bell K, Dinakaran D, Bigras G, Mackey JR, Haji Reza P.

Biomed Opt Express. 2019 Oct 1;10(11):5461-5469. doi: 10.1364/BOE.10.005461. eCollection 2019 Nov 1.


hENT1 Testing in Pancreatic Ductal Adenocarcinoma: Are We Ready? A Multimodal Evaluation of hENT1 Status.

Raffenne J, Nicolle R, Puleo F, Le Corre D, Boyez C, Marechal R, Emile JF, Demetter P, Bardier A, Laurent-Puig P, de Mestier L, Paradis V, Couvelard A, VanLathem JL, MacKey JR, Bachet JB, Svrcek M, Cros J.

Cancers (Basel). 2019 Nov 18;11(11). pii: E1808. doi: 10.3390/cancers11111808.


Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition.

Lewis CW, Bukhari AB, Xiao EJ, Choi WS, Smith JD, Homola E, Mackey JR, Campbell SD, Gamper AM, Chan GK.

Cancer Res. 2019 Dec 1;79(23):5971-5985. doi: 10.1158/0008-5472.CAN-19-1961. Epub 2019 Oct 8.


Comparing docosahexaenoic acid (DHA) concomitant with neoadjuvant chemotherapy versus neoadjuvant chemotherapy alone in the treatment of breast cancer (DHA WIN): protocol of a double-blind, phase II, randomised controlled trial.

Newell M, Mackey JR, Bigras G, Alvarez-Camacho M, Goruk S, Ghosh S, Schmidt A, Miede D, Chisotti A, Postovit L, Baker K, Mazurak V, Courneya K, Berendt R, Dong WF, Wood G, Basi SK, Joy AA, King K, Meza-Junco J, Zhu X, Field C.

BMJ Open. 2019 Sep 17;9(9):e030502. doi: 10.1136/bmjopen-2019-030502.


All-optical Reflection-mode Microscopic Histology of Unstained Human Tissues.

Abbasi S, Le M, Sonier B, Dinakaran D, Bigras G, Bell K, Mackey JR, Haji Reza P.

Sci Rep. 2019 Sep 16;9(1):13392. doi: 10.1038/s41598-019-49849-9.


Community-based exercise for health promotion and secondary cancer prevention in Canada: protocol for a hybrid effectiveness-implementation study.

McNeely ML, Sellar C, Williamson T, Shea-Budgell M, Joy AA, Lau HY, Easaw JC, Murtha AD, Vallance J, Courneya K, Mackey JR, Parliament M, Culos-Reed N.

BMJ Open. 2019 Sep 13;9(9):e029975. doi: 10.1136/bmjopen-2019-029975.


Effects of exercise dose and type during breast cancer chemotherapy on longer-term patient-reported outcomes and health-related fitness: A randomized controlled trial.

An KY, Morielli AR, Kang DW, Friedenreich CM, McKenzie DC, Gelmon K, Mackey JR, Reid RD, Courneya KS.

Int J Cancer. 2020 Jan 1;146(1):150-160. doi: 10.1002/ijc.32493. Epub 2019 Jun 27.


Fine-mapping of a novel premenopausal breast cancer susceptibility locus at Chr4q31.22 in Caucasian women and validation in African and Chinese women.

Kumaran M, Ghosh S, Joy AA, Mackey JR, Cass CE, Zheng W, Yasui Y, Damaraju S.

Int J Cancer. 2020 Mar 1;146(5):1219-1229. doi: 10.1002/ijc.32407. Epub 2019 May 27.


Intensive Imaging Surveillance of Survivors of Breast Cancer May Increase Risk of Radiation-induced Malignancy.

Meyer C, Millán P, González V, Spera G, Machado A, Mackey JR, Fresco R.

Clin Breast Cancer. 2019 Jun;19(3):e468-e474. doi: 10.1016/j.clbc.2019.01.003. Epub 2019 Jan 23.


Curing breast cancer and killing the heart: A novel model to explain elevated cardiovascular disease and mortality risk among women with early stage breast cancer.

Kirkham AA, Beaudry RI, Paterson DI, Mackey JR, Haykowsky MJ.

Prog Cardiovasc Dis. 2019 Mar - Apr;62(2):116-126. doi: 10.1016/j.pcad.2019.02.002. Epub 2019 Feb 22. Review.


Experimental investigation of frequency and amplitude of density wave oscillations in vertical upflow boiling.

O'Neill LE, Mudawar I, Hasan MM, Nahra HK, Balasubramaniam R, Mackey JR.

Int J Heat Mass Transf. 2018 Oct;125:1240-1263. doi: 10.1016/j.ijheatmasstransfer.2018.04.138. Epub 2018 May 16.


Flow condensation pressure oscillations at different orientations.

O'Neill LE, Mudawar I, Hasan MM, Nahra HK, Balasubramaniam R, Mackey JR.

Int J Heat Mass Transf. 2018 Dec;127:784-809. doi: 10.1016/j.ijheatmasstransfer.2018.07.072. Epub 2018 Jul 30.


Experimental investigation into the impact of density wave oscillations on flow boiling system dynamic behavior and stability.

O'Neill LE, Mudawar I, Hasan MM, Nahra HK, Balasubramaniam R, Hall NR, Lokey A, Mackey JR.

Int J Heat Mass Transf. 2018 May;120:144-166. doi: 10.1016/j.ijheatmasstransfer.2017.12.011. Epub 2017 Dec 18.


Assessment of ERBB2/HER2 Status in HER2-Equivocal Breast Cancers by FISH and 2013/2014 ASCO-CAP Guidelines.

Press MF, Seoane JA, Curtis C, Quinaux E, Guzman R, Sauter G, Eiermann W, Mackey JR, Robert N, Pienkowski T, Crown J, Martin M, Valero V, Bee V, Ma Y, Villalobos I, Slamon DJ.

JAMA Oncol. 2019 Mar 1;5(3):366-375. doi: 10.1001/jamaoncol.2018.6012.


NFIB promotes cell survival by directly suppressing p21 transcription in TP53-mutated triple-negative breast cancer.

Liu RZ, Vo TM, Jain S, Choi WS, Garcia E, Monckton EA, Mackey JR, Godbout R.

J Pathol. 2019 Feb;247(2):186-198. doi: 10.1002/path.5182. Epub 2018 Dec 18.


Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer-effects of hypoxia.

Hamann I, Krys D, Glubrecht D, Bouvet V, Marshall A, Vos L, Mackey JR, Wuest M, Wuest F.

FASEB J. 2018 Sep;32(9):5104-5118. doi: 10.1096/fj.201800360R. Epub 2018 Apr 13.


The Authors Respond.

Spera G, Fresco R, Fung H, Mackey JR.

Epidemiology. 2018 Sep;29(5):e40. doi: 10.1097/EDE.0000000000000854. No abstract available.


Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy.

Elander NO, Aughton K, Ghaneh P, Neoptolemos JP, Palmer DH, Cox TF, Campbell F, Costello E, Halloran CM, Mackey JR, Scarfe AG, Valle JW, McDonald AC, Carter R, Tebbutt NC, Goldstein D, Shannon J, Dervenis C, Glimelius B, Deakin M, Charnley RM, Anthoney A, Lerch MM, Mayerle J, Oláh A, Büchler MW, Greenhalf W; European Study Group for Pancreatic Cancer.

Br J Cancer. 2018 Apr;118(8):1084-1088. doi: 10.1038/s41416-018-0005-1. Epub 2018 Mar 9.


Expression of dihydropyrimidine dehydrogenase (DPD) and hENT1 predicts survival in pancreatic cancer.

Elander NO, Aughton K, Ghaneh P, Neoptolemos JP, Palmer DH, Cox TF, Campbell F, Costello E, Halloran CM, Mackey JR, Scarfe AG, Valle JW, McDonald AC, Carter R, Tebbutt NC, Goldstein D, Shannon J, Dervenis C, Glimelius B, Deakin M, Charnley RM, Anthoney A, Lerch MM, Mayerle J, Oláh A, Büchler MW, Greenhalf W; European Study Group for Pancreatic Cancer.

Br J Cancer. 2018 Apr;118(7):947-954. doi: 10.1038/s41416-018-0004-2. Epub 2018 Mar 8.


Germline copy number variations are associated with breast cancer risk and prognosis.

Kumaran M, Cass CE, Graham K, Mackey JR, Hubaux R, Lam W, Yasui Y, Damaraju S.

Sci Rep. 2017 Nov 7;7(1):14621. doi: 10.1038/s41598-017-14799-7.


Meta-analysis of individual patient safety data from six randomized, placebo-controlled trials with the antiangiogenic VEGFR2-binding monoclonal antibody ramucirumab.

Arnold D, Fuchs CS, Tabernero J, Ohtsu A, Zhu AX, Garon EB, Mackey JR, Paz-Ares L, Baron AD, Okusaka T, Yoshino T, Yoon HH, Das M, Ferry D, Zhang Y, Lin Y, Binder P, Sashegyi A, Chau I.

Ann Oncol. 2017 Dec 1;28(12):2932-2942. doi: 10.1093/annonc/mdx514. Review.


A predictive analysis of the SP120 and 10D7G2 antibodies for human equilibrative nucleoside transporter 1 (hENT1) in pancreatic ductal adenocarcinoma treated with adjuvant gemcitabine.

Kalloger SE, Riazy M, Tessier-Cloutier B, Karasinska JM, Gao D, Peixoto RD, Samimi S, Chow C, Wong HL, Mackey JR, Renouf DJ, Schaeffer DF.

J Pathol Clin Res. 2017 Jul 19;3(3):179-190. doi: 10.1002/cjp2.75. eCollection 2017 Jul.


Beta blockers and improved progression-free survival in patients with advanced HER2 negative breast cancer: a retrospective analysis of the ROSE/TRIO-012 study.

Spera G, Fresco R, Fung H, Dyck JRB, Pituskin E, Paterson I, Mackey JR.

Ann Oncol. 2017 Aug 1;28(8):1836-1841. doi: 10.1093/annonc/mdx264.


High Myc expression and transcription activity underlies intra-tumoral heterogeneity in triple-negative breast cancer.

Gupta N, Jung K, Wu C, Alshareef A, Alqahtani H, Damaraju S, Mackey JR, Ghosh S, Sabri S, Abdulkarim BS, Bigras G, Lai R.

Oncotarget. 2017 Apr 25;8(17):28101-28115. doi: 10.18632/oncotarget.15891.


Novel mutations involving βI-, βIIA-, or βIVB-tubulin isotypes with functional resemblance to βIII-tubulin in breast cancer.

Wang W, Zhang H, Wang X, Patterson J, Winter P, Graham K, Ghosh S, Lee JC, Katsetos CD, Mackey JR, Tuszynski JA, Wong GK, Ludueña RF.

Protoplasma. 2017 May;254(3):1163-1173. doi: 10.1007/s00709-016-1060-1. Epub 2016 Dec 9.


Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE 101-Breast): A Randomized Trial for the Prevention of Trastuzumab-Associated Cardiotoxicity.

Pituskin E, Mackey JR, Koshman S, Jassal D, Pitz M, Haykowsky MJ, Pagano JJ, Chow K, Thompson RB, Vos LJ, Ghosh S, Oudit GY, Ezekowitz JA, Paterson DI.

J Clin Oncol. 2017 Mar 10;35(8):870-877. doi: 10.1200/JCO.2016.68.7830. Epub 2016 Nov 28.


Piwi-interacting RNAs and PIWI genes as novel prognostic markers for breast cancer.

Krishnan P, Ghosh S, Graham K, Mackey JR, Kovalchuk O, Damaraju S.

Oncotarget. 2016 Jun 21;7(25):37944-37956. doi: 10.18632/oncotarget.9272.


Profiling of Small Nucleolar RNAs by Next Generation Sequencing: Potential New Players for Breast Cancer Prognosis.

Krishnan P, Ghosh S, Wang B, Heyns M, Graham K, Mackey JR, Kovalchuk O, Damaraju S.

PLoS One. 2016 Sep 15;11(9):e0162622. doi: 10.1371/journal.pone.0162622. eCollection 2016.


Genome-wide profiling of transfer RNAs and their role as novel prognostic markers for breast cancer.

Krishnan P, Ghosh S, Wang B, Heyns M, Li D, Mackey JR, Kovalchuk O, Damaraju S.

Sci Rep. 2016 Sep 8;6:32843. doi: 10.1038/srep32843.


HER2 Gene Amplification Testing by Fluorescent In Situ Hybridization (FISH): Comparison of the ASCO-College of American Pathologists Guidelines With FISH Scores Used for Enrollment in Breast Cancer International Research Group Clinical Trials.

Press MF, Sauter G, Buyse M, Fourmanoir H, Quinaux E, Tsao-Wei DD, Eiermann W, Robert N, Pienkowski T, Crown J, Martin M, Valero V, Mackey JR, Bee V, Ma Y, Villalobos I, Campeau A, Mirlacher M, Lindsay MA, Slamon DJ.

J Clin Oncol. 2016 Oct 10;34(29):3518-3528. doi: 10.1200/JCO.2016.66.6693.


Final Survival Analysis of ROSE/TRIO-012.

Mackey JR, McCarthy N, Gelmon KA, Verma S, Fresco R, Thireau F, Fung H, Martín M.

J Clin Oncol. 2016 Oct 20;34(30):3714-3715. doi: 10.1200/JCO.2016.68.9182. No abstract available.


The Alberta Moving Beyond Breast Cancer (AMBER) Cohort Study: Recruitment, Baseline Assessment, and Description of the First 500 Participants.

Courneya KS, McNeely ML, Culos-Reed SN, Vallance JK, Bell GJ, Mackey JR, Matthews CE, Morielli AR, Cook D, MacLaughlin S, Farris MS, Voaklander S, O'Reilly R, Friedenreich CM.

BMC Cancer. 2016 Jul 14;16:481. doi: 10.1186/s12885-016-2534-4.


Impact of resistance and aerobic exercise on sarcopenia and dynapenia in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial.

Adams SC, Segal RJ, McKenzie DC, Vallerand JR, Morielli AR, Mackey JR, Gelmon K, Friedenreich CM, Reid RD, Courneya KS.

Breast Cancer Res Treat. 2016 Aug;158(3):497-507. doi: 10.1007/s10549-016-3900-2. Epub 2016 Jul 9.


Long-term outcomes after adjuvant treatment of sequential versus combination docetaxel with doxorubicin and cyclophosphamide in node-positive breast cancer: BCIRG-005 randomized trial.

Mackey JR, Pieńkowski T, Crown J, Sadeghi S, Martin M, Chan A, Saleh M, Sehdev S, Provencher L, Semiglazov V, Press MF, Sauter G, Lindsay M, Houé V, Buyse M, Drevot P, Hitier S, Bensfia S, Eiermann W; Translational Research In Oncology (TRIO)/ Breast Cancer International Research Group (BCIRG)-005 investigators.

Ann Oncol. 2016 Jun;27(6):1041-7. doi: 10.1093/annonc/mdw098. Epub 2016 Mar 2.


Motivation for Different Types and Doses of Exercise During Breast Cancer Chemotherapy: a Randomized Controlled Trial.

Courneya KS, Segal RJ, Vallerand JR, Forbes CC, Crawford JJ, Dolan LB, Friedenreich CM, Reid RD, Gelmon K, Mackey JR, McKenzie DC.

Ann Behav Med. 2016 Aug;50(4):554-63. doi: 10.1007/s12160-016-9782-z.


Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance.

Bekele RT, Venkatraman G, Liu RZ, Tang X, Mi S, Benesch MG, Mackey JR, Godbout R, Curtis JM, McMullen TP, Brindley DN.

Sci Rep. 2016 Feb 17;6:21164. doi: 10.1038/srep21164.


Exploring the Feasibility of a Broad-Reach Physical Activity Behavior Change Intervention for Women Receiving Chemotherapy for Breast Cancer: A Randomized Trial.

Vallance JK, Friedenreich CM, Lavallee CM, Culos-Reed N, Mackey JR, Walley B, Courneya KS.

Cancer Epidemiol Biomarkers Prev. 2016 Feb;25(2):391-8. doi: 10.1158/1055-9965.EPI-15-0812. Epub 2015 Dec 16.


A Uridine Glucuronosyltransferase 2B7 Polymorphism Predicts Epirubicin Clearance and Outcomes in Early-Stage Breast Cancer.

Sawyer MB, Pituskin E, Damaraju S, Bies RR, Vos LJ, Prado CM, Kuzma M, Scarfe AG, Clemons M, Tonkin K, Au HJ, Koski S, Joy AA, Smylie M, King K, Carandang D, Damaraju VL, Hanson J, Cass CE, Mackey JR.

Clin Breast Cancer. 2016 Apr;16(2):139-44.e1-3. doi: 10.1016/j.clbc.2015.09.006. Epub 2015 Sep 25.


Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer.

Krishnan P, Ghosh S, Wang B, Li D, Narasimhan A, Berendt R, Graham K, Mackey JR, Kovalchuk O, Damaraju S.

BMC Genomics. 2015 Sep 29;16:735. doi: 10.1186/s12864-015-1899-0.


Targeting lysyl oxidase for molecular imaging in breast cancer.

Wuest M, Kuchar M, Sharma SK, Richter S, Hamann I, Wang M, Vos L, Mackey JR, Wuest F, Löser R.

Breast Cancer Res. 2015 Aug 13;17:107. doi: 10.1186/s13058-015-0609-9.


Reply to H.J. Lee et al.

Mackey JR, Houé V, Thireau F, Lindsay MA, Fresco R.

J Clin Oncol. 2015 Aug 20;33(24):2712-3. doi: 10.1200/JCO.2015.61.6748. Epub 2015 Jul 20. No abstract available.


CRABP1 is associated with a poor prognosis in breast cancer: adding to the complexity of breast cancer cell response to retinoic acid.

Liu RZ, Garcia E, Glubrecht DD, Poon HY, Mackey JR, Godbout R.

Mol Cancer. 2015 Jul 5;14:129. doi: 10.1186/s12943-015-0380-7.


Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression.

Benesch MG, Tang X, Dewald J, Dong WF, Mackey JR, Hemmings DG, McMullen TP, Brindley DN.

FASEB J. 2015 Sep;29(9):3990-4000. doi: 10.1096/fj.15-274480. Epub 2015 Jun 12.


Imaging Radiation Doses and Associated Risks and Benefits in Subjects Participating in Breast Cancer Clinical Trials.

Fresco R, Spera G, Meyer C, Cabral P, Mackey JR.

Oncologist. 2015 Jul;20(7):702-12. doi: 10.1634/theoncologist.2014-0295. Epub 2015 May 29.


A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors.

Chu QS, Sangha R, Spratlin J, Vos LJ, Mackey JR, McEwan AJ, Venner P, Michelakis ED.

Invest New Drugs. 2015 Jun;33(3):603-10. doi: 10.1007/s10637-015-0221-y. Epub 2015 Mar 13.


Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.

Glass OK, Inman BA, Broadwater G, Courneya KS, Mackey JR, Goruk S, Nelson ER, Jasper J, Field CJ, Bain JR, Muehlbauer M, Stevens RD, Hirschey MD, Jones LW.

Br J Cancer. 2015 Mar 3;112(5):825-31. doi: 10.1038/bjc.2014.662. Epub 2015 Jan 13.


Primary results of ROSE/TRIO-12, a randomized placebo-controlled phase III trial evaluating the addition of ramucirumab to first-line docetaxel chemotherapy in metastatic breast cancer.

Mackey JR, Ramos-Vazquez M, Lipatov O, McCarthy N, Krasnozhon D, Semiglazov V, Manikhas A, Gelmon KA, Konecny GE, Webster M, Hegg R, Verma S, Gorbunova V, Abi Gerges D, Thireau F, Fung H, Simms L, Buyse M, Ibrahim A, Martin M.

J Clin Oncol. 2015 Jan 10;33(2):141-8. doi: 10.1200/JCO.2014.57.1513. Epub 2014 Sep 2.


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