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Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.

Rowland A, Ruanglertboon W, van Dyk M, Wijayakumara D, Wood LS, Meech R, Mackenzie PI, Rodrigues AD, Marshall JC, Sorich MJ.

Br J Clin Pharmacol. 2018 Oct 19. doi: 10.1111/bcp.13793. [Epub ahead of print]


Intergenic Splicing between Four Adjacent UGT Genes (2B15, 2B29P2, 2B17, 2B29P1) Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions.

Hu DG, Hulin JA, Wijayakumara DD, McKinnon RA, Mackenzie PI, Meech R.

Mol Pharmacol. 2018 Sep;94(3):938-952. doi: 10.1124/mol.118.111773. Epub 2018 Jun 29.


Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.

Mubarokah N, Hulin JA, Mackenzie PI, McKinnon RA, Haines AZ, Hu DG, Meech R.

Mol Pharmacol. 2018 May;93(5):541-552. doi: 10.1124/mol.117.110619. Epub 2018 Mar 8.


Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites.

Wijayakumara DD, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2018 Apr;365(1):48-59. doi: 10.1124/jpet.117.245936. Epub 2018 Jan 24.


Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species.

Allison SE, Chen Y, Petrovic N, Zhang J, Bourget K, Mackenzie PI, Murray M.

Biochem Pharmacol. 2017 Nov 1;143:79-89. doi: 10.1016/j.bcp.2017.07.020. Epub 2017 Jul 27.


Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells.

Chanawong A, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2017 Jun;361(3):482-491. doi: 10.1124/jpet.117.240317. Epub 2017 Apr 12.


Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells.

Wijayakumara DD, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2017 Jun;361(3):386-397. doi: 10.1124/jpet.116.239707. Epub 2017 Apr 7.


Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.

Kurita A, Miyauchi Y, Ikushiro S, Mackenzie PI, Yamada H, Ishii Y.

J Pharmacol Exp Ther. 2017 May;361(2):199-208. doi: 10.1124/jpet.117.240382. Epub 2017 Feb 22.


Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia.

Miners JO, Chau N, Rowland A, Burns K, McKinnon RA, Mackenzie PI, Tucker GT, Knights KM, Kichenadasse G.

Biochem Pharmacol. 2017 Apr 1;129:85-95. doi: 10.1016/j.bcp.2017.01.002. Epub 2017 Jan 6.


Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.

Hu DG, McKinnon RA, Hulin JA, Mackenzie PI, Meech R.

Int J Mol Sci. 2016 Dec 27;18(1). pii: E40. doi: 10.3390/ijms18010040.


Advances in drug metabolism and pharmacogenetics research in Australia.

Mackenzie PI, Somogyi AA, Miners JO.

Pharmacol Res. 2017 Feb;116:7-19. doi: 10.1016/j.phrs.2016.12.008. Epub 2016 Dec 9. Review.


Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation.

Nakamura T, Yamaguchi N, Miyauchi Y, Takeda T, Yamazoe Y, Nagata K, Mackenzie PI, Yamada H, Ishii Y.

Front Pharmacol. 2016 Nov 14;7:427. eCollection 2016.


Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.

Allison SE, Chen Y, Petrovic N, Zimmermann S, Moosmann B, Jansch M, Cui PH, Dunstan CR, Mackenzie PI, Murray M.

Int J Biochem Cell Biol. 2016 Nov;80:173-178. doi: 10.1016/j.biocel.2016.10.004. Epub 2016 Oct 5.


Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.

Hu DG, Selth LA, Tarulli GA, Meech R, Wijayakumara D, Chanawong A, Russell R, Caldas C, Robinson JL, Carroll JS, Tilley WD, Mackenzie PI, Hickey TE.

Cancer Res. 2016 Oct 1;76(19):5881-5893. Epub 2016 Aug 5.


Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.

Hu DG, Mackenzie PI, McKinnon RA, Meech R.

Drug Metab Rev. 2016;48(1):47-69. doi: 10.3109/03602532.2015.1131292. Epub 2016 Feb 1. Review.


Expression of androgen receptor splice variants in clinical breast cancers.

Hickey TE, Irvine CM, Dvinge H, Tarulli GA, Hanson AR, Ryan NK, Pickering MA, Birrell SN, Hu DG, Mackenzie PI, Russell R, Caldas C, Raj GV, Dehm SM, Plymate SR, Bradley RK, Tilley WD, Selth LA.

Oncotarget. 2015 Dec 29;6(42):44728-44. doi: 10.18632/oncotarget.6296.


The Nonspecific Binding of Tyrosine Kinase Inhibitors to Human Liver Microsomes.

Burns K, Nair PC, Rowland A, Mackenzie PI, Knights KM, Miners JO.

Drug Metab Dispos. 2015 Dec;43(12):1934-7. doi: 10.1124/dmd.115.065292. Epub 2015 Oct 6.


Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective.

Nair PC, Meech R, Mackenzie PI, McKinnon RA, Miners JO.

Drug Metab Rev. 2015 Aug;47(3):335-45. doi: 10.3109/03602532.2015.1071835. Epub 2015 Aug 3. Review.


Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region.

Miyauchi Y, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H, Ishii Y.

Mol Pharmacol. 2015 Oct;88(4):800-12. doi: 10.1124/mol.115.098582. Epub 2015 Aug 4.


Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective.

Nair PC, Meech R, Mackenzie PI, McKinnon RA, Miners JO.

Drug Metab Rev. 2015 Aug 3:1-11. [Epub ahead of print]


Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.

Wijayakumara DD, Hu DG, Meech R, McKinnon RA, Mackenzie PI.

J Pharmacol Exp Ther. 2015 Sep;354(3):417-25. doi: 10.1124/jpet.115.226118. Epub 2015 Jul 10.


Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2.

Allison SE, Petrovic N, Mackenzie PI, Murray M.

Biochem Pharmacol. 2015 Aug 15;96(4):306-14. doi: 10.1016/j.bcp.2015.06.002. Epub 2015 Jun 9.


Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.

Dates CR, Fahmi T, Pyrek SJ, Yao-Borengasser A, Borowa-Mazgaj B, Bratton SM, Kadlubar SA, Mackenzie PI, Haun RS, Radominska-Pandya A.

Cancer Biol Ther. 2015;16(5):714-23. doi: 10.1080/15384047.2015.1026480.


Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins.

Rowland A, Hallifax D, Nussio MR, Shapter JG, Mackenzie PI, Brian Houston J, Knights KM, Miners JO.

Xenobiotica. 2015;45(10):847-57. doi: 10.3109/00498254.2015.1021403. Epub 2015 Mar 24.


Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells.

Chanawong A, Hu DG, Meech R, Mackenzie PI, McKinnon RA.

Drug Metab Dispos. 2015 Jun;43(6):889-97. doi: 10.1124/dmd.114.062935. Epub 2015 Mar 20.


Induction of human UDP-Glucuronosyltransferase 2B7 gene expression by cytotoxic anticancer drugs in liver cancer HepG2 cells.

Hu DG, Mackenzie PI, Lu L, Meech R, McKinnon RA.

Drug Metab Dispos. 2015 May;43(5):660-8. doi: 10.1124/dmd.114.062380. Epub 2015 Feb 23.


A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.

Meech R, Mubarokah N, Shivasami A, Rogers A, Nair PC, Hu DG, McKinnon RA, Mackenzie PI.

Mol Pharmacol. 2015;87(3):442-50. doi: 10.1124/mol.114.093823. Epub 2014 Dec 17.


Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.

Rowland A, Mackenzie PI, Miners JO.

Drug Metab Dispos. 2015 Jan;43(1):147-53. doi: 10.1124/dmd.114.060509. Epub 2014 Nov 7.


Transcriptional regulation of human UDP-glucuronosyltransferase genes.

Hu DG, Meech R, McKinnon RA, Mackenzie PI.

Drug Metab Rev. 2014 Nov;46(4):421-58. doi: 10.3109/03602532.2014.973037. Epub 2014 Oct 22. Review.


Epirubicin upregulates UDP glucuronosyltransferase 2B7 expression in liver cancer cells via the p53 pathway.

Hu DG, Rogers A, Mackenzie PI.

Mol Pharmacol. 2014 Jun;85(6):887-97. doi: 10.1124/mol.114.091603. Epub 2014 Mar 28.


Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues.

Hu DG, Hickey TE, Irvine C, Wijayakumara DD, Lu L, Tilley WD, Selth LA, Mackenzie PI.

Horm Cancer. 2014 Apr;5(2):61-71. doi: 10.1007/s12672-014-0171-4. Epub 2014 Feb 26.


Polymorphisms and haplotypes of the UDP-glucuronosyltransferase 2B7 gene promoter.

Hu DG, Meech R, Lu L, McKinnon RA, Mackenzie PI.

Drug Metab Dispos. 2014 May;42(5):854-62. doi: 10.1124/dmd.113.056630. Epub 2014 Feb 21.


Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies.

Chau N, Elliot DJ, Lewis BC, Burns K, Johnston MR, Mackenzie PI, Miners JO.

J Pharmacol Exp Ther. 2014 Apr;349(1):126-37. doi: 10.1124/jpet.113.212258. Epub 2014 Jan 23.


Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants.

Ishii Y, Koba H, Kinoshita K, Oizaki T, Iwamoto Y, Takeda S, Miyauchi Y, Nishimura Y, Egoshi N, Taura F, Morimoto S, Ikushiro S, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H.

Drug Metab Dispos. 2014 Feb;42(2):229-38. doi: 10.1124/dmd.113.054833. Epub 2013 Nov 19.


The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification.

Rowland A, Miners JO, Mackenzie PI.

Int J Biochem Cell Biol. 2013 Jun;45(6):1121-32. doi: 10.1016/j.biocel.2013.02.019. Epub 2013 Mar 7. Review.


Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity.

Korprasertthaworn P, Rowland A, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO.

Biochem Pharmacol. 2012 Dec 1;84(11):1511-21. doi: 10.1016/j.bcp.2012.08.026. Epub 2012 Sep 5.


Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols.

Ishii Y, Iida N, Miyauchi Y, Mackenzie PI, Yamada H.

Biol Pharm Bull. 2012;35(10):1811-7. Epub 2012 Aug 8.


Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics.

Zhang H, Patana AS, Mackenzie PI, Ikushiro S, Goldman A, Finel M.

Drug Metab Dispos. 2012 Oct;40(10):1935-44. doi: 10.1124/dmd.112.046086. Epub 2012 Jul 10.


Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes.

Meech R, Rogers A, Zhuang L, Lewis BC, Miners JO, Mackenzie PI.

J Biol Chem. 2012 Jul 13;287(29):24122-30. doi: 10.1074/jbc.M112.343608. Epub 2012 May 23.


The glycosidation of xenobiotics and endogenous compounds: versatility and redundancy in the UDP glycosyltransferase superfamily.

Meech R, Miners JO, Lewis BC, Mackenzie PI.

Pharmacol Ther. 2012 May;134(2):200-18. doi: 10.1016/j.pharmthera.2012.01.009. Epub 2012 Feb 1. Review.


Homodimerization of UDP-glucuronosyltransferase 2B7 (UGT2B7) and identification of a putative dimerization domain by protein homology modeling.

Lewis BC, Mackenzie PI, Miners JO.

Biochem Pharmacol. 2011 Dec 15;82(12):2016-23. doi: 10.1016/j.bcp.2011.09.007. Epub 2011 Sep 14.


Application of homology modeling to generate CYP1A1 mutants with enhanced activation of the cancer chemotherapeutic prodrug dacarbazine.

Lewis BC, Mackenzie PI, Miners JO.

Mol Pharmacol. 2011 Nov;80(5):879-88. doi: 10.1124/mol.111.072124. Epub 2011 Aug 4.


The novel UDP glycosyltransferase 3A2: cloning, catalytic properties, and tissue distribution.

MacKenzie PI, Rogers A, Elliot DJ, Chau N, Hulin JA, Miners JO, Meech R.

Mol Pharmacol. 2011 Mar;79(3):472-8. doi: 10.1124/mol.110.069336. Epub 2010 Nov 18.


Forkhead box protein A1 regulates UDP-glucuronosyltransferase 2B15 gene transcription in LNCaP prostate cancer cells.

Hu DG, Mackenzie PI.

Drug Metab Dispos. 2010 Dec;38(12):2105-9. doi: 10.1124/dmd.110.035436. Epub 2010 Aug 24.


Effects of Andrographis paniculata and Orthosiphon stamineus extracts on the glucuronidation of 4-methylumbelliferone in human UGT isoforms.

Ismail S, Hanapi NA, Ab Halim MR, Uchaipichat V, Mackenzie PI.

Molecules. 2010 May 14;15(5):3578-92. doi: 10.3390/molecules15053578.


A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3α,17β-diol glucuronide.

Hu DG, Gardner-Stephen D, Severi G, Gregory PA, Treloar J, Giles GG, English DR, Hopper JL, Tilley WD, Mackenzie PI.

Mol Pharmacol. 2010 Oct;78(4):714-22. doi: 10.1124/mol.110.065953. Epub 2010 Jul 13.


The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors.

Mackenzie PI, Hu DG, Gardner-Stephen DA.

Drug Metab Rev. 2010 Feb;42(1):99-109. doi: 10.3109/03602530903209544.


UGT3A: novel UDP-glycosyltransferases of the UGT superfamily.

Meech R, Mackenzie PI.

Drug Metab Rev. 2010 Feb;42(1):45-54. doi: 10.3109/03602530903205823.


Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.

Kerdpin O, Mackenzie PI, Bowalgaha K, Finel M, Miners JO.

Drug Metab Dispos. 2009 Sep;37(9):1948-55. doi: 10.1124/dmd.109.028225. Epub 2009 Jun 1.

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