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Items: 1 to 50 of 281

1.

UDP-Glucuronosyltransferase (UGT)-Mediated Attenuations of Cytochrome P450 3A4 Activity: UGT Isoform-Dependent Mechanism of Suppression.

Miyauchi Y, Tanaka Y, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H, Ishii Y.

Br J Pharmacol. 2019 Oct 29. doi: 10.1111/bph.14900. [Epub ahead of print]

PMID:
31660580
2.

The UGTome: the expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism.

Hu DG, Hulin JA, Nair PC, Haines AZ, McKinnon RA, Mackenzie PI, Meech R.

Pharmacol Ther. 2019 Oct 21:107414. doi: 10.1016/j.pharmthera.2019.107414. [Epub ahead of print]

PMID:
31647974
3.

Longitudinal Analysis of Bruch Membrane Opening Morphometry in Myopic Glaucoma.

Bhalla M, Heisler M, Han SX, Sarunic MV, Beg MF, Mackenzie PJ, Lee S.

J Glaucoma. 2019 Oct;28(10):889-895. doi: 10.1097/IJG.0000000000001332.

PMID:
31335553
4.

Validation of the size morphology site access score in endoscopic mucosal resection of large polyps in a district general hospital.

Currie AC, Merriman H, Nadia Shah Gilani S, Mackenzie P, McFall MR, Baig MK.

Ann R Coll Surg Engl. 2019 Nov;101(8):558-562. doi: 10.1308/rcsann.2019.0068. Epub 2019 Jun 24.

PMID:
31233327
5.

Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants.

Miyauchi Y, Kimura S, Kimura A, Kurohara K, Hirota Y, Fujimoto K, Mackenzie PI, Tanaka Y, Ishii Y.

Mol Pharmacol. 2019 May;95(5):551-562. doi: 10.1124/mol.118.113902. Epub 2019 Apr 3.

PMID:
30944207
6.

The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms.

Meech R, Hu DG, McKinnon RA, Mubarokah SN, Haines AZ, Nair PC, Rowland A, Mackenzie PI.

Physiol Rev. 2019 Apr 1;99(2):1153-1222. doi: 10.1152/physrev.00058.2017. Review.

PMID:
30724669
7.

Deregulation of the Genes that Are Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Hepatocellular Carcinoma.

Hu DG, Marri S, McKinnon RA, Mackenzie PI, Meech R.

J Pharmacol Exp Ther. 2019 Mar;368(3):363-381. doi: 10.1124/jpet.118.255018. Epub 2018 Dec 21.

PMID:
30578287
8.

Drug and Chemical Glucosidation by Control Supersomes and Membranes from Spodoptera frugiperda (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5.

Chau N, Kaya L, Lewis BC, Mackenzie PI, Miners JO.

Drug Metab Dispos. 2019 Mar;47(3):271-278. doi: 10.1124/dmd.118.084947. Epub 2018 Dec 12.

PMID:
30541877
9.

Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.

Rowland A, Ruanglertboon W, van Dyk M, Wijayakumara D, Wood LS, Meech R, Mackenzie PI, Rodrigues AD, Marshall JC, Sorich MJ.

Br J Clin Pharmacol. 2019 Jan;85(1):216-226. doi: 10.1111/bcp.13793. Epub 2018 Nov 16.

PMID:
30340248
10.

Can radiation oncologists learn to be better leaders? Outcomes of a pilot Foundations of Leadership in Radiation Oncology program for trainees delivered via personal electronic devices.

Turner S, Janssen A, Chan MK, Morris L, Martin R, Mackenzie P, Shaw T.

J Med Imaging Radiat Oncol. 2018 Dec;62(6):847-853. doi: 10.1111/1754-9485.12793. Epub 2018 Sep 5.

PMID:
30183132
11.

Intergenic Splicing between Four Adjacent UGT Genes (2B15, 2B29P2, 2B17, 2B29P1) Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions.

Hu DG, Hulin JA, Wijayakumara DD, McKinnon RA, Mackenzie PI, Meech R.

Mol Pharmacol. 2018 Sep;94(3):938-952. doi: 10.1124/mol.118.111773. Epub 2018 Jun 29.

PMID:
29959221
12.

Strong-Isospin-Breaking Correction to the Muon Anomalous Magnetic Moment from Lattice QCD at the Physical Point.

Chakraborty B, Davies CTH, DeTar C, El-Khadra AX, Gámiz E, Gottlieb S, Hatton D, Koponen J, Kronfeld AS, Laiho J, Lepage GP, Liu Y, Mackenzie PB, McNeile C, Neil ET, Simone JN, Sugar R, Toussaint D, Van de Water RS, Vaquero A; Fermilab Lattice, HPQCD, and MILC Collaborations.

Phys Rev Lett. 2018 Apr 13;120(15):152001. doi: 10.1103/PhysRevLett.120.152001.

PMID:
29756848
13.

Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4α Is Mediated by a Novel Composite Regulatory Element.

Mubarokah N, Hulin JA, Mackenzie PI, McKinnon RA, Haines AZ, Hu DG, Meech R.

Mol Pharmacol. 2018 May;93(5):541-552. doi: 10.1124/mol.117.110619. Epub 2018 Mar 8.

PMID:
29519853
14.

Regulation of UDP-Glucuronosyltransferase 2B15 by miR-331-5p in Prostate Cancer Cells Involves Canonical and Noncanonical Target Sites.

Wijayakumara DD, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2018 Apr;365(1):48-59. doi: 10.1124/jpet.117.245936. Epub 2018 Jan 24.

PMID:
29367276
15.

Activation of ALDH1A1 in MDA-MB-468 breast cancer cells that over-express CYP2J2 protects against paclitaxel-dependent cell death mediated by reactive oxygen species.

Allison SE, Chen Y, Petrovic N, Zhang J, Bourget K, Mackenzie PI, Murray M.

Biochem Pharmacol. 2017 Nov 1;143:79-89. doi: 10.1016/j.bcp.2017.07.020. Epub 2017 Jul 27.

PMID:
28756208
16.

Age and Glaucoma-Related Characteristics in Retinal Nerve Fiber Layer and Choroid: Localized Morphometrics and Visualization Using Functional Shapes Registration.

Lee S, Heisler ML, Popuri K, Charon N, Charlier B, Trouvé A, Mackenzie PJ, Sarunic MV, Beg MF.

Front Neurosci. 2017 Jul 12;11:381. doi: 10.3389/fnins.2017.00381. eCollection 2017.

17.

Exemestane and Its Active Metabolite 17-Hydroexemestane Induce UDP-Glucuronosyltransferase (UGT) 2B17 Expression in Breast Cancer Cells.

Chanawong A, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2017 Jun;361(3):482-491. doi: 10.1124/jpet.117.240317. Epub 2017 Apr 12.

PMID:
28404691
18.

Regulation of UDP-Glucuronosyltransferases UGT2B4 and UGT2B7 by MicroRNAs in Liver Cancer Cells.

Wijayakumara DD, Mackenzie PI, McKinnon RA, Hu DG, Meech R.

J Pharmacol Exp Ther. 2017 Jun;361(3):386-397. doi: 10.1124/jpet.116.239707. Epub 2017 Apr 7.

PMID:
28389526
19.

Quantifying Variability in Longitudinal Peripapillary RNFL and Choroidal Layer Thickness Using Surface Based Registration of OCT Images.

Lee S, Heisler M, Mackenzie PJ, Sarunic MV, Beg MF.

Transl Vis Sci Technol. 2017 Feb 28;6(1):11. doi: 10.1167/tvst.6.1.11. eCollection 2017 Feb.

20.

Anterior Segment Optical Coherence Tomography for Targeted Transconjunctival Suture Placement in Overfiltering Trabeculectomy Blebs.

Heisler M, Quong WL, Lee S, Han S, Beg MF, Sarunic MV, Mackenzie PJ.

J Glaucoma. 2017 May;26(5):486-490. doi: 10.1097/IJG.0000000000000656.

PMID:
28263262
21.

Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation.

Kurita A, Miyauchi Y, Ikushiro S, Mackenzie PI, Yamada H, Ishii Y.

J Pharmacol Exp Ther. 2017 May;361(2):199-208. doi: 10.1124/jpet.117.240382. Epub 2017 Feb 22.

PMID:
28228532
22.

Inhibition of human UDP-glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia.

Miners JO, Chau N, Rowland A, Burns K, McKinnon RA, Mackenzie PI, Tucker GT, Knights KM, Kichenadasse G.

Biochem Pharmacol. 2017 Apr 1;129:85-95. doi: 10.1016/j.bcp.2017.01.002. Epub 2017 Jan 6.

PMID:
28065859
23.

Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.

Hu DG, McKinnon RA, Hulin JA, Mackenzie PI, Meech R.

Int J Mol Sci. 2016 Dec 27;18(1). pii: E40. doi: 10.3390/ijms18010040.

24.

Breast interest group faculty of radiation oncology: Australian and New Zealand patterns of practice survey on breast radiotherapy.

Nguyen K, Mackenzie P, Allen A, Dreosti M, Morgia M, Zissiadis Y, Lamoury G, Windsor A.

J Med Imaging Radiat Oncol. 2017 Aug;61(4):508-516. doi: 10.1111/1754-9485.12566. Epub 2016 Dec 16.

PMID:
27987274
25.

Advances in drug metabolism and pharmacogenetics research in Australia.

Mackenzie PI, Somogyi AA, Miners JO.

Pharmacol Res. 2017 Feb;116:7-19. doi: 10.1016/j.phrs.2016.12.008. Epub 2016 Dec 9. Review.

PMID:
27956261
26.

Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation.

Nakamura T, Yamaguchi N, Miyauchi Y, Takeda T, Yamazoe Y, Nagata K, Mackenzie PI, Yamada H, Ishii Y.

Front Pharmacol. 2016 Nov 14;7:427. eCollection 2016.

27.

Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2.

Allison SE, Chen Y, Petrovic N, Zimmermann S, Moosmann B, Jansch M, Cui PH, Dunstan CR, Mackenzie PI, Murray M.

Int J Biochem Cell Biol. 2016 Nov;80:173-178. doi: 10.1016/j.biocel.2016.10.004. Epub 2016 Oct 5.

PMID:
27720933
28.

Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.

Hu DG, Selth LA, Tarulli GA, Meech R, Wijayakumara D, Chanawong A, Russell R, Caldas C, Robinson JL, Carroll JS, Tilley WD, Mackenzie PI, Hickey TE.

Cancer Res. 2016 Oct 1;76(19):5881-5893. Epub 2016 Aug 5.

29.

Quantitative Optical Coherence Tomography Angiography of Radial Peripapillary Capillaries in Glaucoma, Glaucoma Suspect, and Normal Eyes.

Mammo Z, Heisler M, Balaratnasingam C, Lee S, Yu DY, Mackenzie P, Schendel S, Merkur A, Kirker A, Albiani D, Navajas E, Beg MF, Morgan W, Sarunic MV.

Am J Ophthalmol. 2016 Oct;170:41-49. doi: 10.1016/j.ajo.2016.07.015. Epub 2016 Jul 25.

30.

Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking.

Cua M, Lee S, Miao D, Ju MJ, Mackenzie PJ, Jian Y, Sarunic MV.

J Biomed Opt. 2016 Feb;21(2):26007. doi: 10.1117/1.JBO.21.2.026007.

31.

Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.

Hu DG, Mackenzie PI, McKinnon RA, Meech R.

Drug Metab Rev. 2016;48(1):47-69. doi: 10.3109/03602532.2015.1131292. Epub 2016 Feb 1. Review.

PMID:
26828111
32.

Expression of androgen receptor splice variants in clinical breast cancers.

Hickey TE, Irvine CM, Dvinge H, Tarulli GA, Hanson AR, Ryan NK, Pickering MA, Birrell SN, Hu DG, Mackenzie PI, Russell R, Caldas C, Raj GV, Dehm SM, Plymate SR, Bradley RK, Tilley WD, Selth LA.

Oncotarget. 2015 Dec 29;6(42):44728-44. doi: 10.18632/oncotarget.6296.

33.

B→πll Form Factors for New Physics Searches from Lattice QCD.

Bailey JA, Bazavov A, Bernard C, Bouchard CM, DeTar C, Du D, El-Khadra AX, Freeland ED, Gámiz E, Gottlieb S, Heller UM, Kronfeld AS, Laiho J, Levkova L, Liu Y, Lunghi E, Mackenzie PB, Meurice Y, Neil E, Qiu SW, Simone JN, Sugar R, Toussaint D, Van de Water RS, Zhou R; Fermilab Lattice and MILC Collaborations.

Phys Rev Lett. 2015 Oct 9;115(15):152002. doi: 10.1103/PhysRevLett.115.152002. Epub 2015 Oct 7.

PMID:
26550717
34.

The Nonspecific Binding of Tyrosine Kinase Inhibitors to Human Liver Microsomes.

Burns K, Nair PC, Rowland A, Mackenzie PI, Knights KM, Miners JO.

Drug Metab Dispos. 2015 Dec;43(12):1934-7. doi: 10.1124/dmd.115.065292. Epub 2015 Oct 6.

PMID:
26443648
35.

Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective.

Nair PC, Meech R, Mackenzie PI, McKinnon RA, Miners JO.

Drug Metab Rev. 2015 Aug;47(3):335-45. doi: 10.3109/03602532.2015.1071835. Epub 2015 Aug 3. Review.

PMID:
26289097
36.

Label-Free Density Measurements of Radial Peripapillary Capillaries in the Human Retina.

Yu PK, Balaratnasingam C, Xu J, Morgan WH, Mammo Z, Han S, Mackenzie P, Merkur A, Kirker A, Albiani D, Sarunic MV, Yu DY.

PLoS One. 2015 Aug 7;10(8):e0135151. doi: 10.1371/journal.pone.0135151. eCollection 2015.

37.

Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region.

Miyauchi Y, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H, Ishii Y.

Mol Pharmacol. 2015 Oct;88(4):800-12. doi: 10.1124/mol.115.098582. Epub 2015 Aug 4.

PMID:
26243732
38.

Quantitative Noninvasive Angiography of the Fovea Centralis Using Speckle Variance Optical Coherence Tomography.

Mammo Z, Balaratnasingam C, Yu P, Xu J, Heisler M, Mackenzie P, Merkur A, Kirker A, Albiani D, Freund KB, Sarunic MV, Yu DY.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5074-86. doi: 10.1167/iovs.15-16773.

39.

Insights into the UDP-sugar selectivities of human UDP-glycosyltransferases (UGT): a molecular modeling perspective.

Nair PC, Meech R, Mackenzie PI, McKinnon RA, Miners JO.

Drug Metab Rev. 2015 Aug 3:1-11. [Epub ahead of print]

PMID:
26234632
40.

Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines.

Wijayakumara DD, Hu DG, Meech R, McKinnon RA, Mackenzie PI.

J Pharmacol Exp Ther. 2015 Sep;354(3):417-25. doi: 10.1124/jpet.115.226118. Epub 2015 Jul 10.

PMID:
26163549
41.

Quantitative Comparison of Retinal Capillary Images Derived By Speckle Variance Optical Coherence Tomography With Histology.

Tan PE, Balaratnasingam C, Xu J, Mammo Z, Han SX, Mackenzie P, Kirker AW, Albiani D, Merkur AB, Sarunic MV, Yu DY.

Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3989-96. doi: 10.1167/iovs.14-15879.

42.

Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2.

Allison SE, Petrovic N, Mackenzie PI, Murray M.

Biochem Pharmacol. 2015 Aug 15;96(4):306-14. doi: 10.1016/j.bcp.2015.06.002. Epub 2015 Jun 9.

PMID:
26067757
43.

Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.

Dates CR, Fahmi T, Pyrek SJ, Yao-Borengasser A, Borowa-Mazgaj B, Bratton SM, Kadlubar SA, Mackenzie PI, Haun RS, Radominska-Pandya A.

Cancer Biol Ther. 2015;16(5):714-23. doi: 10.1080/15384047.2015.1026480.

44.

In vivo optical imaging of human retinal capillary networks using speckle variance optical coherence tomography with quantitative clinico-histological correlation.

Chan G, Balaratnasingam C, Xu J, Mammo Z, Han S, Mackenzie P, Merkur A, Kirker A, Albiani D, Sarunic MV, Yu DY.

Microvasc Res. 2015 Jul;100:32-9. doi: 10.1016/j.mvr.2015.04.006. Epub 2015 Apr 24.

PMID:
25917012
45.

Characterization of the comparative drug binding to intra- (liver fatty acid binding protein) and extra- (human serum albumin) cellular proteins.

Rowland A, Hallifax D, Nussio MR, Shapter JG, Mackenzie PI, Brian Houston J, Knights KM, Miners JO.

Xenobiotica. 2015;45(10):847-57. doi: 10.3109/00498254.2015.1021403. Epub 2015 Mar 24.

PMID:
25801059
46.

Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells.

Chanawong A, Hu DG, Meech R, Mackenzie PI, McKinnon RA.

Drug Metab Dispos. 2015 Jun;43(6):889-97. doi: 10.1124/dmd.114.062935. Epub 2015 Mar 20.

PMID:
25795461
47.

Retinal angiography with real-time speckle variance optical coherence tomography.

Xu J, Han S, Balaratnasingam C, Mammo Z, Wong KS, Lee S, Cua M, Young M, Kirker A, Albiani D, Forooghian F, Mackenzie P, Merkur A, Yu DY, Sarunic MV.

Br J Ophthalmol. 2015 Oct;99(10):1315-9. doi: 10.1136/bjophthalmol-2014-306010. Epub 2015 Mar 2.

48.

Induction of human UDP-Glucuronosyltransferase 2B7 gene expression by cytotoxic anticancer drugs in liver cancer HepG2 cells.

Hu DG, Mackenzie PI, Lu L, Meech R, McKinnon RA.

Drug Metab Dispos. 2015 May;43(5):660-8. doi: 10.1124/dmd.114.062380. Epub 2015 Feb 23.

PMID:
25713207
49.

A novel function for UDP glycosyltransferase 8: galactosidation of bile acids.

Meech R, Mubarokah N, Shivasami A, Rogers A, Nair PC, Hu DG, McKinnon RA, Mackenzie PI.

Mol Pharmacol. 2015;87(3):442-50. doi: 10.1124/mol.114.093823. Epub 2014 Dec 17.

PMID:
25519837
50.

Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.

Rowland A, Mackenzie PI, Miners JO.

Drug Metab Dispos. 2015 Jan;43(1):147-53. doi: 10.1124/dmd.114.060509. Epub 2014 Nov 7.

PMID:
25380805

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