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Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts.

Wei R, Hackman RM, Wang Y, Mackenzie GG.

Cancers (Basel). 2019 Oct 5;11(10). pii: E1496. doi: 10.3390/cancers11101496.


Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine.

Luo D, DiGiovanni MG, Wei R, LaComb JF, Williams JL, Rigas B, Mackenzie GG.

Carcinogenesis. 2019 Oct 4. pii: bgz170. doi: 10.1093/carcin/bgz170. [Epub ahead of print]


DHA-SBT-1214 Taxoid Nanoemulsion and Anti-PD-L1 Antibody Combination Therapy Enhances Anti-Tumor Efficacy in a Syngeneic Pancreatic Adenocarcinoma Model.

Ahmed G, Mackenzie GG, Egan J, Amiji MM.

Mol Cancer Ther. 2019 Aug 22. pii: molcanther.1046.2018. doi: 10.1158/1535-7163.MCT-18-1046. [Epub ahead of print]


Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation.

Luo D, Fraga-Lauhirat M, Millings J, Ho C, Villarreal EM, Fletchinger TC, Bonfiglio JV, Mata L, Nemesure MD, Bartels LE, Wang R, Rigas B, Mackenzie GG.

Carcinogenesis. 2019 Apr 17. pii: bgz069. doi: 10.1093/carcin/bgz069. [Epub ahead of print]


Oncogenic Ras/squamous cell carcinoma antigen signaling pathway activation promotes invasiveness and lymph node metastases in papillary thyroid carcinoma.

Luo D, Liu Y, Lin S, Tan L, Du Z, Long M, Zhu Y, Peng X, Zong W, Mackenzie GG, Li H, Ouyang N.

Oncol Rep. 2019 Feb;41(2):1253-1263. doi: 10.3892/or.2018.6895. Epub 2018 Nov 28.


Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models.

Wei R, Mao L, Xu P, Zheng X, Hackman RM, Mackenzie GG, Wang Y.

Food Funct. 2018 Nov 14;9(11):5682-5696. doi: 10.1039/c8fo01397g.


Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium.

Trabert B, Poole EM, White E, Visvanathan K, Adami HO, Anderson GL, Brasky TM, Brinton LA, Fortner RT, Gaudet M, Hartge P, Hoffman-Bolton J, Jones M, Lacey JV, Larsson SC, Mackenzie GG, Schouten LJ, Sandler DP, O'Brien K, Patel AV, Peters U, Prizment A, Robien K, Setiawan VW, Swerdlow A, van den Brandt PA, Weiderpass E, Wilkens LR, Wolk A, Wentzensen N, Tworoger SS; Ovarian Cancer Cohort Consortium (OC3).

J Natl Cancer Inst. 2019 Feb 1;111(2):137-145. doi: 10.1093/jnci/djy100.


Pancreatic cancer: A critical review of dietary risk.

Salem AA, Mackenzie GG.

Nutr Res. 2018 Apr;52:1-13. doi: 10.1016/j.nutres.2017.12.001. Epub 2017 Dec 14. Review.


A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras.

Mallangada NA, Vargas JM, Thomas S, DiGiovanni MG, Vaeth BM, Nemesure MD, Wang R, LaComb JF, Williams JL, Golub LM, Johnson F, Mackenzie GG.

Mol Carcinog. 2018 Sep;57(9):1130-1143. doi: 10.1002/mc.22830. Epub 2018 May 8.


Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin's lymphoma in mice.

Guorgui J, Wang R, Mattheolabakis G, Mackenzie GG.

Arch Biochem Biophys. 2018 Jun 15;648:12-19. doi: 10.1016/ Epub 2018 Apr 18.


Phospho-valproic acid inhibits pancreatic cancer growth in mice: enhanced efficacy by its formulation in poly-(L)-lactic acid-poly(ethylene glycol) nanoparticles.

Mattheolabakis G, Wang R, Rigas B, Mackenzie GG.

Int J Oncol. 2017 Oct;51(4):1035-1044. doi: 10.3892/ijo.2017.4103. Epub 2017 Aug 25. Erratum in: Int J Oncol. 2018 Dec;53(6):2800.


Aldosterone activates the oncogenic signals ERK1/2 and STAT3 via redox-regulated mechanisms.

Queisser N, Schupp N, Schwarz E, Hartmann C, Mackenzie GG, Oteiza PI.

Mol Carcinog. 2017 Aug;56(8):1868-1883. doi: 10.1002/mc.22643. Epub 2017 Mar 30.


Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms.

Supasai S, Aimo L, Adamo AM, Mackenzie GG, Oteiza PI.

Redox Biol. 2017 Apr;11:469-481. doi: 10.1016/j.redox.2016.12.027. Epub 2017 Jan 3.


Liposomal Irinotecan in the Treatment of Refractory Pancreatic Cancer.

Bien H, Mackenzie GG, Choi M.

Recent Pat Anticancer Drug Discov. 2016;11(4):376-383. Review.


Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice.

Mattheolabakis G, Papayannis I, Yang J, Vaeth BM, Wang R, Bandovic J, Ouyang N, Rigas B, Mackenzie GG.

Cancer Prev Res (Phila). 2016 Jul;9(7):624-34. doi: 10.1158/1940-6207.CAPR-15-0344. Epub 2016 May 2.


The novel agent phospho-glycerol-ibuprofen-amide (MDC-330) inhibits glioblastoma growth in mice: an effect mediated by cyclin D1.

Bartels LE, Mattheolabakis G, Vaeth BM, LaComb JF, Wang R, Zhi J, Komninou D, Rigas B, Mackenzie GG.

Carcinogenesis. 2016 Apr;37(4):420-429. doi: 10.1093/carcin/bgw017. Epub 2016 Feb 10.


The PI3K/Akt pathway is involved in procyanidin-mediated suppression of human colorectal cancer cell growth.

Choy YY, Fraga M, Mackenzie GG, Waterhouse AL, Cremonini E, Oteiza PI.

Mol Carcinog. 2016 Dec;55(12):2196-2209. doi: 10.1002/mc.22461. Epub 2016 Jan 15.


Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway.

Nuttall JR, Supasai S, Kha J, Vaeth BM, Mackenzie GG, Adamo AM, Oteiza PI.

J Nutr Biochem. 2015 Nov;26(11):1116-23. doi: 10.1016/j.jnutbio.2015.05.007. Epub 2015 Jun 9.


Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice.

Son JS, Khair S, Pettet DW 3rd, Ouyang N, Tian X, Zhang Y, Zhu W, Mackenzie GG, Robertson CE, Ir D, Frank DN, Rigas B, Li E.

PLoS One. 2015 Jun 29;10(6):e0127985. doi: 10.1371/journal.pone.0127985. eCollection 2015.


Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress.

Huang L, Wong CC, Mackenzie GG, Sun Y, Cheng KW, Vrankova K, Alston N, Ouyang N, Rigas B.

BMC Cancer. 2014 Feb 28;14:141. doi: 10.1186/1471-2407-14-141.


A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice.

Mackenzie GG, Bartels LE, Xie G, Papayannis I, Alston N, Vrankova K, Ouyang N, Rigas B.

Neoplasia. 2013 Oct;15(10):1184-95.


Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice.

Mackenzie GG, Huang L, Alston N, Ouyang N, Vrankova K, Mattheolabakis G, Constantinides PP, Rigas B.

PLoS One. 2013 May 1;8(5):e61532. doi: 10.1371/journal.pone.0061532. Print 2013.


Aerosol administration of phospho-sulindac inhibits lung tumorigenesis.

Cheng KW, Wong CC, Alston N, Mackenzie GG, Huang L, Ouyang N, Xie G, Wiedmann T, Rigas B.

Mol Cancer Ther. 2013 Aug;12(8):1417-28. doi: 10.1158/1535-7163.MCT-13-0006-T. Epub 2013 May 3.


Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats.

Mattheolabakis G, Mackenzie GG, Huang L, Ouyang N, Cheng KW, Rigas B.

Pharm Res. 2013 Jun;30(6):1471-82. doi: 10.1007/s11095-012-0953-8. Epub 2013 Mar 13.


The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies.

Zhou D, Papayannis I, Mackenzie GG, Alston N, Ouyang N, Huang L, Nie T, Wong CC, Rigas B.

Carcinogenesis. 2013 Apr;34(4):943-51. doi: 10.1093/carcin/bgs394. Epub 2013 Jan 21.


Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system.

Sun Y, Rowehl LM, Huang L, Mackenzie GG, Vrankova K, Komninou D, Rigas B.

Breast Cancer Res. 2012 Jan 31;14(1):R20.


Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds.

Huang L, Mackenzie GG, Sun Y, Ouyang N, Xie G, Vrankova K, Komninou D, Rigas B.

Cancer Res. 2011 Dec 15;71(24):7617-27. doi: 10.1158/0008-5472.CAN-11-2349. Epub 2011 Oct 24.


The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine.

Xie G, Nie T, Mackenzie GG, Sun Y, Huang L, Ouyang N, Alston N, Zhu C, Murray OT, Constantinides PP, Kopelovich L, Rigas B.

Br J Pharmacol. 2012 Apr;165(7):2152-66. doi: 10.1111/j.1476-5381.2011.01705.x.


A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain.

Mackenzie GG, Salvador GA, Romero C, Keen CL, Oteiza PI.

Free Radic Biol Med. 2011 Jul 15;51(2):480-9. doi: 10.1016/j.freeradbiomed.2011.04.028. Epub 2011 Apr 30.


Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.

Mackenzie GG, Ouyang N, Xie G, Vrankova K, Huang L, Sun Y, Komninou D, Kopelovich L, Rigas B.

Cancer Prev Res (Phila). 2011 Jul;4(7):1052-60. doi: 10.1158/1940-6207.CAPR-11-0067. Epub 2011 Apr 4.


Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models.

Xie G, Sun Y, Nie T, Mackenzie GG, Huang L, Kopelovich L, Komninou D, Rigas B.

J Pharmacol Exp Ther. 2011 Jun;337(3):876-86. doi: 10.1124/jpet.111.180224. Epub 2011 Mar 21.


The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats.

Huang L, Mackenzie G, Ouyang N, Sun Y, Xie G, Johnson F, Komninou D, Rigas B.

Br J Pharmacol. 2011 Apr;162(7):1521-33. doi: 10.1111/j.1476-5381.2010.01162.x.


Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.

Huang L, Zhu C, Sun Y, Xie G, Mackenzie GG, Qiao G, Komninou D, Rigas B.

Carcinogenesis. 2010 Nov;31(11):1982-90. doi: 10.1093/carcin/bgq149. Epub 2010 Jul 12.


Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.

Mackenzie GG, Sun Y, Huang L, Xie G, Ouyang N, Gupta RC, Johnson F, Komninou D, Kopelovich L, Rigas B.

Gastroenterology. 2010 Oct;139(4):1320-32. doi: 10.1053/j.gastro.2010.06.044. Epub 2010 Jun 20. Erratum in: Gastroenterology. 2012 Mar;142(3):676.


The plasma membrane plays a central role in cells response to mechanical stress.

Verstraeten SV, Mackenzie GG, Oteiza PI.

Biochim Biophys Acta. 2010 Sep;1798(9):1739-49. doi: 10.1016/j.bbamem.2010.06.010. Epub 2010 Jun 19.


Gestational zinc deficiency affects the regulation of transcription factors AP-1, NF-κB and NFAT in fetal brain.

Aimo L, Mackenzie GG, Keenan AH, Oteiza PI.

J Nutr Biochem. 2010 Nov;21(11):1069-75. doi: 10.1016/j.jnutbio.2009.09.003. Epub 2010 Jan 25.


The role of zinc in the modulation of neuronal proliferation and apoptosis.

Adamo AM, Zago MP, Mackenzie GG, Aimo L, Keen CL, Keenan A, Oteiza PI.

Neurotox Res. 2010 Jan;17(1):1-14. doi: 10.1007/s12640-009-9067-4.


Dimeric procyanidins are inhibitors of NF-kappaB-DNA binding.

Mackenzie GG, Delfino JM, Keen CL, Fraga CG, Oteiza PI.

Biochem Pharmacol. 2009 Nov 1;78(9):1252-62. doi: 10.1016/j.bcp.2009.06.111. Epub 2009 Jul 8.


Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect.

Zhao W, Mackenzie GG, Murray OT, Zhang Z, Rigas B.

Carcinogenesis. 2009 Mar;30(3):512-9. doi: 10.1093/carcin/bgp015. Epub 2009 Jan 9.


(-)-Epicatechin and related procyanidins modulate intracellular calcium and prevent oxidation in Jurkat T cells.

Verstraeten SV, Mackenzie GG, Oteiza PI, Fraga CG.

Free Radic Res. 2008 Oct;42(10):864-72. doi: 10.1080/10715760802471452.


NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis?

Mackenzie GG, Rasheed S, Wertheim W, Rigas B.

PPAR Res. 2008;2008:919572. doi: 10.1155/2008/919572.


Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells.

Mackenzie GG, Queisser N, Wolfson ML, Fraga CG, Adamo AM, Oteiza PI.

Int J Cancer. 2008 Jul 1;123(1):56-65. doi: 10.1002/ijc.23477.


Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations.

Mackenzie GG, Adamo AM, Decker NP, Oteiza PI.

Biochem Pharmacol. 2008 Apr 1;75(7):1461-71. doi: 10.1016/j.bcp.2007.12.013. Epub 2008 Jan 5.


Zinc deficiency in neuronal biology.

Mackenzie GG, Zago MP, Aimo L, Oteiza PI.

IUBMB Life. 2007 Apr-May;59(4-5):299-307. Review.


Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT.

Mackenzie GG, Oteiza PI.

J Cell Physiol. 2007 Jan;210(1):246-56.


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