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Items: 1 to 50 of 185

1.

CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation.

Zhong Y, Paudel BP, Ryan DP, Low JKK, Franck C, Patel K, Bedward MJ, Torrado M, Payne RJ, van Oijen AM, Mackay JP.

Nat Commun. 2020 Mar 23;11(1):1519. doi: 10.1038/s41467-020-15183-2.

PMID:
32251276
2.

Contribution of NPY Y5 Receptors to the Reversible Structural Remodeling Of Basolateral Amygdala Dendrites in Male Rats Associated with NPY-mediated Stress Resilience.

Michaelson SD, Tapia APM, McKinty A, Villarroel HS, Mackay JP, Urban JH, Colmers WF.

J Neurosci. 2020 Mar 3. pii: JN-RM-2621-19. doi: 10.1523/JNEUROSCI.2621-19.2020. [Epub ahead of print]

PMID:
32144180
3.

Correction: GATAD2B-associated neurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-related disorder.

Shieh C, Jones N, Vanle B, Au M, Huang AY, Silva APG, Lee H, Douine ED, Otero MG, Choi A, Grand K, Taff IP, Delgado MR, Hajianpour MJ, Seeley A, Rohena L, Vernon H, Gripp KW, Vergano SA, Mahida S, Naidu S, Sousa AB, Wain KE, Challman TD, Beek G, Basel D, Ranells J, Smith R, Yusupov R, Freckmann ML, Ohden L, Davis-Keppen L, Chitayat D, Dowling JJ, Finkel R, Dauber A, Spillmann R, Pena LDM; Undiagnosed Diseases Network, Metcalfe K, Splitt M, Lachlan K, McKee SA, Hurst J, Fitzpatrick DR, Morton JEV, Cox H, Venkateswaran S, Young JI, Marsh ED, Nelson SF, Martinez JA, Graham JM Jr, Kini U, Mackay JP, Pierson TM.

Genet Med. 2020 Apr;22(4):822. doi: 10.1038/s41436-020-0760-2.

PMID:
32047287
4.

GATAD2B-associated neurodevelopmental disorder (GAND): clinical and molecular insights into a NuRD-related disorder.

Shieh C, Jones N, Vanle B, Au M, Huang AY, Silva APG, Lee H, Douine ED, Otero MG, Choi A, Grand K, Taff IP, Delgado MR, Hajianpour MJ, Seeley A, Rohena L, Vernon H, Gripp KW, Vergano SA, Mahida S, Naidu S, Sousa AB, Wain KE, Challman TD, Beek G, Basel D, Ranells J, Smith R, Yusupov R, Freckmann ML, Ohden L, Davis-Keppen L, Chitayat D, Dowling JJ, Finkel R, Dauber A, Spillmann R, Pena LDM; Undiagnosed Diseases Network, Metcalfe K, Splitt M, Lachlan K, McKee SA, Hurst J, Fitzpatrick DR, Morton JEV, Cox H, Venkateswaran S, Young JI, Marsh ED, Nelson SF, Martinez JA, Graham JM Jr, Kini U, Mackay JP, Pierson TM.

Genet Med. 2020 Jan 17. doi: 10.1038/s41436-019-0747-z. [Epub ahead of print] Erratum in: Genet Med. 2020 Feb 12;:.

PMID:
31949314
5.

Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.

Werner MT, Wang H, Hamagami N, Hsu SC, Yano JA, Stonestrom AJ, Behera V, Zong Y, Mackay JP, Blobel GA.

J Biol Chem. 2020 Feb 14;295(7):1898-1914. doi: 10.1074/jbc.RA119.010679. Epub 2019 Dec 2.

PMID:
31792058
6.

A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae.

Latham RD, Torrado M, Atto B, Walshe JL, Wilson R, Guss JM, Mackay JP, Tristram S, Gell DA.

Mol Microbiol. 2020 Feb;113(2):381-398. doi: 10.1111/mmi.14426. Epub 2019 Dec 2.

PMID:
31742788
7.

The NuRD complex and macrocephaly associated neurodevelopmental disorders.

Pierson TM, Otero MG, Grand K, Choi A, Graham JM Jr, Young JI, Mackay JP.

Am J Med Genet C Semin Med Genet. 2019 Dec;181(4):548-556. doi: 10.1002/ajmg.c.31752. Epub 2019 Nov 18.

PMID:
31737996
8.

Peppy: A virtual reality environment for exploring the principles of polypeptide structure.

Doak DG, Denyer GS, Gerrard JA, Mackay JP, Allison JR.

Protein Sci. 2020 Jan;29(1):157-168. doi: 10.1002/pro.3752. Epub 2019 Nov 11.

PMID:
31622516
9.

NPY2 Receptors Reduce Tonic Action Potential-Independent GABAB Currents in the Basolateral Amygdala.

Mackay JP, Bompolaki M, DeJoseph MR, Michaelson SD, Urban JH, Colmers WF.

J Neurosci. 2019 Jun 19;39(25):4909-4930. doi: 10.1523/JNEUROSCI.2226-18.2019. Epub 2019 Apr 10.

10.

The uncharacterized bacterial protein YejG has the same architecture as domain III of elongation factor G.

Mohanty B, Hanson-Manful P, Finn TJ, Chambers CR, McKellar JLO, Macindoe I, Helder S, Setiyaputra S, Zhong Y, Mackay JP, Patrick WM.

Proteins. 2019 Aug;87(8):699-705. doi: 10.1002/prot.25687. Epub 2019 Apr 22.

PMID:
30958578
11.

The stoichiometry and interactome of the Nucleosome Remodeling and Deacetylase (NuRD) complex are conserved across multiple cell lines.

Sharifi Tabar M, Mackay JP, Low JKK.

FEBS J. 2019 Jun;286(11):2043-2061. doi: 10.1111/febs.14800. Epub 2019 Mar 19.

PMID:
30828972
12.

Exploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design.

De Franco S, Vandenameele J, Brans A, Verlaine O, Bendak K, Damblon C, Matagne A, Segal DJ, Galleni M, Mackay JP, Vandevenne M.

Sci Rep. 2019 Feb 21;9(1):2484. doi: 10.1038/s41598-019-38655-y.

13.

A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence.

Lu B, Klingbeil O, Tarumoto Y, Somerville TDD, Huang YH, Wei Y, Wai DC, Low JKK, Milazzo JP, Wu XS, Cao Z, Yan X, Demerdash OE, Huang G, Mackay JP, Kinney JB, Shi J, Vakoc CR.

Cancer Cell. 2018 Dec 10;34(6):970-981.e8. doi: 10.1016/j.ccell.2018.10.015. Epub 2018 Nov 29.

14.

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.

Link S, Spitzer RMM, Sana M, Torrado M, Völker-Albert MC, Keilhauer EC, Burgold T, Pünzeler S, Low JKK, Lindström I, Nist A, Regnard C, Stiewe T, Hendrich B, Imhof A, Mann M, Mackay JP, Bartkuhn M, Hake SB.

Nat Commun. 2018 Oct 16;9(1):4300. doi: 10.1038/s41467-018-06665-5.

15.

Expression, purification and DNA-binding properties of zinc finger domains of DOF proteins from Arabidopsis thaliana.

Moghaddas Sani H, Hamzeh-Mivehroud M, Silva AP, Walshe JL, Mohammadi SA, Rahbar-Shahrouziasl M, Abbasi M, Jamshidi O, Low JK, Dastmalchi S, Mackay JP.

Bioimpacts. 2018;8(3):167-176. doi: 10.15171/bi.2018.19. Epub 2018 Jan 28.

16.

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease.

Schmidt ME, Buren C, Mackay JP, Cheung D, Dal Cengio L, Raymond LA, Hayden MR.

BMC Biol. 2018 Jun 27;16(1):58. doi: 10.1186/s12915-018-0526-3.

17.

NPY Induces Stress Resilience via Downregulation of Ih in Principal Neurons of Rat Basolateral Amygdala.

Silveira Villarroel H, Bompolaki M, Mackay JP, Miranda Tapia AP, Michaelson SD, Leitermann RJ, Marr RA, Urban JH, Colmers WF.

J Neurosci. 2018 May 9;38(19):4505-4520. doi: 10.1523/JNEUROSCI.3528-17.2018. Epub 2018 Apr 12.

18.

The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.

Wai DCC, Szyszka TN, Campbell AE, Kwong C, Wilkinson-White LE, Silva APG, Low JKK, Kwan AH, Gamsjaeger R, Chalmers JD, Patrick WM, Lu B, Vakoc CR, Blobel GA, Mackay JP.

J Biol Chem. 2018 May 11;293(19):7160-7175. doi: 10.1074/jbc.RA117.000678. Epub 2018 Mar 22.

19.

Cause or compensation?-Altered neuronal Ca2+ handling in Huntington's disease.

Mackay JP, Nassrallah WB, Raymond LA.

CNS Neurosci Ther. 2018 Apr;24(4):301-310. doi: 10.1111/cns.12817. Epub 2018 Feb 9. Review.

20.

Refinement of the subunit interaction network within the nucleosome remodelling and deacetylase (NuRD) complex.

Torrado M, Low JKK, Silva APG, Schmidberger JW, Sana M, Sharifi Tabar M, Isilak ME, Winning CS, Kwong C, Bedward MJ, Sperlazza MJ, Williams DC Jr, Shepherd NE, Mackay JP.

FEBS J. 2017 Dec;284(24):4216-4232. doi: 10.1111/febs.14301. Epub 2017 Nov 13.

21.

IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model.

Li C, Lev S, Desmarini D, Kaufman-Francis K, Saiardi A, Silva APG, Mackay JP, Thompson PE, Sorrell TC, Djordjevic JT.

Virulence. 2017 Nov 17;8(8):1833-1848. doi: 10.1080/21505594.2017.1385692. Epub 2017 Dec 8.

22.

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.

O'Geen H, Ren C, Nicolet CM, Perez AA, Halmai J, Le VM, Mackay JP, Farnham PJ, Segal DJ.

Nucleic Acids Res. 2017 Sep 29;45(17):9901-9916. doi: 10.1093/nar/gkx578.

23.

Arabinosylation Modulates the Growth-Regulating Activity of the Peptide Hormone CLE40a from Soybean.

Corcilius L, Hastwell AH, Zhang M, Williams J, Mackay JP, Gresshoff PM, Ferguson BJ, Payne RJ.

Cell Chem Biol. 2017 Nov 16;24(11):1347-1355.e7. doi: 10.1016/j.chembiol.2017.08.014. Epub 2017 Sep 21.

24.

Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P.

Zhang X, Farah N, Rolston L, Ericsson DJ, Catanzariti AM, Bernoux M, Ve T, Bendak K, Chen C, Mackay JP, Lawrence GJ, Hardham A, Ellis JG, Williams SJ, Dodds PN, Jones DA, Kobe B.

Mol Plant Pathol. 2018 May;19(5):1196-1209. doi: 10.1111/mpp.12597. Epub 2017 Nov 16.

25.

Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability.

Gillinder KR, Ilsley MD, Nébor D, Sachidanandam R, Lajoie M, Magor GW, Tallack MR, Bailey T, Landsberg MJ, Mackay JP, Parker MW, Miles LA, Graber JH, Peters LL, Bieker JJ, Perkins AC.

Nucleic Acids Res. 2017 Feb 17;45(3):1130-1143. doi: 10.1093/nar/gkw1014.

26.

Whaddaya Know: A Guide to Uncertainty and Subjectivity in Structural Biology.

Mackay JP, Landsberg MJ, Whitten AE, Bond CS.

Trends Biochem Sci. 2017 Feb;42(2):155-167. doi: 10.1016/j.tibs.2016.11.002. Epub 2017 Jan 12. Review.

PMID:
28089412
27.

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice.

Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay JP, Poljak A, Delerue F, Ke YD, Ittner LM.

Science. 2016 Nov 18;354(6314):904-908.

PMID:
27856911
28.

The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity.

Wai DC, Shihab M, Low JK, Mackay JP.

Nucleic Acids Res. 2016 Nov 2;44(19):9153-9165. Epub 2016 Jul 1.

29.

The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain.

Mohanty B, Helder S, Silva AP, Mackay JP, Ryan DP.

J Mol Biol. 2016 Oct 23;428(21):4298-4314. doi: 10.1016/j.jmb.2016.08.028. Epub 2016 Aug 31.

PMID:
27591891
30.

The yeast transcription elongation factor Spt4/5 is a sequence-specific RNA binding protein.

Blythe AJ, Yazar-Klosinski B, Webster MW, Chen E, Vandevenne M, Bendak K, Mackay JP, Hartzog GA, Vrielink A.

Protein Sci. 2016 Sep;25(9):1710-21. doi: 10.1002/pro.2976. Epub 2016 Jul 15.

31.

Determinants of affinity and specificity in RNA-binding proteins.

Helder S, Blythe AJ, Bond CS, Mackay JP.

Curr Opin Struct Biol. 2016 Jun;38:83-91. doi: 10.1016/j.sbi.2016.05.005. Epub 2016 Jun 14. Review.

PMID:
27315040
32.

CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex.

Low JK, Webb SR, Silva AP, Saathoff H, Ryan DP, Torrado M, Brofelth M, Parker BL, Shepherd NE, Mackay JP.

J Biol Chem. 2016 Jul 22;291(30):15853-66. doi: 10.1074/jbc.M115.707018. Epub 2016 May 27.

33.

The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7.

Schmidberger JW, Sharifi Tabar M, Torrado M, Silva AP, Landsberg MJ, Brillault L, AlQarni S, Zeng YC, Parker BL, Low JK, Mackay JP.

Protein Sci. 2016 Aug;25(8):1472-82. doi: 10.1002/pro.2943. Epub 2016 May 18.

34.

The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.

Zangrandi L, Burtscher J, MacKay JP, Colmers WF, Schwarzer C.

Br J Pharmacol. 2016 Jun;173(11):1756-67. doi: 10.1111/bph.13474. Epub 2016 Apr 21.

35.

The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements.

Luo L, Xue J, Kwan A, Gamsjaeger R, Wielens J, von Kleist L, Cubeddu L, Guo Z, Stow JL, Parker MW, Mackay JP, Robinson PJ.

J Biol Chem. 2016 Apr 29;291(18):9411-24. doi: 10.1074/jbc.M115.703108. Epub 2016 Feb 18.

36.

The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).

Silva AP, Ryan DP, Galanty Y, Low JK, Vandevenne M, Jackson SP, Mackay JP.

J Biol Chem. 2016 Jan 8;291(2):924-38. doi: 10.1074/jbc.M115.683227. Epub 2015 Nov 12.

37.

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.

38.

Paris-Trousseau thrombocytopenia is phenocopied by the autosomal recessive inheritance of a DNA-binding domain mutation in FLI1.

Stevenson WS, Rabbolini DJ, Beutler L, Chen Q, Gabrielli S, Mackay JP, Brighton TA, Ward CM, Morel-Kopp MC.

Blood. 2015 Oct 22;126(17):2027-30. doi: 10.1182/blood-2015-06-650887. Epub 2015 Aug 27.

PMID:
26316623
39.

1H, 13C and 15N resonance assignments of a C-terminal domain of human CHD1.

Mohanty B, Silva AP, Mackay JP, Ryan DP.

Biomol NMR Assign. 2016 Apr;10(1):31-4. doi: 10.1007/s12104-015-9631-1. Epub 2015 Aug 19.

PMID:
26286320
40.

A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells.

Saathoff H, Brofelth M, Trinh A, Parker BL, Ryan DP, Low JK, Webb SR, Silva AP, Mackay JP, Shepherd NE.

Bioorg Med Chem. 2015 Mar 1;23(5):960-5. doi: 10.1016/j.bmc.2015.01.023. Epub 2015 Jan 22.

41.

Ca2+-induced PRE-NMR changes in the troponin complex reveal the possessive nature of the cardiac isoform for its regulatory switch.

Cordina NM, Liew CK, Potluri PR, Curmi PM, Fajer PG, Logan TM, Mackay JP, Brown LJ.

PLoS One. 2014 Nov 13;9(11):e112976. doi: 10.1371/journal.pone.0112976. eCollection 2014.

42.

The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.

Joseph S, Kwan AH, Stokes PH, Mackay JP, Cubeddu L, Matthews JM.

PLoS One. 2014 Oct 13;9(10):e109108. doi: 10.1371/journal.pone.0109108. eCollection 2014.

43.

Trim58 degrades Dynein and regulates terminal erythropoiesis.

Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva AP, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur EL, Weiss MJ.

Dev Cell. 2014 Sep 29;30(6):688-700. doi: 10.1016/j.devcel.2014.07.021. Epub 2014 Sep 18.

44.

The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.

Clifton MK, Westman BJ, Thong SY, O'Connell MR, Webster MW, Shepherd NE, Quinlan KG, Crossley M, Blobel GA, Mackay JP.

PLoS One. 2014 Aug 27;9(8):e106011. doi: 10.1371/journal.pone.0106011. eCollection 2014.

45.

Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA.

Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP.

Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7848-52. doi: 10.1002/anie.201402980. Epub 2014 Jul 9.

46.

Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex.

Alqarni SS, Murthy A, Zhang W, Przewloka MR, Silva AP, Watson AA, Lejon S, Pei XY, Smits AH, Kloet SL, Wang H, Shepherd NE, Stokes PH, Blobel GA, Vermeulen M, Glover DM, Mackay JP, Laue ED.

J Biol Chem. 2014 Aug 8;289(32):21844-55. doi: 10.1074/jbc.M114.558940. Epub 2014 Jun 11.

47.

Ubiquitin fusion constructs allow the expression and purification of multi-KOW domain complexes of the Saccharomyces cerevisiae transcription elongation factor Spt4/5.

Blythe A, Gunasekara S, Walshe J, Mackay JP, Hartzog GA, Vrielink A.

Protein Expr Purif. 2014 Aug;100:54-60. doi: 10.1016/j.pep.2014.05.005. Epub 2014 May 21.

PMID:
24859675
48.

Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus.

Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, Mackay JP, Clubb RT, Guss JM, Gell DA.

J Biol Chem. 2014 Mar 7;289(10):6728-38. doi: 10.1074/jbc.M113.545566. Epub 2014 Jan 14.

49.

A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers.

Gamsjaeger R, O'Connell MR, Cubeddu L, Shepherd NE, Lowry JA, Kwan AH, Vandevenne M, Swanton MK, Matthews JM, Mackay JP.

J Biol Chem. 2013 Dec 6;288(49):35180-91. doi: 10.1074/jbc.M113.482075. Epub 2013 Oct 6.

50.

Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?

Mackay JP, Segal DJ, Crossley M.

Trends Biochem Sci. 2013 Sep;38(9):421-2. doi: 10.1016/j.tibs.2013.06.005. No abstract available.

PMID:
23992945

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