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Items: 1 to 50 of 171

1.

Expression, purification and DNA-binding properties of zinc finger domains of DOF proteins from Arabidopsis thaliana.

Moghaddas Sani H, Hamzeh-Mivehroud M, Silva AP, Walshe JL, Mohammadi SA, Rahbar-Shahrouziasl M, Abbasi M, Jamshidi O, Low JK, Dastmalchi S, Mackay JP.

Bioimpacts. 2018;8(3):167-176. doi: 10.15171/bi.2018.19. Epub 2018 Jan 28.

2.

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease.

Schmidt ME, Buren C, Mackay JP, Cheung D, Dal Cengio L, Raymond LA, Hayden MR.

BMC Biol. 2018 Jun 27;16(1):58. doi: 10.1186/s12915-018-0526-3.

3.

NPY Induces Stress Resilience via Downregulation of Ih in Principal Neurons of Rat Basolateral Amygdala.

Silveira Villarroel H, Bompolaki M, Mackay JP, Miranda Tapia AP, Michaelson SD, Leitermann RJ, Marr RA, Urban JH, Colmers WF.

J Neurosci. 2018 May 9;38(19):4505-4520. doi: 10.1523/JNEUROSCI.3528-17.2018. Epub 2018 Apr 12.

PMID:
29650696
4.

The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.

Wai DCC, Szyszka TN, Campbell AE, Kwong C, Wilkinson-White LE, Silva APG, Low JKK, Kwan AH, Gamsjaeger R, Chalmers JD, Patrick WM, Lu B, Vakoc CR, Blobel GA, Mackay JP.

J Biol Chem. 2018 May 11;293(19):7160-7175. doi: 10.1074/jbc.RA117.000678. Epub 2018 Mar 22.

PMID:
29567837
5.

Cause or compensation?-Altered neuronal Ca2+ handling in Huntington's disease.

Mackay JP, Nassrallah WB, Raymond LA.

CNS Neurosci Ther. 2018 Apr;24(4):301-310. doi: 10.1111/cns.12817. Epub 2018 Feb 9. Review.

PMID:
29427371
6.

Refinement of the subunit interaction network within the nucleosome remodelling and deacetylase (NuRD) complex.

Torrado M, Low JKK, Silva APG, Schmidberger JW, Sana M, Sharifi Tabar M, Isilak ME, Winning CS, Kwong C, Bedward MJ, Sperlazza MJ, Williams DC Jr, Shepherd NE, Mackay JP.

FEBS J. 2017 Dec;284(24):4216-4232. doi: 10.1111/febs.14301. Epub 2017 Nov 13.

PMID:
29063705
7.

IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model.

Li C, Lev S, Desmarini D, Kaufman-Francis K, Saiardi A, Silva APG, Mackay JP, Thompson PE, Sorrell TC, Djordjevic JT.

Virulence. 2017 Nov 17;8(8):1833-1848. doi: 10.1080/21505594.2017.1385692. Epub 2017 Dec 8.

PMID:
28976803
8.

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.

O'Geen H, Ren C, Nicolet CM, Perez AA, Halmai J, Le VM, Mackay JP, Farnham PJ, Segal DJ.

Nucleic Acids Res. 2017 Sep 29;45(17):9901-9916. doi: 10.1093/nar/gkx578.

9.

Arabinosylation Modulates the Growth-Regulating Activity of the Peptide Hormone CLE40a from Soybean.

Corcilius L, Hastwell AH, Zhang M, Williams J, Mackay JP, Gresshoff PM, Ferguson BJ, Payne RJ.

Cell Chem Biol. 2017 Nov 16;24(11):1347-1355.e7. doi: 10.1016/j.chembiol.2017.08.014. Epub 2017 Sep 21.

PMID:
28943356
10.

Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P.

Zhang X, Farah N, Rolston L, Ericsson DJ, Catanzariti AM, Bernoux M, Ve T, Bendak K, Chen C, Mackay JP, Lawrence GJ, Hardham A, Ellis JG, Williams SJ, Dodds PN, Jones DA, Kobe B.

Mol Plant Pathol. 2018 May;19(5):1196-1209. doi: 10.1111/mpp.12597. Epub 2017 Nov 16.

PMID:
28817232
11.

Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability.

Gillinder KR, Ilsley MD, Nébor D, Sachidanandam R, Lajoie M, Magor GW, Tallack MR, Bailey T, Landsberg MJ, Mackay JP, Parker MW, Miles LA, Graber JH, Peters LL, Bieker JJ, Perkins AC.

Nucleic Acids Res. 2017 Feb 17;45(3):1130-1143. doi: 10.1093/nar/gkw1014.

12.

Whaddaya Know: A Guide to Uncertainty and Subjectivity in Structural Biology.

Mackay JP, Landsberg MJ, Whitten AE, Bond CS.

Trends Biochem Sci. 2017 Feb;42(2):155-167. doi: 10.1016/j.tibs.2016.11.002. Epub 2017 Jan 12. Review.

PMID:
28089412
13.

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice.

Ittner A, Chua SW, Bertz J, Volkerling A, van der Hoven J, Gladbach A, Przybyla M, Bi M, van Hummel A, Stevens CH, Ippati S, Suh LS, Macmillan A, Sutherland G, Kril JJ, Silva AP, Mackay JP, Poljak A, Delerue F, Ke YD, Ittner LM.

Science. 2016 Nov 18;354(6314):904-908.

PMID:
27856911
14.

The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity.

Wai DC, Shihab M, Low JK, Mackay JP.

Nucleic Acids Res. 2016 Nov 2;44(19):9153-9165. Epub 2016 Jul 1.

15.

The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain.

Mohanty B, Helder S, Silva AP, Mackay JP, Ryan DP.

J Mol Biol. 2016 Oct 23;428(21):4298-4314. doi: 10.1016/j.jmb.2016.08.028. Epub 2016 Aug 31.

PMID:
27591891
16.

The yeast transcription elongation factor Spt4/5 is a sequence-specific RNA binding protein.

Blythe AJ, Yazar-Klosinski B, Webster MW, Chen E, Vandevenne M, Bendak K, Mackay JP, Hartzog GA, Vrielink A.

Protein Sci. 2016 Sep;25(9):1710-21. doi: 10.1002/pro.2976. Epub 2016 Jul 15.

17.

Determinants of affinity and specificity in RNA-binding proteins.

Helder S, Blythe AJ, Bond CS, Mackay JP.

Curr Opin Struct Biol. 2016 Jun;38:83-91. doi: 10.1016/j.sbi.2016.05.005. Epub 2016 Jun 14. Review.

PMID:
27315040
18.

CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex.

Low JK, Webb SR, Silva AP, Saathoff H, Ryan DP, Torrado M, Brofelth M, Parker BL, Shepherd NE, Mackay JP.

J Biol Chem. 2016 Jul 22;291(30):15853-66. doi: 10.1074/jbc.M115.707018. Epub 2016 May 27.

19.

The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7.

Schmidberger JW, Sharifi Tabar M, Torrado M, Silva AP, Landsberg MJ, Brillault L, AlQarni S, Zeng YC, Parker BL, Low JK, Mackay JP.

Protein Sci. 2016 Aug;25(8):1472-82. doi: 10.1002/pro.2943. Epub 2016 May 18.

20.

The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.

Zangrandi L, Burtscher J, MacKay JP, Colmers WF, Schwarzer C.

Br J Pharmacol. 2016 Jun;173(11):1756-67. doi: 10.1111/bph.13474. Epub 2016 Apr 21.

21.

The Binding of Syndapin SH3 Domain to Dynamin Proline-rich Domain Involves Short and Long Distance Elements.

Luo L, Xue J, Kwan A, Gamsjaeger R, Wielens J, von Kleist L, Cubeddu L, Guo Z, Stow JL, Parker MW, Mackay JP, Robinson PJ.

J Biol Chem. 2016 Apr 29;291(18):9411-24. doi: 10.1074/jbc.M115.703108. Epub 2016 Feb 18.

22.

The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose).

Silva AP, Ryan DP, Galanty Y, Low JK, Vandevenne M, Jackson SP, Mackay JP.

J Biol Chem. 2016 Jan 8;291(2):924-38. doi: 10.1074/jbc.M115.683227. Epub 2015 Nov 12.

23.

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.

24.

Paris-Trousseau thrombocytopenia is phenocopied by the autosomal recessive inheritance of a DNA-binding domain mutation in FLI1.

Stevenson WS, Rabbolini DJ, Beutler L, Chen Q, Gabrielli S, Mackay JP, Brighton TA, Ward CM, Morel-Kopp MC.

Blood. 2015 Oct 22;126(17):2027-30. doi: 10.1182/blood-2015-06-650887. Epub 2015 Aug 27.

25.

1H, 13C and 15N resonance assignments of a C-terminal domain of human CHD1.

Mohanty B, Silva AP, Mackay JP, Ryan DP.

Biomol NMR Assign. 2016 Apr;10(1):31-4. doi: 10.1007/s12104-015-9631-1. Epub 2015 Aug 19.

PMID:
26286320
26.

A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells.

Saathoff H, Brofelth M, Trinh A, Parker BL, Ryan DP, Low JK, Webb SR, Silva AP, Mackay JP, Shepherd NE.

Bioorg Med Chem. 2015 Mar 1;23(5):960-5. doi: 10.1016/j.bmc.2015.01.023. Epub 2015 Jan 22.

27.

Ca2+-induced PRE-NMR changes in the troponin complex reveal the possessive nature of the cardiac isoform for its regulatory switch.

Cordina NM, Liew CK, Potluri PR, Curmi PM, Fajer PG, Logan TM, Mackay JP, Brown LJ.

PLoS One. 2014 Nov 13;9(11):e112976. doi: 10.1371/journal.pone.0112976. eCollection 2014.

28.

The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.

Joseph S, Kwan AH, Stokes PH, Mackay JP, Cubeddu L, Matthews JM.

PLoS One. 2014 Oct 13;9(10):e109108. doi: 10.1371/journal.pone.0109108. eCollection 2014.

29.

Trim58 degrades Dynein and regulates terminal erythropoiesis.

Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva AP, Prabhu D, Yao Y, Aribeana C, Fuchs SY, Mackay JP, Holzbaur EL, Weiss MJ.

Dev Cell. 2014 Sep 29;30(6):688-700. doi: 10.1016/j.devcel.2014.07.021. Epub 2014 Sep 18.

30.

The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins.

Clifton MK, Westman BJ, Thong SY, O'Connell MR, Webster MW, Shepherd NE, Quinlan KG, Crossley M, Blobel GA, Mackay JP.

PLoS One. 2014 Aug 27;9(8):e106011. doi: 10.1371/journal.pone.0106011. eCollection 2014.

31.

Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA.

Vandevenne M, O'Connell MR, Helder S, Shepherd NE, Matthews JM, Kwan AH, Segal DJ, Mackay JP.

Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7848-52. doi: 10.1002/anie.201402980. Epub 2014 Jul 9.

32.

Insight into the architecture of the NuRD complex: structure of the RbAp48-MTA1 subcomplex.

Alqarni SS, Murthy A, Zhang W, Przewloka MR, Silva AP, Watson AA, Lejon S, Pei XY, Smits AH, Kloet SL, Wang H, Shepherd NE, Stokes PH, Blobel GA, Vermeulen M, Glover DM, Mackay JP, Laue ED.

J Biol Chem. 2014 Aug 8;289(32):21844-55. doi: 10.1074/jbc.M114.558940. Epub 2014 Jun 11.

33.

Ubiquitin fusion constructs allow the expression and purification of multi-KOW domain complexes of the Saccharomyces cerevisiae transcription elongation factor Spt4/5.

Blythe A, Gunasekara S, Walshe J, Mackay JP, Hartzog GA, Vrielink A.

Protein Expr Purif. 2014 Aug;100:54-60. doi: 10.1016/j.pep.2014.05.005. Epub 2014 May 21.

PMID:
24859675
34.

Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus.

Dickson CF, Kumar KK, Jacques DA, Malmirchegini GR, Spirig T, Mackay JP, Clubb RT, Guss JM, Gell DA.

J Biol Chem. 2014 Mar 7;289(10):6728-38. doi: 10.1074/jbc.M113.545566. Epub 2014 Jan 14.

35.

A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers.

Gamsjaeger R, O'Connell MR, Cubeddu L, Shepherd NE, Lowry JA, Kwan AH, Vandevenne M, Swanton MK, Matthews JM, Mackay JP.

J Biol Chem. 2013 Dec 6;288(49):35180-91. doi: 10.1074/jbc.M113.482075. Epub 2013 Oct 6.

36.

Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?

Mackay JP, Segal DJ, Crossley M.

Trends Biochem Sci. 2013 Sep;38(9):421-2. doi: 10.1016/j.tibs.2013.06.005. No abstract available.

PMID:
23992945
37.

Semiquantitative and quantitative analysis of protein-DNA interactions using steady-state measurements in surface plasmon resonance competition experiments.

Gamsjaeger R, Kariawasam R, Bang LH, Touma C, Nguyen CD, Matthews JM, Cubeddu L, Mackay JP.

Anal Biochem. 2013 Sep 15;440(2):178-85. doi: 10.1016/j.ab.2013.04.030. Epub 2013 May 31.

PMID:
23727560
38.

Analysis of disease-causing GATA1 mutations in murine gene complementation systems.

Campbell AE, Wilkinson-White L, Mackay JP, Matthews JM, Blobel GA.

Blood. 2013 Jun 27;121(26):5218-27. doi: 10.1182/blood-2013-03-488080. Epub 2013 May 23.

39.

α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond.

Dickson CF, Rich AM, D'Avigdor WM, Collins DA, Lowry JA, Mollan TL, Khandros E, Olson JS, Weiss MJ, Mackay JP, Lay PA, Gell DA.

J Biol Chem. 2013 Jul 5;288(27):19986-20001. doi: 10.1074/jbc.M112.437509. Epub 2013 May 21.

40.

New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217.

Vandevenne M, Jacques DA, Artuz C, Nguyen CD, Kwan AH, Segal DJ, Matthews JM, Crossley M, Guss JM, Mackay JP.

J Biol Chem. 2013 Apr 12;288(15):10616-27. doi: 10.1074/jbc.M112.441451. Epub 2013 Feb 22.

41.

Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C.

Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, Brown LJ.

Biochemistry. 2013 Mar 19;52(11):1950-62. doi: 10.1021/bi4000172. Epub 2013 Mar 6.

PMID:
23425245
42.

¹H, ¹³C and ¹⁵N resonance assignments of an N-terminal domain of CHD4.

Silva AP, Kwan AH, Mackay JP.

Biomol NMR Assign. 2014 Apr;8(1):137-9. doi: 10.1007/s12104-013-9469-3. Epub 2013 Feb 17.

PMID:
23417793
43.

Backbone and side-chain assignments of a tethered complex between LMO4 and DEAF-1.

Joseph S, Kwan AH, Mackay JP, Cubeddu L, Matthews JM.

Biomol NMR Assign. 2014 Apr;8(1):141-4. doi: 10.1007/s12104-013-9470-x. Epub 2013 Feb 16.

PMID:
23417771
44.

Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.

Stokes PH, Liew CW, Kwan AH, Foo P, Barker HE, Djamirze A, O'Reilly V, Visvader JE, Mackay JP, Matthews JM.

J Mol Biol. 2013 Apr 12;425(7):1101-10. doi: 10.1016/j.jmb.2013.01.017. Epub 2013 Jan 23.

PMID:
23353824
45.

The detection and quantitation of protein oligomerization.

Gell DA, Grant RP, Mackay JP.

Adv Exp Med Biol. 2012;747:19-41. doi: 10.1007/978-1-4614-3229-6_2. Review.

PMID:
22949109
46.

Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex.

Dastmalchi S, Wilkinson-White L, Kwan AH, Gamsjaeger R, Mackay JP, Matthews JM.

Protein Sci. 2012 Nov;21(11):1768-74. doi: 10.1002/pro.2153. Epub 2012 Sep 25.

47.

Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

Bhati M, Lee C, Gadd MS, Jeffries CM, Kwan A, Whitten AE, Trewhella J, Mackay JP, Matthews JM.

PLoS One. 2012;7(7):e40719. doi: 10.1371/journal.pone.0040719. Epub 2012 Jul 25.

48.

Interdomain orientation of cardiac troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state.

Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, Brown LJ.

Protein Sci. 2012 Sep;21(9):1376-87. doi: 10.1002/pro.2124.

49.

Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA.

O'Connell MR, Vandevenne M, Nguyen CD, Matthews JM, Gamsjaeger R, Segal DJ, Mackay JP.

Angew Chem Int Ed Engl. 2012 May 29;51(22):5371-5. doi: 10.1002/anie.201200866. Epub 2012 Apr 19. No abstract available.

50.

A rapid method for assessing the RNA-binding potential of a protein.

Bendak K, Loughlin FE, Cheung V, O'Connell MR, Crossley M, Mackay JP.

Nucleic Acids Res. 2012 Aug;40(14):e105. doi: 10.1093/nar/gks285. Epub 2012 Apr 3.

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